• Journal of Pharmacopuncture
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• v.18 no.1
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• pp.63-71
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• 2015

Objectives: This study was carried out to analyze the single-dose toxicity of Eun-Bi San pharmacopuncture injected into the muscle of Sprague-Dawley (SD) rats. Methods: All experiments were performed at Biotoxtech, an institution certified to conduct non-clinical studies under the Good Laboratory Practice (GLP) regulations. Six week old SD rats reared by ORIENTBIO were chosen for this pilot study. The reason SD rats were chosen is that they have been widely used in safety tests in the field of medicine, so the results can be easily compared with many other databases. The Eun-Bi San pharmacopuncture was made in a clean room at the Korean Pharmacopuncture Institute (KPI, K-GMP). The constituents of the Eun-Bi San pharmacopuncture are Angelicae gigantis radix, Strychni semen and Glycyrrhizae radix. These were extracted at low temperature and low pressure in an aseptic room at the KPI. Doses of Eun-Bi San pharmacopuncture, 0.25, 0.5 and 1.0 mL, were administered to the experimental groups, and a dose of normal saline solution, 1.0 mL, was administered to the control group. This study was performed under the approval of the Institutional Animal Ethics Committee of Biotoxtech Co., Ltd. Results: No deaths or abnormalities occurred in any of the four groups. No significant changes in weight, hematological parameters or clinical chemistry between the control group and the experimental groups were observed. To determine if abnormalities existed in any organs and tissues, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs or tissues. Conclusion: The results of this study suggest that treatment with Eun-Bi San pharmacopuncture is relatively safe and that its clinical use may be beneficial. Further evaluations and studies on this subject will be needed to provide more concrete evidence in support of these conclusions.

• Journal of the Korean Society of Hazard Mitigation
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• v.2 no.4 s.7
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• pp.131-141
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• 2002

Precast concrete (PC) panels are often used as retaining walls to support soil pressure. In such a case, the panels should be connected at the location where PC panels meet with a buttress. However, it is not easy to provide enough development length for the reinforcing steels due to the limited width of the buttress. If it happens, the width of buttress should be increased as large enough although it is not desirable. The critical section required for providing the development length is always located where the flexural moment is maximum. Thus it is the place the buttress width ends. Also it is the place that the reinforcing steels stressed to maximum. However, it is possible to make differentiate between the maximum moment location and the most stressed location of reinforcing steels. It means that the most stressed location of reinforcing steels, the critical section, can be moved to the other place where the moment is not maximum. New critical location will have less moment than that of buttress width ends. In consequence, the development length would be longer than that of the typical way of construction. Debonding or cutting technique make it possible to reduce the moment strength of a section. Therefore reinforcing steels are debonded or cut to have a desired flexural strength at a desired place. In this study, five test specimens in full scale were erected to examine the effects of critical section movement in PC panel joints. Test parameters were the length variations of debonded and cut reinforcing steels. The test results showed that the debonding or cutting technique could be used to lengthen the development length in the joint of PC panels.

• The Journal of Internal Korean Medicine
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• v.27 no.3
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• pp.639-652
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• 2006

