• 제목/요약/키워드: state-dependent delay

검색결과 47건 처리시간 0.024초

Establishing a stability switch criterion for effective implementation of real-time hybrid simulation

  • Maghareh, Amin;Dyke, Shirley J.;Prakash, Arun;Rhoads, Jeffrey F.
    • Smart Structures and Systems
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    • 제14권6호
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    • pp.1221-1245
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    • 2014
  • Real-time hybrid simulation (RTHS) is a promising cyber-physical technique used in the experimental evaluation of civil infrastructure systems subject to dynamic loading. In RTHS, the response of a structural system is simulated by partitioning it into physical and numerical substructures, and coupling at the interface is achieved by enforcing equilibrium and compatibility in real-time. The choice of partitioning parameters will influence the overall success of the experiment. In addition, due to the dynamics of the transfer system, communication and computation delays, the feedback force signals are dependent on the system state subject to delay. Thus, the transfer system dynamics must be accommodated by appropriate actuator controllers. In light of this, guidelines should be established to facilitate successful RTHS and clearly specify: (i) the minimum requirements of the transfer system control, (ii) the minimum required sampling frequency, and (iii) the most effective ways to stabilize an unstable simulation due to the limitations of the available transfer system. The objective of this paper is to establish a stability switch criterion due to systematic experimental errors. The RTHS stability switch criterion will provide a basis for the partitioning and design of successful RTHS.

운전자 행태를 고려한 VMS의 실시간 경로안내 정보제공에 관한 연구 (A Study on Providing Real-Time Route Guidance Information by Variable Massage Signs with Driver Behavior)

  • 이창우;정진혁
    • 대한교통학회지
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    • 제24권7호
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    • pp.65-79
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    • 2006
  • ITS 의 한 분야인 첨단교통정보체계 (ATIS: Advance Traveler Information System)는 운전자들에게 통행 전 (pre-trip). 통행 중 (en-route) 교통정보를 제공함으로서 운전자의 경로선택과정에 영향을 미쳐 도로망의 교통량 분산효과를 추구하는 시스템이다. 이중 도로상에서 운전자가 진행하는 방향에 대한 직접적인 정보를 제공하는 VMS 는 ATIS의 정보제공방안중 가장 효과적인 수단이 될 수 있다. 이러한 때 VMS의 정보제공목표는 단순현황정보만을 제공하는 운전자 편의측면과 교통수요를 관리하여 시스템의 성능을 증진시키는 시스템 제어측면으로 구분이 가능하다 하지만 보다 효율적인 도로전광표지의 정보제공을 위해서는 시스템제어 측면의 정보제공이 이루어져야 할 것이다 이러한 교통관리시스템(traffic management system)으로서 VMS 핵심적인 관리전략은 혼잡 (traffic congestion) 또는 돌발 상황(incident)발생 시 지체 (delay)를 최소하기 위한 교통우회전략(Traffic Diversion Strategy)이라 할 수 있다 이를 효과적으로 운영하기 위해서는 첫째, 교통상황 (network traffic condition)에 따라 적정한 우회교통량 (diversion traffic volume) 의 산정이 선행되어야 하고 둘째, 이러한 우회교통량을 제어하기 위해서는 VMS 정보내용 (VMS massage contents)에 따른 운전자의 행태(driver response behavior)가 반영된 정보제공전략 (providing information strategy)이 수립되어야 한다. 이에 본 연구에서는 돌발 상황 발생에 의해 혼잡이 야기될 때 VMS 실시간 경로안내 정보제공에 대해 초점을 맞추었다 이를 위해 첫째로, CA(Cellular Automata) 기반 교통류 사율레이션을 모형을 이용뼈 통행시간 및 대기행렬의 변화가 반영된 시간대별 시스템 최적경로 전환율을 산정하였다. 둘째로, 이항로짓 모형을 이용하여 운영자가 제어할 수 있는 정보특성에 대한 경로전환행태 모형 (route choice behavior model) 을 만들었다 마지막으로 시스템 최적상태 (system Optimum)의 달성을 위한 VMS의 시간대별 정보내용 및 강도를 결정하였다.

