• Journal of Pharmaceutical Investigation
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• 제36권2호
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• pp.109-114
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• 2006

Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles were developed for sustained delivery of water-soluble macromolecules. PLGA nanoparticles were fabricated by spontaneous emulsification solvent diffusion method generating negatively charged particles and heterogeneous size distribution. As a model drug, blue dextran was encapsulated in PLGA nanoparticles. In addition, nanoparticles were also prepared with varying ratio of poloxamer 188 (P188) and poloxamer 407 (P407), and coating with poly(vinyl alcohol) (PVA). Then, the particle size, zeta potential and encapsulation efficiency of nanoparticles containing blue dextran were studied. In vitro release of blue dextran from nanoparticles was also investigated. The surface and morphology of nanoparticles were characterized by scanning electron microscopy (SEM). In case of nanoparticles prepared with PLGA, P407, and different organic solvents, particle size was in the range of $230{\sim}320\;nm$ and zeta potentials of nanoparticles were negative. The SEM images showed that ethyl acetate is suitable for the formulation of PLGA nanoparticles with good appearance. Moreover, ethyl acetate showed higher encapsulation efficiency than other solvents. The addition of P188 to formulation did not affect the particle size of PLGA nanoparticles but altered the release patterns of blue dextran from nanoparticles. However, PVA, as a coating material, altered the particle size with increasing the PVA concentration. The nanoparticles were physically stable in the change of particle size during long-term storage. From the results, the PLGA nanoparticles prepared with various contents of poloxamers and PVA, could modulate the particles size of nanoparticles, in vitro release pattern, and encapsulation of water-soluble macromolecules.

• 한국수산과학회지
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• 제3권4호
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• pp.207-212
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• 1970

멸치절임의 숙성 및 저장 중의 효소 활성 VBN, 세균수, 식염 함유량, 산도, amino-N pH 그리고 지방의 산가에 다음과 같은 결과를 얻었다. 1) Protease 활성은 염수 염장 중에는 증가하고 절임 중에는 식초산의 영향으로 감소하고 이후 차차 거의 일정하게 변화하며 이에 따라 amino-N는 대개 증가하여 숙성한다. 2) Lipase 활성은 염수 염장 중에는 감소하며 vinegar의 첨가로 일단 증가하였다가 절임중에는 증감의 일정한 경향을 볼 수 없다. 그리고산도는 대개 증가하고 있다. 3) VBN와 NaCl 농도는 염수 염장 중에는 급격히 증가하고 절임중에서는 VBN는 완만한 증가를 하며 NaCl 농도는 기의 변화가 없었다. 4) 세균수는 염수 염장함으로써 줄었다가 다시 증가하며 절임함으로써 급격한 감소를 보이고 그 이후에는 일정한 수를 유지 하였다. 5) 절임 제품의 저장성을 유지하기 위해서는 육질의 산도가 $2\%$ 이상이 되도록 vinegar의 산도를 높혀 주어야한다. 6) 염수 염장하는 기간은 8일이 적합하였으며 VBN, 산도, amino-N, lipase 활성 및 관능 검사 성적을 보아서 절임한 후 47일까지 보장할 수 있고 32일 때가 가장 맛이 좋았다.

• 폴리머
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• 제34권1호
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• pp.14-19
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• 2010

여러 원인에 의한 석조문화재의 풍화 손상을 저지할 목적으로 아크릴계 고분자를 이용하는 가압함침 보존 처리방법에서 함침된 고분자와 무기물질인 석재와의 친화성을 높이도록 silane계 아크릴 단량체의 사용을 연구하였다. 기본 단량체인 methyl metacrylate(MMA)에 vinyl trimethoxy silane(VTMS)의 함량을 변화시키고 라디칼 중합으로 MMA-VTMS 공중합체를 얻어 이들 공중합체의 유리전이온도, 평균분자량, 그리고 저장탄성률의 변화를 평가하여 benzoyl peroxide (BPO) 1 wt%, 중합시간 8시간, 그리고 VTMS 5 mol% 혼합의 경우(PMV5)가 최적 혼합비율과 중합조건임을 알 수 있었다. 실제 국내산 화강암과 풍화된 암석의 시편을 함침 보존처리한 후 수분 흡수율, 충격특성, 내산성 및 접착특성 등을 측정한 결과 MMA 단독 사용과 비교하여 PMV5의 경우 모든 특성에 있어서 개선되는 것을 확인하였다.

