• Journal of the Korean Society for Precision Engineering
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• v.29 no.2
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• pp.193-200
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• 2012

Wheel loader is one of the construction machinery capable of variety of tasks and the demand on functional diversity and structural reliability is growing. As a study on the optimal shape design of front axle for wheel loader through the design of experiments, this paper assessed the design parameters affecting the maximum stress. As a result, a value of 126.77 MPa of minimum stress was obtained, and optimal factors showed the values of w = 100.0 mm, ${\theta}=40^{\circ}$ and R = 118 mm. It showed an accuracy of 98.7% compared with the structural analysis.

• KIEAE Journal
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• v.12 no.1
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• pp.91-98
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• 2012

The purpose of this study is to analyze the diversity of architectural characteristics of traditional Hanok using Pyonjakbub(變作法). The roof is essential element of Hanok and the proportion of the roof accounts for about a half of the Hanok elevation. The shape of a roof of Hanok has made by the structural method like Pyonjakbub. For this study, the investigation report of 'Korean traditional houses' and 'Cultural assets of wooden traditional house' published by Cultural Heritage Administration were used as it's references. The results of this study are as follows; Pyonjakbub is appeared differently according to the region and the house dates and it has strongly influenced the architectural characteristics of traditional Hanok-the width of a room, the cross section of inner space of a roof and the length of eaves, etc. In other words, the architectural characteristics of Hanok will be changed by using different Pyonjakbub. Using the proper Pyonjakbub, we will provide more satisfaction to the client who wishes to live in Hanok.

• Journal of the Economic Geographical Society of Korea
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• v.26 no.2
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• pp.73-95
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• 2023

The purpose of this study is to analyze the industrial structural changes and types of specialized in the shipbuilding cities, which are representative sectors of industrial city decline, and explore regional responses. Most cities designated as special areas for industrial crisis response in 2018 are specialized in shipbuilding. While the shift from prosperity to recession since the 2010s is the main factor, each city has responded differently to the industrial crisis. The analysis, targeting seven shipbuilding cities, shows that regions where large shipyards of major corporations with high industrial competitiveness are located have relatively less decline during business fluctuations, and there is a tendency for a decrease in industrial structural diversity during prosperous periods and an increase during recessionary periods. Based on the resistance and recoverability to industrial crises, the industrial paths of shipbuilding cities are classified into four types. Considering regional industrial structure and competitiveness, it is necessary to develop customized support strategies such as maintaining and declining shipbuilding industries and fostering new alternative industries.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.7
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• pp.892-896
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• 2004

A genetic examination using 14 structural loci and 7 microsatellite markers was carried out among random samples of Hu sheep (Hu), Tong sheep (Tong) and Yantse River Delta White goat (YRD); The mean heterozygosity (H), mean polymorphism information contents (PIC) and mean effective numbers of alleles (Ne) calculated based on the data from the above two types of genetic markers were compared. The standard genetic distances among the three populations based on two types of gene frequencies were calculated and compared. The results show that the mean heterozygosity (H), mean polymorphism information contents (PIC) and mean effective numbers of alleles (Ne) based on 7 microsatellite markers are greater than those based on the structural loci. The standard genetic distances based on structural loci among the three populations are: 0.0268-0.2487, the standard genetic distances based on microsatellite markers are: 0.2321-1.2313. The study indicates that structural and microsatellite markers reflect the genetic variation of the three populations consistently: Tong>Hu>YRD. The differentiation between related species or interpopulations can be expressed more effectively by microsatellite markers than structural markers. Oar FCB11, MAF33, Oar AE101, Oar FCB128 and OarFCB304 can be used as representative loci for research on genetic differentiation between sheep and goat.

• Molecules and Cells
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• v.42 no.1
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• pp.56-66
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• 2019

Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif. The HIT superfamily can be divided to five classes with functions in galactose metabolism, DNA repair, and tumor suppression. HINTs are highly conserved from archaea to humans and function as tumor suppressors, translation regulators, and neuropathy inhibitors. Although the structures of HINT proteins from various species have been reported, limited structural information is available for fungal species. Here, to elucidate the structural features and functional diversity of HINTs, we determined the crystal structure of HINT from the pathogenic fungus Candida albicans (CaHINT) in complex with zinc ions at a resolution of $2.5{\AA}$. Based on structural comparisons, the monomer of CaHINT overlaid best with HINT protein from the protozoal species Leishmania major. Additionally, structural comparisons with human HINT revealed an additional helix at the C-terminus of CaHINT. Interestingly, the extended C-terminal helix interacted with the N-terminal loop (${\alpha}1-{\beta}1$) and with the ${\alpha}3$ helix, which appeared to stabilize the dimerization of CaHINT. In the C-terminal region, structural and sequence comparisons showed strong relationships among 19 diverse species from archea to humans, suggesting early separation in the course of evolution. Further studies are required to address the functional significance of variations in the C-terminal region. This structural analysis of CaHINT provided important insights into the molecular aspects of evolution within the HIT superfamily.

• Biomolecules & Therapeutics
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• v.31 no.2
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• pp.141-147
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• 2023

Antibiotic resistance has emerged as a global threat to modern healthcare systems and has nullified many commonly used antibiotics. β-Lactam antibiotics are among the most successful and occupy approximately two-thirds of the prescription antibiotic market. They inhibit the synthesis of the peptidoglycan layer in the bacterial cell wall by mimicking the D-Ala-D-Ala in the pentapeptide crosslinking neighboring glycan chains. To date, various β-lactam antibiotics have been developed to increase the spectrum of activity and evade drug resistance. This review emphasizes the three-dimensional structural characteristics of β-lactam antibiotics regarding the overall scaffold, working mechanism, chemical diversity, and hydrolysis mechanism by β-lactamases. The structural insight into various β-lactams will provide an in-depth understanding of the antibacterial efficacy and susceptibility to drug resistance in multidrug-resistant bacteria and help to develop better β-lactam antibiotics and inhibitors.

