• Genomics & Informatics
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• v.13 no.2
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• pp.45-52
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• 2015

Acute myeloid leukemia is a well characterized blood cancer in which the unnatural growth of immature white blood cell takes place, where several genes transcription is regulated by the micro RNAs (miRNAs). Argonaute (AGO) protein is a protein family that binds to the miRNAs and mRNA complex where a strong binding affinity is crucial for its RNA silencing function. By understanding pattern recognition between the miRNAs-mRNA complex and its binding affinity with AGO protein, one can decipher the regulation of a particular gene and develop suitable siRNA for the same in disease condition. In the current work, HOXA9 gene has been selected from literature, whose deregulation is well-established in acute myeloid leukemia. Four miRNAs (mir-145, mir-126, let-7a, and mir-196b) have been selected to target mRNA of HOXA9 (NCBI accession No. NM_152739.3). The binding interaction between mRNAs and mRNA of HOXA9 gene was studied computationally. From result, it was observed mir-145 has highest affinity for HOXA9 gene. Furthermore, the interaction between miRNAs-mRNA duplex of all chosen miRNAs are docked with AGO protein (PDB ID: 3F73, chain A) to study their interaction at molecular level through an in silico approach. The residual interaction and hydrogen bonding are inspected in Discovery Studio 3.5 suites. The current investigation throws light on understanding of AGO-assisted miRNA based gene silencing mechanism in HOXA9 gene associated in acute myeloid leukemia computationally.

• Korean Journal of Human Ecology
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• v.23 no.5
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• pp.861-871
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• 2014

This study explored applicability of natural dyeing and functional property of base paper using paper yarn and fabrics with green laver extracts. As a result of measuring dyeability and functional property of cotton, silk, and a blended fabric of cotton/mulberry, $60^{\circ}C$ and 40 minutes was the optimal dyeing condition for the cotton fabric under an alkali condition; $50^{\circ}C$ and 60 minutes for the silk fabric; $60^{\circ}C$ and 50 minutes for the blended fabric of cotton/mulberry. As a result of measuring the color fastness after dyeing cotton, silk and the blended fabric of cotton/mulberry, fastness to washing, water, rubbing, dry cleaning and light was superior. In terms of functional property, the silk and the blended fabric of cotton/mulberry were superior concerning antimicrobial properties of the fabric dyed with green laver extracts while the cotton fabric showed 90% or over. Regarding deodorization, the blended fabric of cotton/mulberry was the most superior. All the fabrics were harmless to the human body as they had heavy metal content below the standard. Considering the research results comprehensively, the green laver extracts possibly has enough applicability and functional property as a natural dyes. Moreover, it has potential to be developed new eco-friendly fashion materials.

• Korean Medical Education Review
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• v.9 no.2
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• pp.57-66
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• 2007

Purpose How can be a great doctor with excellence and ethics? In this study, I wanted to find out the characteristics of human environment to make a great doctor. Methods: First, I researched factors and construct of the human environment. So I conceived a model for analyzing human environment with two construction model : Howard Gardner's System Model and Bron-fenbrenner's ecological systems model. Second, I analyzed the life of the Oliver R. Evison M.D. and Ki Ryu Jang M.D. Oliver R. Evison was the pioneer of medicine of Korea and establisher of the Severance Hospital and medical college. Dr KiRyu Jang, who was called 'Schweitzer of Korea', was a good doctor of the poor and weak patients in Korea. Third, I tried to find out a new human environment model to make a great doctor. Results One model for analyzing human environment was made of relationship based on emotion. relationship teaching knowledge and skill, and relationship communicating on value. In the light of analyzing of two great doctors. Oliver R. Evison M.D. and KiRyu Jang M.D, I found out special interrelationship, Hardie, Allen, Severance for Evison, Kyosin Kim, Kyucheol Choi etc. for Ki Ryu Jang These special people were religious actors or social thinkers. Conclusions: To be a great doctor to excel and innovate medical field, medical students should have the chance to meet with people based on religious, ethical and social action, discuss on value across social fields, and can construct the idea to make and realize higher value of medical action. In sum, another important human environment for medical students would be a person who could be communicate with true value.

