• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.9A
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• pp.1285-1294
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• 1999

In this paper we consider the performance of TCP video traffic over ABR with Long-Range Dependent VBR traffic. As compressed coded video traffics are increasing rapidly over Internet, lots of studies are being done for transmitting those traffics efficiently using limited network resources. We consider here the transmitting video service over ABR service in ATM networks, especially satellite networks. CBR or VBR services are suggested in transmitting the video traffic in ATM Forum TM 4.0. But ABR service connection, which is considered as appropriate service for data traffic, can be established with a small amount of bandwidth, MCR (Minimum cell rate). Furthermore ABR service can control the source's transmitting rate using feedback mechanism. Using this feature ABR service can be used in some applications which can control their quality of services corresponding to network loads. Compressed video sources with MPEG-2 are used for Long-Range Dependent VBR traffic here. We model the compressed video source to resemble the MPEG-2 transport streams. These compressed video traffic streams are consisted of three different frames, I-frame, P-frame, and B-frame. So when a network are overloaded, we can control the quality of service using this traffic features. TCP Traffics over ABR need large buffers in ATM switch to satisfy their QoS with background VBR traffics, which have high deviations in bandwidth. Furthermore satellite ATM networks with large feedback delay need large buffers corresponding RTT delay. The performance comparisons among EFCI and ER switch (ERICA+) switches in the network circumstances described above were shown in this paper. We also considered the case with ON-OFF VBR traffics.

• Proceedings of the Korea Crystallographic Association Conference
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• 2003.05a
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• pp.18-18
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• 2003

Thioredoxin (Trx) is a small redox protein that is ubiquitously distributed from achaes to human. In diverse organisms, the protein is involved in various physiological roles by acting as electron donor and regulators of transcription and apoptosis as well as antioxidants. Sequences of Trx within various species are 27～69% identical to that of E. coli and all Trx proteins have the same overall fold, which consists of central five β strands surrounded by four α helices. The N-terminal cysteine in WCGPC motif of Trx is redox sensitive and the motif is highly conserved. Compared with general cysteine, the N-terminal cysteine has low pKa value. The result leads to increased reduction activity of protein. Recently, novel thio.edoxin-related protein (TRP14) was found from rat brain. TRP14 acts as disulfide reductase like Trx1, and its redox potential and pKa are similar to those of Trx1. However, TRP14 takes up electrons from cytosolic thioredoxin reductase (TrxR1), not from the mitochondrial thioredoxin reductase (TrxR2). Biological roles of TES14 were reported to be involved in regulating TNF-α induced signaling pathways in different manner with Trx1. In depletion experiments, depletion of TRP14 increased TNF-α induced phosphorylation and degradation of IκBα more than the depletion Trx1 did. It also facilitated activation of JNK and p38 MAP kinase induced by TNF-α. Unlike Trx1, TRP14 shows neither interaction nor interference with ASK1. Here, we determined three-dimensional crystal structure of TRP14 by MAD method at 1.8Å. The structure reveals that the conserved cis-Pro (Pro90) and active site-W-C-X-X-C motif, which may be involved in substrate recognition similar to Trx1 , are located at the beginning position of strand β4 and helix α2, respectively. The TRP14 structure also shows that surface of TRP14 in the vicinity of the active site, which is surrounded by an extended flexible loop and an additional short a helix, is different from that of Trx1. In addition, the structure exhibits that TRP14 interact with a distinct target proteins compared with Trx1 and the binding may depend mainly on hydrophobic and charge interactions. Consequently, the structure supports biological data that the TRP14 is involved in regulating TNF-α induced signaling pathways in different manner with Trx1.

• IMMUNE NETWORK
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• v.14 no.1
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• pp.21-29
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• 2014

Follicular helper T ($T_{FH}$) cells are recently highlighted as their crucial role for humoral immunity to infection as well as their abnormal control to induce autoimmune disease. During an infection, na$\ddot{i}$ve T cells are differentiating into $T_{FH}$ cells which mediate memory B cells and long-lived plasma cells in germinal center (GC). $T_{FH}$ cells are characterized by their expression of master regulator, Bcl-6, and chemokine receptor, CXCR5, which are essential for the migration of T cells into the B cell follicle. Within the follicle, crosstalk occurs between B cells and $T_{FH}$ cells, leading to class switch recombination and affinity maturation. Various signaling molecules, including cytokines, surface molecules, and transcription factors are involved in $T_{FH}$ cell differentiation. IL-6 and IL-21 cytokine-mediated STAT signaling pathways, including STAT1 and STAT3, are crucial for inducing Bcl-6 expression and $T_{FH}$ cell differentiation. $T_{FH}$ cells express important surface molecules such as ICOS, PD-1, IL-21, BTLA, SAP and CD40L for mediating the interaction between T and B cells. Recently, two types of microRNA (miRNA) were found to be involved in the regulation of $T_{FH}$ cells. The miR-17-92 cluster induces Bcl-6 and $T_{FH}$ cell differentiation, whereas miR-10a negatively regulates Bcl-6 expression in T cells. In addition, follicular regulatory T ($T_{FR}$) cells are studied as thymus-derived $CXCR5^+PD-1^+Foxp3^+\;T_{reg}$ cells that play a significant role in limiting the GC response. Regulation of $T_{FH}$ cell differentiation and the GC reaction via miRNA and $T_{FR}$ cells could be important regulatory mechanisms for maintaining immune tolerance and preventing autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Here, we review recent studies on the various factors that affect $T_{FH}$ cell differentiation, and the role of $T_{FH}$ cells in autoimmune diseases.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.49 no.12
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• pp.1019-1025
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• 2021

