• Radiation Oncology Journal
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• v.2 no.1
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• pp.25-32
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• 1984

The pathological changes of stomach of the rat following 1,000 rad and 1,800 rad single exposure by Cobalt-60 has been made with 50 experimental rats. The dose of 1,000 rad and 1,800 rad single exposure were equivalent of biologic effect of 2,500 rad in 2 1/2 weeks and 6,000 rad in 6 weeks. Following single exposure, the groups of rat were terminated in 1, 2, 4, 8, 12 weeks intervals and the stomach were fixed to formalin solution immediatly after dissection. The pathological changes were as follows : 1. Following 1,000 rad single exposure, the stomach show only mild to moderate submucosal edema in 4,8,12 weeks group. 1 and 2 weeks group show no changes. 2. Following 1,800 rad single exposure, $32\%(8/25)$ of rats were dead by radiation effect and all other groups of stomach revealed variable pathological changes such as submucosal edema, squamous dysplasia, squamous papilloma as well as squamous cell carcinoma. 3. Optimal tolerance dose to the stomach was $4,500\~5,000$rad when irradiation given by supervoltage. The entire stomach was included within the irradiation field, the dose to the stomach should not exceed 6,000 rad. 4. In conclusion, the radiation injury to the stomach were more direct radiation effects to the gastric mucosa rather than secondary changes of radiation injured vessels.

• Journal of Digestive Cancer Reports
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• v.7 no.1
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• pp.13-17
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• 2019

Stomach cancer is the fifth most common malignancy in the world. The incidence of stomach cancer is declining worldwide, however, gastric cancer still remains the third most common cause of cancer death. The tumor, node, and metastasis (TNM) staging system has been frequently used as a method for cancer staging system and the most important reference in cancer treatment. In 2016, the classification of gastric cancer TNM staging was revised in the 8^th American Joint Committee on Cancer (AJCC) edition. There are several modifications in stomach cancer staging in this edition compared to the 7^th edition. First, the anatomical boundary between esophagus and stomach has been revised, therefore the definition of stomach cancer and esophageal cancer has refined. Second, N3 is separated into N3a and N3b in pathological classification. Patients with N3a and N3b revealed distinct prognosis in stomach cancer, and these results brought changes in pathological staging. Several large retrospective studies were conducted to compare staging between the 7^th and 8^th AJCC editions including prognostic value, stage grouping homogeneity, discriminatory ability, and monotonicity of gradients globally. The main objective of this review is to evaluate the clinical and pathological implications of AJCC 8^th staging classification in the stomach cancer.

• Journal of Korean Medical classics
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• v.21 no.3
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• pp.147-155
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• 2008

Seopcheonsa(葉天士) regarded the cause of Stomach-Eum[胃陰] deficiency as the lack of fluid and humor induced the heat by Eum(陰, yin) deficiency constitution, external pathogen, overexertion and fatigue, misused medication etc. He said that the symptoms of Stomach-Eum deficiency was related to indigestion of food and that it induced the short supply of nutrition for the whole body and the symptoms by disabled Earth[土]-engenders-Metal[金]. He presented the treatment of clearing Stomach-Fire[胃熱] and nourishing Stomach-Eum[胃陰], and used Geumgwemaekmundongtang(金匱麥門冬湯). And he emphasized Stomach-Eum to supplement existing Spleen-Yang[脾陽] centered treatment. Dangjonghae(唐宗海) regarded Spleen-Eum[脾陰] as these, first, it was fluid and humor such as digestive enzyme. Secondly, it was nutritive substance itself. Finally, it contained plaster-oil and blood-agglutination which formed flesh with nutritive substance. Seopcheonsa and Dangjonghae both thought that fluid and humor was necessary to digest food. However, Dangjonghae's Spleen-Eum[脾陰] included nutritive substance as the result of digestion. So we can say that Dangjonghae integrated Spleen-Eum with Stomach-Eum and Spleen-nutrient.

