• 한국지반환경공학회 논문집
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• 제13권10호
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• pp.15-23
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• 2012

본 연구에서는 산지 지형에서 토취장을 개발할 경우 상부의 지반 굴착으로 인한 지하수계의 변화를 현장 계측자료와 모델링을 활용하여 예측하고자 하였다. 9개소의 시추조사를 통하여 지층 분포와 수리상수를 구하고 현장 지하수위 조사를 실시하였으며, 물수지 분석에 의한 지하수 함양량을 추정한 후 Modflow 프로그램에 적용함으로써 지하수위 변화를 예측하였다. 토취장 개발로 40 El.m 이상 지역이 제거될 경우를 가정하여 부정류 모델링을 수행한 결과, 토취장 최인접 지역에서 최대 1m 정도의 지하수위 강하가 나타나는 것으로 예측되었다. 또한, 절토로 인한 상부 지형의 제거는 9.4% 및 7.0%의 지하수 함양량과 지표 유출량의 감소를 초래하는 것으로 예측되었는데, 이는 지하수위 변화를 야기하는 요인으로 평가되었다. 향후 토취장 개발이 시작되면 이와 같은 지하수위 변화를 지속적으로 파악하기 위하여 지하수 관측정을 설치 운영할 필요가 있다.

• Imaging Science in Dentistry
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• 제34권3호
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• pp.151-157
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• 2004

Purpose : To evaluate the quantitative accuracy of three-dimensional (3D) images by means of comparing distance measurements on the 3D images with direct measurements of dry human skull according to slice thickness and scanning modes. Materials and Mathods : An observer directly measured the distance of 21 line items between 12 orthodontic landmarks on the skull surface using a digital vernier caliper and each was repeated five times. The dry human skull was scanned with a Helical CT with various slice thickness (3, 5, 7 mm) and acquisition modes (Conventional and Helical). The same observer measured corresponding distance of the same items on reconstructed 3D images with the internal program of V-works 4.0/sup TM/(Cybermed Inc., Seoul, Korea). The quantitative accuracy of distance measurements were statistically evaluated with Wilcoxons' two-sample test. Results: 11 line items in Conventional 3 mm, 8 in Helical 3mm, 11 in Conventional 5mm, 10 in Helical 5mm, 5 in Conventional 7mm and 9 in Helical 7mm showed no statistically significant difference. Average difference between direct measurements and measurements on 3D CT images was within 2mm in 19 line items of Conventional 3mm, 20 of Helical 3mm, 15 of Conventional 5mm, 18 of Helical 5mm, II of Conventional 7mm and 16 of Helical 7mm. Conclusion: Considering image quality and patient's exposure time, scanning protocol of Helical 5mm is recommended for 3D image analysis of the skull in CT.

• Macromolecular Research
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• 제10권3호
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• pp.158-167
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• 2002

In order to endow with new bioactive functionality from small intestine submucosa (SIS) powder as natural source to poly (L-lactide) (PLA) and poly (lactide-co-glycolide) (PLGA) synthetic biodegradable polymer, porous SIS/PLA and SIS/PLGA as natural/synthetic composite scaffolds were prepared by means of the solvent casting/salt leaching methods for the possibility of the application of tissue engineered bone and cartilage. A uniform distribution of good interconnected pores from the surface to core region was observed the pore size of 40~500 ${\mu}{\textrm}{m}$ independent with SIS amount using the solvent casting/salt leaching method. Porosities, specific pore areas as well as pore size distribution also were almost same. After the fabrication of SIS/PLA hybrid scaffolds, the wetting properties was greatly enhanced resulting in more uniform cell seeding and distribution. Five groups as PGA non-woven mesh without glutaraldehyde (GA) treatment, PLA scaffold without or with GA treatment, and SIS/PLA (Code No.3 ; 1 : 12 of salt content, (0.4 : 1 of SIS content, and 144 ${\mu}{\textrm}{m}$ of median pore size) without or with GA treatment were implanted into the back of nude mouse to observe the effect of SIS on the induction of cells proliferation by hematoxylin and eosin, and von Kossa staining for 8 weeks. It was observed that the effect of SIS/PLA scaffolds with GA treatment on bone induction are stronger than PLA scaffolds, that is to say, in the order of PLA/SIS scaffolds with GA treatment > PLA/SIS scaffolds without GA treatment > PGA nonwoven > PLA scaffolds only with GA treatment = PLA scaffolds only without GA treatment for the osteoinduction activity. The possible explanations are (1) many kinds of secreted, circulating, and extracellular matrix-bound growth factors from SIS to significantly affect critical processes of tissue development and differentiation, (2) the exposure of SIS to GA resulted in significantly calcification, and (3) peri-implant fibrosis due to covalent bonding between collagen molecule by crosslinking reaction. In conclusion, it seems that SIS plays an important role for bone induction in SIS/PLA scaffolds for the application of tissue engineering area.

