• 대한기계학회논문집B
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• 제33권6호
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• pp.461-467
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• 2009

Knowledge of airflow characteristics in nasal cavities is essential to understand the physiological and pathological aspects of nasal breathing. Several studies have utilized physical models of the healthy nasal cavity to investigate the relationship between nasal anatomy and airflow. In our laboratory, there have been a series of experimental investigations on the nasal airflow in normal, abnormal, and deformed nasal cavity models by PIV under both constant and periodic flow conditions. In this time normal and several deformed nasal cavity models, which simulate surgical operation, Turbinectomy, are investigated numerically by the FVM general purpose code and PIV analysis. The comparisons of these results are appreciated. Dense CT data and careful treatment of model surface under the ENT doctor's advice provide more sophisticated cavity models. The Davis (LaVision Co.) code is used for PIV flow analysis. Average and RMS distributions have been obtained for inspirational and expirational nasal airflows in the normal and deformed nasal cavities.

• Clinics in Shoulder and Elbow
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• 제17권4호
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• pp.190-193
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• 2014

Recurrent posterior shoulder instability is a debilitating condition that is relatively uncommon, but its diagnosis in young adults is increasing in frequency. Several predisposing factors for this condition have been identified, such as the presence of an abnormal joint surface orientation, an osteochondral fracture of the humeral head or glenoid cavity, and a postero-inferior capsuloligamentary deficit, but their relative importance remains poorly understood. Whilst, conservative treatment is effective in cases of hyperlaxity or in the absence of bone abnormality, failure of conservative treatment means that open or arthroscopic surgery is required. In general, soft-tissue reconstructions are carried out in cases of capsulolabral lesions in which bone anatomy is normal, whereas bone grafts have been required in cases where posterior bony Bankart lesions, glenoid defects, or posterior glenoid dysplasia are present. However, a consensus on the exact management of posterior shoulder instability is yet to be reached, and published studies are few with weak evidence. In our study, we report the reconstruction of the glenoid using iliac bone graft in a patient suffering recurrent posterior shoulder instability with severe glenoid bone defect.

• 대한치과의사협회지
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• 제54권2호
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• pp.134-141
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• 2016

Use of ready-made orthodontic appliance can lead to inefficiencies in the final stages of the orthodontic treatment. Because patients' teeth have anatomic variations, brackets that have been designed to fit on average tooth surface may result in positional discrepancies when leveling and alignment is completed. As a result, additional steps such as rebonding, wire bending and use of auxiliaries may be needed. Even in patients who have normal tooth anatomy and proper tooth size relationships, precise bracket placement is crucial in order to efficiently control the tooth positions. Digital models can provide advantages in clinical orthodontics as virtual tooth setup could be performed, and clinicians can easily visualize the predicted final occlusion. Through this setup model, customized brackets with individualized prescription and archwires that optimally fit with the patients' dental arches can be produced using CAD/CAM technology. Also, the brackets can be accurately placed with an aid of 3D-printed jigs. The purpose of this article is to introduce the commonly used labial and lingual customized orthodontic appliance systems using digital technology.

• BMB Reports
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• 제48권11호
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• pp.624-629
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• 2015

Lysozyme protects us from the ever-present danger of bacterial infection and binds to bacterial lipopolysaccharide (LPS) with high affinity. Beyond its role in the activation of protein C, the endothelial cell protein C receptor (EPCR) plays an important role in the cytoprotective pathway. EPCR can be shed from the cell surface, which is mediated by tumor necrosis factor-α converting enzyme (TACE). However, little is known about the effects of lysozyme on EPCR shedding. We investigated this issue by monitoring the effects of lysozyme on phorbol-12-myristate 13-acetate (PMA)-, tumor necrosis factor (TNF)-α-, interleukin (IL)-1βand cecal ligation and puncture (CLP)-mediated EPCR shedding and underlying mechanism. Data demonstrate that lysozyme induced potent inhibition of PMA-, TNF-α-, IL-1β-, and CLP-induced EPCR shedding. Lysozyme also inhibited the expression and activity of PMA-induced TACE in endothelial cells. These results demonstrate the potential of lysozyme as an anti-EPCR shedding reagent against PMA-mediated and CLP-mediated EPCR shedding.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1479-1483
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• 2008

