• Title/Summary/Keyword: structure-function relationship

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A Study on the Monolayer Film Electronics (단분자막 전자소자에 대한 연구)

  • Lee, Yong-Soo;Shin, Dong-Myung;Kim, Tae-Wan;Choi, Jong-Sun;Kang, Dou-Yol;Sohn, Byoung-Chung
    • Journal of the Korean Applied Science and Technology
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    • v.16 no.3
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    • pp.249-254
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    • 1999
  • The N-docosyl N'-methyl viologen-$(TCNQ)_2$, (DMVT) was synthesized. We investigated the ${\pi}-A$ isotherm of DMVT to find the optimal deposition condition. Temperature-dependent current-voltage characteristics of the DMVT LB films shows that there is an increase in conductivity at 330K or so. The in-plane electrical conductivity at room temperature is in the range of $10^{-7}{\sim}10^{-6}S/cm$. From the plot of logarithmic conductivity as a function of reciprocal temperature, two types of activation energies, 0.04eV and 0.73eV, were obtained depending on the temperature range. The Ohmic behaviour was observed below 0.6V and the Schottky effect was confirmed at $2.5{\sim}6V$, when the I-V characteristics was measured with Al/LB film/Al structure. I-V measurement for Al/LB film/ITO structure showed the asymmetrical I-V relationship, which resulted from the rectification property.

Estimation of Excitation Forces from Measured Response Data (진동응답 계측결과를 이용한 기진력의 추정)

  • 한상보
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.19 no.1
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    • pp.45-60
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    • 1995
  • It is attempted to estimate excitation force of a linear vibratory system using measured vibration responses. The excitation force is estimated from the relationship between the vibration response and system characteristic matrices which are extracted from both the mathematical model of the system and actual response in contrast to the usual approach of inverting the frequency response matrices. This extraction scheme is based on the fact that the vibration response can be expressed in term of linear combination of frequency domain modal vectors defined as mutually orthonormal basis vectors in frequency domain. The extracted frequency domain basis vectors are very stable in computational manipulation. It is found that the estimated excitation force is in good agreement with actually measured force except at the natural frequencies the structure, which is the common feature still to be overcome by the research efforts in this area. From the results of this paper, this disagreement is considered to come from the discrepancy between the model and actual value of the mass, damping and stiffness of the structure.

Using Harmonic Analysis and Optimization to Study Macromolecular Dynamics

  • Kim Moon-K.;Jang Yun-Ho;Jeong Jay-I.
    • International Journal of Control, Automation, and Systems
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    • v.4 no.3
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    • pp.382-393
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    • 2006
  • Mechanical system dynamics plays an important role in the area of computational structural biology. Elastic network models (ENMs) for macromolecules (e.g., polymers, proteins, and nucleic acids such as DNA and RNA) have been developed to understand the relationship between their structure and biological function. For example. a protein, which is basically a folded polypeptide chain, can be simply modeled as a mass-spring system from the mechanical viewpoint. Since the conformational flexibility of a protein is dominantly subject to its chemical bond interactions (e.g., covalent bonds, salt bridges, and hydrogen bonds), these constraints can be modeled as linear spring connections between spatially proximal representatives in a variety of coarse-grained ENMs. Coarse-graining approaches enable one to simulate harmonic and anharmonic motions of large macromolecules in a PC, while all-atom based molecular dynamics (MD) simulation has been conventionally performed with an aid of supercomputer. A harmonic analysis of a macroscopic mechanical system, called normal mode analysis, has been adopted to analyze thermal fluctuations of a microscopic biological system around its equilibrium state. Furthermore, a structure-based system optimization, called elastic network interpolation, has been developed to predict nonlinear transition (or folding) pathways between two different functional states of a same macromolecule. The good agreement of simulation and experiment allows the employment of coarse-grained ENMs as a versatile tool for the study of macromolecular dynamics.

Noise-reduction Function and its Affecting Factors of Plant Communities

  • Song, Xiu-hua;Wu, Qian-qian;Yu, Dong-ming;PIAO, Yong-ji;Cho, Tae-Dong
    • Journal of Environmental Science International
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    • v.25 no.10
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    • pp.1407-1415
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    • 2016
  • In this study, we investigated the relationship between noise reduction and the community structure of nine groups of typical plant communities as well as the reduction in noise at different frequencies. The semantic differential method was adopted to explore the perception of noise reduction. The results indicated that there was a significantly positive correlation between noise reduction and coverage, a significantly negative correlation between noise reduction and bifurcate height, and a negative correlation between noise reduction and bare rate. However, there was no significant correlation between noise reduction and height, diameter at breast height, or crown width. The reduction of middle-frequency noise was better than that of low- and high-frequency noise. The indicators "quiet" and "calm" showed that plant communities could reduce the noise perceived by humans. However, overly dense woodland caused nervousness, fear, depression, and other negative effects. Relatively open environments and those with large forest gaps obtained the highest evaluation.

