• Proceedings of the KSME Conference
• /
• 2000.04a
• /
• pp.387-392
• /
• 2000

In cementless total hip replacement(THR), an initial stability of the femoral component is important to long term fixation of femoral stem. The initial stability has close relationship with the relative displacement of prosthesis and spongy bone at the proximal of femur. After implantation of the prosthesis. the surrounding bone is partially shielded from load carrying and starts to resort. Stress shielding is the cause of the loss of proximal bone. Assessing stress distribution of femur is important to predict stress shielding. The initial stability and the stress shielding were investigated for two loading conditions approximating a single leg stance and a stair climbing. Three types of stems were studied by the finite element method to analyze the biomechanical effects of distal filling of cementless femoral stems, Three types of stems employed are a distal filling stem, a distal flexible stem, and a distal tapered stem.

• Journal of Microbiology and Biotechnology
• /
• v.32 no.1
• /
• pp.126-140
• /
• 2022

Stem cells can be applied usefully in basic research and clinical field due to their differentiation and self-renewal capacity. The aim of this study was to establish an effective novel therapeutic cellular source and create its molecular expression profile map to elucidate the possible therapeutic mechanism and signaling pathway. We successfully obtained a mesenchymal stem cell population from human embryonic stem cells (hESCs) cultured on chemically defined feeder-free conditions and treated with connective tissue growth factor (CTGF) and performed the expressive proteomic approach to elucidate the molecular basis. We further selected 12 differentially expressed proteins in CTGF-induced hESC-derived mesenchymal stem cells (C-hESC-MSCs), which were found to be involved in the metabolic process, immune response, cell signaling, and cell proliferation, as compared to bone marrow derived-MSCs(BM-MSCs). Moreover, these up-regulated proteins were potentially related to the Wnt/β-catenin pathway. These results suggest that C-hESC-MSCs are a highly proliferative cell population, which can interact with the Wnt/β-catenin signaling pathway; thus, due to the upregulated cell survival ability or downregulated apoptosis effects of C-hESC-MSCs, these can be used as an unlimited cellular source in the cell therapy field for a higher therapeutic potential. Overall, the study provided valuable insights into the molecular functioning of hESC derivatives as a valuable cellular source.

• Nuclear Engineering and Technology
• /
• v.55 no.8
• /
• pp.2905-2918
• /
• 2023

The valve assembly used in nuclear power plants is important safety-related equipment. In the new standard, the physical attributes are measured using a valve diagnosis test, which is used in the expansion to other non-tested valves using a quantitative test-basis methodology. With a motor-operated actuator, the state of stem's lubrication is related to physical attributes such as the stem factor and the friction coefficient. This study analyzed the numerical transient of fluid and solid lubrication with a squeeze film effect due to the loading rate on the stem and the stem nut using the experimental data. The differential equation that governs the motion mechanism of the stem and stem nut is established and analyzed. The flow rate, the fluid and the solid contact forces are calculated with the friction coefficient. Finally, we found that a change in the friction coefficient results from a change of the shear force in the solid contact mode during the interchange process between the solid contact mode and the fluid contact mode. The qualitative understanding of the squeeze film effect is expanded quantitatively for forces, thread surface distance, velocity, and acceleration, with consideration of the metal solid contact and fluid contact.

• BMB Reports
• /
• v.44 no.5
• /
• pp.347-351
• /
• 2011

The testis is major male gonad responsible for spermatogenesis and steroidogenesis. Much knowledge is still remained to be learned about the control of these events. In this study, we performed a comprehensive bioinformatics analysis on 1,196 mouse testis proteins screened from public protein database. Integrated function and pathway analysis were performed through Database for Annotation, Visualization and Integrated Discovery (DAVID) and ingenuity Pathway Analysis (IPA), and significant features were clustered. Protein membrane organization and gene density on chromosomes were analyzed and discussed. The enriched bioinformatics analysis could provide clues and basis to the development of diagnostic markers and therapeutic targets for infertility and male contraception.

• Journal of Information Science Theory and Practice
• /
• v.2 no.1
• /
• pp.35-47
• /
• 2014

Korean researchers' scientific outputs are increasing rapidly with the growth of both Korea's economy and industry size. This is the time to analyze the scientific output (STEM area) of Korea over the last 40 years. For this analysis, this study used the SCIE database of Web of Science (WoS), which is a representative global Citation Index Service. The objects of analysis are every Korean document published in the SCIE journal, and the research scopes are (1) analysis of citation and subject categories and (2) analysis of co-authorship. Through this study, characteristics such as cited trend and research trend by subject, and the status of collaboration between Korea and other countries including the 50 states of the USA were revealed.

• Bulletin of the Korean Chemical Society
• /
• v.29 no.5
• /
• pp.1063-1064
• /
• 2008

• Proceedings of the Korean Nuclear Society Conference
• /
• 2002.10a
• /
• pp.92-92
• /
• 2002

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 2007.11a
• /
• pp.49-54
• /
• 2007

• Journal of Korean Society of Forest Science
• /
• v.108 no.3
• /
• pp.357-363
• /
• 2019

This study was conducted to develop a stem volume table for Quercus acutissima in Korea by using Kozak's stem taper equation. In total, 2700 tree samples were collected around the country, and growth performance was investigated through compiling data on diameters by stem height and stem analysis. In order to test the stem taper equation's fitness, the fitness index (FI), bias, and mean absolute deviation (MAD) were analyzed. The fitness of the equation was estimated at 97%, bias as 0.017, and MAD turned out to be 1.118, respectively. Furthermore, there was a statistically significant volume difference between the current volume table and the new volume table (p = 0.0008, <0.005). The result indicates that using the new volume table that reflects the actual forest will reduce the loss when assessing wood resources and will improve the accuracy of forest statistics for national and local governments. A stem volume table, the main result of this research, which is utilized in the estimated stem taper equation, will provide growth information for Quercus acutissima, one of the main broadleaf species in Korea, and will function as a management indicator for rational forest management.

• Proceedings of the KOSOMBE Conference
• /
• v.1997 no.11
• /
• pp.484-488
• /
• 1997

Three-dimensional finite element analyses were used to compare the stress distribution and the stability of the fixation among seven different tibial components and to investigate the effect due to implant materials in total knee arthroplasty. The components included an intact tibia(Type I), Cemented Cobalt-Chromium tibial tray implanted with a PMMA cemented Co-Cr stem(Type II), Cemented Co-Cr tibial tray with a uncemented Co-Cr stem(Type III), Cemented Ultra High Molecular Weight Polyethylene (UHMWPE) tibial tray with a cemented UHMWPE stem (Type IV), Cemented UHMWPE tray with a uncemented UHMWPE stem(Type V), Cemented Co-Cr tray without a stem(Type VI), and Cemented UHMWPE tray without a stem(Type VII). Uncemented components were assumed to have complete bony in growth and a rigid state of fixation between component and bone. The interface between bone/cement/component of cemented components was also assumed to be fully bonded. Bi-condylar forces were applied. The results indicated that Uncemented stem components provided lower bone stress shielding and stress concentration. The UHMWPE tray and stem component showed better agreement with the intact tibia than the Co-Cr Alloy tray and stem components. If the implant tray can be fixed firmed without a stem, Cemented PE tray without a stem(Type VII) may be recommended to give the best characteristics in the sense of stress distribution and stability.