• Journal of the Korean earth science society
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• v.31 no.4
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• pp.348-353
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• 2010

The scattered light of solar radiance near the infrared ray area was observed to measure $H_2O$ and $O_2$ absorption lines. The changes of $H_2O$ and $O_2$ equivalent width were calculated on the basis of the measurement. $O_2$ equivalent width showed negative correlation with the amount of solar radiance; $O_2$ equivalent width had a tendency to diminish as the amount of the solar radiance increased and to increase as the amount of the solar radiance decreased. On the other hand, $H_2O$ equivalent width showed the positive correlation with the amount of solar radiance. Especially it was noted that the sum of equivalent width of absorption lines created by $H_2O$ and $O_2$ in a day was fairly constant. It is implied that the constant equivalent width is caused by the complementary development of photodissociation and recombination in $O_2$ and $H_2O$.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.8
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• pp.1593-1598
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• 2012

In this paper, we propose an intelligent signal control method based on fuzzy logic applicable in real time. We design membership functions to model occupied time and the number of vehicles for each lane. A priority for each signal phase is computed by the popular Max-Min fuzzy inference based on control rules and membership degrees of prepared two functions at any given time. A tie breaking scheme is considering weighted sum of the rate of occupied time per number of vehicles in that block and the standard deviation of these blocks. Only a signal phase with the highest priority is opened and all others are closed and the duration of the phase opening is computed proportional to the rate of number of weighting vehicles in that signal per all weighted vehicles. The simulation result shows that the proposed method is more efficient than the static control in all simulation conditions in $2{\times}3$ experimental designs with the number of vehicles in intersection and congestion degrees that have all three levels.

• International Journal of Highway Engineering
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• v.10 no.4
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• pp.161-170
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• 2008

This study deals with the accident models by vehicle type. The goal is to develop the accident models by vehicle type using the data of 143 4-legged signalized intersections in Cheongju. In pursuing the above, this study gives the particular attentions to explaining the relationships between the values of EPDO(equivalent property damage only) and the traffic and geometric elements. The main results analyzed are the followings. First, 6 negative binomial models are developed, which are all significant at the 90% confidence level. Second, the values of ${\rho}^2$ by vehicle type are 0.14307(auto), 0.35556(large van), 0.21684(small van), 0.205152(motocycle), 0.32338(light-duty truck) and 0.29046(heavy-duty truck), that are all analyzed to be statistically significant. Finally, the common variable included in all models is ADT(average daily traffic), and the specific variable(SV) of auto is analyzed to be the sum of lane width of main road, SV of large van is the average yellow time, and SV of small van is the difference in the number of lane between main and minor road.

• Journal of Educational Research in Mathematics
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• v.9 no.1
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• pp.263-278
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• 1999

Computer with various powerful functions has profound potential for mathematics instruction and learning. As computer technology progress, its applicability to mathematics education become more comprehensive. Not only its functional development but various psychological positions also changed the way computer technology utilized in mathematics education. In behaviorist's perspective, computer viewed as a teaching machine and constructivist viewed computer as microworld where students could explore various mathematical contents. Both theoretical positions emphasized individual aspect of learning because behaviorist tried to individualize learning using computer and constructivist focused on the process of individual construction. But learning is not only a individual event but also a social event. Therefore we must take social aspect into account. This is especially important when it comes to computer based learning. So far, mathematics loaming with computer weighed individual aspect of loaming. Even in microworld environment, learning should be mediated by teacher and collaborative learning activities. In this aspect, the roles of teacher and peers are very important and socio-cultural perspective sheds light on the computer based learning. In socio-cultural perspective, the idea of scaffold is very important in learning and students gradually internalize the social dimension and scaffolding is gradually faded. And in the zone of proximal development, teacher and more competent peers guide students to formulate their own understanding. In sum, we must take following points into account. First of all, computer should not be viewed as a medium for individualized teaming. That is, interaction with computer should be catalyst for collaborative activities with peers. So, exploration in computer environment has to be followed by small group activities including small group discussion. Secondly, regardless of the role that computer would play, teacher should play a crucial role in computer based learning. This does not mean teacher should direct every steps in learning process. Teacher's intervention should help student construct actively. Thirdly, it is needed to conceptualize computer in learning situation as medium. This would affect learning situation and result in the change of pre-service and in-service teacher training. Computer to be used effectively in mathematics classroom, researches on assessment of computer based learning are needed.

