• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권1호
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• pp.60-64
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• 2004

Squamous papilloma is a benign proliferation of stratified squamous epithelium, resulting in a papillary or verruciform mass. Verrucous carcinoma is a differentiated variant of squamous cell carcinoma and may present diagnostic difficulties as it may be erroneously diagnosed as squamous papilloma. Squamous papilloma is similar to other oral mucosa malignancy in microscopic view. So, it is difficult to distinguish between squamous cell papilloma and other oral mucosa malignancy. Here are three patients. they were diagnosed as squamous papilloma initially, but the lesion was recurred. In recurred lesion, verrucous carcinoma or squamous cell carcinoma were found. So we report that recurred oral mucosa malignency(verrucous carcinoma or squamous cell carcinoma) which was diagnosed as squamous papilloma.

• Journal of Chest Surgery
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• 제47권1호
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• pp.55-58
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• 2014

Mixed squamous cell and glandular papilloma of the lung is an extremely rare benign epithelial tumor showing a mixture of squamous and glandular epithelium. Here, we report a case of mixed squamous cell and glandular papilloma that presented as a solitary nodule in the left lower lobe of a 64-year-old woman. Chest computed tomography demonstrated a lobulated mass in the basal segment of the left lower lobe. The patient underwent a lobectomy under the suspicion of lung malignancy. The histopathological diagnosis was mixed squamous cell and glandular papilloma.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제39권5호
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• pp.224-230
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• 2013

Objectives: Papilloma frequently develops as a benign tumor of the head and neck area, but its potential for malignant transformation has yet to be studied. This study aims to provide basic information for papillomas using the immunohistochemical staining of matrix metalloproteinase 2 (MMP-2) and human papilloma virus (HPV) 16 and 18. Materials and Methods: To evaluate the malignant transformation of papillomas, the selected tissue samples were serially diagnosed with pre-cancerous papilloma (with epithelial dysplasia, pseudo-epitheliomatous hyperplasia) or malignant lesion (squamous cell carcinoma, SCC) after the first diagnosis (squamous papilloma, inverted papilloma). The selected tissues were stained with an antibody to MMP-2 and HPV 16-E7, HPV 18-L1. A statistical analysis was performed according to each transformation step. Results: The epithelial layer of papilloma and pre-cancerous papilloma lesions had a similar MMP-2 expression, but that of the malignant lesion had a significantly increased MMP-2 expression. HPV 16 and 18 infection rates were 28.6%, 33.3% and 63.6% in papillomas, pre-cancerous papilloma lesions, and SCC. Conclusions: A relatively high MMP-2 expression and HPV 16 or 18 infection of papillomas may be associated with early events in the multistep processes of malignant transformation of papillomas.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권4호
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• pp.271-275
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• 2012

Squamous cell papillomas are one of the most common lesions of the oral mucosa with a mucosa of the hard and soft palate, including the uvula, palate, tongue and lips. As an oral lesion, it raises concerns because of its clinical appearance, which may mimic exophytic carcinoma. Its pathogenesis is related to the human papilloma virus (HPV), but there is controversy regarding its viral origin. Many considered its pathogenesis as being from the HPV. But recent literature suggests that the presence of HPV may be merely an incidental finding unrelated to the development of a squamous papilloma. We accidentally found a patient not related to the HPV of oral squamous papilloma on the tongue, and we will report this case with literature review.

• 한국임상수의학회지
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• 제33권2호
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• pp.122-123
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• 2016

A dog (Maltese, 4-year-old, intact male) was referred to the hospital because of the multiple cabbage-shaped nodular masses on penis, preputial fornix and inner layer of prepuce with the free-roaming history. Those appearance was similar with the characteristic of transmissible venereal tumor (TVT). As a result, it was tentatively diagnosed as TVT by the veterinarian of a local clinic and treated with vincristine sulfate. However, the lesion did not regress. Histologically, the mass was consisted of fibrovascular connective tissue stalks and keratinized stratified squamous epithelium, and koilocytosis and intranuclear inclusion body were not shown in the epithelial layer. In addition, inflammatory changes were minimal in the tissue of mass. Based on these findings, this case was diagnosed as venereal squamous papilloma. As the treatments of TVT and papilloma differs, practitioners must be cautious with the diagnosis.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1981년도 제15차 학술대회연제순서 및 초록
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• pp.12.2-12
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• 1981