• Journal of Haehwa Medicine
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• v.18 no.1
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• pp.49-66
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• 2009

1. Hiccup is usually named as Hae yek, Hyel yek, Yel yek. 2. The cause of hiccup are stomach cold, rising of stomach fire, stagnation of vital energy and stagnationof phlegm, yang deficiency of spleen and kideny, deficiency of stomach-yin, or mental disorder due to the stagnation of phlegm, dyspepsia, depressed vital energy. 3. Vicera and Bowels related with Hiccup are lung, spleen, stomach, and heart. 4. The treatment of hiccup are dispel cold by warming the middle warmer due to stomach cold, expel the heat-evil to loose hollow-organ due to rising up of stomach yin, regulate vital energy and dissipate phlegm due to stagnation of vital energy and stagnation of phlegm, warm and recuperate both of spleen and kidney due to spleen and kidney yang deficiency, nourish the stomach to promote the production of body fluid due to deficiency of stomach yin. 5. Regarding neuropsychiatric aspect of hiccup, qi movement disorder was the main mechanism of disease and qi depression was the main cause. The prescriptions for neuropsychiatric hiccup were Mokhwangjogisan Pyunjakjunghyangsan, Daegwakhyangsan, and Haeaedan.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4725-4732
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• 2012

Aim: The incidence of stomach cancer in Mizoram is highest in India. We have conducted a population based matched case-control study to identify environmental and genetic risk factors in this geographical area. Methods: A total of 102 histologically confirmed stomach cancer cases and 204 matched healthy population controls were recruited. GSTM1 and GSTT1 genotypes were determined by PCR and H. pylori infections were determined by ELISA. Results: Tobacco-smoking was found to be an important risk factor for high incidence of stomach cancer in Mizoram. Meiziol (local cigarette) smoking was a more important risk factor than other tobacco related habits. Cigarette, tuibur (tobacco smoke infused water) and betel nut consumption synergistically increased the risk of stomach cancer. Polymorphisms of GSTM1 and GSTT1 genes were not found to be directly associated with stomach cancer in Mizoram. However, they appeared to be effect modifiers. Persons habituated with tobacco smoking and/or tuibur habit had increased risk of stomach cancer if they carried the GSTM1 null genotype and GSTT1 non-null genotype. Conclusion: Tobacco smoking, especially meiziol is the important risk factor for stomach cancer in Mizoram. GSTM1 and GSTT1 genes modify the effect of tobacco habits. This study is a first step in understanding the epidemiology of stomach cancer in Mizoram, India.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8815-8822
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• 2014

Background: The incidence of stomach cancer in India is highest in the state of Mizoram. In this population based matched case-control study, we evaluated the relationship between CYP450 2E1 RsaI polymorphism and risk of stomach cancer taking into considering various important dietary habits along with tobacco, alcohol consumption and H. pylori infection status. Materials and Methods: A total of 105 histologically confirmed stomach cancer cases and 210 matched healthy population controls were recruited. CYP2E1 RsaI genotypes were determined by PCR-RFLP and H. pylori infection status by ELISA. Information on various dietary, tobacco and alcohol habits was recorded in a standard questionnaire. Results: Our study revealed no significant association between the CYP2E1 RsaI polymorphism and overall risk of stomach cancer in Mizoram. However, we observed a non-significant protective effect of the variant allele (A) of CYP2E1 against stomach cancer. Tobacco smokers carrying C/C genotype have three times more risk of stomach cancer, as compared to non-smokers carrying C/C genotype. Both Meiziol and cigarette current and past smokers who smoked for more than 10 times per day and carrying the (C/C) genotype are more prone to develop stomach cancer. Smoke dried fish and preserved meat (smoked/sun dried) consumers carrying C/C genotype possesses higher risk of stomach cancer. No significant association between H. pylori infection and CYP2E1 RsaI polymorphism in terms of stomach cancer was observed. Conclusions: Although no direct association between the CYP2E1 RsaI polymorphism and stomach cancer was observed, relations with different tobacco and dietary risk habits in terms of developing stomach cancer exist in this high risk population of north-eastern part of India. Further in-depth study recruiting larger population is required to shed more light on this important problem.

• Journal of Korean Medical classics
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• v.30 no.3
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• pp.167-180
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• 2017

Objectives : The purpose of this paper is to extinguish the debates surrounding the sentences found in Suwen Kailun that deal with flocking to stomach and closure in lung. The paper seeks to do this through studying the assertions of historical doctors and their theories regarding the topic. Methods : The interpretations of annotators regarding these sentences were studied, and text DB was searched to collect and analyze materials related to the theories of the relationship between stomach and lung. Results : The sentences of flocking to stomach and closure in lung, judging from their contexts, seem to be related to the symptom of Sanjiao ke or Liufu ke. However, they may be pointing to internal organs' ke as a whole based on the close relationship between stomach and lung. They could mean either the abnormality of mechanism of stomach and lung could cuase ke or that Zhuoqi could accumulate inside of stomach to cause phlegm-fluids thereby blocking thorax and causing cough. Theory of Warm disease, too, provides a number of treatment suggestions for stomach, lung damages such as supporting Yin and dispersing dampness. Conclusions : The study of the sentences regarding flocking to tomach and closure in lung is expected to not only provide an analysis of the sentences, but also provide a perspective and a method for clinical treatments.

