• BMB Reports
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• v.35 no.1
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• pp.28-40
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• 2002

Apoptosis is a mode of cell death that plays an important role in both pathological and physiological processes. Research during the last decade has delineated the entire machinery needed for cell death, and its constituents were found to pre-exist in cells. The apoptotic cascade is triggered when cells are exposed to an apoptotic stimulus. It has been known for several years that inhibitors of protein synthesis can potentiate apoptosis that is induced by cytokines and other inducers. Until 1996, it was not understood why protein synthesis inhibitors potentiate apoptosis. Then three reports appeared that suggested the role of the transcription factor NF-${\kappa}B$ activation in protecting the cells from TNF-induced apoptosis. Since then several proteins have been identified that are regulated by NF-${\kappa}B$ and are involved in cell survival, proliferation, and protection from apoptosis. It now seems that when a cell is attacked by an apoptotic stimulus, the cell responds first by activating anti-apoptotic mechanisms, which mayor may not be followed by apoptosis. Whether or not a cell undergoes proliferation, the survival, or apoptosis, appears to involve a balance between the two mechanisms. Inhibitors of protein synthesis seem to suppress the appearance of protein that are involved in anti-apoptosis. The present review discusses how NF-${\kappa}B$ controls apoptosis.

• Journal of Biomedical Engineering Research
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• v.22 no.6
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• pp.487-496
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• 2001

In this study, a galvanic stimulator providing bipolar mode controlled by a PIC(peripheral interface controller) was constructed to evaluate vestibular function The maximum load and maximum current intensity of the constant current source were 3$k\Omega$ and 5mA. respectively. and it could Produce DC, sine wavers. or Pulse waves. Eve movements of 20 normal subjects by galvanic stimulation were analyzed using a commercial videooculogragh. During stimulating with DC for 30 sec. we recorded the response of eye movement with current intensity of 0.75. 1 2, and 3 mA. Nystagmus occurred to all the subjects when the galvanic stimulus intensity was larger than 2 mA. Average SPV(slow Phase eye movement velocity) and the number of nystagmus increased from 7.1 to 4.8 deg/sec and from 17 to 48, respectively, when the stimulus current increased from 0.75 to 3 mA. All the fast eye movement of the nystagmus were the direction of the negative electrode. The asymmetry which means the difference between right- and left-eye movements decreased when the stimulus intensity increased. It is expected that this study would be useful in evaluating vestibular function and in studying basic Physiology mechanism of vestibular ocular reflex by galvanic stimulus .

• Journal of Korea Game Society
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• v.10 no.4
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• pp.15-22
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• 2010

The purpose of this research is to analyze players' emotion pattern for conducting a quest in Role Playing Game(RPG). We have rebuilt up the action and content of gameplay related to category to set up five action classes of game players based on the literature review about the human behavior classification. Moreover, Mabinogi game includes the composition of various quests by story-centered expanse. We classified the quest structure of the tutorial mode, initial state, of its game into the cognitive action. We build the model of the correlation between cognitive behavior patterns of gameplay and emotions derived from targeting ten novices. The result of this research reveals that gameplayers' stimulus levels are identified to emotion pattern. It is enable to grope to concrete the design of the quest and the level in a specified state. Moreover, players' emotion variation is indicated to the type of expression of fun elements. We expect to use a device to induce the curiousness and the challenge for conducting the higher goal of game in the whole.

• Journal of the Korean Institute of Landscape Architecture
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• v.18 no.1
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• pp.19-32
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• 1990

The perception of landscape structure can he formed mode clearly, with including an auditory stimulus to a visual aspect. The waterfall, as an landscape element, will be considered of not only it's function and structure in landscape architecture designing but also harmony with environment which it has been situated, and contribution to the public goad. The purpose of this study was to establish more 7rational and practical design theory for the construction of waterfall. The number of subjects investigated were 47 of waterfall located in Mt. Palgong. In this study, the acoustic character of the waterfalls were investigated as an excellent effect to mask easily sensible noises. The correlations between the structure of waterfalls and water 1a17ing sound, which were useful for waterfall design and construction, were examined. It was discovered that the position of double distance of waterfall height From the waterfall is significant in the visual and acoustic perception of waterfall.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.12 no.1
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• pp.71-81
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• 1987

