• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1545-1551
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• 2015

Purpose: Rectal cancers with high microsatellite-instable have clinical and pathological features that differentiate them from microsatellite-stable or low-frequency carcinomas, which was studied rarely in stage II rectal cancer, promoting the present investigation of the usefulness of microsatellite-instability status as a predictor of the benefit of adjuvant chemotherapy with fluorouracil in stage II rectal cancer. Patients and Methods: Data of 460 patients who underwent primary anterior resection with a double stapling technique for rectal carcinoma at a single institution from 2008 to 2012 were retrospectively collected. All patients experienced a total mesorectal excision (TME) operation. Survival analysis were analyzed using the Cox regression method. Results: Five-year rate of disease-free survival (DFS) was noted in 390 (84.8%) of 460 patients with stage II rectal cancer. Of 460 tissue specimens, 97 (21.1%) exhibited high-frequency microsatellite instability. Median age of the patients was 65 (50-71) and 185 (40.2%) were male. After univariate and multivariate analysis, microsatellite instability (p= 0.001), female sex (p<0.05) and fluorouracil-based adjuvant chemotherapy (p<0.001), the 3 factors were attributed to a favorable survival status independently. Among 201 patients who did not receive adjuvant chemotherapy, those cancers displaying high-frequency microsatellite instability had a better 5-year rate of DFS than tumors exhibiting microsatellite stability or low-frequency instability (HR, 13.61 [95% CI, 1.88 to 99.28]; p= 0.010), while in 259 patients who received adjuvant chemotherapy, there was no DFS difference between the two groups (p= 0.145). Furthermore, patients exhibiting microsatellite stability or low-frequency instability who received adjuvant chemotherapy had a better 5-year rate of DFS than patients did not (HR, 5.16 [95% CI, 2.90 to 9.18]; p<0.001), while patients exhibiting high-frequency microsatellite instability were not connected with increased DFS (p= 0.696). It was implied that female patients had better survival than male. Conclusion: Survival status after anterior resection of rectal carcinoma is related to the microsatellite instability status, adjuvant chemotherapy and gender. Fluorouracil-based adjuvant chemotherapy benefits patients of stage II rectal cancer with microsatellite-stable or low microsatellite-instable, but not those with high microsatellite-instable. Additionally, free of adjuvant chemotherapy, carcinomas with high microsatellite-instable have a better 5-year rate of DFS than those with microsatellite-stable or low microsatellite-instable, and female patients have a better survival as well.

• Journal of Power Electronics
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• 제10권6호
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• pp.777-783
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• 2010

In order to drive gas discharge lamps, DC-AC converters with a LCC resonant tank, whose output voltage is adjusted by a variable frequency control are frequently used. However, when they are activated by varying the operating frequency, converters are frequently damaged by unstable operation, due to the rising and falling of the operating frequency near the resonant frequency. To solve this problem, a simple protection circuit for the power supply of a gas discharge lamp is proposed in this paper. This circuit senses the primary current of the main transformer. Using this protection circuit, the operating frequency of the lamp driving inverter system is kept close to and on the right side of the resonant frequency and the inverter is always operated in the ZVS condition. The resulting stable variable frequency operation allows various gas discharge lamps to be tested without the risk of damaging the main switches, because the protection circuit can protect the power MOSFETs of bridge converters from abnormal conditions. The validity and effectiveness of the proposed protection circuit are verified through the experimental results.

• 대한의용생체공학회:의공학회지
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• 제30권6호
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• pp.521-528
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• 2009

This study is about to evaluation of postural stability according to characteristics of electrical stimulation on the ankle muscles. We measured body sway(center of pressure, COP) when various parameters of electrical stimulation was applied to ankle muscles in stable and unstable posture. Subjects consisted of 10 young adults, and electrical stimulation was delivered on right and left of tibialis anterior and Achilles tendon. The body sway was measured during electrical stimulation of three duty cycle and frequencies in stable posture and three amplitudes of sensory threshold in unstable posture. Consequently, the COP Shift is higher during electrical stimulation of 1/30(duty ratio) and 100Hz(frequency) in stable posture. In unstable posture, 100% amplitude of sensory threshold induced postural stability. These findings are important for the rehabilitation system of postural stability and the use of electrical stimulation as somatosensory information.

