• Structural Engineering and Mechanics
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• v.51 no.4
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• pp.627-641
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• 2014

Functionally graded steels (FGSs) are a family of functionally graded materials (FGMs) consisting of ferrite (${\alpha}$), austenite (${\gamma}$), bainite (${\beta}$) and martensite (M) phases placed on each other in different configurations and produced via electroslag remelting (ESR). In this research, the flow stress of dual layer austenitic-martensitic functionally graded steels under hot deformation loading has been modeled considering the constitutive equations which describe the continuous effect of temperature and strain rate on the flow stress. The mechanism-based strain gradient plasticity theory is used here to determine the position of each layer considering the relationship between the hardness of the layer and the composite dislocation density profile. Then, the released energy of each layer under a specified loading condition (temperature and strain rate) is related to the dislocation density utilizing the mechanism-based strain gradient plasticity theory. The flow stress of the considered FGS is obtained by using the appropriate coefficients in the constitutive equations of each layer. Finally, the theoretical model is compared with the experimental results measured in the temperature range $1000-1200^{\circ}C$ and strain rate 0.01-1 s-1 and a sound agreement is found.

• Transactions of Materials Processing
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• v.19 no.3
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• pp.185-190
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• 2010

Application of CAE analyses are wide spread in shaping processes and structural safety verification of plastic products. The importance of CAE analysis and its contributions are getting increase since the processibility and structural safety of product can be predicted. CAE analysis for complex shaped product need a lot of time for modeling and computation compare with simpler one. Therefore careful simulation modeling is required for complex shaped product. Structural analysis for plastic door handle of automobile has been performed and structural safety has been investigated for various load directions and modeling cases. Large stress occurred at the hinge in handle regardless of load direction and modeling case. Consequently hinge is considered structurally very weak among the parts in plastic door handle. It is concluded that simple modeling rather than total modeling with adequate boundary condition equivalent to real situation gives reasonable computational results with saving modeling effort and computation time.

• Computational Structural Engineering
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• v.5 no.4
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• pp.5-12
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• 1992

고체역학의 구성은 크게 탄성론과 소성론(혹은 비탄성론)으로 나눌 수 있다. 전자는 회복가능한 변형을 후자는 회복불가능한 변형을 다루며, 이 두 이론은 응력과 변형의 실험적 관찰에 기초하기 때문에 거시적인 현상론의 성격을 갖고 있다. 체계적으로 잘 정리되어있는 탄성론과는 달리, 소성범위안에서의 복잡한 응력-변형도 관계는 종종 소성론으로 설명되지 않는다. 이점이 많은 연구자들 사이에 완전한 의견의 일치를 보지 못하고 있는 원인이나, 지난 수십년 동안 소성론의 기본틀에 대한 많은 진전이 있었다. 본 고에서는 소성론의 역사에 대한 "간략한" 역사적 고찰과 탄소성 "대변위"를 연구하는 현 역학사회의 관심의 촛점을 소개하고자 한다.

• Structural Engineering and Mechanics
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• v.9 no.3
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• pp.215-226
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• 2000

Computational procedure within the framework of return mapping technique has been presented to integrate the constitutive behavior of a concrete model. Developed by Ohtani and Chen, this concrete model is based on multiple hardening concept, and is rate-independent and associative. Consistent tangent operator suitable for finite element analysis is derived to preserve the rate of convergence. Accuracy of the integration technique is verified and compared with available experimental data. Computational efficiency is demonstrated by comparing with results based on elasto-plastic tangent.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1990.04a
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• pp.70-74
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• 1990

The finite plasticity in strain space is viewed by formulating the consistency condition and the thermodynamic condition with respect to proposed state variables. The Naghi-Trapp work assumption is used to obtain a constraint equation, and the normality equation is formulated. Finally, an elastoplastic tangent modulus, which is based on the derived equations in strain space, is proposed.

• BMB Reports
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• v.50 no.5
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• pp.237-246
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• 2017

Synapse is the basic structural and functional component for neural communication in the brain. The presynaptic terminal is the structural and functionally essential area that initiates communication and maintains the continuous functional neural information flow. It contains synaptic vesicles (SV) filled with neurotransmitters, an active zone for release, and numerous proteins for SV fusion and retrieval. The structural and functional synaptic plasticity is a representative characteristic; however, it is highly vulnerable to various pathological conditions. In fact, synaptic alteration is thought to be central to neural disease processes. In particular, the alteration of the structural and functional phenotype of the presynaptic terminal is a highly significant evidence for neural diseases. In this review, we specifically describe structural and functional alteration of nerve terminals in several neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD).

