• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2001년도 추계학술대회 논문집
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• pp.138-143
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• 2001

Based on mild slope equation and parabolic approximation the forward diffraction of monochromatic waves by a straight breakwater are studied numerically. The characteristics and effects of stem wave along breakwater and the relations between the stem wave and incident wave angle are discussed.

• The Korean Journal of Physiology and Pharmacology
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• 제16권1호
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• pp.1-9
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• 2012

Because the average human life span has recently increased, the number of patients who are diagnosed with neurodegenerative diseases has escalated. Recent advances in stem cell research have given us access to unlimited numbers of multi-potent or pluripotent cells for screening for new drugs for neurodegenerative diseases. Neural stem cells (NSCs) are a good model with which to screen effective drugs that increase neurogenesis. Recent technologies for human embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) can provide human cells that harbour specific neurodegenerative disease. This article discusses the use of NSCs, ESCs and iPSCs for neurodegenerative drug screening and toxicity evaluation. In addition, we introduce drugs or natural products that are recently identified to affect the stem cell fate to generate neurons or glia.

• 대한약리학회:학술대회논문집
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• 대한약리학회 2006년도 The 6th Congress of the Federation of Asian and Oceanian Physiological Societies
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• pp.82.1-82.1
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• 2006

• Bulletin of the Korean Chemical Society
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• 제33권6호
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• pp.1983-1988
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• 2012

Stem cell transplantation is emerging as a possible new treatment for liver cirrhosis, and recent animal studies have documented the benefits of stem cell therapy in a hepatic fibrosis model. However, the underlying mechanism of stem cell therapy is still unclear. Among the proposed mechanisms, the cell replacement mechanism is the oldest and most important, in which permanently damaged tissue can be replaced by normal tissue to restore function. In the present study, Cy5.5-labeled superparamagnetic iron oxide (SPIO) was used to label human mesenchymal stem cells. The uptake of fluorescently labeled nanoparticles enabled the detection and monitoring of the transplanted stem cells; therefore, we confirmed the direct incorporation and differentiation of SPIO into the hepatocyte-like transplanted stem cells by detecting human tyrosine aminotransferase (TAT), well-known enzymatic marker for hepatocyte-specific differentiation.

• 한국산업융합학회 논문집
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• 제20권5호
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• pp.395-404
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• 2017

Cultivating soybeans in rice paddy field reduces labor costs and increases the yield. Soybeans, however, are highly susceptible to excessive soil water in paddy field. Controlled drainage system can adjust groundwater level (GWL) and control soil moisture content, resulting in improvement soil environments for optimum crop growth. The objective of this study was to fit the soybean growth data (canopy height and stem diameter) using Gompertz model and Logistic model at different GWL and validate those models. The soybean, Daewon cultivar, was grown on the lysimeters controlled GWL (20cm and 40cm). The soil textures were silt loam and sandy loam. The canopy height and stem diameter were measured from the 20th days after seeding until harvest. The Gompertz and Logistic models were fitted with the growth data and each growth rate and maximum growth value was estimated. At the canopy height, the $R_2$ and RMSE were 0.99 and 1.58 in Gompertz model and 0.99 and 1.33 in Logistic model, respectively. The large discrepancy was shown in full maturity stage (R8), where plants have shed substantial amount of leaves. Regardless of soil texture, the maximum growth values at 40cm GWL were greater than the value at 20cm GWL. The growth rates were larger at silt loam. At the stem diameter, the $R_2$ and RMSE were 0.96 and 0.27 in Gompertz model and 0.96 and 0.26 in Logistic model, respectively. Unlike the canopy height, the stem diameter in R8 stage didn't decrease significantly. At both GWLs, the maximum growth values and the growth rates at silt loam were all larger than the values at sandy loam. In conclusion, Gompertz model and Logistic model both well fit the canopy heights and stem diameters of soybeans. These growth models can provide invaluable information for the development of precision water management system.