• 대한정형도수물리치료학회지
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• 제12권1호
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• pp.16-26
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• 2006

The purpose of this study was to investigate the influence of the various knee angles and ground state on the muscular activities and fatigue of the ankle muscles by integrated electromyograms (iEMG) and median frequency of tibialis anterior (TA), peroneus longus (PL), flexor digitorum longus (FDL) and gastrocnemius (GC). Ten healthy male subjects were participated into stable and balance ball sessions at four angles of knee joint. The surface electromyograms (sEMG) were recorded from the TA, PL, FDL and GC on stable and balance ball with full weight bearing at four knee angles of $0^{\circ}$, $15^{\circ}$, $30^{\circ}$ and $45^{\circ}$. The time serial data of the surface electromyographic signals were transformed into integrated and frequency serial data by fast fourier transformation. On the stable ground, the iEMG signals of the TA, PL, FDL and GC were significantly higher at $45^{\circ}$ and $30^{\circ}$ of knee angles than $0^{\circ}$ and $15^{\circ}$ of knee flexion (p<0.05). On the balance ball, the iEMG of the TA, PL, FDL and GC were significantly higher at $45^{\circ}$ and $30^{\circ}$ of knee angles than $0^{\circ}$ and $15^{\circ}$ of knee flexion (p<0.05). The median frequency of the TA, PL, FDL and GC were significantly lower at $45^{\circ}$ and $30^{\circ}$ of knee angles than $0^{\circ}$ and $15^{\circ}$ of knee on the stable ground (p<0.05). On the balance ball, also the median frequency of the TA, PL, FDL and GC were significantly lower at $45^{\circ}$ and $30^{\circ}$ of knee angles than $0^{\circ}$ and $15^{\circ}$ of knee flexion (p<0.05). The iEMG of the TA, PL, FDL and GC were significantly higher on the balance ball at $0^{\circ}$, $15^{\circ}$, $30^{\circ}$ and $45^{\circ}$ of knee angles compared with stable ground. The median frequency of the TA, PL, FDL and GC were significantly lower on the balance ball at $0^{\circ}$, $15^{\circ}$, $30^{\circ}$ and $45^{\circ}$ of knee angles compared with stable ground. These results indicate that the ground conditions and angles of the knee joint involved to muscular activities and fatigue of ankles muscles, may performed at first on stable ground and then balance ball in order to $0^{\circ}$, $15^{\circ}$, $30^{\circ}$ and $45^{\circ}$ of knee flexion.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2002년도 ITC-CSCC -2
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• pp.1062-1065
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• 2002

We demonstrate the MMIC(monolithic microwave integrated circuit) frequency doublers generating stable and low-cost 29 ㎓ local oscillator signals from 14.5 ㎓ input signals. These devices were designed and fabricated by using the MMIC integration process of 0.1 $\mu\textrm{m}$ gate-length PHEMTs (pseudomorphic high electron mobility transistors). The measurements showed S$\_$11/ of -9.2 dB at 14.5 ㎓, S/sub22/ of -18.6 dB at 29 ㎓ and a minimum conversion loss of 18.2 dB at 14.5 ㎓ with an input power of 6 dBm. The fundamental signal of 14.5㎓ was suppressed below 15.2 dBc compared with the second harmonic signal at the output port, and the isolation characteristics of the fundamental signal between the input and the output port were maintained above 30 dB in the frequency range of 10.5 ㎓ to 18.5 ㎓.

• 한국주조공학회지
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• 제26권2호
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• pp.92-97
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• 2006

Contact material is widely used as electrical parts. Ag-Cd alloy has a good wear resistance and stable contact resistance. But the disadvantages of Ag-Cd alloy are coarse Cd oxides and harmful metal, Cd. To solve the disadvantages of that, Ag-Sn alloy that has stable and fine Sn oxide at high temperature has been developed. In order to optimize Sn amount that affects the formation of the oxide layer on the surface, we worked for the microstructures and properties of Ag-Sn material fabricated by rapid solidification process. The experimental procedure were melting using high frequency induction, melt spinning, and internal oxidation. We have shown that the optimized Sn amount for high hardness is 7.09 wt%Sn. Surface oxide layer forms when Sn amount is over 9.45 wt%. The size of Sn oxide is 20 nm.

