• 제목/요약/키워드: stucture-activity

검색결과 3건 처리시간 0.018초

4-(Nitrobenzyl)Pyridine에 의한 에폭시드 및 알킬화합물의 변이원성 잠재력에 대한 구조활성 및 광화학효과의 연구 (Photosensitization Effect and Structure-Activity on Mutagenic Potential by 4-(Nitrobenzyl)Pyridine (4-NBP) Test, of Epoxides, Olefins and Alkylating Agents)

  • 김재현;엄애선
    • 한국환경보건학회지
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    • 제27권2호
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    • pp.43-50
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    • 2001
  • This paper reviews the results of a series of efforts to develop structure-activity models for slow-reacting chemicals and olefins whose toxicity may be enhanced by the ultraviolet radiation. Photoinduced toxicity of 14 compounds was found to be a different result of competing factors of structure, having carbon-carbon double bonds. To mimic the biological consequences of photooxidative damage in mammalian cells, the photochemical mutagenicith of 14 chemicals was tested in the CAS. Simple olefins were photochemically mutagenic or carcinogenic with irradiation, increasing the alkylating activity from zero level to 0.87(abs/gram) for styrene, 0.25 for 1-butene, 0.11 for 1-hexene, respectively, whereas no photochemical mutagenicity was observed with 1-octene in the absence of the CAS. Oxide compounds, however, showed a decreasing trend of photoalkylating activities in the presence or absence of the CAS. We found that the structure-activity relationship was not applicable to our data.

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드렁허리(Monopterus albus) 혈청내 lgM유사 면역글로불린의 구조적 특성 (Structural Characterization of an IgM-like Immunoglobulin in the Serum of Swamp Eel, Monopterus albus)

  • 손영종;이정우;장정순
    • 한국동물학회지
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    • 제33권1호
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    • pp.103-107
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    • 1990
  • BSA로 면역시킨 드렁허리의 혈청에서 lgM 유사면역글로불린의 정제한 후 그 구조적 특성을 구명하였다. 면역후 항혈청에서는 항원특이 항체능이 증가되었다. 정제된 lgM 유사면역글로불린은 199kD의 분자량을 갖는 단량체 4개가 결합된 800kD의 단백질이었으며, 단량체는 70kD인 H-사슬 2개와 29.5kD인 L-사슬 2개가 결합된 형태였다. 또한 드렁허리의 lgM 유사면역글로불린은 lgM의 특성과 같이 포유류 적혈구에 대하여 약한 응집력을 나타냈다.

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천해양식어업발달과정에 관한 연구 - 기술개발활동을 중심으로 - (A Study of Technical Development of Mariculture in the Coastal Water)

  • 최정윤
    • 수산경영론집
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    • 제16권1호
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    • pp.91-124
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    • 1985
  • Mariculture is contrasted with inland aqua-culturing fisheries. It is defind as the Industry of rearing Aquaorganism in limited coastal area relatively shallow in depth. Then, It's coming into being realization of Mariculture in it is long in history that Mariculture was realized in Korea. But it is from the early part of 1960s, that this industry has normally developed. Owing to 200 miles economy-zone problems of coastal countries, the development of deep sea fishing was limited, so the Korean Government has now appreciated the importance of cultured industries in the field of coastal fisheries. And the Korean Mariculture the output of which was only 18, 000 M/T in '60s attained 540, 000M/T in 1980s, has now occupied its relative importance in Korean Fisheries Industry. So the purpose of this report is to suggest the prospect of technical development of mariculture in the future of Korea, through the analysis of the various problems that affect upon the individual management '||'&'||' fishing ground utilization, along with the appreciation of "how to extend of those technical innovation" and "how the fishermen's technique level is extended at this stage. According to this study, the result is summarized as follows. First, Maricultural technique is classified into 8 sub-techniques as follows, as shown in fig. 1.Fig. 1. The Formation structure of mariculture technique Second, the change of technical method of mariculture in coastal area of Korea has made as 5 stages; 1) Scattering of culturing organism 2) Culturing by putting stone and installing bamboo 3) Culturing by installing rope and seeding 4) Culturing of putting objectives in cages 5) Culturing fish by feed Third, the maricultural fisheries of Korea has about 70 years long in history. It began from 1910s. But at that time there was no special technique in aquaculture and its technique was confined in searching out the object of species. The species was laver, oyster ect.Forth, although realization of mariculture in Korea has been long time, it is of late from 1960s that this has been industrial with normal development, and its technique of mariculture has mainly has developed from 1970s. Its result not only contributed to the high growth in Korean ecconomy along with the well balanced development between industires, but also it played a great role for the resolution of nation's food problem. Especially maricultural production has shown its sustained annual increase of 13.8% during the last 20 years. So the portion of mariculture among total fisheries stucture was extended from 4.1% in the early 1960s to 22.4% in 1980s.Fifth, it could be safely said that such development in maricultural field is resulted from the activity of aquacultural institutes such as Fisheries Reseach '||'&'||' Development production of major kinds such as Oyster, Sea-mustard, and Laver etc. As well as in the innovation of aquaculturing method with synthetic fiber utilization. FRDA has played important role in the efficient propargation of new aquacultural technique.Sixth, as for the change in aquaculture structure and its during period between 1970s and 1980s, the private management participation shown 25% increase from household number of 45, 173 to 56, 268 in total number. And in the respect of the management scale, of their management decreased, while it showed an increase in relative large scale management, the increase over 3 employees compared with other fisheries field between '70s and 80s. This must be an major trait to be recorded, Now the data above mentioned are shown as in table 1 and 2.Table 1. The maricultural fishing ground development situation in 982.Table 2. The mariculture management as seen in the employmnet size in high seasion.Owing to the technical innovation, of the mariculture in coastal area new income of fishermen increased and it also is true that the number of fishermen participating in its industrialization increased. But the problem being from now on is the self-discharge of the destruction fishing ground considered resulted from rapid expansion in aquaculture industry and the preventive system of sentility of fishing ground. sentility of fishing ground.

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