• Structural Engineering and Mechanics
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• 제33권5호
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• pp.589-604
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• 2009

In the field of predicting structural safety and reliability the operating conditions play an essential role. Since the time and cost limitations are a significant factors in engineering it is important to predict the future operating conditions as close to the actual state as possible from small amount of available data. Because of the randomness of the environment the shape of measured load spectra can vary considerably and therefore simple distribution functions are frequently not sufficient for their modelling. Thus mixed distribution functions have to be used. In general their major weakness is the complicated calculation of unknown parameters. The scope of the paper is to investigate the load spectra growth for actual operating conditions and to investigate the modelling and extrapolation of load spectra with algorithm for mixed distribution estimation, REBMIX. The data obtained from the measurements of wheel forces and the braking moment on proving ground is used to generate load spectra.

• 통합자연과학논문집
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• 제10권1호
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• pp.7-13
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• 2017

Neuromedin U receptor 1 is a GPCR protein which binds with the neuropeptide, neuromedin. It is involved in the regulation of feeding and energy homeostasis and related with immune mediated inflammatory diseases like asthma. It plays an important role in maintaining the biological clock and in the regulation of smooth muscle contraction in the gastrointestinal and genitourinary tract. Analysing the structural features of the receptor is crucial in studying the pathophysiology of the diseases related to the receptor important. As the three dimensional structure of the protein is not available, in this study, we have performed the homology modelling of the receptor using 5 different templates. The models were subjected to model validation and two models were selected as optimal. These models could be helpful in analysing the structural features of neuromedin U receptor 1 and their role in disorders related to them.

• 통합자연과학논문집
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• 제10권3호
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• pp.119-124
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• 2017

Glucagon-like peptide 2 receptor, a GPCR, binds with the glucagon-like peptide, GLP-2 and regulates various metabolic functions in the gastrointestinal tract. It plays an important role in the nutrient homeostasis related to nutrient assimilation by regulating mucosal epithelium. GLP-2 receptor affects the cellular response to external injury, by controlling the intestinal crypt cell proliferation. As they are therapeutically attractive towards diseases related with the gastrointestinal tract, it becomes essential to analyse their structural features to study the pathophysiology of the diseases. As the three dimensional structure of the protein is not available, in this study, we have performed the homology modelling of the receptor based on single- and multiple template modeling. The models were subjected to model validation and a reliable model based on the validation statistics was identified. The predicted model could be useful in studying the structural features of GLP-2 receptor and their role in various diseases related to them.

• 국제학술발표논문집
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• The 2th International Conference on Construction Engineering and Project Management
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• pp.140-149
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• 2007

Indian construction companies have only 0.05% market share in the 3-4 trillion dollar global construction business and only two Indian construction companies figure in the ENR "Top 225 Global Contractors 2006" list. Hence, while enormous scope for growth exists, international construction experience is limited. This study explores the risks as perceived by Indian companies venturing abroad since risks in international construction differ from home market risks. Literature survey identified a number of risk factors that were evaluated by the experts, highlighting fourteen important risk factors. Interpretive Structural Modelling (ISM) was used to develop a hierarchical model showing the relationships between the different risk factors, thus helping to focus on the key risks for effective risk management. The study shows that poor project management is a key risk forming the hub of the system, while political instability has maximum influence. The results of the study can be used by managers to visualise the risks in perspective and prioritise the mitigation effort.

• 통합자연과학논문집
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• 제16권1호
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• pp.33-38
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• 2023

The follicle stimulating hormone receptor (FSHR) is a glycoprotein hormone, that belongs to the GPCR superfamily. FSHR plays a major role in reproduction. The aberrant activation of FHS receptor leads to infertility and several reproductive disorders. The recently recognized roles of the FSHR in diverse extragonadal tissues is also closely related to Alzheimer's disease and cancers. Analysing the structural characteristics of the receptor is important in understanding the pathophysiology of diseases associated with the receptor. In this present study, homology modelling of FSHR-TM domain was developed using four different templates. Totally 20 models were developed using single template-based approach and selected three based on the validation of RC plot, RMSD, ProSA, QMEAN and ERRAT values. The developed models would be useful for further research on the structural characteristics and binding characteristics of the FSHR-TM domain.