비강 및 부비동에 발생하는 유두종은 비교적 드문 양성종양으로서 수술적 제거후에도 재발이 잘되고 악성화되는 경향이 있는 정도로 알려져 있다. 유두종의 3 Type중 특히 희귀한 균상 유두종은 Microscopically stratified squamous epithelium으로 덮힌 Cornification의 형태를 보이며 출현의 경향은 별로 없는 것으로 알려져 있다. 저자들은 최근 55세 남자의 우측 비강측벽에 발생한 균상유두종 한례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 한국임상수의학회지
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• 제31권4호
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• pp.319-321
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• 2014

12년령 접종 수컷 개가 전북대학교 수의과 대학에 왼쪽 편측성의 유루증으로 내원하였다. 확대경을 통한 안검사에서 왼쪽 안검 결막에 매우 작은 덩어리가 있는 것이 발견되었다. 이 조직을 외과적으로 제거하여 조직검사를 실시한 결과 편평상피 세포에 바이러스성 변화가 없는 중등도의 유두세포 증식이 관찰되었다. 조직 검사를 바탕으로 비바이러스성 편평세포 유두종으로 진단하였다. 조직 제거 후에 환자의 유루증은 완전히 해결되었다. 본 증례는 개에서 결막의 비바이러스성 편평세포 유두종에 의해 발생한 유루증을 치료한 것이다.

• 대한기관식도과학회지
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• 제15권2호
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• pp.81-86
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• 2009

A 57 year old human immune virus(HIV)-positive male presented with a progressive dyspnea for 6 months. Chest CT showed multiple polypoid masses arising from upper tracheal wall. Bronchoscopic examination revealed that multiple large cauliflower-like polypoid tumors was obstructing tracheal lumen. They were diagnosed as multiple squamous papillomas and were removed by Nd:YAG laser photocoagulation and rigid bronchoscopic treatment. The tumors were histologically diagnosed as squamous papilloma infected with human papilloma virus(HPV) type 6 and 11 in in-situ hybridization. Rigid bronchoscopy might be safer and more efficient than flexible bronchoscopy for the treatment of multiple tracheal papillomatosis obstructing tracheal lumen because of easy establishment of airway patency and direct use of rigid bronchoscope itself for tumor resection.

• 대한세포병리학회지
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• 제15권1호
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• pp.28-32
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• 2004

It was reported that the main cause of intraepithelial neoplasm and squamous cell carcinoma of the uterine cervix is human papilloma virus infection, and that the expression of p16 is increased in cells infected by human papilloma virus. We performed an immunocytochemical staining for protein p16 in 17 cases of cervocovaginal smears initially diagnosed as atypical squamous cells of undetermined significance, to know whether the staining could help the differentiation of neoplastic cells from reactive atypical cells. Of 17 smears, 6 were diagnosed finally as high grade intraepithelial neoplasm or invasive squamous cell carcinoma by follow-up biopsy and smear, and 5 of the 6 were positive for p16. Three were diagnosed as koilocytosis, and one of them was weakly positive for p16. Eight were diagnosed as reactive atypical cells, and all of them were negative for p16. We thought that immunocytochemical staining of p16 in cervocovaginal smears could help the differentiation of neoplastic cells from reactive atypical cells.

• 대한두경부종양학회지
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• 제25권1호
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• pp.28-32
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• 2009

Background : The most frequently reported risk factors for head and neck suamous cell carcinoma are smoking and alcohol. But in a recent overview, human papilloma virus(HPV) infection was revealed the important carcinogenic factor in oropharyngeal cancer. We aimed to clarify whether HPV directly effects on the oncogenesis and biologic behavior of hean and neck squamous cell carcinoma by comparison with infection prevalence, and physical status of virus. Material and Method : We used HPV genotyping DNA chip(Biocore, Korea, Seoul) arrayed by multiple oligonucleotide probes of L1 sequence of 26 types of HPV and HPV genotypes are identified by fluorescence scanner. The copy numbers of HPV E2 and E6 open reading frames(ORF) were assessed using a TaqMan-based 5'-exonuclease quantitative real-time PCR assay. The ratio of E2 to E6 copy numbers was calculated to determine the physical status of HPV-16 viral gene. Results : We observed a significant difference in HPV prevalence between tonsillar cancer group and control group(73.1% vs. 11.6%), and most of the HPVs were type 16(87.2%) and integrated(94.1%) state. In terms of oral tongue cancer, we demonstrate that 30.5% has integrated HPV-16 in cancer tissue. But Glottic cancer only 1% is related to HPV-16 integration. Conclusion : This study revealed significant relationship of HPV prevalence with oropharyngeal and oral tongue squamous cell carcinoma. Most of HPV were 16 type and integrated or mixed, HPV-16 integration could be directly related to the carcinogenesis.