• 치위생과학회지
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• 제12권3호
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• pp.253-258
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• 2012

치과용 아말감은 수은, 구리, 아연, 은과 같은 여러 가지 금속으로 이루어진 합금으로 구성되었다. 아말감은 내구성과 진료 시 사용의 편리성과 경제적인 이유로 치과영역에서 가장 흔히 사용되고 효과적인 수복물질로 이용되었다. 하지만 수복물질로서의 대중성과 긴 역사에도 불구하고 아말감에 포함된 수은의 노출로부터 가져올 수 있는 잠재적 부작용 또는 합병증에 대한 염려로 논란이 계속되고 있다. 특히 어린이들의 경우 수은의 독성에 대한 위험성이 더 높기 때문에 우리는 어린이에게서 치과용 아말감과 요중 수은농도의 관련성에 대하여 알아보고자 하였다. 대도시 지역 내 두 개 초등학교 1~4학년 재학생을 대상으로 하여 구강검진과 설문조사를 시행하였으며, 구강검진 당일 채취한 소변시료를 이용하여 요중 수은농도를 분석하였다. 결과는 구강 내 아말감 충전치아가 없는 아동과 비교 했을 때 79개 이상, 10개 이상 갖는 아동의 요중 수은농도가 높아지는 상관관계가 나타났다. 결론적으로 어린이의 구강 내 아말감 충전치면수와 요중 수은농도는 관련성이 있는 것으로 사료된다.

• 대한디지털의료영상학회논문지
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• 제14권2호
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• pp.9-14
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• 2012

Exposed dose of young child should be managed necessarily. Young child is more sensitive than adult of a Radioactivity, especially, and lives longer than adult. Must reduce exposed dose which follows The ALARA(As Low As Reasonably Achievable)rule is recommended by ICRP(International Commission on Radiological Protection)within diagnostic useful range. Therefore, We have to prepare Pediatric DRL(Diagnostic Reference Level) in Korea as soon as possible. Consequently, in this study, wish to estimate organ dose and effective dose using PCXMC Program(a PC-Based Monte Carlo Program), and measure ESD(Entrance surface dose)and organ dose using Glass dosimeter, and then compare with DRL which follows EC(European Commission)and NRPB(National Radiological Protection Board). Using glass dosimeter and PCXMC programs conforming to the International Committee for Radioactivity Prevention(ICRP)-103 tissue weighting factor based on the item before the organs contained in the Chest, Skull, Pelvis, Abdomen in the organ doses and effective dose and dose measurements were evaluated convenience. In a straightforward way to RANDO phantom inserted glass dosimeter(GD352M)by using the hospital pediatric protocol, and in a indirect way was PCXMC the program through a virtual simulation of organ doses and effective dose were calculated. The ESD in Chest PA is 0.076mGy which is slightly higher than the DRL of NRPB(UK) is 0.07mGy, and is lower than the DRL of EC(Europe) which is 0.1mGy. The ESD in Chest Lateral is 0.130mGy which is lower than the DRL of EC(Europe) is 0.2mGy. The ESD in Skull PA is 0.423mGy which is 40 percent lower than the DRL of NRPB(UK) is 1.1mGy and is 28 percent lower than the DRL of EC(Europe) is 1.5mGy. The ESD in Skull Lateral is 0.478mGy which is half than the DRL of NRPB(UK) is 0.8mGy, is 40 percent lower than the DRL of EC(Europe) is 1mGy. The ESD in Pelvis AP is 0.293mGy which is half than the DRL of NRPB(UK) is 0.60mGy, is 30 percent lower than the DRL of EC(Europe)is 0.9mGy. Finally, the ESD in Abdomen AP is 0.223mGy which is half than the DRL of NRPB(UK) is 0.5mGy, and is 20 percent lower than the DRL of EC is 1.0mGy. The six kind of diagnostic radiological examination is generally lower than the DRL of NRPB(UK)and EC(Europe) except for Chest PA. Shouldn't overlook the age, body, other factors. Radiological technician must realize organ dose, effective dose, ESD when examining young child in hospital. That's why young child is more sensitive than adult of a Radioactivity.