In nearly all space environments, the solar cell degradation is dominated by protons[1]. Even through a GEO orbit lines in the electron radiation belts, the protons emitted from any solar event will still dominate the degradation[1]. Since COMS launch on June 26 2010, the proton events with the fluence of more than approximately 30 times the average level of perennial observations were observed between January 23 - 29 2012 and March 07 - 14 2012[16]. This paper studies the solar cell degradation by solar proton events in January and March 2012 for the open circuit voltage(Voc) of a witness cell and the short circuit current(Isc) of a section connected to a shunt switch. To evaluate the performance of solar cell, the flight data of voltage and current are corrected to the temperature, the Earth-Sun distance and the Sun angle and then compare with the solar cell characteristics at BOL. The Voc voltage dropped about 23.6mV compare after the March 2012 proton events to before the January 2012 proton events. The Voc voltage dropped less than 1% at BOL, which is 2575mV. The Isc current decreased negligible, as expected, in the March 2012 proton events.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.21 no.6
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• pp.117-125
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• 2007

Recently, a fuel cell with low voltage and high current output characteristics is remarkable for new generation system. It needs both a DC-DC step-up converter and DC-AC inverter to be used in fuel cell generation system. Therefor, this paper, consists of an isolated DC-DC converter to boost the fuel cell voltage 380[VDC] and a PWM inverter with LC filter to convent the DC voltage to single-phase 220[VAC]. Expressly, The fuel cell system which it proposes DC-DC the efficient converter used PWM the phase transient control law and it depended to portion resonance ZVS switching, loss peek voltage and electric current of realization under make schedule, switching frequency anger and the switch reduction. And mind benevolence it sprouted 2 in stop circuit and it added and a direct current voltage and the electric current where the ingredient is reduced in load side ripple stable under make whom it will be able to supply. Besides the efficiency of 92[%]is obtained over the wide output voltage regulation ranges and load variations. Also, under make over together the result leads simulation and test, the propriety confirmation.

• Transactions of the Korean hydrogen and new energy society
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• v.24 no.3
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• pp.223-229
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• 2013

Polymer Electrolyte Membrane Fuel Cell (PEMFC) is a power generation system to convert chemical energy of fuels and oxidants to electricity directly by electrochemical reactions. As a catalyst support for PEMFCs, carbon black has been generally used due to its large surface area and high electrical conductivity. However, under certain circumstances (start up/shut down, fuel starvation, ice formation etc.), carbon supports are subjected to serve corrosion in the presence of water. Therefore, it would be desirable to switch carbon supports to corrosion-resistive support materials such as metal oxide. $TiO_2$ has been attractive as a support with its stability in fuel cell operation atmosphere, low cost, commercial availability, and the ease to control size and structure. However, low electrical conductivity of $TiO_2$ still inhibits its application to catalyst support for PEMFCs. In this paper, to explore feasibility of $TiO_2$ as a catalyst support for PEMFCs, $TiO_2$ nanofibers were synthesized by electrospinning and calcinated at 600, 700, 800 and $900^{\circ}C$. Effects of calcination temperature on crystal structure and electrical conductivity of electrospun $TiO_2$ nanofibers were examined. Electrical conductivity of $TiO_2$ nanofibers increased significantly with increasing calcination temperature from $600^{\circ}C$ to $700^{\circ}C$ and then increased gradually with increasing the calcination temperature from $700^{\circ}C$ to $900^{\circ}C$. It was revealed that the remarkable increase in electrical conductivity could be attributed to phase transition of $TiO_2$ nanofibers from anatase to rutile at the temperature range from $600^{\circ}C$ to $700^{\circ}C$.

