• Journal of Radiation Protection and Research
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• 제36권1호
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• pp.1-7
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• 2011

A simple mathematical model of simultaneous combined action of environmental agents has been proposed to describe the synergistic interaction of microwave and high ambient temperature treatment on animal heating. The model suggests that the synergism is caused by the additional effective damage arising from an interaction of sublesions induced by each agent. These sublesions are considered to be ineffective if each agent is taken individually. The additional damage results in a higher body temperature increment when compared with that expected for an independent action of each agent. The model was adjusted to describe the synergistic interaction, to determine its greatest value and the condition under which it can be achieved. The prediction of the model was shown to be consistent with experimental data on rabbit heating. The model appears to be appropriate and the conclusions are valid.

• 환경생물
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• 제20권4호
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• pp.277-286
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• 2002

An increase in the overall biological effect under the combined action of ionizing radiation with another inactivating agent can be explained in two ways. One is the supposition that synergism may attribute to a reduced cellular capacity of damn-ge repair after the combined action. The other is the hypothesis that synergism may be related to an additional lethal or potentially lethal damage that arises from the interaction of sublesions induced by both agents. These sublesions ave considered to be in-effective when each agent is applied separately. Based on this hypothesis, a simple mathematical model was established. The model can predict the greatest value of the synergistic effect, and the dependence of synergy on the intensity of agents applied, as well. This paper deals with the model validation and the peculiarity of simultaneous action of various factors with radiation on biological systems such as bacteriophage, bacterial spores, yeast and mammalian cells. The common rules of the synergism aye as follows. (1) For any constant rate of exposure, the synergy can be observed only within a certain temperature range. The temperature range which synergistically increases the effects of radiation is shifted to the lower temperature fer thermosensitive objects. Inside this range, there is a specific temperature that maximizes the synergistic effect. (2) A decrease in the exposure rate results in a decrease of this specific temperature to achieve the greatest synergy and vice versa. For a constant temperature at which the irradiation occurs, synergy can be observed within a certain dose rate range. Inside this range an optimal intensity of the physical agent may be indicated, which maximizes the synergy. As the exposure temperature reduces, the optimal intensity decreases and vice versa. (3) The recovery rate after combined action is decelerated due to an increased number of irreversible damages. The probability of recovery is independent of the exposure temperature for yeast cells irradiated with ionizing or UV radiation. Chemical inhibitors of cell recovery act through the formation of irreversible damage but not via damaging the recovery process itself.

• 환경생물
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• 제26권1호
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• pp.1-7
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• 2008

A mathematical model for the synergistic interaction of physical and chemical environmental agents was suggested for quantitative prediction of irreversibly damaged cells after combined exposures. The model took into account the synergistic interaction of agents and was based on the supposition that additional effective damages responsible for the synergy are irreversible and originated from an interaction of ineffective sublesions. The experimental results regarding the irreversible component of radiation damage of diploid yeast cells simultaneous exposed to heat with ionizing radiation ($^{60}Co$) or UV light (254 nm) are presented. It was shown that the cell ability of the liquid holding recovery decreased with an increase in the temperature, at which the exposure was occurred. A good correspondence between experimental results and model prediction was demonstrated. The importance of the results obtained for the interpretation of the mechanism of synergistic interaction of various environmental factors is discussed.

• 한국유기농업학회지
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• 제3권1호
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• pp.11-22
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• 1994

Exposing plant organs to high doses of ionizing irradiation, penetrating into the plant tis-sues and cells, along the track structure of particles, lesions, and sublesions are formed on the molecules and organelles. As a result, disorders in the growth and development as well as chlorophyll-deficiency symptoms occur. The time scale of their reparation, recovery and over compensation during ontogenesis, constitutes a question of high theoretical and practical importanced, with special regard to nuclear fallout. With an aim to model the “ut supra”stated phenomena, the seeds of bean, Echo elit licensed variety, were irradiated by 300 Gy dose of X-ray-irradiation (120 kV:4.5 mA). According to the data obtained, the biosynthesis of photosynthetic pigments, will have been completed by the beginning of flowering. In consequence of the overcompensation of the repairing processes, the organs of plants developed from irradiated seeds, showed a partly differing correlative growth, compared to those of control plants. In order to characterize the vivo response of radiation-injured plants, a new method and approach were used. The changes of the electric capacitance of the plants during their ontogenesis, were continously monitored and recorede via a computer-aided and controlled measurement. In view of the data collected in such a way, the repairing plants may respond more quickly and intensively to the changes of environmental factors.