A Structure-Function Relationship Exists for Ginsenosides in Reducing Cell Proliferation and Inducing Apoptosis in THP-1 Cells

  • Popovich David G.;Kitts David D.
    • Proceedings of the Ginseng society Conference
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    • 2002.10a
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    • pp.545-555
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    • 2002
  • Ginsenosides of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol classification including the aglycones, PD, PI and ginsenosides Rh2, Rhl were shown to posses characteristic effects on proliferation of THP-l human leukaemia cells. A similar result was not apparent for ginsenoside Rg3 or dexamathasone. The concentration to inhibit $50\%$ of cells $(LC_{50})$ for PD, Rh2, PI and Rhl were 13 ${\mu}g/mL,\;15{\mu}g/mL,\;19{\mu}g/mL\;and\;210\;{\mu}g/mL$ respectively. Cell cycle analysis showed apoptosis with PD and PI treatment of THP-1 cells resulting in a build up of sub-G1 cells after 24, 48 and 72 hours of treatment. Rh2, and dexamathasone treatments also increased apoptotic cells after 24 hours, where as Rhl did not. After 48 and 72 hours Rh2, Rhl and dexamathasone similarly increased apoptosis, but these effects were significantly (P<0.05) lower than observed for both PD and PI treatments. Furthermore, treatments that produced the largest build up of apoptotic cells were also found to have the largest release of lactate dehydrogenase (LDH). It can be concluded from these studies that the presence of sugars to PD and PI aglycone structure reduces the potency to induce apoptosis, and alternately alter membrane integrity. These cytotoxic effects to THP-l cells were different from dexamethasone.

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Isolation and Characterization of a Novel Triolein Selective Lipase from Soil Environmental Genes

  • Lim, Hee Kyung;Han, Ye-Jin;Hahm, Moon-Sun;Park, Soo Youl;Hwang, In Taek
    • Microbiology and Biotechnology Letters
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    • v.48 no.4
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    • pp.480-490
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    • 2020
  • A novel lipase gene, Lip-1420, was isolated from a metagenomic library constructed from reed marsh from Mt. Jumbong in Korea, comprising 112,500 members of recombinant plasmids. The DNA sequence of Lip-1420-subclone (5,513 bp) was found to contain at least 11 ORFs according to the GenBank database. The ORF-3 gene was inserted into the pET21a plasmid containing the C-terminal 6-His tag and transformed into E. coli BL21(DE3) to express the recombinant lipase protein. Lip-1420 was purified using a fast protein liquid chromatography system. The gene was registered in GenBank (MH628529). The values of Km and Vmax were determined as 0.268 mM and 1.821 units, respectively, at 40℃ and pH 8.0, using p-nitrophenyl palmitate as the substrate. This lipase belongs to family IV taxonomically because it has conserved HGGG and GDSAG motifs in the constitutive amino acid sequence. According to the predicted structural model, the binding sites are represented by residues H78, G81, D150, S151, A152, V181, and D236. Finally, Lip-1420 showed triolein selectivity for methanolysis between triolein (18:1) and tristearin (18:0) substrates. Further study of the selective mechanism and structure-function relationship of this new lipase could be useful for more practical applications.

Predicting the seismic behavior of torsionally-unbalanced RC building using resistance eccentricity

  • Abegaz, Ruth A.;Kim, In-Ho;Lee, Han Seon
    • Structural Engineering and Mechanics
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    • v.83 no.1
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    • pp.1-17
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    • 2022
  • The static design approach in the current code implies that the inherent torsional moment represents the state of zero inertial torsional moments at the center of mass (CM). However, both experimental and analytical results prove the existence of a large amount of the inertial torsional moment at the CM. Also, the definition of eccentricity by engineers, which is referred to as the resistance eccentricity, is defined as the distance between the center of mass and the center of resistance, which is conceptually different from the static eccentricity in the current codes, defined as the arm length about the center of rotation. The difference in the definitions of eccentricity should be made clear to avoid confusion about the torsion design. This study proposed prediction equations as a function of resistance eccentricity based on a resistance eccentricity model with advantages of (1) the recognition of the existence of torsional moment at the CM, (2) the avoidance of the confusion by using resistance eccentricity instead of the design eccentricity, and (3) a clear relationship of applied inertial forces at the CM and resisting forces. These predictions are compared with the seismic responses obtained from time-history analyses of a five-story building structure under moderate and severe earthquakes. Then, the trend of the resistance eccentricity corresponding to the maximum edge drift is investigated for elastic and inelastic responses. The comparison given in this study shows that these prediction equations can serve as a useful reference for the prediction in both the elastic and the inelastic ranges.