• 전기학회논문지
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• 제65권4호
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• pp.533-538
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• 2016

In a power grid that has a high penetration of wind power, the highly-fluctuating output power of wind turbine generators (WTGs) adversely impacts the power quality in terms of the system frequency. This paper proposes a power smoothing scheme of a variable-speed WTG that can smooth its fluctuating output power caused by varying wind speeds, thereby improving system frequency regulation. To achieve this, an additional loop relying on the frequency deviation that operates in association with the maximum power point tracking control loop, is proposed; its control gain is modified with the rotor speed. For a low rotor speed, to ensure the stable operation of a WTG, the gain is set to be proportional to the square of the rotor speed. For a high rotor speed, to improve the power smoothing capability, the control gain is set to be proportional to the cube of the rotor speed. The performance of the proposed scheme is investigated under varying wind speeds for the IEEE 14-bus system using an EMTP-RV simulator. The simulation results indicate that the proposed scheme can mitigate the output power fluctuation of WTGs caused by varying wind speeds by adjusting the control gain depending on the rotor speed, thereby supporting system frequency regulation.

• 한국연소학회지
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• 제13권4호
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• pp.8-15
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• 2008

When a circular cylinder is placed at the center of a slot burner nozzle, once stable Woflhard-Parker type laminar lean premixed flame is changed to an oscillating flame with self-induced noise. The wrinkled flame surface showed the same pattern and frequency of the Karman vortex street at the downstream of a circular cylinder. The interaction of flame with Karman vortex street is observed to be responsible for flame oscillation. The measured flame oscillation frequency is very similar to the estimated Karman vortex shedding frequency based on the St-Re relationship of the flow past circular cylinder, which could be considered as a strong evidence for the interaction between laminar pre-mixed flame and a Karman vortex street. As Reynolds number increases oscillation frequency decreases and the self-induced noise level increases as well as the flame front is more severly wrinkled. This result suggests that the flame/vortex interaction becomes more active at higher Re.

• 전력전자학회논문지
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• 제27권1호
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• pp.80-83
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• 2022

This paper proposes an initial rotor polarity detection algorithm of a single-phase permanent magnet synchronous motor (SP-PMSM) related to stable open-loop starting for sensorless operation. Generally, the SP-PMSM needs an asymmetric air-gap structure to can avoid the initial starting failure at zero torque point. Therefore, the rotor polarity information can be obtained by using the DC offset current direction of a stator current through a high frequency voltage injection into an SP-PMSM with an asymmetric air gap. In this paper, the proposed rotor initial polarity detection algorithm is verified through several experimental results.

• Journal of Electrical Engineering and Technology
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• 제10권3호
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• pp.1363-1369
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• 2015

The frequency of a power system should be maintained within the allowed limits for stable operation. When a disturbance such as generator tripping occurs in a power system, the frequency is recovered to the nominal value through the inertial, primary, and secondary responses of the operating synchronous generators (SGs). However, for a power system with high wind penetration, the system inertia will decrease significantly because wind generators (WGs) are operating decoupled from the power system. This paper proposes a dynamic droop-based inertial control for a WG. The proposed inertial control determines the dynamic droop depending on the rate of change of frequency (ROCOF). At the initial period of a disturbance, where the ROCOF is large, the droop is set to be small to release a large amount of the kinetic energy (KE) and thus the frequency nadir can be increased significantly. However, as times goes on, the ROCOF will decrease and thus the droop is set to be large to prevent over-deceleration of the rotor speed of a WG. The performance of the proposed inertial control was investigated in a model system, which includes a 200 MW wind power plant (WPP) and five SGs using an EMTP-RV simulator. The test results indicate that the proposed scheme improves the frequency nadir significantly by releasing a large amount of the KE during the initial period of a disturbance.