Objective : The etiology of chronic prostatitis is likely multifactorial, resulting from either a cascade of events after an initiating factor or from a variety of etiologic mechanisms. There is substantiating evidence to support the role of the inflammatory responses in its pathogenesis, and the clinical value in the evaluation of therapeutic efficacy. Forsythiae Frucus has been traditionally used in treatment of inflammatory diseases, including of prostatitis and urinary tract inflammation. In this study, we investigated the effects of Forsythiae Frucus on inflammatory cytokines and cyto-pathological alternation in the rat model of chronic non-bacterial prostatitis induced by castration and $17{\beta}$-estradiol treatment. Methods : Two-month-old rats were treated with $17{\beta}$-estradiol after castration for induction of experimental non-bacterial prostatitis. which is similar to human chronic prostatitis in histopathological profiles. Forsythiae Frucus as an experimental specimen, and testosterone as a positive control, were administered orally. The prostates were evaluated by histopathologlcal parameters including the epithelial score and epithelio-stromal ratio for glandular damage. and the expression of inflammatory cytokine genes including interleukin (IL)-$1{\beta}$, IL-5, IL-12, tumor necrosis factor (TNF)-$\alpha$. eotaxin, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2(cox-2). Results : While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation. the rats treated with Forsythiae Frucus showed a diminished range of tissue damage. Epithelial score was improved in the Forsythiae Frucus group over that of the control (P<0.05). The epithelia-stromal ratio was lower in the Forsythiae Frucus group when compared to that of the control (P<0.05). In the reverse transcription-polymerase chain reaction (RT-PCR) of inflammatory cytosine genes. Forsythiae Frucus inhibited the expression of IL-$1{\beta}$, TNF-$\alpha$, iNOS, cox-2 genes, while it modulated the expression of IL-5, which is an anti-inflammatory cytokine. Conclusions : These findings suggest that Forsythiae Frucus may protect the glandular epithelial cells and also inhibit stromal proliferation in association with the immune modulation including the suppression of inflammatory cytokines and increase of anti-inflammatory cytokines. From theses results. we suggest that Forsythiae Frucus could be a useful remedy agents for treating chronic non-bacterial prostatitis.

• Journal of Korean Neurosurgical Society
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• v.29 no.4
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• pp.536-542
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• 2000

Objective : This study was performed to evaluate the relationships among intracranial pressure(ICP), cerebral perfusion pressure(CPP), and cerebral arteriovenous oxygen difference($AVDO_2$) which were used as parameters of adequacy of cerebral blood flow to support cerebral metabolism after severe head injury and also to examine the association between delayed cerebral infarction and outcome. Material and Method : The authors studied the ICP, CPP and $AVDO_2$ before and after treatment on 34 head-injured patients from June 1996 to December 1997 and examined the association with the change of an ICP, CPP and $AVDO_2$ following treatment and the development of delayed cerebral infarction. Sixteen patients underwent craniotomy for hematoma evacuation and eighteen patients received mannitol to decrease ICP. Results : The development of delayed cerebral infarction was demonstrated in 3(42.9%) out of 7 patients in no improvement group and 13(48.1%) out of 27 patients in improvement group with an increased ICP following treatment. Also, the development of delayed cerebral infarction was demonstrated in 8(50%) out of 16 patients in no improvement group and 8(44.4%) out of 18 patients in improvement group with a decreased CPP following treatment. The association with changes of ICP and CPP following treatment and development of delayed cerebral infarction was not statistically significant(p>0.01). However, 11(78.6%) out of 14 patients who demonstrated an increase in $AVDO_2$ and 5(25%) out of 20 patients who demonstrated a decrease in $AVDO_2$ following treatment developed delayed cerebral infarction. No improvement(reduction) in $AVDO_2$ following treatment was significantly associated with the development of delayed cerebral infarction(p<0.01). All of 16 patients with delayed cerebral infarction showed poor prognosis. Conlcusion : The change of $AVDO_2$ rather than those of ICP and CPP was considered more important factor for the development of the delayed cerebral infarction and poor outcome.

• Journal of KIISE:Computing Practices and Letters
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• v.5 no.6
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• pp.782-792
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• 1999