저용량 스트렙토조토신 유도 당뇨 흰쥐에서 화살나물.상엽 복합 처방의 항당뇨 활성 (Antidiabetic Activity of Formula Containing Euonymus Alatus (Thunb.) Sieb. and Mori Folium in Multiple Low Dose Streptozotocin-induced Diabetic Rats)

  • 김희자;이성현;정성현
    • 약학회지
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    • 제48권4호
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    • pp.247-253
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    • 2004
  • We investigated the hypoglycemic effect of formula containing Euonymus alatus (EA) and Mori Folium (MF) in multiple low dose (MLD) streptozotocin (STZ)-induced diabetic rats. In order to iduce hyperglycemic state 25 mg/kg of STZ was injected intraperitoneally for 5 consecutive days. SD rats were randomly divided into diabetic control and treatment groups. Treatment groups were administered with either 250 mg/kg of EA and 250 mg/kg of MF (E1Ml), or 500 mg/kg of EA mixed with same dose of MF (E2M2) for 3 weeks. Blood glucose levels and body weights were measured every 5th or 6th day. E1Ml and E2M2 both significantly reduced food intake, water intake, and fasting blood and urine glucose levels as compared to those in diabetic control group in a dose dependent manner. Body weight in diabetic control group was increased slightly after 3 weeks. Treatment group, however, showed gradual increase in body weights during 3 week-period. While plasma insulin levels of the diabetic control group were decreased to the level of 387$\pm$14 pg/ml from 534$\pm$36 pg/ml, those levels in E1Ml and E2M2-treated groups were both markedly increased by 13% and 26%, respectively. Urine glucose levels in E1Ml and E2M2-treated groups were also remarkably reduced by 17 and 26% compared to the levels of diabetic control group. While expression of membrane-bound glucose transporter-4 (GLUT-4) protein in skeletal muscle was reduced by 45% in diabetic control compared to the normal control, GLUT-4 protein expressions in E1Ml and E2M2-treated groups were augmented by 2 and 3.5 times compared to the diabetic control, respectively. Pancreatic HE staining experiments showed that E2M2-treated group revealed much less infiltrated mononuclear cells, indicating that E2M2 efficiently blocked insulitis induced by multiple low dose streptozotocin. Taken together, we conclude that formula containing EA and MF may prevent or delay the development of hyperglycemia through overexpression of GLUT-4 protein in skeletal muscle and prevention of insulitis.

개에서 포도 및 건포도 섭취가 신부전에 미치는 영향 (Renal failure associated with ingestion of grapes and raisins in dogs)

  • 육진엽;김철호;김태융;강정부
    • 대한수의학회지
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    • 제45권2호
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    • pp.287-296
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    • 2005
  • This experiments was designed to observe the effect of period and dose of ingestion of grapes on renal failure in dog. After the dogs had been mixed of general feed, raisins from U.S.A and fresh grapes from Chile selling in Korea. We observed the clinical sign, and analyzed the blood and urine using by biochemical test. The experiment was executed by the two following groups. The experiment group 1. derived renal failure by supplying the mixed general feed with fresh grapes and dry grapes 15 g per weight kg, 2 times a day (AM 09, PM 21), the experiment group 2. executed to derive renal failure by supplying the mixed general feed with fresh grapes and dry grapes 40 g per weight kg, 2 times a day. Extraction of blood for analysis was conducted one time a day and clinical test for renal failure was executed by means of a blood analysis, biochemical analysis, urine analysis, excretory urography (E.U) and E.R.D-$screen^{TM}$ urine test (Heska, USA). The results of group 1 were normal ranges (BUN 9.0~22.6 mg/dl, creatinine 0.8~1.2 mg/dl, Ca 9.7~12.3 mg/dl, Pi 2.9~4.6 mg/dl), renal failure was not observed. On the 3rd day in group 2, azotemia was arisen from the increasing BUN 83 mg/dl (7~25 mg/dl), creatinine 2.3 mg/dl (0.5~1.4 mg/dl), when executed urine was tested by E.R.D-$screen^{TM}$ test using in the early kidney disease diagnosis, microalbumine state was high positive, and it showed stale delay by using excretory urography (EU). This study demonstrated that acute renal failure by grapes and raisins dependent on food dose, and specific characters of individual.