A study on the building site excavated in the Oeseonmi-ri, Uljin (울진 외선미리 발굴 건물지에 관한 연구)

  • Kim, Chan-Yeung
    • Journal of architectural history
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    • v.16 no.2
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    • pp.79-98
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    • 2007
  • The building site was presumed as the Howonjeokwon or the Dasiwonji established at the traffic route among western inland areas in old Pyeonghaegun. The groundwork was composed inclination terrace of two steps. The upper step was the territory of the main house of ceremony symbolic+lodging function and the down step was divided in the territory of both Ikrang-chae of boarding and lodging management function and the territory of Haengrang-chae pavilion of rest reception management. The building composition by each territory formed space differentiation with the line of flow according to the thorough rule of court rank. The arrangement composition set the strong center axis in tandem, and it was the building arrangement interpreting the territory and the rule of court rank by function as the relationship of master and servant and was the building type emphasizing on the whole unity with the geometric symmetry structure. The Dasiwonji and the Hyeeumwonji had the common point which is the traffic architecture of semi governmental management reinforcing the boarding lodging function in the place which a visitor stayed. The Haeeumwonji and Dasiwonji had the difference in the size, but was the same in the composition system of construction. The external space and the system of the line of flow decided from the functional territory separation and the hierarchical rank as thorough as the geometric arrangement focusing on the whole unity. Namely, it was the strict and unusual system of the line of flow depended on the thorough rule of court rank than the efficient approach or arrangement of the line of flow. After being established to be the Howonjeokwon at the end of Koryeo, it disappeared at the time of the invasion of Japanese pirates when it was the time of the King Woo in Koryeo. It is presumed that it was continued until both wars, Imjin Byeongja, ago after changing its name to the Dasiwon, being restored to the small size at the end of Koryeo at the early of Choseon.

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A new multi-stage SPSO algorithm for vibration-based structural damage detection

  • Sanjideh, Bahador Adel;Hamzehkolaei, Azadeh Ghadimi;Hosseinzadeh, Ali Zare;Amiri, Gholamreza Ghodrati
    • Structural Engineering and Mechanics
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    • v.84 no.4
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    • pp.489-502
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    • 2022
  • This paper is aimed at developing an optimization-based Finite Element model updating approach for structural damage identification and quantification. A modal flexibility-based error function is introduced, which uses modal assurance criterion to formulate the updating problem as an optimization problem. Because of the inexplicit input/output relationship between the candidate solutions and the error function's output, a robust and efficient optimization algorithm should be employed to evaluate the solution domain and find the global extremum with high speed and accuracy. This paper proposes a new multi-stage Selective Particle Swarm Optimization (SPSO) algorithm to solve the optimization problem. The proposed multi-stage strategy not only fixes the premature convergence of the original Particle Swarm Optimization (PSO) algorithm, but also increases the speed of the search stage and reduces the corresponding computational costs, without changing or adding extra terms to the algorithm's formulation. Solving the introduced objective function with the proposed multi-stage SPSO leads to a smart feedback-wise and self-adjusting damage detection method, which can effectively assess the health of the structural systems. The performance and precision of the proposed method are verified and benchmarked against the original PSO and some of its most popular variants, including SPSO, DPSO, APSO, and MSPSO. For this purpose, two numerical examples of complex civil engineering structures under different damage patterns are studied. Comparative studies are also carried out to evaluate the performance of the proposed method in the presence of measurement errors. Moreover, the robustness and accuracy of the method are validated by assessing the health of a six-story shear-type building structure tested on a shake table. The obtained results introduced the proposed method as an effective and robust damage detection method even if the first few vibration modes are utilized to form the objective function.

A study on characteristics of composition method of inner foundation in stone stupa (석탑 기단부 적심구성방법에 대한 특성 고찰 - $7{\sim}8$세기 석탑 중 해체 수리한 석탑을 중심으로 -)

  • Chung, Hae-Doo;Jang, Suk-Ha
    • Journal of architectural history
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    • v.16 no.5
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    • pp.55-66
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    • 2007
  • Through analysing on construction cases of stupa built in A.D. 7,8th, I have researched about these : constructive methods of inner soil of stupa, spatial compositions, characteristics of structures, arrangements of inner soil and etc. And cases analysed are six ; Mireuksajiseoktap(stone pagoda of Mireuksa Temple site), Gameunsajisamcheumgseoktap(three storied stone pagoda of Gameunsa Temple site), Goseonsajisamcheungseoktap(three storied stone pagoda of Goseonsa Temple site), Wolseong nawolliocheungseoktap(five storied stone pagoda in Nawonri, Wolseong), Guksagokseoktap(three storied stone pagoda in Guksa valley), Giamgokseoktap(three storied stone pagoda in Giam valley). Additionally we researched about inner soil of Sacheonwangsaji tapji(basement of stone stupa site in Sacheonwang Temple site) to speculate on composition of Synthetically, the foundation could be divided as core space and outer space. ; the former as structural function and the latter as ornamental function. And the core area could be divided again as center column space and buffer space. The relationship between core spaces and its formation are as belows; First, according to the area of foundation and scale of stone pagoda, formations of core are differed. As the scale of stone pagoda goes bigger, and the area of foundation goes larger, the structure of stone pagoda comprised by center column type and layered-core which endure upper load independently. On the contrary, as the scale of stone pagoda goes smaller, and the area of foundation goes lesser, the structure of stone pagoda tend to use only center column to endure upper part. Second, spatial composition of core area is comprised as two spaces, one which endure upper load and buffer space which absorb side pressure and upper pressure. The buffer space tend to be used in case of those structures which could not endure side pressure or have lots of joint. In some cases, it was located below the cover stone of foundation and gained upper load. And in case that have not gained pressure from side stone, the buffer space are comprised by smalle stone or roof tile to get structural supplement.

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