효과적인 ATM 망의 관리는 연결 지향 환경, 다양한 서비스 등급, 대규모 트래픽, 가상 망 구성 그리고 여러가지 트래픽 유형 등과 같은 다양한 ATM 특성을 다룰 수 있어야만 한다. 이를 위해 ATM 포럼에서는 ATM 장치, 사설망, 공중망 및 그들간의 상호작용을 지원하기 위한 ATM 망 관리 참조 모델을 정의하였으며, 그 중 하나가 서로 다른 판매자로부터의 ATM 장비들간의 상호동작성을 보장하기 위해 SNMP 기반 망 관리 프로토콜을 통해 상호 연결된 인터페이스를 관리할 수 있도록 정의된 통합 지역 관리 인터페이스(ILMI) 프로토콜이다. ILMI의 목적은 두 인접한 ATM 장치로 하여금 그들 간에 공통의 ATM 링크에 대한 동작 파라메타를 자동적으로 구성할 수 있도록 함으로서, 관리자에 의해 수동 구성이 아닌 ATM 장치 상호간의 플러그 앤 플러그 기능을 지원하는데 있다. 본 논문에서는 이러한 ILMI 기술을 바탕으로 공중망 ATM 교환기에 연결된 가입자의 물리 인터페이스, ATM 계층 인터페이스, VPC 및 VCC의 구성 및 상태 정보를 효율적으로 관리하며, 가입자 시스템의 ATM 주소를 자동으로 등록, 관리할 수 있도록 하는 가입자 인터페이스 관리 시스템(SIMS)을 설계하고, 구현하였다. Abstract An effective ATM management must address the various features of ATM such as connection-oriented environment, varying class of service, large scale traffic, virtual network configurations and, and multiple traffic types. For this, ATM network management reference model defined by ATM Forum describes the various types of network management needed to support ATM devices, private networks, public networks, and the interaction between them. One of these types is Integrated Local Management Interface (ILMI) defined to manage interconnected interface through SNMP-based network management protocol for ensuring the interoperability of ATM devices from different vendors. The purpose of ILMI is to enable two adjacent ATM devices to automatically configure the operation parameters of the common ATM link between them and then to provide a Plug and Plug function to any ATM devices with not a passive configuration by manager but a automatic configuration. This paper design and implement a Subscriber Interface Management System (SIMS) which provide automatic registration and management of ATM address of subscriber system and efficiently manages physical interface of subscriber who is connected to public ATM switch, ATM layer interface, configuration information and status information of VPC and VCC.

• Korean Journal of Dental Materials
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• v.42 no.2
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• pp.95-106
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• 2015

Hardening mechanism associated with post-firing heat treatment of softening heat treated and then firing simulated Pd-Ag-Au alloy for bonding porcelain was examined by observing the change in hardness, crystal structure and microstructure. By post-firing heat treatment of as-cast, solution treated and pre-firing heat treated specimens at $650^{\circ}C$ after casting, the hardness value increased within 10 minutes. Then, hardness consistently increased until 30 minutes, and gap of hardness value among the specimens was reduced. The increase in hardness after post-firing heat treatment was caused by grain interior precipitation in the matrix. The softening heat treatment did not affect the increase in hardness by post-firing heat treatment. The precipitated phase from the parent Pd-Ag-Au-rich ${\alpha}$ phase with face-centered cubic structure by post-firing heat treatment was $Pd_3$(Sn, In) phase with face-centered tetragonal structure, which has lattice parameters of $a_{200}=4.0907{\AA}$, $c_{002}=3.745{\AA}$. From above results, appropriate post-firing heat treatment in order to support the hardness of Pd-Ag-Au metal substructure was expected to bring positive effects to durability of the prosthesis.

• Korean Journal of Remote Sensing
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• v.18 no.4
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• pp.209-220
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• 2002

We carried out studies on SAR image intensity and interferometric phase over oyster sea farms. Strong backscattering was observed in amplitude images, and that was considered as a radar signal double bouncing from horizontal bars. These sea farming structures are not visible in satellite optical images except IKONOS image, so that it demonstrates the value of radar remote sensing as an effective tool in support of sea farm detection. The intensity of the image is sensitive to system parameters including wavelength, polarization, and look direction, but does not correlate to tide height. We found that the strongest backscattering can be obtained by L-band HH-polarization with a look direction perpendicular to the horizontal bar. We also succeeded in generating 21 coherent JERS-1 SAR interferometric pairs over the oyster farms. The general trend of the fringe rate of the interferometric phases appeared to be governed by altitude of ambiguity. The general trend was modeled by an inverse function and removed to have a residual phase. The residual phase showed a linear relation with the tide height. The results demonstrate for the first time that SAR can possibly be used to estimate sea level. However, the r.m.s. error of a regression line is 11.7 cm, and that is so far too large to make reliable assessments of sea level in practical applications. Further studies is required to improve the accuracy specifically using multi-polarization SAR data.