To fuly utilize the availability of the ISDN, it is very important to develop the ISDN user terminals which can provide various user services. In this paper, the basic concept of the ISDN user terminal is briefly studied and, based on this study, a stimulus type digital telephone which can be connected directly to the ISDN is designed. This digital telephone can provide the basic voice service and has general functions such as voice encoding / decoding(PCM is used), user-network signalling, digital tone supply, channel selection, key pad and atatus display. Echo cancellation method is adopted for the digital subscirber loop transmission and user-network signalling is implemented according to the LAPD(Link Access Procedure on D-channel) protocol recommended by the CCITT's recommendations I.440-I.441. The validity of designed S/W and H/W functions are verified by testing them with ISDN circuit switching emulator described in the first part of this paper.

• The Journal of the Korea Contents Association
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• v.13 no.4
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• pp.361-375
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• 2013

While the mobile application market is growing fast, the revenues of the majority apps are declining. Moreover, paid mobile application prices and purchases have been slow because of intensifying competition. However, the conventional studies focused only on the acceptance factor of mobile applications, so they cannot explain the phenomenon such as acceptance resistance for paid mobile applications. Therefore, our study tries to analyze the factors for the acceptance resistance of users for paid mobile applications. The research model in this paper, which is based on S-O-R model, verified through surveys how social influence and app characteristics affect user perception and how user perception affects to app resistance. The results of our study showed that paid mobile applications happened to be destroyed in front of the chasm because of the perceived loss. Consequently, the results implicate that the developers should lower the initial price and actively react to the negative reviews in order to lower the perceived loss. Moreover, the results verified that a sense of self-efficacy can lower application acceptance resistance by including personal properties to our research model as control variables.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.24 no.65
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• pp.51-63
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• 2001

The present experiment investigated the possibility of evaluating of the human sensibility contingent on the speed and modes of driving using the responses from the autonomic nervous system, subjective assessments, Simulator Sickness (55) in dynamic simulator. The three conditions of the speed of driving were 40 $\pm$ 10 km/h, 100$\pm$10 km/h, 160 $\pm$ 10 km/h, and the participant was instructed to drive the car for three minutes on the elliptical track. It is programed in such a way that the modes of driving can be changed smoothly using road DB in Dynamic Simulator, and for signifying the change of the condition the road signs were used. The instruction was given to the participant to drive the car on the fixed speed of 20 km/h for 30 seconds, then to drive the car on sudden-start mode of driving from the 20 km/h to 160 km/h within 10 seconds. For the sudden-stop mode of driving, it was instructed that stop the car from the speed of 160km/h to 20km/h within 10 seconds when the subject see the road sign, then drive the car at the fixed speed of 20 km/h for 30 seconds. The results of the subjcetive assessment showed that the level of pleasantness and the tension was increased, and physiological response showed that the level of activity of the autonomic responses were also increased as the speed of the car increased. Also, for results on the driving modes showed that the level of pleasantness was highest for the sudden-stop, next highest was sudden-start, and the lowest was 20 km/h fixed speed condition for the subjective assessment, and tile order of the level of activation of the autonomic nervous system showed the same results as above. From the results of the present study it was concluded that the presentation and evaluation of the stimulus for the human sensitivity is possible in dynamic simulator.

• Korean Journal of Acupuncture
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• v.30 no.3
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• pp.161-170
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• 2013