• 콘크리트학회논문집
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• 제15권3호
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• pp.392-399
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• 2003

본 연구는 한중콘크리트 시공 시 초기보온 대책 중 가장 손쉽고 경제적일 것으로 사료되는 단열 보온양생을 대상으로 하였다. 실험은 한중콘크리트 시공조건을 상정하여 기존 거푸집과 각종 단열재 조합에 따른 단열거푸집간의 온도이력을 검토하여 효율적인 단열거푸집을 개발하고자 하였다. 실험결과 $-10^{\circ}C$ 일정인 외기온도 조건에서 벽용 거푸집의 경우, 일반 유로폼인 경우는 초기 24시간 이전에 급속한 온도저하에 의해 $0^{\circ}C$ 이하로 약 7시간 정도 지속되었고, PP＋스티로폼＋합판인 경우는 영상의 온도를 유지하고, 강도발현도 우수하며, 단열거푸집간 비교적 가격도 저렴하여 우수한 단열거푸집임이 밝혀졌다. 슬래브용 거푸집 실험의 경우, 하부는 단열거푸집으로 고정하고, 콘크리트 표면 양생방법을 달리하였을 때, 콘크리트의 온도이력을 측정한 결과, 노출시킨 경우 약 10시간 이후부터 영하로 저하하였고, 비닐+양생포의 경우 약 42시간 이후부터 영하로 저하하였다. 반면, 비닐＋스티로폼+양생포를 사용한 양생의 경우에는 약 55시간 이후부터 영하로 저하하여 노출이나 일반적으로 많이 사용되는 비닐＋양생포와 비교하여 우수한 단열효과임이 밝혀졌다. 7일 및 28일에 있어 슬래브의 코어 압축강도를 측정한 결과는 단열재를 사용하였을 때 크게 나타났다.

• Journal of Periodontal and Implant Science
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• 제32권1호
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• pp.129-142
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• 2002

Epithelial-mesenchymal interaction plays a important role in cell growth and differentiation. This interaction is already well known to have an importance during the organ development as well as cell growth and differentiation. However, in vitro experimental model is not well developed to reproduce in vivo cellular microenvironment which provide a epithelial-mesenchymal interaction. Because conventional monolayer culture lacks epithelial-mensenchymal interaction, cultivated cells have an morphologic, biochemical, and functional characteristics differ from in vivo tissue. Moreover, it's condition is not able to induce cellular differention due to submerged culture condition. Therefore, the aims of this study were to develop and evaualte the in vitro experimental model that maintains epithelial-mesenchymal interaction by organotypic raft culture, and to characterize biologic properties of three-dimensionally reconstituted oral keratinocytes by histological and immunohistochemical analysis. The results were as follow; 1. Gingival keratinocytes reconstituted by three-dimensional organotypic culture revealed similar morphologic characteristics to biopsied patient specimen showing stratification, hyperkeratinosis, matutation of epithelial architecture. 2. Connective tissue structure was matured, and there is no difference during stratification period of epithelial 3-dimensional culture. 3. The longer of air-exposure culture on three-dimensionally reconstituted cells, the more epithelial maturation, increased epithelial thickness and surface keratinization 4. In reconstitued mucosa, the whole epidermis was positively stained by anti-involucrin antibody, and there is no difference according to air-exposured culture period. 5. The Hsp was expressed in the epithelial layer of three-dimensionally cultured cells, especially basal layer of epidermis. The change of Hsp expression was not significant by culture stratification. 6. Connexin 43, marker of cell-cell communication was revealed mild immunodeposition in reconstitued epithelium, and there is no significant expression change during stratification. These results suggest that three-dimensional oragnotypic co-culture of normal gingival keratinocytes with dermal equivalent consisting type I collagen and gingival fibroblasts results in similar morphologic and immunohistochemical characteristics to in vivo patient specimens. And this culture system seems to provide adequate micro-environment for in vitro tissue reconstitution. Therefore, further study will be focused to study of in vitro gingivitis model, development of novel perioodntal disease therapeutics and epithelial-mensenchymal interaction.

