• Genomics & Informatics
• /
• 제21권3호
• /
• pp.38.1-38.8
• /
• 2023

Non-small cell lung cancer (NSCLC) is an important cause of cancer-associated deaths worldwide. Therefore, the exact molecular mechanisms of NSCLC are unidentified. The present investigation aims to identify the miRNAs with predictive value in NSCLC. The two datasets were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed miRNAs (DEmiRNA) and mRNAs (DEmRNA) were selected from the normalized data. Next, miRNA-mRNA interactions were determined. Then, co-expression network analysis was completed using the WGCNA package in R software. The co-expression network between DEmiRNAs and DEmRNAs was calculated to prioritize the miRNAs. Next, the enrichment analysis was performed for DEmiRNA and DEmRNA. Finally, the drug-gene interaction network was constructed by importing the gene list to dgidb database. A total of 3,033 differentially expressed genes and 58 DEmiRNA were recognized from two datasets. The co-expression network analysis was utilized to build a gene co- expression network. Next, four modules were selected based on the Z_summary score. In the next step, a bipartite miRNA-gene network was constructed and hub miRNAs (let-7a-2-3p, let-7d-5p, let-7b-5p, let-7a-5p, and let-7b-3p) were selected. Finally, a drug-gene network was constructed while SUNITINIB, MEDROXYPROGESTERONE ACETATE, DOFETILIDE, HALOPERIDOL, and CALCITRIOL drugs were recognized as a beneficial drug in NSCLC. The hub miRNAs and repurposed drugs may act a vital role in NSCLC progression and treatment, respectively; however, these results must validate in further clinical and experimental assessments.

• 한국콘텐츠학회논문지
• /
• 제10권11호
• /
• pp.20-29
• /
• 2010

KFD 웹 데이터베이스 시스템은 가족미술치료사들의 요구사항을 반영하여, 방대한 평가 자료의 관리 및 효율적인 사정평가 과정의 지원을 위해 개발된 프로토타입 시스템이다. 그러나 KFD 웹 데이터베이스 시스템은 내담자가 그림을 그리는 동안의 행동패턴, 얼굴 표정, 그리고 음성 정보등과 같은 중요한 관찰요소들에 관한 정보는 얻을 수 없다는 문제점이 있다. 따라서 본 논문에서는 웹 카메라와 그림판 툴을 이용하여 내담자의 KFD 작업 과정을 녹화하고, 녹화된 영상 내의 주요 이벤트들을 인덱싱하여 가족미술치료사가 KFD 동영상을 분석하고 검색할 수 있도록 온톨로지 기반의 이벤트 분석 및 검색 시스템을 제안한다. 즉 새롭게 제안된 시스템에서는 가족 구성원에 관한 내담자의 이벤트 및 행동분석에 관한 요약 보고서와 함께 비디오 검색 서비스가 제공된다. 제안된 KFD 동영상 내의 이벤트 분석 및 검색 시스템은 가족치료사에게 내담자의 작업태도 및 행동, 그리고 KFD 작성과정에 대한 정량적이고, 객관적인 정보를 제공함으로써 보다 강화된 KFD 사정 평가를 지원할 수 있다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권1호
• /
• pp.259-263
• /
• 2015