• Steel and Composite Structures
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• v.50 no.1
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• pp.89-105
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• 2024

Multichannel analysis of surface waves (MASW) method has exhibited broad application prospects in the nondestructive detection of interfacial debonding in steel-concrete composite structures (SCCS). However, due to the structural diversity of SCCS and the high stealthiness of interfacial debonding defects, the feasibility of MASW method needs to be investigated in depth. In this study, synthetic parametric study on MASW nondestructive debonding detection for SCCSs is performed. The aim is to quantitatively analyze influential factors with respect to structural composition of SCCS and MASW measurement mode. First, stress wave composition and propagation process in SCCS are studied utilizing 2D numerical simulation. For structural composition in SCCS, the thickness variation of steel plate, concrete core, and debonding defects are discussed. To determine the most appropriate sensor arrangement for MASW measurement, the effects of spacing and number of observation points, along with distances between excitation points, nearest boundary, as well as the first observation point, are analyzed individually. The influence of signal type and frequency of transient excitation on dispersion figures from forwarding analysis is studied to determine the most suitable excitation signal. The findings from this study can provide important theoretical guidance for MASW-based interfacial debonding detection for SCCS. Furthermore, they can be instrumental in optimizing both the sensor layout design and signal choice for experimental validation.

• Korean Institute of Interior Design Journal
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• v.21 no.4
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• pp.68-76
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• 2012

Contemporary architecture has a tendency to concretely approach based on the concept of Deuleuze's 'fold' diversity problems creating continuously potential diversities within Post-structural paradigm. Contemporary architecture relates to human life through its relation with human being. The research investigates through case study the possible relation of the concept of Deulezue's 'fold', one of his concepts of 'unfolding' based on Monadology, with logic of creation that constructs a space in contemporary architectural space. Eight contemporary architectural spaces since 1990 with architectural embodiment of Deulezue's 'fold' concept have been selected as cases. Based on the fact that the potential possibility of a space can be embodied by the thinking of 'fold', the research draws four physical activities such as 'properties connection', 'beyond border', 'diversity of circulation' and 'potential opportunity', through which it studies on the principle of actualization of space creation. Consideration of metaphysical theory as a pre-modern and outdated one may lose a huge potentiality. Leibniz's metaphysics can be rediscovered as a model that provides diverse potentiality. The concept of 'fold' in Monadology needs be reconsidered because it possibly suggests a methodology that embodies through the actualization of space the meanings underlain in contemporary architectural space.

• Fashion & Textile Research Journal
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• v.15 no.1
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• pp.1-11
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• 2013

This study analyzed the expressive characteristics of padding in contemporary fashion. The methodology of this study was quantified through documentaries, fashion collections, and internet news. The results of expressive characteristics and methods were as follow. First, variability showed the creation of dwelling space by air filling, detail mode by zipper, and diversity of recycled filling by zipper pocket. It reflected the pursuit of nomadism and subversion of permanence by change of filling. Second, it was sexual symbolicity that showed the blurred androgynous silhouette by air filling and padding bar design of the chest, stomach, shoulder for the male body silhouette. It emphasized male sexual identity and power through the expression of a modern ideal body. Third, decoration displayed various crafts (such as knitting), various fabric such as polapolis, suedette, corduroy, denim, leather, knit, and spangle. It reflected visual pleasure, scarcity and various interpretations. Fourth, playfulness character forms throug hair filling, unfamiliar fashion items, diversity of silhouette and change of uses. It reflected a pleasant feeling through astonishment and surprise, nostalgia involved in memory and childhood play and disembarrassment from reality. Fifth, simplicity showed the elimination of a sportswear's factor with regular wad quilting, elimination of wad quilting, wad quilting following the structural line of clothes and the structual line of clothes omitted. It reflected disembarrassment from stereotype and an emphasis on essential elements.

• Journal of Technology Innovation
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• v.12 no.2
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• pp.99-126
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• 2004

Japan's economic clusters are characterized by their high level of diversity. In essence, Japanese economic clusters are not limited to single industries; they comprise numerous manufacturing industries and firms which cluster in specific heterogeneous economic zones, vice political boundaries. Japanese manufacturing sectors are showing an increased level of diversity, resulting in the spread of experience and knowledge among clusters, and sustained growth at the point of industrial structural transformation. Japan's Ministry of Education, Culture, Sports, Science and Technology (MEXT) proposed the creation of intellectual clusters for the purpose of promoting research and development(R&D) activities resulting in the stimulation and development of new technologies. The Ministry of Economy Trade and Industry (METI) is also proposing the industrial cluster plan with the aim to promote the local rebirth and revitalization of the Japanese industrial sector. This paper proposes a methodological analysis which will result in the integration of the two policies currently implemented by the Japanese government. If the current policies are not coordinated and integrated, artificial firms and sectors will continue to hamper innovation and discourage competitiveness, which will ultimately result in Japan's loss of economic opportunities within Asia. In the worst case, failure to act on current economic deficiencies illuminated in this paper could cost Japan its position as an Asian economic leader.