• Korean Journal of Head & Neck Oncology
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• v.8 no.1
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• pp.25-30
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• 1992

The causes of treatment failure in head and neck cancer are locoregional recurrence, distant metastasis and second primary cancer. The favorite sites of second primary cancer are head and neck, lung and esophagus. But, the incidence of stomach cancer in Korea is the highest of all, high incidence of stomach cancer is expected in head and neck cancer patients. We experienced 2 cases of stomach cancer after successful treatment of primary head and neck cancer at Kang Nam St. Mary's hospital. The first case was a 60-year-old male with nasopharyngeal non-keratinizing carcinoma(stage III, T1N1M0). He received three cycles of induction chemotherapy including cisplatin and 5-fluorouracil followed by radiotherapy which resulted in complete response. Five months after completion of radiotherapy. stomach adenocarcinoma(stage IV, T4N2M1) was diagnosed. He received one cycle of FAM chemotherapy and died 4 months after diagnosis of stomach cancer. The second case was a 50-year-old male with pyriform sinus squamous cell carcinoma(stage II, T2N0M0). He received curative partial pharyngolaryngectomy followed by radiotherapy which result in free of disease. Four months after completion of radiotherapy. stomach adenocarcinoma(stage IV, T4N2M1) was diagnosed. Bypass gastrojejunostomy was performed. The screening test for stomach cancer including upper gastrointestinal X-xay series and/or endoscope of the stomach should be performed periodically for the patients with head and neck cancer in Korea.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.27-32
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• 2016

Stomach cancer, the fourth most common cancer and the second leading cause of cancer-related death through the world, is very common in parts of Iran. Geographic variation in the incidence of stomach cancer is due to many different factors. The aim of this study was to assess the geographical and spatial distribution of stomach cancer in Iran using data from the cancer registry program in Iran for the year 2009. The reported incidences of stomach cancer for different provinces were standardized to the world population structure. ArcGIS software was used to analyse the data. Hot spots and high risk areas were determined using spatial analysis (Getis-Ord Gi). Hot and cold spots were determined as more than or less than 2 standard deviations from the national average, respectively. A significance level of 0.10 was used for statistical judgment. In 2009, a total of 6,886 cases of stomach cancers were reported of which 4,891 were in men and 1,995 in women (standardized incidence rates of 19.2 and 10.0, respectively, per 100,000 population). The results showed that stomach cancer was concentrated mainly in northwest of the country in both men and women. In women, northwest provinces such as Ardebil, East Azerbaijan, West Azerbaijan, Gilan, and Qazvin were identified as hot spots (p<0.1). In men, all northwest provinces, Ardabil, East Azerbaijan, Gilan, Qazvin, Zanjan and Kurdistan, the incidences were higher than the national average and these were identified as hot spots (P<0.01). As stomach cancer is clustered in the northwest of the country, further epidemiological studies are needed to identify factors contributing to this concentration.

• Korean Journal of Veterinary Research
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• v.38 no.1
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• pp.183-199
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• 1998

The effects of electroacupuncture(EA) on gastrointestinal motility were investigated in 6 horses. Three acupuncture points ; Guan Yuan Shu(BL-26), Wei Shu(BL-21) and Da Chang Shu(BL-25) were stimulated for 20 minutes by EA at separate occasions under varying condition ; 2V-1Hz, 2V-5Hz, 2V-30Hz, 4V-1Hz, 4V-5Hz and 4V-30Hz. Myoelectric activity of stomach and cecum was monitored to investigate the gastrointestinal motility. Electromyogram(EMG) recordings were carried out before, 0, 20 minutes after and 40 minutes after the EA stimulation. EMG bipolar electrode was surgically implanted in seromuscular layer of greater curvature in the stomach and between medial band and ventral band in the cecum. The EA stimulation and monitoring were not commenced until 15 days after electrode implantation. The EA stimulation of Wei Shu influenced on stomach motility and that of Da Chang Shu on, cecum motility. However, the EA stimulation of Guan Yuan Shu influenced on both the stomach and the cecum motility. The myoelectrical spike burst amplitude of the stomach and the cecum was significantly(p<0.05) increased by 2V-1Hz stimulation, but the myoelectrical spike burst frequence of the stomach and the cecum was significantly decreased by 2V-30Hz or 4V-30Hz stimulation. The myoelectrical spike burst duration of the stomach and the cecum was significantly lengthened by 4V-30Hz and 2V or 4V-30Hz stimulation, respectively.