Background: In the field of cancer, the ICD-10 coding convention is based on the site of a neoplasm in the body and usually ignores the morphology, thus the same code may be assigned to tumors of different morphologic types in an organ. Nowadays, all general (provincial) and center hospitals in Thailand are equipped with the hospital information system (HIS) database. Objective: This study aimed to find the characteristics and magnitude of agreement represented by the positive predictive value (PPV) of provisional cancer diagnoses in the HIS database in Pattani Hospital in Thailand in comparison with the final cancer diagnosis of the ICD-10 codes generated from a well established cancer registry in Songklanagarind Hospital, the medical school hospital of Prince of Songkla University. Materials and Methods: Data on cancer patients residing in Pattani province who visited Pattani Hospital from January 2007 to May 2011 were obtained from the HIS database. The ICD-10 codes of the HIS computer database of Pattani Hospital were compared against the ICD-10 codes of the same person recorded in the hospital-based cancer registry of Songklanagarind Hospital. The degree of agreement or positive predictive value (PPV) was calculated for each sex and for both sexes combined. Results: A total of 313 cases (15.9%) could be matched in the two databases. Some 222 cases, 109 males and 113 females, fulfilled the criteria of referral from Pattani to Songklanagarind Hospitals. Of 109 male cancer cases, 76 had the same ICD-10 codes in both hospitals, thus, the PPV was 69.7% (95%CI: 60.2-78.2%). Agreement in 76 out of 113 females gave a PPV of 67.3% (95%CI: 57.8-75.8%). The two percentages were found non-significant with Fisher's exact p-value of 0.773. The PPV for combined cases of both sexes was 68.5% (95%CI: 61.9-74.5%). Conclusions: Changes in final diagnosis in the referral system are common, thus the summary statistics of a hospital without full investigation facilities must be used with care, as the statistics are biased towards simple diseases able to be investigated by available facilities. A systematic feedback of patient information from a tertiary to a referring hospital should be considered to increase the accuracy of statistics and to improve the comprehensive care of cancer patients.

• 보건행정학회지
• /
• 제27권2호
• /
• pp.128-138
• /
• 2017

Background: The purpose of this study is to analyze the effects of differential coinsurance policy on prescription drug coverage of outpatients by types of medical institutions. Methods: In this study, we used a sample cohort database of the National Health Insurance Service and frequency analysis and marginal logistic regression model using generalized estimating equation were used for statistical analysis. Results: The summary on the major research is followed. First, about 16% of patients who used only tertiary or general hospital due to 52 ambulatory care sensitive conditions before policy implementation moved to hospitals and clinics. However, about 57% of them still use tertiary or general hospital. Second, the factors influencing the utilization of hospitals and clinics after the implementation of the policy were gender, age, and income level. As a result, the policy is effective to reduce the medical use of outpatient mental patients in tertiary or general hospital, but the effect is not significant. Conclusion: Therefore, in order to achieve the purpose of the policy for establishing the health care delivery system, it is necessary to adjust the co-payment so as to feel the burden on the co-payment when the outpatient for 52 ambulatory care sensitive conditions is used at the tertiary or general hospital.

• 한국정밀공학회지
• /
• 제22권4호
• /
• pp.136-143
• /
• 2005

Open architecture controller (OAC) is well known technology in factory automation. To better understand the requirements of OAC, authors have discussed the OAC related topics with a number of control experts who represents different segments of the machining industry. There is no common concept that is accepted or used, however, the common ideas for OAC is the control system that is hardware independent, interchangeable, and easily scalable. This paper presents summary of the understaning and requirements of OAC. Based on the requirements of OAC, authors developed the software based PC-CNC. The main focus of the PC-CNC was on the user customization capability and open interface between control networks in manufacturing system. This paper introduces the developed PC-CNC briefly. In addition to introduction of the PC-CNC, to fill the gap between end users and vendors of OAC, this paper presents two applications using OAC. One is a remote monitoring system. The OPC (Ole for Process Control) standard interface was used to monitor the status of open architecture CNC across network. The other is the remote production management module for machine tools using standard database interface.

• 한국멀티미디어학회논문지
• /
• 제6권5호
• /
• pp.797-804
• /
• 2003

장면 전환검출 (scene change detection)은 영상 정보의 색인 (indexing) 및 검색을 위한 전처리로서 비디오 검색 시스템의 전체 성능을 좌우하는 중요한 기술로 현재 많은 연구가 진행되고 있다. 본 논문에서는 급격한 움직임 및 조명 변화, 빠르게 연속적으로 등장하는 장면 전환에 강건한 급격한 장면 전환 검출 기법과 디졸브, 페이드 등의 장면 전환을 보다 효과적으로 검출할 수 있는 점진적인 장면 전환 검출 기법 및 추출된 셧 (shot)의 내용을 DCT DC 이미지 버퍼링과 누적 히스토그램 교차 함수 (accumulative histogram intersection measure)에 의해 대표 프레임으로 추출하는 새로운 알고리즘을 제안하고, 모의 실험 결과 기존 방식에 비해 보다 우수한 성능을 보임을 입증하였다.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2003년도 추계학술대회 논문집 전력기술부문
• /
• pp.178-180
• /
• 2003

Since faults often occur on power system, relay protection has become an important part to protect the equipments of power system efficiently and safely. Database can store the data about the relay protection efficiently, and these data must be shown to users through the web. Proset2000(an overall program system to protect power system) can realize this function in some measure, but it needs to be developed. This paper is about the further development of Proset2000. In this paper, web of Proset2000 is made by ASP programming technology, and users can browse and search the useful data through the web. There are some new functions, such as the summary of setting values, the message board and the management of administrator.