• The KIPS Transactions:PartC
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• v.13C no.7 s.110
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• pp.889-896
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• 2006

ATM Forum has defined a guaranteed frame rate (GFR) service to serve Internet traffic efficiently. The GFR service provides virtual connections (VCs) for minimum cell rate (MCR) guarantees and allows them to fairly share the residual bandwidth. And ATM Forum has recommended a frame-based generic cell rate algorithm (F-GCRA) as a frame classifier, which determines whether an Am cell is eligible to use the guaranteed bandwidth in a frame level. An ATM switch accommodates cells in its buffer or drops them in a frame level according to current buffer occupancy. A FIFO shared buffer has so simple structure as to be feasibly implemented in switches, but has not been able to provide an MCR guarantee for each VC without buffer management based on per-VC accounting. In this paper, we enhance the F-GCRA frame classifier to guarantee an MCR of each VC without buffer management based on per-VC accounting. The enhanced frame classifier considers burstness of TCP traffic caused by congestion control algorithm so as to enable each VC to use its reserved bandwidth sufficiently. In addition, it is able to alleviate the unfairness problem in usage of the residual bandwidth. Simulation results show that the enhanced frame classifier satisfies quality of services (QoSs) of the GFR service for the TCP traffic.

• Journal of Microbiology and Biotechnology
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• v.9 no.1
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• pp.70-77
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• 1999

An extremely cadmium-tolerant budding yeast, Hansenula anomala B-7 underwent a morphological switch in response to either heat shock treatment or cadmium stress, respectively. It exhibited a morphological transition from a unicellular yeast form to a pseudohyphae-like coagulation when subjected to prolonged heat shock treatment. In contrast, the yeast cells showed an irregularity in surface morphology when given thermal stress for a short time. Patterns of proteins expressed in the pseudohyphae-like cells demonstrated that several proteins were overexpressed while others were underexpressed in comparison with those prepared from the cells in the yeast form. It was a striking feature, however, that nearly 40％ of the proteins extracted from the cells in the pseudohyphae form appeared to be composed of a single polypeptide. This polypeptide was apparently overexpressed during the pseudohyphae phase and its molecular weight was estimated to be 58 kDa according to SDS-PAGE analysis. However, a significant level of the protein was not observed in the cells before transition to pseudohyphae. The architecture of the cell shape was also damaged when incubated in a medium containing more than 1,000 ppm (8.9mM) of cadmium ions, although able to proliferate at a slow rate. However, the irregularity in the cell morphology exerted either by the brief heat shock treatment or by the cadmium stress with the high concentrations of the metal ions was not repaired, even though the damaged cells were allowed to grow for sufficient time in fresh, cadmium-free medium.

• Journal of Veterinary Clinics
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• v.33 no.4
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• pp.187-193
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• 2016

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions. This study aims to show that the actions of growth factors associated with PDGFR-${\alpha}$, PDGFR-${\beta}$, VEGFR-2, c-KIT, and c-ABL, which are used in veterinary medicine, are expressed in canine intractable tumors. This study used archival cases of canine paraganglioma, gastrointestinal adenocarcinoma, hepatocellular carcinoma, and renal cell carcinoma. Tissues had been immunohistochemical analysis. The antibodies used were PDGFR-${\alpha}$, PDGFR-${\beta}$, c-kit, VEGFR-2, and c-Abl. PDGFR-${\alpha}$ was expressed only in HCC, and PDGFR-${\beta}$ was expressed in all tumors. VEGFR was also only expressed in HCC, and c-KIT has been expressed in HCC, paraganglioma, and small intestinal adenocarcinoma. c-Abl was expressed in all cancers, but was weakly expressed in paraganglioma, while more than moderately expressed in other tissues. In conclusion, this study investigated how TKIs used in human medicine can be applied to canine intractable tumors, through immunohistochemistry. The results indicate that there may be an application for TKIs in treating canine intractable tumors.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.6 no.2
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• pp.236-247
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• 2002

We propose a cell－multiplexing scheme for the real－time communication service in ATM network and a new service discipline guarantee end-to-end delay based on pseudo-isochronous cell switching. The proposed scheme consists of two level frame hierarchy, upper and lower frame, which is used to assign the bandwidth and to guarantee the requested delay bound, respectively. Since the Proposed algorithm employs two level frame hierarchy, it can overcome the coupling problem which is inherent to the framing strategy It can be comparatively reduce the complexity, and still guarantee the diverse delay bounds of end-to-end. Besides, it consists of two components, traffic controller and scheduller, as the imput traffic description model and regulates the input traffic specification. The function of the traffic controller is to shape real -time traffic to have the same input pattern at every switch along the path. The end-to-end delay is bounded by the scheduller which can limit the delay variation without using per-session jitter controllers, and therefore it can decrease the required buffer size. The proposed algorithm can support the QoS's of non-real time traffic as well as those of real time traffic.