• Nutrition Research and Practice
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• 제14권2호
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• pp.109-116
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• 2020

BACKGROUND/OBJECTIVES: Excessive intake of simple sugars induces obesity and increases the risk of inflammation. Thus, interest in alternative sweeteners as a sugar substitute is increasing. The purpose of this study was to determine the effect of saccharin on inflammation in 3T3-L1 adipocytes. MATERIALS/METHODS: 3T3-L1 preadipocytes were differentiated into adipocytes. The adipocytes were treated with saccharin (0, 50, 100, and 200 ㎍/mL) for 24 h. Inflammation was induced by exposure of treated adipocytes to lipopolysaccharide (LPS) for 18 h and cell proliferation was measured. The concentration of nitric oxide (NO) was measured by using Griess reagent. Protein expressions of nuclear factor kappa B (NF-κB) and inhibitor κB (IκB) were determined by western blot analysis. The mRNA expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin 1β (IL-1β), interleukin 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor-α (TNF-α) were determined by real-time PCR. RESULTS: Compared with the control group, the amount of NO and the mRNA expression of iNOS in the LPS-treated group were increased by about 17.6% and 46.9%, respectively, (P < 0.05), and those parameter levels were significantly decreased by saccharin treatment (P < 0.05). Protein expression of NF-κB was decreased and that of IκB was increased by saccharin treatment (P < 0.05). Saccharin decreased the mRNA expression of COX-2 and the inflammation cytokines (IL-1β, IL-6, MCP-1, and TNF-α) (P < 0.05). CONCLUSIONS: The results of this study suggest that saccharin can inhibit LPS-induced inflammatory responses in 3T3-L1 adipocytes via the NF-κB pathway.

• 자원리싸이클링
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• 제21권4호
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• pp.3-15
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• 2012

재제조는 사용 후 제품을 일련의 과정을 거쳐 신품의 성능수준으로 복원하는 방법으로 물질 재활용에 비하여 자원에너지 절감효과가 높고 환경부하가 작아 경제성과 환경성을 동시에 만족하는 고부가가치 자원순환방법이다. 재제조를 통한 자원순환은 최근 이슈가 되고 있는 자원수급 불균형 및 일자리 부족 등의 문제 해결에도 크게 기여할 수 있다. 이에 본 연구에서는 재제조의 특성 및 효과를 고찰하고, 우리나라와 미국, 유럽, 일본, 중국 등 해외 주요국의 재제조산업 현황, 기술수준, 제도 등을 비교, 분석하여 문제점을 도출하였으며, 이를 바탕으로 국내 재제조산업 활성화를 위한 발전 과제를 제시하였다.

• 한국학교수학회논문집
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• 제3권1호
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• pp.149-163
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• 2000

The Ministry of Education have had us practice the performance test as a substitute proposal, however, all the more for the idealistic purport, our education front does not have such a sufficient condition as to practice the performance test for many classes and miscellaneous duties and over-populated class, and that practice has been enforced so abruptly without any drastic preparation and has caused much confusion from the beginning of that enforcement. Thus, these problematic concerns are remained as the tasks of the teachers to be solved by themselves in the front of education, and herein I came to do this research. The followings are the conclusions that I got as the results of the research (1) Performance test style should be applied in consideration of the students' achievement level and the gap of the teachers' recognition; descriptive test, portfolio assignment and formative test styles were proper for the students lacking basic study ability. (2) Descriptive test should have its beginning with the question items to which students can write the problem solving procedure logically rather than those to evaluate the creation ability and thinking ability: and putting down specifically the assessment standard could prevent students' confusion and scheme the impartiality of the assessment. (3) Portfolio assignment evaluation should be given with as interesting and suitable amounts as possible so that the students can do by themselves. (4) Utilizing the performance test table enabled easy management of documentary evidence. And it is needless to say that the success of the performance test should have preceding conditions like the teachers' understanding and their positive participation. Therefore, I'd like to give suggestions herein like the followings; (1) The performance test should not always be made into grades, and there is a need to develop the test gradually in the condition that the education surroundings permit by checking time, frequency, ratio and contents of the test while practicing the multiple choice writing test. (2) As long as the performance test has the aims of improving the studying and learning activities, any performance test only for the sake of making numerals with the thought that assessment is the disposal of the grades should be avoided, and the change of the lecturing styles and development of various assessing types and studying materials should be endeavored to confirm with the aims.