Effects of Pahs and Pcbs and Their Toxic Metabolites on Inhibition of Gjic and Cell Proliferation in Rat Liver Epithelial Wb-F344 Cells

  • Miroslav, Machala;Jan, Vondracek;Katerina, Chramostova;Lenka, Sindlerova;Pavel, Krcmar;Martina, Pliskova;Katerina, Pencikova;Brad, Upham
    • 한국환경성돌연변이발암원학회지
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    • 제23권2호
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    • pp.56-62
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    • 2003
  • The liver progenitor cells could form a potential target cell population fore both tumor-initiating and -promoting chemicals. Induction of drug-metabolizing and antioxidant enzymes, including AhR-dependent CYP1A1, NQO-1 and AKR1C9, was detected in the rat liver epithelial WB-F344 "stem-like" cells. Additionally, WB-F344 cells express a functional, wild-type form of p53 protein, a biomarker of genotoxic events, and connexin 43, a basic structural unit of gap junctions forming an important type of intercellular communication. In this cellular model, two complementary assays have been established for detection of the modes of action associated with tumor promotion: inhibition of gap junctional intercellular communication (GJIC) and proliferative activity in confluent cells. We found that the PAHs and PCBs, which are AhR agonists, released WB-F344 cells from contact inhibition, increasing both DNA synthesis and cell numbers. Genotoxic effects of some PAHs that lead to apoptosis and cell cycle delay might interfere with the proliferative activity of PAHs. Contrary to that, the nongenotoxic low-molecular-weight PAHs and non-dioxin-like PCB congeners, abundant in the environment, did not significantly affect cell cycle and cell proliferation; however both groups of compounds inhibited GJIC in WB-F344 cells. The release from contact inhibiton by a mechanism that possibly involves the AhR activation, inhibition of GJIC and genotoxic events induced by environmental contaminants are three important modes of action that could play an important role in carcinogenic effects of toxic compounds. The relative potencies to inhibit GJIC, to induce AhR-mediated activity, and to release cells from contact inhibition were determined for a large series of PAHs and PCBs and their metabolites. In vitro bioassays based on detection of events on cellular level (deregulation of GJIC and/or proliferation) or determination of receptor-mediated activities in both ?$stem-like^{\circ}{\times}$ and hepatocyte-like liver cellular models are valuable tools for detection of modes of action of polyaromatic hydrocarbons. They may serve, together with concentration data, as a first step in their risk assessment.

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복합 통행행태모형을 이용한 동적 기.종점 통행량 추정 (Dynamic OD Estimation with Hybrid Discrete Choice of Traveler Behavior in Transportation Network)

  • 김채만;조중래
    • 대한교통학회지
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    • 제24권6호
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    • pp.89-102
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    • 2006
  • 정적 기 종점 통행량을 가정함으로써 갖는 동적 시뮬레이션 모형의 현실 모사 능력의 한계를 극복하기 위하여 동적 기 종점 통행량 추정 모형을 개발하였다 동적 기 종점 통행량 추정은 통행자의 출발시간, 통행수단. 통행경로 선택 행태모형을 결합한 복합통행행태 수요시뮬레이션 모형을 이용하였다 본 연구에서 개발된 수요 시뮬레이션 모형과 기 개발된 공급 시뮬레이션 모형인 LiCROSiM-P를 결합하여 통합 시뮬레이션 모형을 구축하였다. 단속류/연속류가 공존하는 다경로 가로망에서 출발시간/수단선택/통행경로 선택모형은 AGtt(기 종점통행시간의 시뮬레이션 시간과 기대치의 차이 백분율)는 수렴하지 않고, 평균스케줄지체는 안정 상태로 수렴하는 것으로 나타났다. 통합 시뮬레이션 모형은 교통시설공급 변화와 통행자의 속성 변화에 따른 기 종점 통행량 변화 추정과 효과분석이 가능함을 모형의 적용을 통해 제시하였다. 따라서 통합시뮬레이션 모형은 수요관리정책, 교통시설변화, 교통정보제공 등이 가져오는 출발시간, 통행수단, 통행경로변화를 반영한 시스템의 효과분석이 가능하다