• 한국수산과학회지
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• 제37권1호
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• pp.24-32
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• 2004

A mathematical model is used to investigate nitrogen dynamics in the intensive aquaculture ponds in the western coast of Korea. Parameters associated with water quality, sediments and growing of shrimp (Fenneropenaeus chinensis) are measured to calibrate the model for feeding ponds A and B and storage ponds. The model describes the fate of nitrogen including loadings of ammonia from feeds, phytoplankton assimilation, nitrification, sedimentation, volatilization and discharge. The model obtains good agreements with the measured values of TAN $(NH_4,\;NH_3),\;NO(NO_2,\;NO_3)$ and Chl (chlorophyll a). Impacts of water exchange on TAN and Chl are investigated, showing that the range of 0.01-0.2 (/day) cannot effectively reduce TAN but reduces Chl. Nitrogen in the ponds A is removed by sedimentation $66\%,$ volatilization $8\%,$ discharge of particulate and dissolved $8\%.$ The pond B shows $56\%\;and\;26\%$ of sedimentation and volatilization, respectively, to yield $10\%.$ decrease and 8c/o increase compared to those in the pond A. While the pond A has larger area (1.02:0.66 ha) and same stocking density (0.025 md./L) at the beginning of culture, the pond B obtains higher stocking density (0.0065:0.0091 md./L), longer feeding period (103:121 day) and resultant higher shrimp production (1.15:2.13 t/ha/cycle) at harvest. This is possibly due to the hydraulic characteristics driven by paddlewheels. At low ratio of the low speed area and the pond area, the rate of sedimentation is high, while the rate of gas exchange is low. Thus, the measurement and model analysis suggest that water quality and shrimp production are positively correlated with the hydraulic characteristics in the shrimp ponds.

• 한국GIS학회:학술대회논문집
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• 한국GIS학회 2008년도 공동추계학술대회
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• pp.153-161
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• 2008

Agriculture and forest are basis for livelihood in Nepal while both sectors constitute around 40 percent of the national product and over two-thirds of the economically active population is dependent on agriculture. However, radical changes in land use, depletion in crops production and food availability are major threats due to loss of soil fertilityand severe environmental degradation. In this study, we used time series data from 1986/87 to 2005/06 about food crop production and population published by Government of Nepal, Ministry of Agriculture and Cooperatives and Central Bureau of Statistics. Descriptive statistics and ArcGIS were used to assess and map the food security status of Nepalese Terai based on the local food demand and supply system. Food supply to demand ratio(FSDR) was the main idea of assessment. Our results showed that out of 20 districts, only 8 districts were categorised under secured food districts whereas 5 districts were still under food unsecured situation. The analysis further revealed that 7 districts had faced food deficit more than 8-16 times during the last 20 year periods. Data further showed that there was surplus food supply relative to the requirements dictated by FSDR. However, the average FSDR was less than 1.2(less than 20% surplus) exploring fact that most of the districts were not producing sufficient food to cope up the food shock and after 1995 it was relatively stagnant. Our prediction reveals that food supply in Terai even in the future would remain at almost the same level as now, and there will not more than 16-17% surplus by 2021 considering medium vibrant population growth. The findings thus, indicate that Terai may not be a food secure region in the future, even though the region is considered as a food storage house of Nepal. In addition, this paper suggests ways to make future comprehensive case studies more widely comparable in Terai, Nepal.

• 대한전자공학회논문지SD
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• 제38권2호
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• pp.103-113
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• 2001

본 논문은 0.6㎛ CMOS 기술로 LZSS 알고리즘과 엔트로피 부호를 이용한 부호기/복호기 단일-칩의 본 논문은 0.6uul CMOS 기술로 LZSS 알고리즘과 엔트로피 부호를 이용한 부호기/복호기 단일-칩의 VLSI 설계 및 구현에 관하여 기술하였다. 처리 속도 50MHz를 갖는 사전탐색처리장치(DISP)의 메모리는 2K×Bbit 크기를 사용하였다. 이것은 매번 33개 클럭 중 한 개의 클럭은 사전의 WINDOW 배열을 갱신으로 사용하고 나머지 클럭은 주기마다 한 개의 데이터 기호를 바이트 단위로 압축을 실행한다. 결과적으로, LZSS 부호어 출력에 엔트로피 부호를 적용하여 46%의 평균 압축률을 보였다. 이것은 LZSS에 보다 7% 정도의 압축 성능이 향상된 것이다.

• Imaging Science in Dentistry
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• 제30권4호
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• pp.265-274
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• 2000

Purpose: The aims of the present study are to determine the optimum compression rate in terms of file size reduction and diagnostic quality of the images after compression and evaluate the transmission speed of original or each compressed image. Materials and Methods: The material consisted of 24 extracted human premolars and molars. The occlusal surfaces and proximal surfaces of the teeth had a clinical disease spectrum that ranged from sound to varying degrees of fissure discoloration and cavitation. The images from Digora system were exported in TIFF and the images from conventional intraoral film were scanned and digitalized in TIFF by Nikon SF-200 scanner (Nikon, Japan). And six compression factors were chosen and applied on the basis of the results from a pilot study. The total number of images to be assessed were 336. Three radiologists assessed the occlusal and proximal surfaces of the teeth with 5-rank scale. Finally diagnosed as either sound or carious lesion by one expert oral pathologist. And sensitivity, specificity and k value for diagnostic agreement was calculated. Also the area (Az) values under the ROC curve were calculated and paired t-test and oneway ANOVA test was performed. Thereafter, transmission time of the image files of the each compression level was compared with that of the original image files. Results: No significant difference was found between original and the corresponding images up to 7% (1 : 14) compression ratio for both the occlusal and proximal caries (p<0.05). JPEG3 (1 : 14) image files are transmitted fast more than 10 times, maintained diagnostic information in image, compared with original image files. Conclusion: 1 : 14 compressed image file may be used instead of the original image and reduce storage needs and transmission time.

