• Journal of Gastric Cancer
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• 제17권1호
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• pp.1-10
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• 2017

Gastric cancer (GC) has high mortality owing to its aggressive nature. Tumor angiogenesis plays an essential role in the growth, invasion, and metastatic spread of GC. The aim of this work was to review the angiogenic biomarkers related to the behavior of GC, documented in the literature. A search of the PubMed database was conducted with the MeSH terms: "Stomach neoplasms/blood [MeSH] or stomach neoplasms/blood supply [MeSH] and angiogenic proteins/blood [Major]". A total of 30 articles were initially collected, and 4 were subsequently excluded. Among the 26 articles collected, 16 examined the role of vascular endothelial growth factor (VEGF), 4 studied endostatin, 3 investigated angiopoietin (Ang)-2, 2 studied the Ang-like protein 2 (ANGTPL2), and 1 each examined interleukin (IL)-12, IL-8, and hypoxia inducible factor. Regarding VEGF, 6 articles concluded that the protein was related to lymph node metastasis or distant metastases. Five articles concluded that VEGF levels were elevated in the presence of GC and decreased following tumor regression, suggesting that VEGF levels could be a predictor of recurrence. Four articles concluded that high VEGF levels were correlated with poor prognosis and lower survival rates. Ang-2 and ANGTPL2 were elevated in GC and associated with more aggressive disease. Endostatin was associated with intestinal GC. VEGF is the most extensively studied angiogenic factor. It is associated with the presence of neoplastic disease and lymph node metastasis. It appears to be a good biomarker for disease progression and remission, but not for diagnosis. The data regarding other biomarkers are inconclusive.

• Tuberculosis and Respiratory Diseases
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• 제68권1호
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• pp.22-28
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• 2010

Background: Vascular endothelial growth factor (VEGF) is a potent mediator of angiogenesis. VEGF production is regulated by HIF-$1{\alpha}$ and EGFR. This study examined the relationship between the clinicopathological factors and VEGF, HIF-$1{\alpha}$ and EGFR protein overexpression, and evaluated their prognostic value in patients with a surgically resected non-small cell lung cancer (NSCLC). Methods: Patients who underwent a surgical resection at Kangnam St. Mary's hospital were reviewed retrospectively. The core biopsy samples from 54 patients with NSCLC were assembled on a tissue microarray (TMA), and immunohistochemical staining for the VEGF, HIF-$1{\alpha}$ and EGFR proteins was performed. The overexpression of these proteins was evaluated in relation to age, gender, histology and staging by univariate analysis. The clinicopathological prognostic factors were analyzed. Results: Multivariate analysis performed by Cox regression (odds ratio 2.8, 95% CI 1.0~8.2, p=0.046) revealed HIF-$1{\alpha}$ overexpression to be an unfavorable factor. There was no correlation between the overexpression of these proteins and the clinicopathological factors. VEGF showed a positive relationship with EGFR, but there was no statistical significance [$p(x^2)=0.06$]. Conclusion: HIF-$1{\alpha}$ overexpression predicts shorter survival in patients with a surgically resected NSCLC. Therefore, HIF-$1{\alpha}$ may be a poor prognostic factor in NSCLC.

• 천문학논총
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• 제32권1호
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• pp.197-199
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• 2017

Using the InfraRed Camera (IRC) on board the infrared astronomical satellite AKARI we study the ${3.3{\mu}m}$ polycyclic aromatic hydrocarbon (PAH) feature and its connection to active galactic nucleus (AGN) properties for a sample of 54 hard X-ray selected bright AGN, including both Seyfert 1 and Seyfert 2 type objects. The sample is selected from the 9-month Swift/BAT survey in the 14-195 keV band and all of the sources have known neutral hydrogen column densities ($N_H$). The ${3.3{\mu}m}$ PAH luminosity ($L_{3.3{\mu}m}$) is used as a proxy for star-formation (SF) activity and hard X-ray luminosity ($L_{14-195keV}$) as an indicator of the AGN power. We explore for possible difference of SF activity between type 1 (un-absorbed) and type 2 (absorbed) AGN. We use several statistical analyses taking the upper-limits of the PAH lines into account utilizing survival analysis methods. The results of our log($L_{14-195keV}$) versus log($L_{3.3{\mu}m}$) regression shows a positive correlation and the slope for the type 1/unobscured AGN is steeper than that of type 2/obscured AGN at a $3{\sigma}$ level. Also our analysis shows that the circum-nuclear SF is more enhanced in type 2/absorbed AGN than type 1/un-absorbed AGN for low $L_{14-195keV}$ luminosity/low Eddington ratio AGN, while there is no significant dependence of SF activity on the AGN type in the high $L_{14-195keV}$ luminosities/Eddington ratios.

