• Journal of the Korean BIBLIA Society for library and Information Science
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• v.7 no.1
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• pp.293-317
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• 1994

The Purpose of this study is to verify the effect of the searcher's subject background on the result of online database searches. To achieve this purpose, an experimental method was adopted. 180 students performed online searches in the three different libraries chosen for this study. The subjects were classified into two groups according to the scores of the test. Data concerning processes, behavior, and results of the searches performed by the subjects in real situations were gathered. Immediately following the searches, the extent of their subject background were assessed through interview. The search effect consists of the 4 elements： search efficiency (the number of terms used per unit time), the number of relevant documents, the number of relevant documents per unit time, precision ratio. The major findings of this study are summarized as belows. 1. The searchers with strong subject background has significantly higher efficiency in searches made. Group A (of those with strong subject back-ground) use more search terms per unit time than Group B (of those with weak subject background) do. 2. In the searches made by those with strong subject background, more relevant documents art retrieved. 3. In the searches made by those with strong subject background, more relevant documents per unit time are retrieved. 4. The searchers with strong subject background has significantly higher precision ratio in searches made. In the searches made by those with strong subject background, more relevant documents of documents retrieved are retrieved.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.31B no.8
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• pp.31-38
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• 1994

This paper presents an improved interpolation algorithm which enables to find a unit function in $H^{\infty}$. From the proposed algorithm the interpolation problem on the infinity point with multiplicity can be solved. This is based on the DPL algorithm the acquired unit function has low order and can be directly applied to strong/simultaneous stabilization problem in control systems. Finally, we verify that poles of transfer function of closed-loop system exist in stable region while investgating internal stability.

• East Asian mathematical journal
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• v.17 no.1
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• pp.71-85
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• 2001

The strong convergences of solutions to a nonlinear Volterra equation are studied in Banach space. As an application, a nonlinear heat flow in a homogeneous bar of unit length of a material with memory is investigated.

• Communications for Statistical Applications and Methods
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• v.10 no.3
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• pp.665-678
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• 2003

In this paper we suggest the new calibration estimator, which is called to the recalibration estimator, and its variance estimator using two-phase sampling technique according to the auxiliary information having strong correlation with the variable of interest under the unit nonresponse. In this unit nonresponse situation, an available information may exists at the level of whole population or the first-phase sample. The proposed recalibration estimator derives from the first and second phase weights respectively.

• Journal of Microbiology and Biotechnology
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• v.8 no.6
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• pp.705-709
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• 1998

In the course of screening for the substances suppressing bleb formation of K562 cell induced by phorbol 12, 13-dibutyrate (PDBu), an inhibitor, chaetoglobosin A (CgA) was isolated from a cultured broth of unidentified fungus. CgA showed a strong inhibitory activity with the $IC_{50}$ value of 60 pM against bleb formation on K562 cells induced by PDBu, but it did not inhibit the activity of protein kinase C (PKC) in vitro. The inhibitory activity of CgA might be due to the modulation of actin filaments on the cell membrane. CgA exhibited strong cytotoxicity against various human cancer cell lines.

• Mass Spectrometry Letters
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• v.11 no.4
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• pp.113-117
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• 2020

Cytochrome P450 2J2 (CYP2J2) is a member of the cytochrome P450 superfamily, and is known to be arachidonic acid epoxygenase that mediates the formation of four bioactive regioisomers of epoxyeicosatrienoic acids (EETs). CYP2J2 is also involved in the metabolism of drugs such as albendazole, astemizole, danazol, ebastine, and terfenadine. CYP2J2 is highly expressed in the heart and cancer tissues. In this study, the inhibitory potential of ten natural products against CYP2J2 activity was evaluated using human liver microsomes and tandem mass spectrometry. Among them, bilobetin, which is a kind of biflavonoid, exhibits a strong inhibitory effect against the CYP2J2-mediated astemizole O-demethylation (IC50 = 0.73 μM) and terfenadine hydroxylation (IC50 = 0.89 μM). This result suggests that bilobetin can be used as strong CYP2J2 inhibitor in drug metabolism study.

