• The Journal of Internal Korean Medicine
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• v.23 no.2
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• pp.274-279
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• 2002

The sick sinus syndrome refers to a combination of symptoms (dizziness, confusion, fatigue, syncope, and congestive heart failure) caused by sinus node dysfunction and marked sinus bradycardia, sinoarterial block, or sinus arrest. 'Abdominal pulsation' means a disagreeable symptom that is defined as sensation of beating at the abdomen. We experienced a 84 year-old female patient who had dizziness, fatigue, abdominal pulsation and frequent voiding. These symptoms were related to previous episodes and presumed sick sinus syndrome by symptoms, ECGs and 24 hrs of holter monitoring. In the point of Differentiation of Syndrome (辨證), this patient was diagnosed as 'Water retention(水氣)' and was administered with Yeonggyechulgam-tang(岺桂朮甘湯). After the treatment, abdominal pulsation (frequency) and dizziness (VAS) were improved. Futhermore, the interval of voiding was longer and each volume of urination increased.

• Korean Journal of Head & Neck Oncology
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• v.16 no.2
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• pp.212-215
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• 2000

Background and Objective: Kikuchi's disease(KD) is an idiopathic, self-limited lymphadenopathy that was described as a distinctive type of necrotizing lymphadenitis affecting primarily cervical lymph nodes of young adults independently by Kikuchi and Fujimoto et al at first in 1972. The purpose of this study is a knowledge about clinicopathologic findings, many laboratory tests and differentiation of KD from other lymphadenitis due to lymphoma, systemic lupus erythematosus(SLE) and many viral disease. Materials and Methods: Thirty-four case of KD collected at Chonnam University Hospital in Kwang-Ju from 1992 through 2000 were evaluated with retrospective chart review. Results: The patients were consisted of 11 men and 23 women. All patients had tender or nontender cervical mass and fever was the most common associated symptom. The others was pain, weight loss, chills, cold sweating and headache et al. Multiple bilateral involvement of cervical lymphnodes was 25 cases(74%) and solitary involvement was 9 cases(26%). In laboratory tests, leukopenia was 12 cases(75%), elevated ESR 5 cases (34%) and elevated LDH 11 cases(69%). Conclusion: KD is necessary to differentiate from lymphoma and SLE, because of the different of therapeutic modality and prognosis. The diagnosis is established on the basis of histopathologic studies with excisional biopsy of lymph node.

• Journal of Pharmacopuncture
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• v.17 no.3
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• pp.62-69
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• 2014

Objectives: The purpose of this study is to report a case series of advanced cancer patients whose cancer pain was relieved by using autonomic nerve pharmacopuncture (ANP) treatment. ANP is a subcutaneous injection therapy of mountain ginseng pharmacopuncture (MGP) along the acupoints on the spine (Hua-Tuo-Jia-Ji-Xue; 0.5 cun lateral to the lower border of the spinous processes of vertebrae) to enhance the immune system and to balance autonomic nerve function. Methods: Patients with three different types of cancer (gastric cancer, lung cancer, colon cancer with distant metastases) with cancer pain were treated with ANP. 1 mL of MGP was injected into the bilateral Hua-Tuo-Jia-Ji-Xue on the T1-L5 sites (total 12-20 mL injection) of each patient's dorsum by using the principle of symptom differentiation. During ANP treatment, the visual analogue scale (VAS) for pain was used to assess their levels of cancer pain; also, the dosage and the frequency of analgesic use were measured. Results: The cancer pain levels of all three patients improved with treatment using ANP. The VAS scores of the three patients decreased as the treatment progressed. The dosage and the frequency of analgesics also gradually decreased during the treatment period. Significantly, no related adverse events were found. Conclusion: ANP has shown benefit in controlling cancer pain for the three different types of cancer investigated in this study and in reducing the dosage and the frequency of analgesics. ANP is expected to be beneficial for reducing cancer pain and, thus, to be a promising new treatment for cancer pain.

• Korean Journal of Agricultural Science
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• v.44 no.2
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• pp.145-180
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• 2017

Alternanthera mosaic virus (AltMV) is a member of the genus Potexvirus which has been known for less than twenty years, and has been detected in Australasia, Europe, North and South America, and Asia. The natural host range to date includes species in at least twenty-four taxonomically diverse plant families, with species in at least four other families known to be infected experimentally. AltMV has been shown to differ from Potato virus X (PVX), the type member of the genus Potexvirus, in a number of ways, including the subcellular localization of the Triple Gene Block 3 (TGB3) protein and apparent absence of interactions between TGB3 and TGB2. Differences between AltMV variants have allowed identification of viral determinants of pathogenicity, and identification of residues involved in interactions with host proteins. Infectious clones of AltMV differing significantly in symptom severity and efficiency of RNA silencing suppression have been produced, suitable either for high level protein expression (with efficient RNA silencing suppression) or for Virus-Induced Gene Silencing (VIGS; with weaker RNA silencing suppression), demonstrating a range of utility not available with most other plant viral vectors. The difference in silencing suppression efficiency was shown to be due to a single amino acid residue substitution in TGB1, and to differences in subcellular localization of TGB1 to the nucleus and nucleolus. The current state of knowledge of AltMV biology, including host range, strain differentiation, host interactions, and utility as a plant viral vector for both protein expression and VIGS are summarized.