• Proceedings of the Materials Research Society of Korea Conference
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• 2007.11a
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• pp.113.1-113.1
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• 2007

• Korean Journal of Biological Psychiatry
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• v.8 no.1
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• pp.3-19
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• 2001

Recent basic and clinical studies demonstrate a major role for neural plasticity in the etiology and treatment of depression and stress-related illness. The neural plasticity is reflected both in the birth of new cell in the adult brain(neurogenesis) and the death of genetically healthy cells(apoptosis) in the response to the individual's interaction with the environment. The neural plasticity includes adaptations of intracellular signal transduction pathway and gene expression, as well as alterations in neuronal morphology and cell survival. At the cellular level, repeated stress causes shortening and debranching of dendrite in the CA3 region of hippocampus and suppress neurogenesis of dentate gyrus granule neurons. At the molecular level, both form of structural remodeling appear to be mediated by glucocorticoid hormone working in concert with glutamate and N-methyl-D-aspartate(NMDA) receptor, along with transmitters such as serotonin and GABA-benzodiazepine system. In addition, the decreased expression and reduced level of brain-derived neurotrophic factor(BDNF) could contribute the atrophy and decreased function of stress-vulnerable hippocampal neurons. It is also suggested that atrophy and death of neurons in the hippocampus, as well as prefrontal cortex and possibly other regions, could contribute to the pathophysiology of depression. Antidepressant treatment could oppose these adverse cellular effects, which may be regarded as a loss of neural plasticity, by blocking or reversing the atrophy of hippocampal neurons and by increasing cell survival and function via up-regulation of cyclic adenosine monophosphate response element-binding proteins(CREB) and BDNF. In this article, the molecular and cellular mechanisms that underlie stress, depression, and action of antidepressant are precisely discussed.

• Journal of Ginseng Research
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• v.46 no.3
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• pp.376-386
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• 2022

Background: Brain-derived neurotrophic factor (BDNF)-tropomyosin-related kinase B (TrkB) plays a critical role in the pathogenesis of depression by modulating synaptic structural remodeling and functional transmission. Previously, we have demonstrated that the ginsenoside Rb1 (Rb1) presents a novel antidepressant-like effect via BDNF-TrkB signaling in the hippocampus of chronic unpredictable mild stress (CUMS)-exposed mice. However, the underlying mechanism through which Rb1 counteracts stress-induced aberrant hippocampal synaptic plasticity via BDNF-TrkB signaling remains elusive. Methods: We focused on hippocampal microRNAs (miRNAs) that could directly bind to BDNF and are regulated by Rb1 to explore the possible synaptic plasticity-dependent mechanism of Rb1, which affords protection against CUMS-induced depression-like effects. Results: Herein, we observed that brain-specific miRNA-134 (miR-134) could directly bind to BDNF 30 UTR and was markedly downregulated by Rb1 in the hippocampus of CUMS-exposed mice. Furthermore, the hippocampus-targeted miR-134 overexpression substantially blocked the antidepressant-like effects of Rb1 during behavioral tests, attenuating the effects on neuronal nuclei-immunoreactive neurons, the density of dendritic spines, synaptic ultrastructure, long-term potentiation, and expression of synapse-associated proteins and BDNF-TrkB signaling proteins in the hippocampus of CUMS-exposed mice. Conclusion: These data provide strong evidence that Rb1 rescued CUMS-induced depression-like effects by modulating hippocampal synaptic plasticity via the miR-134-mediated BDNF signaling pathway.

• International Journal of High-Rise Buildings
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• v.3 no.2
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• pp.99-106
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• 2014

This paper presents the determination of the structural system of the Changsha IFC T1 tower with 452 m in architectural height and 440.45 m in structural height. Sensitivity analyses are carried out by varying the location of belt trusses and outriggers. The enhancement of seismic capacity of the outer frame by reasonably adjusting the column size is confirmed based on parametric studies. The results from construction simulation including the non-load effect of structures demonstrate that the deformation of vertical members has little effect on the load-bearing capacity of belt trusses and outriggers. The elastoplastic time-history analysis shows that the overall structure under rare earthquake load remains in an elastic state. The influence of the frame shear ratio and frame overturning moment ratio on the proposed model and equivalent mega column model is investigated. It is found that the frame overturning moment ratio is more applicable for judging the resistance of the outer frame against lateral loads. Comparison is made on the variation of these two effects between a classical frame-core tube-outrigger structure and a structure with diagonal braces between super columns under rare earthquakes. The results indicate that plasticity development of the top core cube of the braced structure may be significantly improved.