Objectives : Our study aimed to investigate the sustained effects of sham (SHAM) and verum acupuncture (ACUP) into the post-stimulus resting state. Methods : In contrast to previous studies, in order to define the changes in resting state induced by acupuncture, changes were evaluated with a multi-method approach by using regional homogeneity (ReHo) and amplitude of low frequency fluctuation (ALFF). Twelve healthy participants received SHAM and ACUP stimulation right GB34 (Yanglingquan) and the neural changes between post- and pre-stimulation were detected. Results : The following results were found; in both ReHo and ALFF, the significant foci of; left and right middle frontal gyrus, left medial frontal gyrus, left superior frontal gyrus, and right posterior cingulate cortex, areas that are known as a default mode network, showed increased connectivity. In addition, in ReHo, but not in ALFF, brain activation changes in the insula, anterior cingulate cortex, and the thalamus, which are associated with acupuncture pain modulation, were found. Conclusions : In this study, results obtained by using ReHo and ALFF, showed that acupuncture can modulate the post-stimulus resting state and that ReHo, but not ALFF, can also detect the neural changes that were induced by the acupuncture stimulations. Although more future studies with ReHo and ALFF will be needed before any firm conclusions can be drawn, our study shows that particularly ReHo could be an interesting method for future clinical neuroimaging studies on acupuncture.

• Journal of the Korean Society of Costume
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• v.29
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• pp.23-38
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• 1996

The purpose of this study was to analyze the characteristics of the Minimal Art represented in the second half 20th century fashion. All the mode of dress worn this century have developed from the stimulus of a chang-ing society fired by new discoveries and a zest for the new and different. It would appear that even more dramatic changes will soon occur in our clothing styles the effects of which will be farreaching. Many of today's styles intended to dress our psyche rather than our bodies and this if fully understood by the new designers whose influ-ence will become increasingly more potent as we approach the new century. The highly developed material civilization resulted in human alienations environmental distruption, l By this fact human being of the 20th century was to overcome social com-plexity. Accordingly their search for simplicity was interested in the 60's style. Especially the formativeness of the 60s style was repre-sented in the second half 20th century fashion. In this paper it was focused that how the characteristics of the Minimal Art was expressed in the second half 20th century fashion. minimalism was a quest for basic elements repesenting the fundamental esthetic values of art. without regard to issues of content. At its most extreme it reduced art not ot an eter-nal essence but to an arid simplicity. "Primary Structure" the most suitable name suggested for this type conveys its two salient characteristics : extreme simplicity of shapes and a kinship with architecture. minimalist works are charcterized by huge dimensions coldness and absolute aesthetic neutrality. minimalist artists ambition is to de-fine through the most rudimentary materials such as plywood galvanized iron aluminum plastic and wood a new order of the space. The environment is just as important as the object itself. Similary the use of new tough materials. such as vinyl metal and plastic at late half of the 20th century fashion related to the formativeness of the Minimal Art. And the style of 20th fashion was holded the internal meanings in common the formativeness of the Minimal Aet thorough the various texture pat-tern silhouette etc.uette etc.

• Science of Emotion and Sensibility
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• v.1 no.2
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• pp.13-22
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• 1998

The sense of touch has both objective and subjective characteristics. During hand evaluation of the fabrics. psycho physiological processes such as emotion and stimulation. On other site, the mode of touch (passive vs. active) is also capable to modulate somatosensory responses. I.e., suppress somatocensory perception during active electrocortical responses to passive and active touch of the textiles with different subjective emotional preference. The study was carried out on 36 female college students. Physiological signals were acquired by Grass and BIOPAC 100 systems with AcqKnowledge variables, namely heart rate (HR), respiratory sinus arrhythmia (RSA), pulse transit time (PTT), respiration rate (RSP) and skin conductance parameters (SCL, amplitude, risetime and number of SCRs) were analyzed for baseline and stimulation conditions. Analysis was manifested in a form of moderate HR acceleration. RSP increase, RSA decrease (lowered vagal tone), decreased PTT and increased electrodermal activity (increased SCL, several SCRs) that reflects general sympathetic activation. Parietal EEG effects (on contra-lateral side to stimulated hand)were featured by short-term alpha-blocking, slightly reduced theta, significantly increased delta and enhanced fast beta activity with few variations across stimuli. The main finding of the study was that most and least preferred textures exhibited significant differences in autonomic (HR, RSP, PTT, SCR, and at less extent in RSA and SCL) and electrocortical responses (delta, slow and fast alpha, fast beta relative power). These differences were recorded both in passive and active stimulation modes, thus demonstrating reproducibility of distinction between most and least emotionally preferred tactile stimuli, suggesting influence of psychological factors, such as emotional property of stimulus, on physiological outcome.