The three main physiological functions of nose are air-conditioning, filtering and smelling. Knowledge of airflow characteristics in nasal cavities is essential to understand the physiological and pathological aspects of nasal breathing. Several studies have utilized physical models of the healthy nasal cavity to investigate the relationship between nasal anatomy and airflow. In our laboratory, there have been a series of experimental investigations on the nasal airflow in normal and deformed nasal cavity models by PIV under both constant and periodic flow conditions. In this time, airflow inside normal nasal cavity is investigated numerically by the FVM general purpose code. The comparisons with PIV measurement are appreciated. Heat and humidity transfer is dealt numerically. Dense CT data and careful treatment of model surface under the ENT doctor’s advice provide more sophisticated cavity models for both PIV experiment and numerical grid system. Average and RMS velocity distributions have been obtained for inspirational and expirational nasal. Temperature distribution, heat and humidity transfer through the mucosa are obtained.

• 대한치과의사협회지
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• 제56권6호
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• pp.314-322
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• 2018

Among developmental anomalies of tooth shape, fusion and gemination are comparatively common. Developed with different etiologies, both fusion and gemination show similar clinical features. Therefore, many clinicians have difficulty diagnosing those morpho-anatomic anomalies. The purpose of this study is to report malformed right maxillary first molar in a 20-year-old female. With the aid of computed tomography (CT), the tooth was diagnosed as fusion with supernumerary tooth and dental caries lesion was detected. After performing direct pulp capping, the tooth was permanently restored with microhybrid composite resin using direct method to alter union groove into smooth surface for improving oral hygiene management. Until 6 months of follow-up visits, patient's chief complaint was resolved and tooth is still vital. In conclusion, identifying exact anatomy, conservative treatment and improving oral hygiene are essential in managing unusual morphologic anomalies of tooth.

• 대한한의학방제학회지
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• 제26권4호
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• pp.283-294
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• 2018

Objectives : Mahaengeuigam-Tang (MHEGT) has been used as a traditional medicine for the treatment of rheumatic aerthritis, rheumatisim, eczema and asthma. The aim of this study was to investigate the molecular mechanisms of MHEGT for cartilage protection in monosodium iodoacetate(MIA)-induced osteoarthritis, particularly focusing on apoptosis. Method : Thirty young male Sprague-Dawley rats were used for the study. Rats were intra-articularly injected with 2 mg MIA in a total volume of 50 ㎕ saline. In MHEGT group, MHEGT extract was orally administered once daily to MIA-induced osteoarthritis rats, and rats of control group were given with saline only. At 4 weeks after MIA injection, all animals were sacrificed, and the histological changes and articular thickness were assessed by hematoxylin and eosin staining. Moreover, the immunohistochemical analyses of BAX and Bcl-2 were carried out. Results : The histomorphological examinations revealed that MHEGT reduced MIA-induced cartilage damage. And, MHEGT ameliorated the severity of cartilage surface damages after MIA injection. Furthermore, MHEGT suppressed the MIA-induced increases of pro-apoptotic BAX protein and increased the protein expression of anti-apoptotic Bcl-2 protein. Conclusion : These findings indicate that MHEGT protects against MIA-induced cartilage damage by inhibition of the apoptotic pathway, demonstrating significant protection of cartilage against osteoarthritis. These results suggest that MHEGT may potentially have clinical applications in the treatment of osteoarthritis.