• The International Journal of Costume Culture
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• v.4 no.3
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• pp.182-194
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• 2001

The main purpose is to study lines on different body types and to disguise any imperfections by using diverse princess lines. We separated festers body shapes into specific body types, A, H by applying both the direct and the indirect measurements. Following are the results of the study: 1. nose are the resulting illusion effects when the shoulder width of the princess line was fixed. In case of the armhole princess line, the illusion that the waist intervals were narrow or wide in A-line silhouette. In case the shoulder princess line, when the waist interval was narrow, it appeared to show narrow shoulder in A-line silhouette. While the wide waist interval shows the wide shoulder width in H-line silhouette. It regards body type H in the same light as H-line silhouette when the waist interval is narrow, it appeared to show narrow shoulder width in A-line silhouette. When the waist interval was wide, it appeared to give the narrow shoulder width. 2. When the princess lines waist width was fixed in order to study illusion effects of waist widths. Generally, for body type A, Whether the waist interval princess line is narrow or wide, the princess line is located comparatively wide, in A-line silhouette appeared to show relatively slender waist. For body type H, whether the waist interval is narrow or wide, the princess line us situated comparatively narrow interval, H-line silhouette appeared to show sum waist but the differences are not significant 3. The illusion of the hip were studied by fixating the width of the skirt and varying the locations of princess line and waist widths. For the location of both armhole and shoulder princess line in H and A-line silhouette, the narrow shoulder width and the waist appeared to show narrow hips. mile they are wide appeared to show wide hips. 4. With both waist and skirt width fuel, all two body types showed taller and slender postures when the princess line originated from the shoulder compare to the armhole.

• Economic and Environmental Geology
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• v.19 no.spc
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• pp.121-130
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• 1986

In the Janggun mine, stannite occurs as anhedral grains, up to 500 micrometer in long dimension, closely associated with sphalerite, chalcopyrite, arsenopyrite, pyrrhotite, galena and rhodochrosite in the periphery of the South ore body. In reflected light, stannite is grayish yellow green in color and exhibits moderate bireflectance and strong anisotropism without any intenal reflections. Reflection; Rmax. =29.0, Rmin. =27.8 percent at a wavelength of 560nm, and VHN; 219~244kg/mm at a 50g load. The chemical composition on the average from 35 spot analyses by electron microprobe is, Cu 28.0, Fe 12.7, Zn 2.9, Mn 0.2, Sn 25.8, S 30.3, sum 99.9 (all in weight percent); the corresponding chemical formula as calculated on the basis of total atoms=8 is, Cu 1.88 Fe 0.97 Zn 0.19 Mn 0.02 Sn 0.93 S 4.01, which fulfills approximately the ideal formula of $Cu_2FeSnS_4$. The strongest reflections on the X-ray diffraction patterns are; $3.10{\AA}$ (10) (112), $2.72{\AA}$ (5) (020, 004), $1.922{\AA}$ (5) (024), $1.642{\AA}$ (3) (132), $1.244{\AA}$ (3) (143, 136, 235), $1.111{\AA}$(3) (244), $0.958{\AA}$ (1) (048, 422), the patterns are identical with those of literature. From the textural evidence of the microscopic observation, the mineral is considered to have been formed at the middle stage of hydrothermal lead-zinc-silver mineralization.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.18 no.7
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• pp.1663-1670
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• 2014

Recently, lots of research works have been actively focused on the DVC (Distributed Video Coding) techniques which provide a theoretical basis for the implementation of light video encoder. However, most of these studies have showed poorer performances than the conventional standard video coding schemes such as MPEG-1/2, MPEG-4, H.264 etc. In order to overcome the performance limits of the conventional approaches, several channel-divided distributed video coding schemes have been designed in such a way that some information are obtained while generating side information at decoder side and then these are provided to the encoder side, resulting in channel-divided video coding scheme. In this paper, the interpolation scheme by weighted sum of multiple motion-compensated interpolation frames is introduced and a new channel-divided DVC scheme is designed to effectively describe noisy channels based on the motion vector and its matching characteristics. Through several simulations, it is shown that the proposed method performs better than the conventional methods at low bit-rate and keeps the reconstructed visual quality constantly.