• Asian Pacific Journal of Cancer Prevention
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• 제15권1호
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• pp.369-374
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• 2014

Background: Colorectal cancer (CRC) is the fourth most common cause of cancer death in the world. Genetic variants in 8q24.21 including rs10505477 and rs6983267 have been hypothesized to be involved in susceptibility to CRC. This study aims to investigate the possible association between these loci and their haplotypes with CRC risk in Iranian population. Materials and Methods: Subjects were recruited from two hospitals in Tehran. The rs10505477 and rs6983267 polymorphisms were genotyped by TaqMan real time PCR using subject genomic DNA, extracted either from formalin-fixed, paraffin-embedded tissue of patients or from blood of the controls by standard methods. Results: A total of 715 subjects (380 CRC patients and 335 matched controls) were genotyped in this study. Allele and genotype analysis of the rs10505477 and rs6983267 polymorphisms by gender, age at diagnosis, tumor location, tumor grade, and tumor node metastasis (TNM) showed no significant association with CRC risk. There was a significant relationship between GG haplotype and susceptibility to age at diagnosis for both <60 and ${\geq}60$ (p=0.0005 and p=0.000004, respectively) and between GT and CRC in the age at diagnosis ${\geq}60$ (Table 3: p=0.031). The GG haplotype was less frequent in CRC patients with the age at diagnosis <60, but was more common in subjects with the age at diagnosis ${\geq}60$. Conclusions: Results of this study suggests that the rs6983267 and rs10505477 polymorphisms alone may not be relevant to CRC risk, but their GG haplotype plays a notable role in age at diagnosis of CRC in the Iranian population.

• Investigative Magnetic Resonance Imaging
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• 제24권3호
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• pp.132-140
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• 2020

Purpose: To retrospectively determine whether specialized magnetic resonance imaging (MRI) reading performed by an experienced radiologist affected the successful assessment of extraprostatic extension (EPE) in the presence of biopsy-related hemorrhage after prostate biopsy. Materials and Methods: Two hundred consecutive patients with biopsy-proven prostate cancer underwent MRI. General radiologist and subspecialized radiologist readings were unpaired and reviewed in random order by a radiologist who was blinded to patients' clinical details and histopathologic data. The extent of hemorrhage was assessed on T1-weighted (T1W) MRI using a 1-4 scale, and the likelihood of EPE was assessed for each of the four categories. Histopathologic specimens served as the reference standard. The area under the curve (AUC) of the standard reading was compared to that of the specialized reading. Results: Post-biopsy hemorrhage was subjectively graded as ≥ 3 in 101 patients (50.5%) by standard reading, and in 100 patients (50.0%) by specialized reading. The standard and specialized readings disagreed for 40 (20.7%) of the patients (kappa [κ] = 0.35; 95% CI, 0.14-0.48). Of these, specialized reading was the correct interpretation for 21 patients (52.5%). The sensitivity (75% vs. 44%; P = 0.002) and area under the receiver operating characteristics (AUROC) (0.83 vs. 0.67; P = 0.008) of the specialized readings were significantly higher than those of the standard readings, while there was no significant difference in specificity (84% vs. 87%; P = 0.434). Conclusion: The reinterpretation of MRI by experienced radiologists significantly improves the diagnosis of EPE in prostate cancer in the presence of post-biopsy hemorrhage.

• 대한예방한의학회지
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• 제24권3호
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• pp.57-67
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• 2020

Background : The Life cycle Health Promotion Programs using Traditional Korean Medicine (the Life cycle HaPPs-TKM) are the on-going 3rd stage projects that have centered on the development and dissemination of the standard life cycle HaPPs-TKM in the local community. The purpose of the study was to introduce the development background of the standard life cycle HaPPs-TKM and to suggest its activation plan. Methods : Academic and government research reports on the life cycle HaPPs-TKM were analyzed to introduce the development process, development backgrounds and the details of KM-HPP for each life cycle, such as infants and toddlers, adolescents, pregnant women, adults and the elderly. Results : We reviewed the development process of the standard life cycle HaPP-TKM consisted of a series of diagnosis on community members' health problems, establishment of project purpose, research on the involvement of KM intervention in a project, and final development of the project model. And we rediscovered that in the development backgrounds of KM-HPP, there were beneficial goals to manage and promote public health conditions for each life cycle. Conclusion : To activate life cycle HaPPs-TKM, we would recommend that activation plan should include six factors through systematic analysis of research reports. These factors consist of diversified goals for each life-cycle, competency reinforcement of local project manager, diversified Korean Medicinal modalities to enhance Sasang Constitution and Qigong, development of standard Outcome Index, periodical holding of performance contest, and improved guidance of government and associated entities through whole process of HaPP-TKM.

• 비파괴검사학회지
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• 제30권4호
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• pp.330-337
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• 2010

본 논문은 원전 증기발생기(SG, steam generator) 세관의 정밀 진단을 위한 차세대 탐촉자인 배열형 와전류 탐촉자의 특성 해석에 대한 3차원 전자기 수치해석을 수행하였다. 다양한 결함 해석을 위해 ASME(American Society of Mechanical Engineers) 표준시험편과 X-probe combo 표준보정시험편(inline EXP/spiral groove combo standard)을 선정하여 탐상신호를 획득하고, 실제 실험 신호와 비교하여 결과의 타당성을 검증하였다. 표준 보정 시험편의 해석 결과를 바탕으로 원전 SG 세관에서 주로 발생하고 있는 pitting, SCC(stress corrosion cracking), multiple SCC, wear 결함에 대하여 탐상신호를 획득하였다. 해석 대상으로는 원자력발전소 SG 세관으로 사용하고 있는 Inconel 600 도체관을 사용하였고, 이때의 시험주파수는 300 kHz이다. 본 논문을 통하여 각각의 결함에 대한 신호 특성을 파악하여 배열형 와전류 탐촉자의 결함의 종류에 따른 신호 특성을 확인할 수 있었다. 본 논문의 결과는 배열형 와전류 탐촉자의 와전류 탐상 신호 평가시 도움이 될 것이다.