• Journal of Oriental Neuropsychiatry
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• v.11 no.2
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• pp.63-78
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• 2000

Headache is one of the most common medical complaints. It is not so easy to manage headache. especially if it is chronic although it seldom cause serious problem. There are many psychological factor known to induce, maintain an aggravate symptom in patients with chronic headache. The purpose of this study is to investigate clinical characteristics with ABR-2000 was carried out for 57 patients who had been suffered from headache for 6 months from march to August 2000.The results were as follows:1. According to the statics, on the whole woman's rate was higher than man's, and the mean duration of the headache was 8.06 years.2. Common associated symptoms were nausea. dyspepsia, dizziness, palpitation, fatigue, depression, etc.3. According to oriental medical differentiation of symptoms and signs, the rate of stagnation of the liver-qi's fire-transmission(肝變化火), deficiency of blood(血虛) and plegm syncope (痰厥), these three types were hghest.4. Result of analyzing ABR-2000 is that the rate of low response is higher than high response's on each item. But result of Graph A is that the rate of high response in higher than that of low response only in deficiency of Yin(陰虛) and the rate of high response in stagnation of the liver-qi's fire-transmission(肝變化火) and deficiency of blood (血虛) is comparatively high. Result of Graph R is that the rate of high response in wind-heat(風熱), deficiency of blood(血虛) and plegm syncope(痰厥) is comparatively higher than in others.

• Journal of Korean Neurosurgical Society
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• v.54 no.5
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• pp.390-398
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• 2013

Objective : We determined whether the relationship between the neuropsychological performance of patients with mild traumatic brain injury (TBI) and their psychopathological characteristics measured by disability evaluation are interrelated. In addition, we assessed which psychopathological variable was most influential on neuropsychological performance via statistical clustering of the same characteristics of mild TBI. Methods : A total of 219 disability evaluation participants with mild brain injury were selected. All participants were classified into three groups, based on their psychopathological characteristics, via a two-step cluster analysis using validity and clinical scales from the Minnesota Multiphasic Personality Inventory (MMPI) and Symptom Checklist-90-revised (SCL-90-R). The Korean Wechsler Adult Intelligence Scale (K-WAIS), Korean Memory Assessment Scale (K-MAS) and the Korean Boston Naming Test (K-BNT) were used to evaluate the neurocognitive functions of mild TBI patients. Results : Over a quarter (26.9%) experienced severe psychopathological symptoms and 43.4% experienced mild or moderate psychopathological symptoms, and all of the mild TBI patients showed a significant relationship between neurocognitive functions and subjective and/or objective psychopathic symptoms, but the degree of this relationship was moderate. Variances of neurocognitive function were explained by neurotic and psychotic symptoms, but the role of these factors were different to each other and participants did not show intelligence and other cognitive domain decrement except for global memory abilities compared to the non-psychopathology group. Conclusion : Certain patients with mild TBI showed psychopathological symptoms, but these were not directly related to cognitive decrement. Psychopathology and cognitive decrement are discrete aspects in patients with mild TBI. Furthermore, the neurotic symptoms of mild TBI patients made positive complements to decrements or impairments of neurocognitive functions, but the psychotic symptoms had a negative effect on neurocognitive functions.

• Journal of Physiology & Pathology in Korean Medicine
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• v.30 no.2
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• pp.124-130
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• 2016

The aim of this study was to suggest the future direction of diagnostic and evaluative pattern identification questionnaire (PIQ) by reviewing the state of development and utilization of PIQ according to Korean classification of disease-U (KCD-U). We surveyed the database of OASIS, NDSL, KISS, DBPIA, and Pub-med to know the kinds of developed and developing PIQ of Korean medicine. We used 'Pattern Identification' and 'Questionnaire' to find suitable papers. The inclusion criteria met 47 cases. The number of PIQ before 2000yrs, between 2001 to 2005, 2006-2010, 2011-2015 were 2, 5, 18, 22cases. The number of PIQ belonged to the disease of Korean medicine, the pathological symptom of korean medicine, the Sasang constitutional pattern identification and etc according to KCD-U were 20(42.6%), 8(17%), 9(19.1%) and 10(21.3%). Twenties among forty seven PIQ were validated, and the rest of them were not validated. The distribution of the numbers of PIQ were significantly different according to KCD-U (p=0.003). The direction of Utilization of PIQ was 36 questionnaires in diagnosing PI, 14 cases in evaluating health state, 4cases in evaluating effects of a treatment and 8 ones in diagnosing Sasang constitutional types. This study reveals the status on validated and non-validated PIQ of Korean medicine and suggests the basic information for the direction of developing PIQ in the future.