• 한국환경보건학회지
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• 제44권3호
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• pp.259-266
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• 2018

Objectives: Considered the "national fish" in Korea, the walleye pollock (Gadus chalcogrammus) has disappeared in the East Sea (Sea of Japan), a main habitat and fishing ground for the species. The reason for the disappearance is still a matter of controversy. This study was performed to investigate the long-term relationship between the walleye pollock catch and various meteorological and oceanographic factors in these waters. Methods: Fishery data on walleye pollock and data on meteorological and marine environmental factors over the 30 years (1981-2010) were obtained from the official national database. Time series analysis and correlation and regression analyses were performed to study the relationships. Results: Both air temperature and sea surface temperature in the East Sea rose over these 30 years, and the latter became more prominent. Salinity and dissolved oxygen showed a tendency to decrease while concentrations of nutrients such as nitrite nitrogen and nitrate nitrogen showed an increasing tendency. Sea surface temperature, air temperature, atmospheric pressure, and wind grade were negatively correlated with the catch size of walleye pollock (p<0.05), but salinity was positively correlated (p<0.001). Conclusion: The results of this study indicate that climate change, especially ocean warming, affected the habitat of walleye pollock. The results also indicate that lower sea surface and air temperatures, milder wind grade, and higher salinity were preferred for the survival of the fish species. It is necessary to pay attention to changes of the ocean ecosystem in terms of environmental pollution as well as seawater temperature.

• 한국임상약학회지
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• 제21권2호
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• pp.145-155
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• 2011

The objective of this study was to determine whether any pretreatment parameters were associated with pharmacological effect or toxicity parameters after vincristine administration and to describe a mathematical model, which explains the interpatient pharmacodynamic variability. The relationship between patient characteristics and vincristine dose and hematological toxicity were evaluated. 68 pediatric and adolescence patients and 107 adults with acute lymphoblastic leukemia were treated with vincristine $1.5mg/m^2/day$ IV and other anticancer drugs as scheduled. Complete blood counts and other blood test results were obtained. The input variables were age, gender, weight, lean body weight (LBW), height, body surface area, vincristine dose and total vincristine dose. The outcome measures were nadir values (white blood cells, absolute neutrophil counts, hemoglobin, and platelets); the absolute decrease, relative decrease, and survival fraction of blood cells. Polynomial regression analysis was carried out to determine the other significant covariates. The variability of $WBC_{nadir}$ was modeled with good precision and accuracy with a two-covariate model. This model should be validated and improved on with further clinical data. We believe that such pharmacodynamic modeling should be explored further to determine its performance and clinical relevance compared with modeling using pharmacokinetic parameter.

• 한국전자거래학회지
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• 제16권3호
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• pp.129-143
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• 2011

현대 산업에서 기업 간 협업은 기업의 생존과 경쟁력 강화를 위해 그 중요성이 부각 되고 있고, 정보시스템의 활용이 기업 간 협업에 영향을 마친다는 연구들은 수차례 진행되어 왔지만 중소기업의 모기업과의 협업 관계에서의 세부적이고 객관적인 연구는 미비한 실정이다. 따라서 본 논문에서는 중소기업의 모 기업과의 정보시스템을 이용한 협업관계를 보다 현실적으로 연구하기 위해 조산, 자동차, 조선, 자동차, 전자 업종의 대기업 협력업체들을 대상으로 중소협력업체들의 IT 시스템 활용 수준 및 모기업과의 협업 지원 수준을 분석하고, IT 시스템 활용 수준이 기업들 간의 협업 지원 수준에 영향을 미치는 것이 업무 영역별로 유의한지의 여부를 회귀분석을 이용하여 검토하였다. 그 결과 각 업무 영역별로 IT 시스템 활용 수준 및 모기업과의 협업 지원 수준이 다소 차이가 나며, 중소기업의 IT 활용 수준이 모기업과의 협업 지원 수준에 영향을 미친다는 것을 확인할 수 있었다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권1호
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• pp.43-50
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• 2018