• 한국버섯학회지
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• 제12권4호
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• pp.367-370
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• 2014

총탄소함량은 T4를 제외한 모든 처리구에서 대등하였으며, 총질소함량은 T3에서 2.17%로 대조구에 가장 근접한 값을 나타내었다. C/N율은 T4에서 39로 다른 처리구보다 높았다. 혼합배지에 따른 자실체의 생육특성을 조사한 결과 갓직경은 T2에서 가장 컸고, 대직경은 T2와 T4에서 가장 컸고, 대길이는 T1과 T2에서 가장 많았다. 유효경수는 T1과 T3에서 가장 많았다. 혼합배지에 따른 처리구별 수량은 T3에서 171g/병으로 대조구와 대등하였고, 회수율도 89.2%로 대조구와 대등한 결과를 나타내었다.

• 한국강구조학회 논문집
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• 제16권4호통권71호
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• pp.493-500
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• 2004

본 논문에서는 복합재료로 이루어진 원통형 쉘 구조물을 해석모델로 설정하였으며, 좌굴의 링 보강재 보강효과에 대해서 연구하였다. 유한요소법으로 해석을 수행하였으며, 보강재의 요소는 3차원 보요소를 사용하였고, 쉘 요소는 적용성이 뛰어난 평면쉘요소를 사용하였으며, 대체 전단 변형률장을 도입하여 잠김현상을 극복하였다. 본 연구에서 링 보강재는 횡리브(Rib)의 형태이다. 이러한 보강재가 원통형 쉘의 좌굴에 미치는 영향을 고찰하였다. 즉, 보강재의 위치 변화, 보강재의 크기 변화, 쉘의 변장비 변화, 쉘의 지점조건의 변화, 복합재료의 화이버 보강각도 변화 등 다양한 파라미터 연구를 통해서 쉘의 좌굴거동을 분석하였다. 여러가지 설계변수에 대한 보강된 쉘의 거동에 대한 정확한 이해로부터 효율적인 보강설계를 제시하고자 하였으며, 원통형 쉘의 좌굴해석시 좋은 참고자료로 활용할 수 있으리라 기대된다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1997년도 춘계학술대회
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• pp.74-74
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• 1997

Chicory is used popularly. We use leaves of the plant as ordinary mea1, and roots as a substitute of tea materials. It also has been asserted that it has clinical effects on weakness, hepatic disease, diabetes, etc. However, experimental evidences are so insufficient that we started these studies. For antiinflammatory activity, MeOH Ex. was orally administered to rats, and decreased amounts of paw edema induced by carrageenan injection were measured. For bile secretion increament, rats were administered total MeOH, EtOAc fraction, and BuOH fraction Ex. respectively. One hour later, bile ducts were cannulated, and we collected bile every 20 minutes for 4 hours. For hepatoprotective activity, CCl$_4$-intoxicated mouse were treated with MeOH Ex., then s-GPT, S-GOT, and liver weight were measured. For antidiabetic activity, rats were induced diabetes by streptozocin 45mg/kg(i.v) injection. One week later, 1000mg/kg of total MeOH Ex. of chicory root was orally administered. We divided rats into three groups. Group 1 rats were administered only once, group 2 ones once a day for one week, and group 3 ones for three weeks. The concentrations of serum glucose were measured before and after administration. For antihypertensive activity, SHR were administrated total MeOH Ex. of chicory once a day for 8 days, and were measured blood pressure on 1st, 3rd, 6th and 8th day. Total MeOH, EtOAc fraction, and BuOH fraction Ex. increased bile secretion in rats, and decreased liver toxicity induced by CCl$_4$ in mouse. Total MeOH, Ex. of chicory roots has antiinflammatory effect, and decreased blood glucose concentration in group 2 and 3 rats. It was revealed not lowering blood pressure significantly in SHR.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
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• pp.215-216
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• 2013

The silicide is a compound of Si with an electropositive component. Silicides are commonly used in silicon-based microelectronics to reduce resistivity of gate and local interconnect metallization. The popular silicide candidates, CoSi2 and TiSi2, have some limitations. TiSi2 showed line width dependent sheet resistance and has difficulty in transformation of the C49 phase to the low resistive C54. CoSi2 consumes more Si than TiSi2. Nickel silicide is a promising material to substitute for those silicide materials providing several advantages; low resistivity, lower Si consumption and lower formation temperature. Nickel silicide (NiSi) nanowire (NW) has features of a geometrically tiny size in terms of diameter and significantly long directional length, with an excellent electrical conductivity. According to these advantages, NiSi NWs have been applied to various nanoscale applications, such as interconnects [1,2], field emitters [3], and functional microscopy tips [4]. Beside its tiny geometric feature, NW can provide a large surface area at a fixed volume. This makes the material viable for photovoltaic architecture, allowing it to be used to enhance the light-active region [5]. Additionally, a recent report has suggested that an effective antireflection coating-layer can be made with by NiSi NW arrays [6]. A unique growth mechanism of nickel silicide (NiSi) nanowires (NWs) was thermodynamically investigated. The reaction between Ni and Si primarily determines NiSi phases according to the deposition condition. Optimum growth conditions were found at $375^{\circ}C$ leading long and high-density NiSi NWs. The ignition of NiSi NWs is determined by the grain size due to the nucleation limited silicide reaction. A successive Ni diffusion through a silicide layer was traced from a NW grown sample. Otherwise Ni-rich or Si-rich phase induces a film type growth. This work demonstrates specific existence of NiSi NW growth [7].