• International Journal of Naval Architecture and Ocean Engineering
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• 제10권3호
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• pp.367-375
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• 2018

The present paper considers the contact between energy-saving device of ice-class vessel and ice block. The main objective of this study is to clarify the tendency of the ice impact force and the structural response as well as interaction effects of them. The contact analysis is performed by using LS-DYNA finite element code. The main collision scenario is based on Finnish-Swedish ice class rules and a stern duct model is used as an energy-saving device. For the contact force, two modelling approaches are adopted. One is dynamic indentation model of ice block based on the pressure-area curve. The other is numerical material modelling by LS-DYNA. The authors investigated the sensitivity of the structural response against the ice contact pressure, the interaction effect between structure and ice block, and the influence of eccentric collision. The results of these simulations are presented and discussed with respect to structural safety.

• Earthquakes and Structures
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• 제6권1호
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• pp.19-43
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• 2014

A risk assessment framework for evaluating building structures is implemented in this study. This framework allows considering sources of uncertainty both on structural capacity and seismic demand. In particular randomness on seismic load, incident angle, material properties, floor mass and structural damping are considered; in addition the choice of fibre modelling versus plastic hinge model is also considered as a source of uncertainty. The main objective of this work is to study the contribution of these sources of uncertainty on the fragilities of steel and steel-reinforced concrete composite 3D building structures. The fragility curves are expressed in the form of a two-parameter lognormal distribution where vertical statistics in conjunction with metaheuristic optimization are implemented for calculating the two parameters.

• Earthquakes and Structures
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• 제6권6호
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• pp.611-625
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• 2014

This paper presents a simple methodology that integrates an improved storey shear modelling, Incremental Dynamic Analysis and Monte Carlo Simulation in order to carryout vulnerability analysis towards development of fragility curves for Unreinforced Brick Masonry buildings. The methodology is demonstrated by developing fragility curves of a single storey Unreinforced Brick Masonry building for which results of experiment under lateral load is available in the literature. In the study presented, both uncertainties in mechanical properties of masonry and uncertainties in the characteristics of earthquake ground motion are included. The research significance of the methodology proposed is that, it accommodates a new method of damage grade classification which is based on 'structural performance characteristics' instead of 'fixed limiting values'. The usefulness of such definition is discussed as against the existing practice.

• Computers and Concrete
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• 제20권5호
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• pp.511-519
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• 2017

The reliability of reinforced concrete structures is frequently compromised by the deterioration caused by reinforcement corrosion. Evaluating the effect caused by reinforcement corrosion on structural behaviour of corrosion damaged concrete structures is essential for effective and reliable infrastructure management. In lifecycle management of corrosion affected reinforced concrete structures, it is difficult to correctly assess the lifecycle performance due to the uncertainties associated with structural resistance deterioration. This paper presents a stochastic deterioration modelling approach to evaluate the performance deterioration of corroded concrete structures during their service life. The flexural strength deterioration is analytically predicted on the basis of bond strength evolution caused by reinforcement corrosion, which is examined by the experimental and field data available. An assessment criterion is defined to evaluate the flexural strength deterioration for the time-dependent reliability analysis. The results from the worked examples show that the proposed approach is capable of evaluating the structural reliability of corrosion damaged concrete structures.

• 농촌지도와개발
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• 제30권3호
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• pp.131-141
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• 2023

This study aims to examine the structural relationships among leisure activity, psychological capital, and quality of life in rural healing tourists. Data were collected from 407 workers who had experience in rural healing tourism through an online survey. SPSS 28.0 and AMOS 28.0 were used for frequency, confirmatory factor, and structural equation modelling analysis. The results of structural equation modelling indicate participation in leisure activities had a positive effect on psychological capital. Psychological capital had a positive effect on quality of life. The results of this study suggest that leisure activities play an important role in improving workers' psychological capital. Through rural healing tourism, various outdoor activities, cultural activities, and social interaction with people using rural resources can help improve the psychological capital of workers.