• Bulletin of the Korean Chemical Society
• /
• v.7 no.2
• /
• pp.154-155
• /
• 1986

• Geomechanics and Engineering
• /
• v.16 no.2
• /
• pp.169-176
• /
• 2018

An attempt has been made here to study the propagation of SH-type surface waves in an elastic medium, which is initially stressed and heterogeneous and has a point source inside the medium. The upper portion of the composite medium is a sandy layer. It is situated on an initially stressed heterogeneous half-space, whose density, rigidity and internal friction are function of depth. The analysis has been carried out by using Fourier transform and Green's function approach. The phase velocity has been investigated for several particular situations. It has been shown that the results of the study agree with those the case of Love wave propagation in a homogeneous medium in the absence of the sandy layer, when the initial stress is absent. In order to illustrate the validity of the analysis presented here, the derived analytical expression has been computed numerically, by considering an illustrative example and the variances of the concerned physical variables have been presented graphically. It is observed that the velocity of shear wave is amply influenced by the initial stress and heterogeneity parameters and the presence of the sandy layer. The study has an important bearing on investigations of different problems in the earth's interior and also in seismological studies.

• Transactions of Materials Processing
• /
• v.32 no.1
• /
• pp.35-40
• /
• 2023

In the case of a wire with a very fine diameter during the multi-stage drawing process, the heterogeneity of the deformation in the radial direction tends to develop strongly as the amount of deformation is accumulated. It is known that the heterogeneity of deformation in the radial direction of the wire is closely related to the process parameters during the multi-stage drawing process. In this study, finite element analysis (FEA) was used to theoretically examine the effect of friction between the surface of the wire and the drawing die during the multi-stage drawing process of Cu-0.2wt%Mg alloy on the deformation heterogeneity developed in the radial direction of the wire. The distribution of effective strain, radial strain, circumferential strain, and shear strain developed in the radial direction of the wire during the multi-stage drawing process was analyzed while changing the friction coefficient, and the results were analyzed and compared for each path and position. The FEA results revealed that the shear strain developed in the radial direction of the wire during the multi-stage drawing process of Cu-0.2wt%Mg alloy showed the most non-uniform distribution and was also severely affected by the friction coefficient.

• 한국데이터정보과학회:학술대회논문집
• /
• 2006.04a
• /
• pp.49-54
• /
• 2006

When using response surface designs, the experimental trials should be carried out in blocks in case of heterogeneity of conditions. When we use nearly orthogonal blocking, we need evaluate the degree of orthogonal blocking. Graphical methods for evaluating the degree of orthogonal blocking are suggested.

• Journal of the Korean Data and Information Science Society
• /
• v.17 no.3
• /
• pp.669-675
• /
• 2006

When using response surface designs, the experimental trials should be carried out in blocks in case of heterogeneity of conditions. When we use nearly orthogonal blocking, we need evaluate the degree of orthogonal blocking. Graphical methods for evaluating the degree of orthogonal blocking are suggested.

• Biomolecules & Therapeutics
• /
• v.27 no.1
• /
• pp.63-70
• /
• 2019

Myeloid-derived suppressor cells (MDSCs) that are able to suppress T cell function are a heterogeneous cell population frequently observed in cancer, infection, and autoimmune disease. Immune checkpoint molecules, such as programmed death 1 (PD-1) expressed on T cells and its ligand (PD-L1) expressed on tumor cells or antigen-presenting cells, have received extensive attention in the past decade due to the dramatic effects of their inhibitors in patients with various types of cancer. In the present study, we investigated the expression of PD-1 on MDSCs in bone marrow, spleen, and tumor tissue derived from breast tumor-bearing mice. Our studies demonstrate that PD-1 expression is markedly increased in tumor-infiltrating MDSCs compared to expression in bone marrow and spleens and that it can be induced by LPS that is able to mediate $NF-{\kappa}B$ signaling. Moreover, expression of PD-L1 and CD80 on $PD-1^+$ MDSCs was higher than on $PD-1^-$ MDSCs and proliferation of MDSCs in a tumor microenvironment was more strongly induced in $PD-1^+$ MDSCs than in $PD-1^-$ MDSCs. Although we could not characterize the inducer of PD-1 expression derived from cancer cells, our findings indicate that the study on the mechanism of PD-1 induction in MDSCs is important and necessary for the control of MDSC activity; our results suggest that $PD-1^+$ MDSCs in a tumor microenvironment may induce tumor development and relapse through the modulation of their proliferation and suppressive molecules.