• 한국방사성폐기물학회:학술대회논문집
• /
• 한국방사성폐기물학회 2005년도 Proceedings of The 6th korea-china joint workshop on nuclear waste management
• /
• pp.76-85
• /
• 2005

The conceptual study of Accelerator Driven System (ADS) had lasted for about five years and ended in 1999 in China. As one project of 'the major state basic research program (973)' in energy domain, which is sponsored by the China Ministry of Science and Technology (MOST), a five years program of basic research for ADS physics and related technology has been launched since 2000 and passed national review last month. CIAE (China Institute of Atomic Energy), IHEP (Institute of High Energy Physics), PKU-IHIP (Institute of Heavy Ion Physics in Peking University) and other institutions are jointly carrying on the research. The research activities are focused on HPPA physics and technology, reactor physics of external source driven sub-critical assembly, nuclear data base and material study. For HPPA, a high current injector consisting of an ECR ion source, LEBT and a RFQ accelerating structure of 3.5MeV has been built. In reactor physics study, a series of neutron multiplication experimental study has been carried out and is being carrying on. The VENUS facility has been constructed as the basic experimental platform for the neutronics study in ADS blanket. It's a zero power sub-critical neutron multiplying assembly driven by external neutron produced by a pulsed neutron generator. The theoretical, experimental and simulation study on nuclear data, material properties and nuclear fuel circulation related to ADS is carrying on to provide the database for ADS system analysis. The main results on ADS related researches will be reported.

• 대한한의학원전학회지
• /
• 제32권1호
• /
• pp.191-204
• /
• 2019

Objectives : Focusing on Wujutong's critiques for Xiebaisan misuse, this study investigates how Xiebaisan and its constituent drugs have historically been used by medical doctors and analyzes the disputes in the controversial context with a summary. Methods : The contents of Xiebaisan prescription were collected and examined from the past literature and medical database, and the issues related to the debate were examined by analyzing the contents. Results : In the results of exploring the opinions of medical doctors, in general, Xiebaisan and Sangbaipi, a major medicinal drug, were seen to play a role in the work of reinforcing and reducing. In particular, Ye Tianshi was used with cold and pungent medicine to Xiebaisan as a method of releasing heat with pungent medicine for acute fever in spring, and at the same time, care was taken to avoid depletion of secretion in the stomach. Conclusions : Wujutong's critique is that in early symptoms of viral infection, the misuse of Xiebaisan seems to emphasize the adverse effects of the illness. It is hoped that further research on Xiebaisan incremental medication will be conducted in the future to help clinical applications of Xiebaisan system medication.

• International Journal of Internet, Broadcasting and Communication
• /
• 제13권4호
• /
• pp.121-128
• /
• 2021

In order to design a real time big data collection and analysis system of manufacturing data in a smart factory, it is important to establish an appropriate wired/wireless communication system and protocol. This paper introduces the latest communication protocol, OPC-UA (Open Platform Communication Unified Architecture) based client/server function, applied user interface technology to configure a network for real-time data collection through IoT Integration. Then, Database is designed in MES (Manufacturing Execution System) based on the analysis table that reflects the user's requirements among the data extracted from the new cutting process automation process, bush inner diameter indentation measurement system and tool monitoring/inspection system. In summary, big data analysis system introduced in this paper performs SPC (statistical Process Control) analysis and visualization analysis with interface of OPC-UA-based wired/wireless communication. Through AI learning modeling with XGBoost (eXtream Gradient Boosting) and LR (Linear Regression) algorithm, quality and visualization analysis is carried out the storage and connection to the cloud.