• 콘크리트학회논문집
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• 제25권2호
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• pp.137-144
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• 2013

철근콘크리트(reinforced concrete) 구조부재에서 철근의 부식으로 인한 문제점을 개선하고자 섬유보강 복합재료(FRP) 보강근(rebar)을 사용하는 것에 대한 연구가 꾸준히 진행되어져 오고 있다. 하지만 이러한 FRP 보강근을 사용한 콘크리트 부재의 환경에 대한 장기거동에 대한 연구가 아직도 미흡한 수준이다. 이 연구는 GFRP(glass fiber reinforced polymer) 보강근을 사용한 콘크리트 부재를 온도 약 $46^{\circ}C$와 습도가 80%인 인위적인 실험실에서 최대 300일까지 노출시킨 후의 장기 거동에 대한 실험적 연구를 제시하였다. 비교를 위하여 두가지 서로 다른 GFRP 보강근과 철근을 보강한 콘크리트 보 시험체를 제작하였다. 실험 결과, 장기 노출환경에서도 GFRP 보강근을 보강한 콘크리트 보 시험체의 파괴형태는 철근 보강 콘크리트 보시험체와 매우 유사한 파괴형태를 나타내었으며, 노출 시간에 따른 하중저항 감소값은 철근이 보강된 경우가 GFRP 보강근이 보강된 경우보다 하중저항 감소값이 크게 일어났다. 또한 GFRP 보강근 보강 콘크리트 보 시험체를 설계할 시에는 철근 보강보다 취성파괴에 대한 충분한 대비가 요구됨을 알 수 있었다. 그리고 압축파괴에 대한 변형도 계수(deformability factor)는 모든 경우에서 노출시간에 관계없이 큰 변화가 없음을 알 수 있었다.

• Advances in concrete construction
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• 제10권2호
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• pp.171-183
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• 2020

The main objective of this study is the assessment of the ability of limestone mortars to resist to different chemical attacks. The ability of polypropylene (PP) fibres waste used as reinforcement of these concrete materials to enhance their durability is also studied. Crushed sand 0/2 mm which is a fine limestone residue obtained by the crushing of natural rocks in aggregates industry is used for the fabrication of the mortar. The fibres used, which are obtained from the waste of domestic plastic sweeps' fabrication, have a length of 20 mm and a diameter ranging between 0.38 and 0.51 mm. Two weight fibres contents are used, 0.5 and 1%. The durability tests carried out in this investigation included the water absorption by capillarity, the mass variation, the flexural and the compressive strengths of the mortar specimens immersed for 366 days in 5% sodium chloride, 5% magnesium sulphate and 5% sulphuric acid solutions. A mineralogical analysis by X-ray diffraction (XRD) and a visual inspection are used for a better examination of the quality of tested mortars and for better interpretation of their behaviour in different solutions. The results indicate that the reinforcement of limestone mortar by PP fibres waste is an excellent solution to improve its chemical resistance and durability. Moreover, the presence of PP fibres waste does not affect significantly the water absorption by capillarity of mortar nether its mass variation, when exposed to chloride and sulphate solutions. While in sulphuric acid, the mass loss is higher with the presence of PP fibres waste, especially after an exposure of 180 days. The results reveal that these fibres have a considerable effect of the flexural and the compressive behaviour of mortar especially in acid solution, where a reduction of strength loss is observed. The mineralogical analysis confirms the good behaviour of mortar immersed in sulphate and chloride solutions; and shows that more gypsum is formed in mortar exposed to acid environment causing its rapid degradation. The visual observation reveals that only samples exposed to acid attack during 366 days have showed a surface damage extending over a depth of approximately 300 ㎛.

• 대한기계학회논문집A
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• 제34권11호
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• pp.1721-1725
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• 2010

본 논문에서는 뒷면 노광법과 감광제의 열분해법을 이용하여 다양한 형상을 가지는 탄소 마이크로니들의 제조방법과 제조된 마이크로니들을 사용하여 소수성 표면제어에 대한 연구를 수행하였다. SU-8 이 도포된 표면마스크 뒷면으로부터 자외선을 조사하여 다양한 지름, 간격, 그리고 높이를 가지는 폴리머 마이크로니들을 제조하였다. 이니들은 이후 열처리공정을 통해서 수축, 열변형 등의 형상변화를 거치면서 10 이상의 높은 종횡비와 나노사이즈의 뾰족한 팁을 가지는 탄소 재질의 마이크로니들로 변하게 된다. 탄소 마이크로니들을 가지는 석영기판은 친수성표면을 가지고 있기 때문에 표면에너지가 낮은 물질을 처리하여 소수성 정도를 제어하였다. HMDS 처리는 SU-8 니들보다는 탄소 니들의 경우에 표면의 소수성 조절에 효과가 있음을 접촉각의 측정과 XPS 측정결과로부터 확인할 수 있었다. 본 논문에서 제시하는 탄소 마이크로니들의 제조기술과 표면처리기술은 세포분석 및 바이오분야 그리고 자기세정분야 등에서 유용하게 사용될 수 있다.