• 한국지진공학회논문집
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• 제9권5호
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• pp.63-74
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• 2005

이 연구의 목적은 비탄성 유한요소해석을 이용하여 철근콘크리트 교각의 내진성능을 평가하는데 있다. 정확하고 올바른 성능평가를 위하여 신뢰성 있는 비선형 유한요소해석 프로그램을 사용하였다. 사용된 프로그램은 철근콘크리트 구조물의 해석을 위한 RCAHEST이다. 손상지수는 지진하중하의 철근콘크리트 교각의 손상을 수치적으로 정량화하는 방법으로서 제안되었다. 이 연구에서는 철근콘크리트 교각의 내진성능평가를 위해 제안한 해석기법을 신뢰성 있는 연구자의 실험결과와 비교하여 그 타당성을 검증하였다.

• Journal of Pharmaceutical Investigation
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• 제31권2호
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• pp.101-106
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• 2001

Alginate-chitosan (anion-cationic polymeric complex) was prepared to control the release rate of silver sulfadiazine (AgSD). Na-alginate (2%) solution containing AgSD was gelled in $CaCl_2$ solution. The gel beads formed were immediately encapsulated with chitosan (CS). The gel matrix and membrane were then reinforced with chondroitin-6-sulfate (Ch6S). Release rate of AgSD from the gel matrix was investigated by placing alginate beads in the sac of cellulose membrane simmered in HEPES-buffer solution. The concentration of AgSD released was analyzed by UV at 264 nm. Incorporation capacity of AgSD in Ca-alginate gel was more than 90%. Alginate-Ch6S-CS could control the release rate of AgSD. The amount of AgSD release was dependent on the AgSD loading dose. Incorporation of tripolyphosphate (polyanionic crosslinker) onto the alginate-Ch6S-CS bead increased the release rate of AgSD. Collagen-coating had no influence on the AgSD release rate. Alginate-Ch6S-CS beads with a sufficiently high AgSD encapsulation were capable of controlling the release of the drug over 10 days. In summary, alginate-Ch6S-CS beads could be used as a sustained delivery for AgSD and provide local targeting with low silver toxicity and patient discomfort.

• Journal of Pharmaceutical Investigation
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• 제41권5호
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• pp.279-288
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• 2011

The Dexamethasone (DEX) loaded chitosan microspheres were prepared by thermal denaturation and chemical cross-linking method using a dierent concentration of glutaraldehyde as chemical cross-linking agent. The prepared microspheres were evaluated for the percentage of Drug Loading (DL), Encapsulation Efficiency (EE) and surface morphology by Scanning Electron Microscopy (SEM). DL and EE were found to be maximum range of 10.0 to 10.79 % and 58.19 to 64.73 % respectively. The SEM Photographs of the resultant microspheres exhibited fairly smooth surfaces and predominantly spherical in appearance. In addition, Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) shown that there was no interaction between the drug and polymer. In vitro and in vivo release studies revealed that the release of dexamethasone was sustained and extended up to 63 days and effectively controlled by the extent of cross-linking agent. Non-clinical parameters such as paw volume, hematological parameters like Erythrocyte Sedimentation Rate (ESR), Paced Cell Volume (PCV), Total Leucocytes Count (TLC), Hemoglobin (Hb), Differential Cell Count (DCC) were investigated in Fruend's Complete Adjuvant (FCA) induced arthritic rats. Radiology and histopathological studies were also performed in order to evaluate the therapeutic efficacy of the DEX-loaded microspheres in extenuating the rat arthritic model.

• Carbon letters
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• 제10권3호
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• pp.208-212
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• 2009

Alginate-chitosan blend containing coconut-based activated carbon was prepared as a drug delivery carrier in order to improve the loading and releasing capacity of the drug. The activated carbon was incorporated as effective adsorbent for drug due to the extremely high surface area and pore volume, high adsorption capacity, micro porous structure and specific surface activity. Alginate-chitosan blend containing coconut-based activated carbon showed the sustained release for a longer period. Alginate-chitosan blend showed higher release of drug as the pH increased and higher release of drug as the content of chitosan decreased due to the pH-dependent solubility of blend components.

• 한국환경과학회지
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• 제9권3호
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• pp.185-191
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• 2000

Sustainable development has been the key concept, both in economic policies and in environmental management since 1970s. In the view of systems ecology, sustainable resource use strategies are considered to be essential in achieving sustainable development. During the last three decades, the discipline of systems ecology has applied ecological energetic analysis to the evaluation of the contribution of natural environments to economic systems. ENERGY analysis of main energy flows driving the economy of humans and life support systems of a city was made including environmental energies, fuel, and inputs, all expressed as solar emjoules. Total EMERGY use of Pusan was 3.89 E22 sej/yr, about 90 percent of it was purchased sources from outside during eleven years from 1985 to 1995. EMERGY flows from the environment were less than 10 percent. EMERGY yield ratio and environmental loading ratio were 1.10 and 10.45, respectively. EMERGY sustainability index is there(ore less than one, which is indicative of highly developed consumer oriented economies. Development of a city has been achieved in the short run by the economic growth, but it can be sustained in the long run by the use of renewable resource systems.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집A
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• pp.951-955
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• 2001

The experimental comparison between bonded and unbonded types stem-cement interface was carried out on axisymmetric stem-cement-aluminum model of the femoral component of a total hip replacement. Human femur was modeled in non-tapered and tapered($7.5^{\circ}$) aluminum hollow cylinders to emulate the diaphyseal and metaphyseal segments of the femur. For unbonded type, we tested stems with three different taper angles($5^{\circ},\;7.5^{\circ},\;10^{\circ}$). In every case, the cement-aluminum interface was designed to endure 8MPa shear strength. (a measured value at cement-bone interface) We tested aluminum models under axial loading for both cases. As an experimental result, it was found that unbonded stem sustained more axial load as bonded stem in both cases, diaphyseal and metaphyseal models. The unbonded types failed in cement mantle under axial compressive load, while the bonded ones failed in shear at cement-aluminum interface. These results suggest that a polished stem will sustain much higher axial load than a roughened stem. And a polished stem will make more stable cement-bone interface that may promote better osteosythesis around the stem.