대퇴경부 골절 환자의 입원 생활 (The Hospital Life of the Patient with Femoral Neck Fracture)

  • 김경자;지성애
    • 간호행정학회지
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    • 제2권1호
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    • pp.35-56
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    • 1996
  • Nowerdays, the increase of traffic accidents and old age population make the Femoral Neck Fracture(FNF) patients increase. By the improvement of education and standard of living the patients demand better medical service than before. This study is designed to give practical help for the FNF patients by observing their hospital life and establish practical nursing strategies for the FNF patients. For these purposes the Ethnographic Participant Observation was adopted. By this study is focused on the hospital life patient's view. For this end, the field study adopted orthopedic ward in the C University Hospital with 400 beds in Seoul. The object patients of the study were twelve patients. The patients experienced five stages : Embarrassment, Conflict, Stability, Independent, and Extension Stage. The findings and prepared nursing strategies are stated as follows. First, in the Embarrassment Stage they suffered embarrassment, anxiety, pain, they could not do ordinary things. The patients who accidental fractures had anxiety from unfamiliar tests and from hospitalization itself. They lamented that they could not ordinary things, and do nothing but obeying the hospital, and endure the pain. They recognized the changed environment and resigned themselves to life in the ward. In this stage, full openness by the nurses is needed. Second, the attribute of the Conflict Stage were conflict, fear, curiosity, belief, reflection. When they sign the consentment form, they experience conflicts about the possibility of complication, fear of recovery from anesthesia, curiosity about the operation procedure, post - operation state, reflection on their past life, and promise to care for their family members after discharge and keep their religious life faithfully. And they accepted the operation depending on God, believing in modern medicine, and the surgeon. Asking for their changed informations, they expected positive results from the operation. In this stage, an empathic attitude by the nurses is needed. Third, the attribute of the Stability Stage were relief, gratitude, difficulty with excretion, and pain. When they awoke from anesthesia, they felt relief because of a the end of the operation, but they experienced extreme pain, difficulty of excretion in bed. They accepted the changed environment and expected recovery. In this stage, support by the nurses is needed. Fourth, the attributes of the Independence Stage were freedom, exercise, nurturing, anxiety, and discomfort. When they ambulated and exercised, they experienced freedom. They showed exhibited weakness of the digestive organs and discomfort hospital's space, structure, and facilities, the delay of medical certificate issue the lack of prompt response by the medical agents. They ate nurturious food and felt anxiety on the end of hospital life and returning to their ordinary life. They showed the independence of overcoming their environment by increasing exercise and expected their discharges. In this stage, respect by the nurses is needed for the patients to, overcome their environment and prepare for their independence. Fifth, the attributes of the Extension Stage were pessimism, isolation, dissatisfaction, and pain. Accompanied injury and old age made their ward life extend to over seven weeks. They exhibited weariness, melancholy, skeptisis, general pessimistic feeling, and desperation caused by their isolated life. They experienced the digestive discomfort caused by the prolonged medication and psycological pain caused by long-time hospitalization. As a, result, their dissatisfaction on the human, physical, and systematic environments had been increased. They acquired critical power and sought for something to do spending their time. They expected vaguely about the returning of their ordinary life. In this stage, counseling is needed by the nurse to overcome positively their psychological, social, and physical problems. The process of the FNF patient's ward life starts from the dependent state, when they are hospitalized, and gradually progresses to self-fulfillment in order to keep independent life. As a result, the FNF patients showed "Response in Challenge" or "Adaptation in Conflict" through their experiences of social, physical, and psychological difficulties.

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