• Nuclear Engineering and Technology
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• v.50 no.8
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• pp.1217-1233
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• 2018

Following a surge of interest in multi-unit risk in the last few years, many recent studies have suggested methods for multi-unit probabilistic safety assessment (MUPSA) and addressed several related aspects. Most of the existing studies though focused on two-unit nuclear power plant (NPP) sites or used rather simplified probabilistic safety assessment (PSA) models to demonstrate the proposed approaches. When considering an NPP site with three or more units, some approaches are inapplicable or yield very conservative results. Since the number of such sites is increasing, there is a strong need to develop and validate practical approaches to the related MUPSA. This article provides several detailed approaches that are applicable to multi-unit Level 1 PSA for sites with up to six or more reactor units. To validate the approaches, a multi-unit Level 1 PSA model is developed and the site core damage frequency is estimated for each of four representative multi-unit initiators, as well as for the case of a simultaneous occurrence of independent single-unit initiators in multiple units. For this purpose, an NPP site with six identical OPR-1000 units is considered, with full-scale Level 1 PSA models for a specific OPR-1000 plant used as the base single-unit models.

• MALSORI
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• no.35_36
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• pp.13-24
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• 1998

This study aims at examining the relationship between tonal events and their related vowel and syllable duration in Korean. Two things were investigated: one is to see if there is a hierarchical relationship in prosodic unit-final-lengthening and the other is to see if accentual phrase initial high tone syllable gets lengthened. Generally, higher prosodic units show larger degree of lengthening of the final vowel and also final syllable duration than the lower ones except for accentual phrase: Mean duration of utterance-final or intonational-phrase-final syllable(and its vowels) was longer than that of accentual-phrase-final or word-final syllable(and its vowels). However, mean duration of accentual phrase final syllable was shorter than that of word final syllable. Mean vowel duration of accentual phrase initial high tone syllable was shorter than that of any other prosodic unit. Its mean syllable duration, however, was longer than that of accentual-phrase-final or word-final syllable, indicating that strong consonants(fortis and aspirated) frequently appear in the accentual phrase initial position and this position is a prosodically strong position showing longer duration as well as high tone.

• Bulletin of the Korean Chemical Society
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• v.22 no.7
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• pp.727-731
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• 2001

Conjugated-non-conjugated alternating block copolymers containing distyrylarylene units were synthesized via Wittig reaction for chemiluminescent fluorophores. The polymers were differentiated from others by the presence of aromatic unit in the chromophoric block. When UV-VIS, photoluminescence and chemiluminescence spectra of these materials were compared with copolymers, a strong bathochromic effect was observed. A more pronounced red shift and higher chemiluminscence efficiency were observed in the polymer with anthracene ring. Sodium salicylate-catalyzed reaction of bis(2-carbopentyloxy-3,5,6-trichlorophenyl) oxalate with hydrogen peroxide produced a strong chemiluminescence from blue to yellow-green light emission with wavelength of 450-537 nm in the presence of the fluorophore. The chemiluminescent intensity decayed exponentially. The glow of chemiluminescence maintained more than l2 hr and was visible with the naked eye.

• Applied Biological Chemistry
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• v.41 no.8
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• pp.608-610
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• 1998

To investigate the inhibitory activity of 2-hydroxy-3-amino-4-phenylbutyrate-harboring aminopeptidase N inhibitors, p-nitro-AHPA-peptide derivatives (1 and 2) and an AHPA-peptide derivative (3) were synthesized by chain elongation from C-terminal end using DCC/HOBt as a coupling reagent. The peptides $1{\sim}3$ exerted strong inhibitory activities against aminopeptidase N with $IC_{50}$ values of 1.8, 7.3 and $24.0\;{\mu}g/ml$, respectively, and cytotoxicity on cancer cell lines in vitro.