• 지질공학
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• 제9권2호
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• pp.135-145
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• 1999

동적 하중을 받는 지반반응 평가시 필요한 가장 중요한 변수 중에 하나가 지반의 전단탄성계수(G)이다. 지반의 동특성은 시간에 따라 변화하게 되는데, 이 점은 흔히 간과되어져 왔다. 이번 연구를 통하여 일정구속압에서 시간에 따라 변하는 토질 최대전단탄성계수($G_{max}$) 및 그 영향요소에 관해 고찰해보고 몇몇 경험식을 제안하고자 한다. 경험식 작성을 위해 고려된 요소는 선행응력과 선행변형율, 입자크기와 지속응력, 소성지수 등이고, 실제로 가장 큰 영향을 미치는 평균입자직경과 소성지수를 이용한 두개의 경험식을 작성하였다. 끝으로 $G_{max}$의 일시적 변화와 그 원인, 그리고 시간에 따라 증가하는 G가 시사하는 점에 대해 서술한다

• Structural Engineering and Mechanics
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• 제39권4호
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• pp.465-498
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• 2011

Concrete structures are generally cracked in flexural tension at working loads. Concrete beams with asymmetric section details and crack patterns exhibit different flexural rigidity depending upon the sense of the applied flexural moment. In this paper, three different models, having the same natural period, of such SDOF bilinear dynamical systems have been proposed. The Model-I and Model-II have constant damping coefficient, but the latter is characterized by two stiffness coefficients depending upon the sense of vibration amplitude. The Model-III, additionally, has two damping coefficients as well. In this paper, the dynamical response of Model-III to sinusoidal loading has been investigated and compared with that of Model-II studied earlier. It has been found that Model-III exhibits regular and irregular sub-harmonics, jump phenomena and strong sensitivity to initial conditions, forcing frequency, system period as well as the sense of peak sinusoidal force. The constant sustained load has been found to affect the natural period of the dynamical system. The predictions of Model-I have been compared with those of the approximate linear model adopted in present practice. The behaviour exhibited by different models of the SDOF cracked elastic concrete structures under working loads and the theoretical and practical implications of the approach followed have been critically evaluated.

• Macromolecular Research
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• 제15권7호
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• pp.646-655
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• 2007

To achieve targeted drug delivery for chemotherapy, a ligand-mediated nanoparticulate drug carrier was designed, which could identity a specific receptor on the surfaces of tumor cells. Biodegradable poly(ethylene oxide)/poly$({\varepsilon}-caprolactone)$ (PEG/PCL) amphiphilic block copolymers coupled to biotin ligands were synthesized with a variety of PEG/PCL compositions. Block copolymeric nanoparticles harboring the anticancer drug paclitaxel were prepared via micelle formation in aqueous solution. The size of the biotin-conjugated PEG/PCL nanoparticles was determined by light scattering measurements to be 88-118 nm, depending on the molecular weight of the block copolymer, and remained less than 120 nm even after paclitaxel loading. From an in vitro release study, biotin-conjugated PEG/PCL nanoparticles containing paclitaxel evidenced sustained release profiles of the drug with no initial burst effect. The biotin-conjugated PEG/PCL block copolymer itself evidenced no significant adverse effects on cell viability at $0.005-1.0{\mu}g/mL$ of nanoparticle suspension regardless of cell type (normal human fibroblasts and HeLa cells). However, biotin-conjugated PEG/PCL harboring paclitaxel evidenced a much higher cytotoxicity for cancer cells than was observed in the PEG/PCL nanoparticles without the biotin group. These results showed that the biotin-conjugated nanoparticles could improve the selective delivery of paclitaxel into cancer cells via interactions with over-expressed biotin receptors on the surfaces of cancer cells.

• Archives of Pharmacal Research
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• 제29권10호
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• pp.928-933
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• 2006

Percutaneous delivery of NSAIDs has advantages of avoiding hepatic first pass effect and delivering the drug for extended period of time at a sustained, concentrated level at the inflammation site that mainly acts at the joint and the related regions. To develop the new topical formulations of pranoprofen that have suitable bioadhesion, the gel was formulated using hydroxypropyl methylcellulose (HPMC) and poloxamer 407. The effects of temperature on drug release was performed at $32^{\circ}C$, $37^{\circ}C$ and $42^{\circ}C$ according to drug concentration of 0.04%, 0.08%, 0.12%, 0.16%, and 0.2% (w/w) using synthetic cellulose membrane at $37{\pm}0.5^{\circ}C$. The increase of temperature showed the increased drug release. The activation energy (Ea), which were calculated from the slope of lop P versus 1000/T plots was 11.22 kcal/ mol for 0.04%, 10.79 kcal/mol for 0.08%, 10.41 kcal/mol for 0.12% and 8.88 kcal/mol for 0.16% loading dose from the pranoprofen gel. To increase the drug permeation, some kinds of penetration enhancers such as the ethylene glycols, the propylene glycols, the glycerides, the non-ionic surfactants and the fatty acids were incorporated in the gel formulation. Among the various enhancers used, propylene glycol mono laurate showed the highest enhancing effects with the enhancement factor of 2.74. The results of this study suggest that development of topical gel formulation of pranoprofen containing an enhancer is feasible.