• Korean Journal of Soil Science and Fertilizer
• /
• v.29 no.4
• /
• pp.328-335
• /
• 1996

Using literature data on back titration curves of some typical Korean soils and minerals we calculated the distribution functions of aparent surface dissociation constants for these materials using site heterogeneity approach. The studied materials exhibited broad range of apparent surface dissociation constants. The dominant surface sites for all samples appeared to be very weakly acidic. However, the relative amounts of surface sites differed among particular materials.

• Wind and Structures
• /
• v.12 no.3
• /
• pp.281-283
• /
• 2009

Marquardt method is used to estimate the aerodynamic parameters in urban area of Beijing City, China, including displacement length (d), roughness length ($z_0$) and friction velocity (u*) and drag coefficient. The surface drag coefficient defined as the ratio between friction velocity and mean wind speed is 0.125 in our research, which is close to typical urban area value. The averaged d and $z_0$ are 1.2 m and 7.6 m. d and $z_0$ change with direction because of the surface heterogeneity over urban surface and reach their maximum values at S-SW sector, this tendency agrees with the surface rough element distribution around the observation tower.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.33 no.2 s.109
• /
• pp.60-70
• /
• 2005

This study was carried out to elucidate the vertical characteristics of soil properties at six planted sites of land reclaimed from the sea, in Gwangyang Bay, Jeollanam-do Province, Korea. Based on the types of planting site, the chemical properties of the vertical soil layers varied. The vertical variation was great in the planting sites $Z_1\;and\;Z_2$, but less varied in the mounded planting sites $Z_3,\;Z_5,\;and\;Z_6$. Major reasons for the vertical variation in soil chemical properties included differences in the accumulation of organic matter, soil disturbance by heavy construction equipment, and heterogeneity of soil properties between soil horizons. As soil depths increased, soil salts varied. The electrical conductivity (ECe) increased in the lower areas of planting sites $Z_1\;and\;Z_2$, and the disturbed, saline planting site $Z_3$, but decreased in the lower areas of $Z_3,\;Z_5,\;and\;Z_6$. These tendencies did not coincided with exchange cation concentrations $(Na^+,\;K^+,\;Mg^{++},\;Ca^{++})$. Both total carbon (T-C) and total nitrogen (T-N) accumulated more in the lower areas of planting sites than in the higher areas, and levels were higher closer to the surface than in the soil depths. It is supposed that these tendencies are related to the accumulation of fallen leaves or other organic matter at the soil surface, and the soil chemicals then slowly move downward from the surface. Impediments to tree growth included soil hardiness, high soil salinity and exchangeable cation concentration, low soil moisture content, acidic or alkaline soil, low organic matter, heterogeneity of soil texture and establishment of soil stratification.

• The Korean Journal of Physiology and Pharmacology
• /
• v.24 no.6
• /
• pp.529-543
• /
• 2020

In contrast to ventricular myocytes, the structural and functional importance of atrial transverse tubules (T-tubules) is not fully understood. Therefore, we investigated the ultrastructure of T-tubules of living rat atrial myocytes in comparison with ventricular myocytes. Nanoscale cell surface imaging by scanning ion conductance microscopy (SICM) was accompanied by confocal imaging of intracellular T-tubule network, and the effect of removal of T-tubules on atrial excitation-contraction coupling (EC-coupling) was observed. By SICM imaging, we classified atrial cell surface into 4 subtypes. About 38% of atrial myocytes had smooth cell surface with no clear T-tubule openings and intracellular T-tubules (smooth-type). In 33% of cells, we found a novel membrane nanostructure running in the direction of cell length and named it 'longitudinal fissures' (LFs-type). Interestingly, T-tubule openings were often found inside the LFs. About 17% of atrial cells resembled ventricular myocytes, but they had smaller T-tubule openings and a lower Z-groove ratio than the ventricle (ventricular-type). The remaining 12% of cells showed a mixed structure of each subtype (mixed-type). The LFs-, ventricular-, and mixed-type had an appreciable amount of reticular form of intracellular T-tubules. Formamide-induced detubulation effectively removed atrial T-tubules, which was confirmed by both confocal images and decreased cell capacitance. However, the LFs remained intact after detubulation. Detubulation reduced action potential duration and L-type Ca²⁺ channel (LTCC) density, and prolonged relaxation time of the myocytes. Taken together, we observed heterogeneity of rat atrial T-tubules and membranous ultrastructure, and the alteration of atrial EC-coupling by disruption of T-tubules.