• 생명과학회지
• /
• 제34권4호
• /
• pp.236-244
• /
• 2024

Melanin은 대부분의 식물과 동물에서 발견되는 자연 색소로, 피부와 모발의 색을 결정하는 게 관여한다. Melanogenesis는 일반적으로 피부를 자외선과 같은 외부 자극으로부터 보호하기 위한 반응으로 melanocyte에서 수행한다. Tyrosinase는 기질인 tyrosine을 melanin으로 생합성 하는데 관여한다. 그러나 melanin의 과다 생성은 melasma, blotch, hyperpigmentation, 그리고 피부암과 같은 피부질환으로 이어질 수 있다. Kojic acid 및 arbutin과 같은 미백 물질에 대한 연구가 수행되었지만, 부작용으로 인해 일부 국가에서는 사용을 금지하거나 제한하고 있다. 따라서 본 연구에서는 기능성화장품의 새로운 미백재료로서 잠재력을 연구하기 위해 겨자무(horseradish)를 선택하였다. 더 나아가 효율적인 추출을 위해 아임계수 추출을 사용하였다. 연구 결과, 아임계수 200℃ 추출물은 높은 DPPH 라디칼 소거능, 총 페놀 함량, tyrosinase 저해능 그리고 B16-F10 melanoma 세포주의 melanin 생성 억제 효과를 나타내었다. B16-F10 melanoma 세포주에 대한 세포 독성을 조사하기 위해 MTT reduction assay 및 형태학적 변화를 관찰하였으며, 그 결과, 겨자무 methanol 추출물 및 아임계수 200℃에서는 세포독성이 확인되지 않았다. 결론적으로, 이 연구는 화장품의 천연 미백 기능성소재로서 가능성을 제안하는 바이다.

• 한국원자력학회:학술대회논문집
• /
• 한국원자력학회 2004년도 추계학술발표회 발표논문집
• /
• pp.83-84
• /
• 2004

• 한국환경과학회:학술대회논문집
• /
• 한국환경과학회 1999년도 정기총회 및 봄 학술발표회 프로그램 The Korean Environmental Sciences Society
• /
• pp.145-148
• /
• 1999

• 한국원자력학회:학술대회논문집
• /
• 한국원자력학회 1999년도 추계학술발표회요약집
• /
• pp.60.2-60
• /
• 1999

• 설비공학논문집
• /
• 제15권6호
• /
• pp.461-470
• /
• 2003

The purpose of this study is to investigate the performance of a transcritical cycle for hot water heating using $CO_2$ as a working fluid. Some of the main parameters that affect the practical performance of the $CO_2$ system are discussed; the performance on the variation of refrigerant charge, changes in flow conditions of secondary fluids, and that with or without internal heat exchanger, The experimental results show that the optimum charge is approximately the same for various mass flow rates of the secondary fluid at gas cooler. The experimental results on the effect of secondary fluids are in general agreement with the experimental results of transcritical cycle in the open literature and show similar trend for conventional subcritical vapor compression cycles. The heat exchanger effectiveness increases with an increase of the heat exchange area of the internal heat exchanger regardless of the mass flow rate at the gas cooler.

• Ocean Systems Engineering
• /
• 제3권3호
• /
• pp.167-180
• /
• 2013

Hydrodynamic characteristics of a bluff cylinder oscillating along transverse direction in steady flow were experimentally investigated at Reynolds number of $2{\times}10^5$. The effects of non-dimensional frequency, oscillating amplitude and Reynolds number on drag force, lift force and phase angle are studied. Vortex shedding mechanics is applied to explain the experimental results. The results show that explicit similarities exist for hydrodynamic characteristics of an oscillating cylinder in high and low Reynolds number within subcritical regime. Consequently, it is reasonable to utilize the test data at low Reynolds number to predict vortex induced vibration of risers in real sea state when the Reynolds numbers are in the same regime.

• KIEE International Transactions on Power Engineering
• /
• 제4A권1호
• /
• pp.1-5
• /
• 2004

The model of a power system with load dynamics is studied by investigating qualitative changes in its behavior as the reactive power demand at a load bus is increased. The load is created using induction motors parallel with the constant power and constant impedance load. As the load increases, the system experiences various bifurcations such as sub critical and supercritical Hopf, period-doubling and saddle-node bifurcation. The latter may lead the system to voltage collapse. A nonlinear controller is used to control the subcritical Hopf bifurcation and hence mitigate voltage collapse. It is applied to the KEPCO (Korean Electric Power Company) system to demonstrate its validity.

• Journal of Mechanical Science and Technology
• /
• 제19권2호
• /
• pp.540-548
• /
• 2005

This paper concerns the application and demonstration of sliding mode observer for aeroelastic system, which is robust to model uncertainty including mass and stiffness of the system and various disturbances. The performance of a sliding mode observer is compared with that of a conventional Kalman filter to demonstrate robustness and disturbance decoupling characteristics. Aeroelastic instability may occur when an elastic structure is moving even in subcritical flow speed region. Simulation results using sliding mode observer are presented to control aeroelastic response of flapped wing system due to various external excitations as well as model uncertainty and sinusoidal disturbances in subcritical incompressible flow region.

• Wind and Structures
• /
• 제6권5호
• /
• pp.347-356
• /
• 2003

Experimental studies on drag reduction of a circular cylinder of diameter D were conducted in the subcritical flow regime at Reynolds numbers in the range $4{\times}10^4{\leq}Re{\leq}10^5$. To shield the cylinder rear surface from the pressure deficit of the unsteady vortex generation in the near wake, two shield plates were attached downstream of the separation points to form a cavity at the base region. The chord of the shield plates, L, ranged from 0.22 to 1.52 D and the cavity width, G, was in the range from 0 to 0.96 D. It is concluded that significant drag reductions from that of a plain cylinder may be achieved by proper sizing of the shield plates and the base cavity. The study shows that using a pair of shield plates at G/D of 0.86 and angular position ${\theta}$ of ${\pm}121^{\circ}$ results in a configuration with percentage drag reduction of 40% for L/D of 0.5, and 55% for L/D of 1.0.

• 대한기계학회논문집B
• /
• 제27권3호
• /
• pp.319-325
• /
• 2003

We investigate the spectra and the pseudospectra in plane Poiseuille flow, plane Couette flow and Blasius flow. At subcritical Reynolds number, the spectra are lied strictly inside the stable complex half-plane, but the pseudospectra are lied in the unstable half-plane, reflecting the large linear transient growth that certain perturbations may excite. It means that the smooth flows may become to turbulent even though all the eigenmodes decay monotonically. We found that pseudospectra is one reason that causes subcritical transition in plane Poiseuille flow and plane Couette flow and bypass transition in Blasius flow.