• 한국산학기술학회논문지
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• 제21권2호
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• pp.280-286
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• 2020

일반적으로 사용되고 있는 합성수지인 PVC, PET 소재로 이루어진 카드는 쉽게 산화되거나 분해되지 않아서 사용 후에 폐기물로써 소각 또는 매립 처리되어지고 있으며, 소각 과정에서 환경호르몬과 연소가스등의 공해 문제를 일으킨다. 또한 매립 시에는 분해되지 않고 반영구적으로 쓰레기로 남아있어 환경오염을 일으키는 문제점 있다. 본 연구에서는 현재 사용하고 있는 카드의 문제점을 해결할 수 있는 대체 재료로써 대표적인 생분해성 소재인 폴리락트산(PLA : Polylacticacid)을 사용하여 이러한 문제점을 해결하고자 하였다. 그러나 PLA 소재로만 얇은 시트형태의 카드 기재가 만들어질 경우 재료 본래의 물성이 제한되어 저온 충격강도, 고온 안정성, 휨(Bending) 특성 등이 불충분하여 카드로써의 사용범위도 제한될 수밖에 없는 문제점을 가지고 있다. 이를 해결하기 위하여 PLA와 물성보강을 위한 원료의 적절한 배합 조성비를 검토하고, 결정화 핵제 및 첨가제 등의 조성물 검토와 나노컴파운드 기술을 통한 최적의 생분해성 컴파운드 조성물을 제조, 평가 하였다. 또한, 어닐링 (Annealing) 기술을 적용한 라미네이팅 공정을 통해 생분해성 범용 카드로써의 고기능화를 검증하였다.

• Structural Engineering and Mechanics
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• 제49권4호
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• pp.491-498
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• 2014

During the past years, the protection of the environment has become a major concern out passing the state frontiers to reach a planetary dimension. Depository waste sites have become a serious problem in terms of their locations and costs. On the other hand, the construction industry has a leading place in terms of quantities of waste produced from the start to the end of each construction site, by the large amounts of raw materials used and their respective consequences on the environment. The recycling of quarry wastes products, of demolished concrete, bricks and large quantities of waste resulting from the transformation of marble blocks can provide ideal solutions and advantages for the preservation of the environment, to become a supplementary source of aggregates. The main purpose of this study is to show technically the possibility of recuperating the aggregates of marble wastes as a partial substitute or total in the mortars. The aggregates used in this study is a sand of marble wastes (excess loads of sand exposed to bad weather conditions) of the quarry derived from Fil-fila marble (Skikda, east of Algeria). To achieve this work, we have studied the effect of sand substitution of marble wastes in the mortar with rates of (25, 50, 75, 100%); comparing the results obtained with reference samples (0%), the properties when the samples are fresh, and the mechanical performances of mortars at solid state (loss and gain of weight, dimensional variations). The introduction of recycled sand in the mortars gives good results and can be used as granulates.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2883-2888
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• 2014

Background: Realgar which contains arsenic components has been used in traditional Chinese medicine (TCM) as an anticancer drug. However, neither Realgar nor its formula are soluble in water. As a result, high dose of Realgar has to be administered to achieve an effective blood medicine concentration, and this is associated with adverse side effects. The objective of the present study was to increase the solubility of a formula using hydrometallurgy technology as well as investigating its effects on in vitro and in vivo cell proliferation and apoptosis in Sarcoma-180 cell line. Materials and Methods: Antiproliferative activity of Realgar Bioleaching Solution (RBS) was evaluated by MTT assay. Further, effects of RBS on cell proliferation and apoptosis were studied using flow cytometry and transmission electron microscopy. Kunming mice were administered RBS in vivo, where arsenic specifically targeted solid tumors. Results: The results indicated that RBS extract potently inhibited the tumor growth of Sarcoma-180 cell line in a dose-dependent manner. Flow cytometry and transmission electron microscopy further indicated that RBS significantly induced cell apoptosis through the inhibition of cell cycle pathway in a dose-dependent manner. Further, on RBS administration to mice, arsenic was specifically targeted to solid tumor.s Conclusions: RBS could substitute for traditional Realgar or its formula to work as a potent tool in cancer treatment.