Purpose: Clostridium difficile colonization and infection are commonly associated with poor outcomes in patients with pediatric inflammatory bowel disease (PIBD). We aimed to investigate the prevalence of C. difficile colonization and infection at the time of diagnosis and to evaluate risk factors associated with the development of C. difficile infection during the course of PIBD treatment. Methods: We retrospectively enrolled a total of 59 children who were newly diagnosed with PIBD at the tertiary medical center. All patients underwent C. difficile toxin assays and cultures initially and at every follow-up during the disease course. Kaplan-Meier survival analysis and Cox regression test were used for statistical analysis. Results: Initial cultures for C. difficile were positive in 13 (22.0%) of 59 PIBD patients, whereas initial toxin assays were positive in 3 patients (5.1%). During treatment, C. difficile cultures converted to positive in 28 (47.5%) in addition to 13 patients who were initially culture-positive, and C. difficile toxins converted to positive in 13 (22.0%) in addition to 3 originally toxin-positive patients. Antibiotic usage alone was significantly associated with the development of C. difficile colonization (p=0.011), and the length of hospitalization was associated with the development of C. difficile infection (p=0.032). Conclusion: C. difficile colonization and infection occur frequently during the disease course of PIBD. Antibiotic usage and longer hospital stay were significant risks factors for the conversion of C. difficile status in PIBD patients undergoing treatment.

• 한국치위생학회지
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• 제6권1호
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• pp.25-35
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• 2006

The purpose of this study is to forecast patient satisfaction and service value through the staged regression analysis of the relation between each factor and its satisfaction and service value, following the measurement of the quality of dental care service that patients recognize. And a self-administered survey was used for this study. The subjects of this survey were 394 outpatients of dental clinics located in K city in the period from Dec. 5, 2004 to Feb. 19, 2005, the questionnaire was composed of a total of 31 questions to measure the quality of overall dental care service(22 questions), the patient satisfaction(6 questions) and the service value(3 questions). The 7 points Likert scale ranging from "very poor"(1-point) to "very high"(7-point) was used for these questions The results of study could be summarized as follows: 1. The most useful index to predict patient satisfaction turned out to be "internal environment", followed by "treatment process and waiting time", "dentist", "external environment", and "dental hygienist". 2. The service value had a significant effect on the "internal environment", "dentist", "treatment process and waiting time". 3. The most useful index to predict the service value turned out to be "treatment process and waiting time", followed by "internal environment" and "dentist". Today, the quality of dental care service is becoming a prime concern since it is directly connected to a matter of survival of medical service organizations. Dental clinics desperately need patient-oriented marketing strategies in order to actively cope with changing medical environment. They also need to thoroughly examine possible measures to maximize the service value by establishing a variety of service strategies which can promote service quality that patients recognize.

• 한국콘텐츠학회논문지
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• 제20권5호
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• pp.291-302
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• 2020

아이돌이 주도하는 한국의 대중음악은 이제 전세계적인 팬덤을 확보하였다. 이로 인해, 아티스트를 넘어서 한국의 경제 상황에도 커다란 영향력을 행사하고 있다. 즉, 아이돌 그룹 하나가 크게 히트를 치면 조 단위의 외화를 벌어들일 수 있게 된 것이다. 따라서 아이돌 그룹을 성공시키고 이를 유지시키는 것이 상당히 중요한 과제로 떠올랐다. 본 연구에서는 소속사가 손익분기점으로 삼는 데뷔 후 3년차 및 평균적인 재계약 직후 시점인 8년차 아이돌의 생존여부를 인공신경망, 의사결정나무, 랜덤 포레스트를 활용하여 예측해보고자 한다. 그리고 생존에 있어 무엇이 중요한 요인인지를 나무 모델의 특성중요도 및 로지스틱 회귀분석을 활용하여 설명하였다. 그 결과, 데뷔 시점의 경쟁자 수, 최초 그룹의 구성원 수, 다루는 장르의 수 등의 요인이 유의하다는 결론을 얻을 수 있었다. 이를 통해, 최종적으로 아이돌 그룹을 보다 효율적으로 기획, 관리함으로써 산업 경쟁력을 증진할 수 있을 것으로 기대한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9927-9931
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• 2014

The objectives of this study were to examine serum periplakin expression in patients with urothelial carcinoma of the urinary bladder and in normal controls, and to examine relationships with clinicopathological findings. Detection of serum periplakin was performed in 50 patients and 30 normal controls with anti-periplakin antibodies using the automatic dot blot system, and a micro-dot blot array with a 256 solid-pin system. Levels in patients with urothelial carcinoma of the urinary bladder were significantly lower than those in normal controls (0.31 and 5.68, respectively; p<0.0001). The area under the receiver-operator curve level for urothelial carcinoma of the urinary bladder was 0.845. The sensitivity and specificity, using a cut-off point of 4.045, were 83.7% and 73.3%, respectively. In addition, serum periplakin levels were significantly higher in patients with muscle-invasive cancer than in those with nonmuscle-invasive cancer (P = 0.03). In multivariate Cox proportional hazards regression analysis, none of the clinicopathological factors was associated with an increased risk for progression and cancer-specific survival. Examination of the serum periplakin level may play a role as a non-invasive diagnostic modality to aid urine cytology and cystoscopy.