• 치과방사선
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• 제8권1호
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• pp.23-27
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• 1978

The purpose of the present investigation is to determine how frequently radiopaque zones are seen on standard intraoral films and to research some other things about radiopaque zones. This study obtained the following results: 1. According to the standard intraoral films of the charts that were kept at the Dept. of Oral Diagnosis in Seoul National University Hospital, radiopaque zones were found in the rate of 4.1% among 1150 cases of amalgam-restored teeth that were treated at least two years ago. 2. Out of teeth that possessed radiopaque zones, 38.3% had radiolucent area between amalgam restoration and radiopaque zone. 3. Out of teeth that possessed radiopaque zones, 36.2% had cement base between amalgam restoration and radiopaque zone. 4. Out of teeth that possessed radiopaque zones, no tooth had periapical radiolucency. 5. Radiopaque zones were found more frequently in the mandibular teeth than the maxillary teeth. 6. According to the result of direct x-ray taking of 50 teeth that were treated at least 2 years ago, 6% had radiopaque zone.

• 한국가축번식학회지
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• 제17권4호
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• pp.347-356
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• 1994

A simpled and sensitive microplate enzyme immunoassay(EIA) was developed for the determination of progesterone concentration in serum, based on progesterone monoclonal antibody as anti-progesterone, horseradish peroxidase(HRP) as enzyme-label and tetramethylbenzidine(TMB) as substrate. The assay has a sensitivity of 5 pg-120pg/well and intra- and inter-assay coefficients of variation for progesterone standard curve (1.0ng~10.0ng/ml) were ranged 2.5~9.9% and 1.7.8.0%, respectively, determination coefficient of the regressio equation of our standard curve(R2=0.990$\pm$0.007) were high, and this is the same level as that of commercial kit(Hormonost Bio-Lab, Germany, R2=0.98~0.99). The progesterone concentration of serum determined by both kits (Work & Bio-Lab) were significantly correlated (r=0.95, P<0.01) although a little higher value were resulted in our kit than that of commercial kit. It generally is these results indicated that the microplate-EIA can be cused for the determination of progesterone in serum, as well as, for the determination of the early pregnancy diagnosis.

• International Journal of Vascular Biomedical Engineering
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• 제1권1호
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• pp.3-12
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• 2003

Ultrasonic pulsed Doppler velocimetry has become a standard international method of classifying carotid disease. Because the measured angle adjusted velocity increases as the Doppler angle increases, examinations should be performed at a convenient standard Doppler examination angle. An angle of 60 degrees is achievable throughout most examinations. Multiple Doppler viewing angles allow the acquisition of velocity vectors during the cardiac cycle, revealing the complex velocity patterns. Ultrasonic velocimetry (whether Doppler or time domain) is based on changes in the phase of the ultrasound echo. Other examinations can be done based on the echo phase. Slow motions of organs such as the brain can be used to monitor changes in edema. Measurements of tissue strain due to the pulsatile filling of the arterioles. This plethysmographic imaging method can display differences in tissue perfusion because of different tissue types and changes in autonomic activity.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2005년도 제36회 하계학술대회 논문집 D
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• pp.2846-2848
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• 2005

This paper proposes a pattern classification algorithm for the defect distribution of Hard Disk Drive (HDD). In the HDD productions, the defect pattern of defective HDD set is important information to diagnosis of defective HDD set. In this paper, 5 characteristics are determined for the classification to six standard defect pattern classes. A fuzzy inference system is proposed, the inputs of which are 5 characteristic values and the outputs are the possibilities that the input pattern is classified to the standard patterns. Classification result is the pattern with maximum possibility. The proposed algorithm is implemented with a PC system for defective HDD sets and shows its effectiveness.

• 대한치과교정학회지
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• 제9권1호
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• pp.125-131
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• 1979

The templates for male and female were constructed respectively by use of 36 male and 52 female cephalometric roentgenograms in Hellman Dental Age IV A with normal occlusion. The grids were drawn to show 1 standard deviation and 2 standard deviation on every reference point. 1. When the template is used for cephalometric analysis, w e can obtain comparatively accurate diagnosis even one or two refernces are distorted, because several references are used for analysis. 2. The method of using the template is simple enough to perform cephalometric analysis easily. 3. If the templates are constructed for every age and sex, we can predict the growth patterns of the patients in the period of growth.

• 대한전기학회논문지:시스템및제어부문D
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• 제54권6호
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• pp.383-389
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• 2005

This paper proposes a pattern classification algorithm for the defect distribution of Hard Disk Drive (HDD). In the HDD production, the defect pattern of defective HDD set is important information to diagnosis of defective HDD set. In this paper, 5 characteristics are determined for the classification to six standard defect pattern classes. A fuzzy inference system is proposed, the inputs of which are 5 characteristic values and the outputs are the possibilities that the input pattern is classified to standard patterns. Therefore, classification result is the pattern with maximum possibility. The proposed algorithm is implemented with the PC system for defective HDD sets and shows its effectiveness.