• 한국연초학회지
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• 제26권1호
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• pp.35-42
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• 2004

This study was carried out to examinate the effect of aging period on chromatic, chemical and organoleptic characteristics, and to evaluate of optimum aging period for each grade in burley leaf tobacco. The leaf tobaccos were produced in 2000, and threshed, redried and packed in carton box under the current methods. Four grades of processed leaf(A3T, B1T, C1W and D3W) were stored during 24 months (May 10, 2001 to April 31, 2003) in warehouse of Chungju Leaf Tobacco Processing Factory. The leaf tobaccos were sampled at three month intervals for analysis of chromatic, chemical and organoleptic properties. pH values of four grades, and Yellow(b) of A3T and BIT were also significantly decreased during the aging. Filling values, tar, nicotine and CO contents of tobacco smoke, and puff number of cigarettes were not significantly changed during the aging. Positive correlation coefficients were significantly observed between irritation of the calculated attributes from contents of volatile oil components in leaf tobacco and that of the panel sensory attributes. The ratio of maximum change in irritation attribute was larger than that in taste attribute during aging. The calculated irritations of 18～24 months aging for A3T and B1T were significantly lower than zero-aging, while those of C1W and D3W were not significant among aging periods. The panel irritations of 12～15 months aging for four grades were low tendency. The results suggest that decrease of aging period for thin leaf from 21～24 to 12～15 months may be beneficial to save storage cost in burley tobacco.

• 한국연초학회지
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• 제26권1호
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• pp.27-34
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• 2004

This study was carried out to examinate the effect of aging period on chromatic, chemical and organoleptic characteristics, and to evaluate of optimum aging period for each grade in flue-cured leaf tobacco. The leaf tobaccos were produced in 2000, and threshed, redried and packed in carton box under the current methods. Four grades of processed leaf(A3O, B1O, C1L and D3L) were stored during 24 months(May 10, 2001 to April 31, 2003) in warehouse of Chungju Leaf Tobacco Processing Factory. The leaf tobaccos were sampled at three month intervals for analysis of chromatic, chemical and organoleptic properties. Yellow(b), pH values and total sugar contents of four grades were significantly decreased during the aging. Filling values, tar, nicotine and CO contents of tobacco smoke, and puff number of cigarettes were not significantly changed during the aging. Positive correlation coefficients were significantly observed between taste and irritation of the calculated attributes from contents of volatile oil components in leaf tobacco and those of the panel sensory attributes. The ratio of maximum change in taste attribute was larger than that in irritation attribute during aging. The optimum aging periods estimated by taste for A3O, B1O, C1L and D3L were 17.8, 14.9, 10.8, and 9.8 months, respectively. The thin leaf(Primings and Cutters) undergo satisfactory aging earlier as compared to bodied leaf(Leaf and Tips). The results suggest that decrease of aging period for thin leaf from 18～21 to 9～12 months may be beneficial to save storage cost in flue-cured tobacco.

• 한국지구과학회지
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• 제32권6호
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• pp.586-594
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• 2011

2002년 4월에 발사된 Gravity Recovery and Climate Experiment(GRACE) 위성의 중력시간변화 측정을 통해, 기후 및 환경 변화에 의한 지구 내 질량 재배치 연구가 가능해 졌다. GRACE 중력 자료는 구면조화 함수의 계수인 중력 스펙트럼 형태로 제공이 되며, 이를 구면조화 함수를 이용하여 원하는 지역의 중력 변화 또는 질량 변화로 환산을 해야 한다. 하지만, GRACE 중력 자료는 측정 잡음 이외에도 공간적인 알리아스 에러가 존재하여, 질량 재배치 효과를 확인하기 위해서는 중력 스펙트럼의 처리 과정이 필요하다. 이 연구에서는 GRACE 자료를 처리하는 가장 일반적인 방법을 소개하고, 처리된 중력 자료를 이용한 연구 사례를 소개하였다. GRACE 중력 자료를 이용하여 광범위한 지구과학 연구가 진행 중이지만, 그 중 가장 활발한 연구 분야인 육지의 물수지 연구, 빙하 변화 연구 그리고 해수면 상승 연구 등을 중심으로 소개하였다. GRACE 위성과 유사한 인공위성 중력 관측 사업이 2020년까지 계획되어 있으며, 향후 수십년간 축적된 인공위성 중력 자료는 지구 환경 변화 연구에 핵심적인 자료로 활용될 것으로 기대된다.