• The Journal of Korean Medicine
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• v.36 no.3
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• pp.53-64
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• 2015

Objectives: The aim of study was to develop a standard instrument of oriental medical evaluation lung cancer. Methods: For this study, the committee advisor was organized by 10 Korean Medicine professors of the Korean Association of Traditional Oncology. The items and structure of the instrument were quoted from the instrument of pattern identification for lung cancer. We had a consultation with the committee twice and took additional advice from it via E-mail. Results: According to the research, we determined the Korean oriental medical assessment tool for lung cancer comprised of the 6 types of patterns of syndrome differentiation. The advisor committee gave the answers about discrimination between bian-zheng and su-zheng, mean weight of each symptom and sign. The final weight was calculated from the combination of the ratio of bian-zheng and mean weight. Conclusions: The instrument of oriental medical evaluation for lung cancer was developed through experts' discussion. If the validity and the reliability of this instrument are validated through additional clinical trial, the instrument of oriental medical evaluation for lung cancer is expected to be applied to the later research.

• The Journal of Korean Medicine
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• v.17 no.1 s.31
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• pp.447-464
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• 1996

Hyperemesis gravidarum is one of the most common symptom in the early pregnancy and if it cause severe malnutrition by means of heavy vomiting as a basic sign of disease of pregnant syndrome, appropriate treatments are necessary. In the clinics the methods of treatment of hyperemesis gravidarum include herb-medication usually. But herb-medication therapy is rather difficult because during pregnancy it may cause vomiting by the smell and taste of herbs. So the author investigated the literatures referred to the external treatments of hyperemesis gravidarum excluding herb-medication and the results obtained here were as follows. 1. The external methods of treatment of hyperemesis gravidarum are various and include moxibustion, the method of applying drug at the umbilicus, ear-acupuncture method, pressure massage therapy, naso-spray method, acupoint injection, intervenous injection 2. Among the external methods of treatment of hyperemesis gravidarum , the method of applying drug at the umbilicus is most variable and almost all prescriptions use Zingiber officinalis Rose, characteristically. 3. Ear-pressure massage method to treat the hyperemesis gravidarum uses the car-acupoints of Gan, We, Shin-mun, Gyo-gam. 4. Among the external methods of treatment of hyperemesis gravidarum , moxibustion, pressure massage, and acupoint injection select frequently Nae-gwan(PC6), Chok-samni(ST36) and Chung-wan(CV12). 5. In the both the internal and external methods of treatment of hyperemesis gravidarum one have to differentiate syndromes in the viewpoint of oriental medicine and treat with the principls of treatment and prescriptions which are fit to each differentiation model under the principle of regulating the stomach and relieving vomiting.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.1
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• pp.1-7
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• 2011

The aim of the present study was to investigate the development of theory of the deficiency of yin-yang in the spleen-stomach(脾胃). The spleen-stomach theory is a very valuable composition of the oriental medicine. Its first theoretical basis was established by Li Dong Yuan(李東垣) who wrote Piweilun("脾胃論"). He insisted the importance of spleen yang(脾陽) which is the "postnatal base of life" by transforming and transporting of food essence and fluids and raises the clear. After him, his theory had influenced many descendant medical men. one of them, Ye Tian Shi(葉天士) found out the differences of between stomach and spleen. Especially he focused on the stomach yin(胃陰) which is easy to be exhausted by dry-fire(燥火). And he also made another remedy, "the stomach yang should be moved well(宣通胃陽)", which emphasize on that cold and stagnant cause the deficiency of the stomach yang. After that, spleen yin(脾陰) theory was set up by Tang Zong Hai(唐宗海). His spleen yin(脾陰) was deeply related with digestive enzymes and pancreas, because his theory was established by comparing oriental and western medicine. These four theories became the theoretical basis of the deficiency of yin-yang in the spleen-stomach(脾胃), and similar symptom of the spleen-stomach(脾胃) could be categorized according to the pattern identification(辨證) which was developed from these four theory.