• Journal of The Korean Society of Agricultural Engineers
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• v.63 no.6
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• pp.77-88
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• 2021

Duck industry had a rapid growth in recent years. Nevertheless, researches to improve duck house environment are still not sufficient enough. Moisture generation of duck house litter is an important factor because it may cause severe illness and low productivity. However, the measuring process is difficult because it could be disturbed with animal excrements and other factors. Therefore, it has to be calculated according to the environmental data around the duck house litter. To cut through all these procedures, we built several machine learning regression model forecasting moisture generation of litter by measured environment data (air temperature, relative humidity, wind velocity and water contents). 5 models (Multi Linear Regression, k-Nearest Neighbors, Support Vector Regression, Random Forest and Deep Neural Network). have been selected for regression. By using R-Square, RMSE and MAE as evaluation metrics, the best accurate model was estimated according to the variables for each machine learning model. In addition, to address the small amount of data acquired through lab experiments, bootstrapping method, a technique utilized in statistics, was used. As a result, the most accurate model selected was Random Forest, with parameters of n-estimator 200 by bootstrapping the original data nine times.

• Cross-Cultural Studies
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• v.45
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• pp.109-143
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• 2016

This article examines distinctive linguistic shifts of translational English in an effort to verify the validity of the translation universals hypotheses, including simplification, explicitation, normalization and leveling-out, which have been most heavily explored to date. A large-scale study involving comparable corpora of translated and non-translated English newspaper texts has been carried out to typify particular linguistic attributes inherent in translated texts. The main findings are as follows. First, by employing the parameters of STTR, top-to-bottom frequency words, and mean values of sentence lengths, the translational instances of simplification have been detected across the translated English newspaper corpora. In contrast, the portion of function words produced contrary results, which in turn suggests that this feature might not constitute an effective test of the hypothesis. Second, it was found that the use of connectives was more salient in original English newspaper texts than translated English texts, being incompatible with the explicitation hypothesis. Third, as an indicator of translational normalization, lexical bundles were found to be more pervasive in translated texts than in non-translated texts, which is expected from and therefore support the normalization hypothesis. Finally, the standard deviations of both STTR and mean sentence lengths turned out to be higher in translated texts, indicating that the translated English newspaper texts were less leveled out within the same corpus group, which is opposed to what the leveling-out hypothesis postulates. Overall, the results suggest that not all four hypotheses may qualify for the label translation universals, or at least that some translational predictors are not feasible enough to evaluate the effectiveness of the translation universals hypotheses.

• Journal of Korean Tunnelling and Underground Space Association
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• v.20 no.6
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• pp.1105-1123
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• 2018

The main risk factors of tunnel excavation through urban areas are ground settlement and surface sink which caused by ground conditions, excavation method, groundwater condition, excavation length, support method, etc. In the process of ground settlement assessment, the numerical analysis should be conducted considering the displacement and stress due to tunnel excavation. Therefore a technique that can simplify such process and easily evaluate the influence of tunnel excavation is needed. This study focused on the tunnelling-induced ground settlement which is main consideration of underground safety impact assessment. The parametric numerical analyses were performed considering such parameters as ground conditions, tunnel depth, and lateral distance from tunnel center line, etc. A simplified ground settlement evaluation chart was suggested by analyzing tendency of ground subsidence, lateral influence area and character by depth. The applicability of the suggested settlement evaluation chart was verified by comparative numerical analysis of settlement characteristics.