• Korean Journal of Acupuncture
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• 제37권4호
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• pp.245-252
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• 2020

Objectives : The objective of this study was to examine the acupoint location of Kyoshin (KI8) from classic literatures. Methods : A review of KI8 location along the meridian route from 18 classics of acupuncture and moxibustion - 『Huangdineijing·Lingshu』, 『Huangdimingtangjingjixiao』, 『Zhenjiujiayijing』, 『Huangdineijingtaisu』, 『Huangdimingtangjiujing』, 『Beijiqianjinyaofang』, 『Waitaimiyaofang』, 『Ishimpo』, 『Taipingshenghuifang』, 『Tongrenshuxuezhenjiutujing』, 『Shengjizonglu』, 『Zhenjiuzishengjing』, 『Shisijingfahui』, 『Shenyingjing』, 『Zhenjiujuying』, 『Yixuerumen』, 『Zhenjiudacheng』, and 『Yizongjinjian』 - was performed. Then, KI7 location on classics and current standard KI8 location were compared. Results : Based on modern standard acupoint location system, the acupoint of KI8 is located on the medial aspect of the leg, in the depression posterior to the medial border of the tibia and it is on the route of spleen meridian. But no classics of acupuncture and moxibustion said KI8 was located on the route of spleen meridian. In addition, KI8 location on classics was largely described as being located in front of KI7, but only in 『Yizongjinjian』 was it written that KI8 was located posterior to KI7. Conclusions : Through a classic literature review, it is possible to explain that KI8 is located posterior to spleen meridian. The acupoint of KI8 seems to be located between medial border of flexor pollicis longus and flexor digitorum longus based on anatomical location.

• Clinics in Shoulder and Elbow
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• 제25권2호
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• pp.163-169
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• 2022

Distal humerus fractures (DHFs) are challenging to treat due to the locally complex osseous and soft tissue anatomy. Adequate exposure of the articular surface of the distal humerus is crucial when performing an anatomical reconstruction of the elbow. Even though "triceps-on" approaches are gaining popularity, one of the most commonly used surgical treatments for DHF is olecranon osteotomy. The incidence of complications related to this approach is unclear. This review was performed to assess the type and frequency of complications that occur with the olecranon osteotomy approach in the treatment of DHF. A literature search was conducted in the PubMed/Medline, Embase, and Cochrane Library digital databases up to February 2020. Only English articles describing complications of olecranon osteotomy in the treatment of DHF were included. Data on patient and surgical characteristics and complications were extracted. Statistical analysis was performed using SPSS. A total of 41 articles describing 1,700 osteotomies were included, and a total of 447 complications were reported. Of these 447 complications, wound infections occurred in 4.2% of osteotomies, of which 1.4% were deep infections and 2.8% were superficial. Problems related with union occurred in 3.7% of osteotomies, 2% of which represented non-union and 1.7% delayed union. The high risk of complications in olecranon osteotomy must be considered in the decision to perform this procedure in the treatment of DHF.

• 식물분류학회지
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• 제44권3호
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• pp.191-201
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• 2014

동아시아산 황기속의 외부형태학적 특징과 과피, 종피의 해부구조 및 표면 형태를 조사하여 분류학적으로 유용한 형질을 찾고자 하였다. 연구 결과, 황기속의 외부형태, 과피, 종피의 형태 및 해부학적 특징 중 생활사, 소엽의 형태, 꽃차례, 꽃잎의 색, 종자의 색, 과피의 형태, 과피 표면에서 털의 존재유무, 봉선의 구조, 그리고 내과피 층의 두께가 종을 나누는 식별형질로 사용될 수 있음을 확인하였다. 이를 바탕으로 중국에서 황기라는 약재로 사용되어지고 있는 4종의 형태 및 해부학적인 특성을 비교한 결과, 서로 같은 군으로 유집되었다. 한편, 분류학적으로 논쟁이 되고 있는 정선황기와 갯황기에서는 두 분류군간에 형태적 차이점을 발견 할 수 없었다. 따라서 금후 정선황기, 갯황기, A. bhotanensis의 종간 분류학적 처리를 명확히 규명하기 위하여 염기서열 및 분자세포학 수준에서의 연구가 필요하다.