• Journal of Ecology and Environment
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• 제38권4호
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• pp.485-491
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• 2015

This study was conducted to develop stem volume models for the volume estimation of Quercus glauca Thunb. in Jeju Island, Republic of Korea. Furthermore, this study validated the developed stem volume models using an independent dataset. A total of 167 trees were measured for their diameter at breast height (DBH), total height and stem volume using non-destructive sampling methods. Eighty percent of the dataset was used for the initial model development while the remaining 20% was used for model validation. The performance of the different models was evaluated using the following fit statistics: standard error of estimate (SEE), mean bias absolute mean deviation (AMD), coefficient of determination (R²), and root mean square error (RMSE). The AMD of the five models from the different DBH classes were determined using the validation dataset. Model 5 (V = aD^bH^c), which estimates volume using DBH and total height as predicting variables, had the best SEE (0.02745), AMD (0.01538), R² (0.97603) and RMSE (0.02746). Overall, volume models with two independent variables (DBH and total height) performed better than those with only one (DBH) based on the model evaluation and validation. The models developed in this study can provide forest managers with accurate estimations for the stem volumes of Quercus glauca in the subtropical forests of Jeju Island, Korea.

• BMB Reports
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• 제50권8호
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• pp.417-422
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• 2017

Cisplatin is the most effective and widely used chemotherapeutic agent for many types of cancer. Unfortunately, its clinical use is limited by its adverse effects, notably bone marrow suppression leading to abnormal hematopoiesis. We previously revealed that neuropeptide Y (NPY) is responsible for the maintenance of hematopoietic stem cell (HSC) function by protecting the sympathetic nervous system (SNS) fibers survival from chemotherapy-induced bone marrow impairment. Here, we show the NPY-mediated protective effect against bone marrow dysfunction due to cisplatin in an ovarian cancer mouse model. During chemotherapy, NPY mitigates reduction in HSC abundance and destruction of SNS fibers in the bone marrow without blocking the anticancer efficacy of cisplatin, and it results in the restoration of blood cells and amelioration of sensory neuropathy. Therefore, these results suggest that NPY can be used as a potentially effective agent to improve bone marrow dysfunction during cisplatin-based cancer therapy.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집A
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• pp.932-938
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• 2001

This study is concerned with the shape optimization of stem for the artificial hip prosthesis with unbonded cement mantle. The artificial hip prosthesis with unbonded cement mantle allows a stem to slip on cement mantle because of polished stem surface. Unbonded cement mantle type has several advantages compared with bonded cement mantle type, for example, small micro motion, preventing stress shielding and so on. In this study, 2-dimensional axisymmetric model was developed with considering characteristics of unbonded cement mantle. Moreover, optimal shape of stem was obtained by using feasible direction method. The objective of this optimization is maximizing supported vertical loading. The slip motion and stresses of stem, cement mantle and bone is used for constraints. The optimal shape which obtained by this study has slope of 0.15 in proximal part and maintains the width about 5mm in distal part In addition, simplified 3-dimensional analysis which applying optimal shape is carried out. The result of 3-dimensional analysis showed that optimal shape has some advantages for cement mantle stress. However, more realistic 3-dimensional analysis which including bending effect, complex geometries etc. is needed in further research.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 춘계학술대회 논문집
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• pp.179-180
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• 2006

In this study, the effect of stem-end design on contact pressure and stress distribution in revision TKR was investigated using finite element method. The finite element model of tibia, including the cortical bone, the cancellous bone and canal, was developed based on CT images. The stem models with various stem lengths, diameters and frictional coefficients, and press-fit effects were considered. The results showed that the longer stem length, the stronger press-fit, the bigger stem diameter, and the higher frictional coefficient increased both peak contact pressure and the highest Von-Mises stress values. We hypothesized that peak contact pressure and Von-Mises stress distribution around the stem, may be related to the stem end pain. The results of this study will be useful to design the stem endand reduce the end-of-stem pain in revision TKR.

• Journal of Yeungnam Medical Science
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• 제32권1호
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• pp.1-7
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• 2015

Over several decades, a hierarchical cancer stem cell (CSC) model has been established in development of solid cancers, including hepatocellular carcinoma(HCC). In terms of this concept, HCCs originate from liver CSCs. Clinically HCCs show a wide range of manifestations from slow growth to very aggressive metastasis. One of the reasons may be that liver CSCs originate from different cells. This review describes the basic concept of CSCs and the cellular origin of liver CSCs.