• 한국수의병리학회지
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• 제5권2호
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• pp.39-42
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• 2001

A reference range data base containing organ weight values on animals used in 4 week and 13 week toxicity tests is described. Data listed include the values of minimum, maximum, mean and standard deviation for each of the following organ weights. Organs: Brain, heart, liver, spleen, kidney, adrenal gland, testis, ovary. This study was undertaken to determine organ weight reference values of Ktc: SD rats

• 한방안이비인후피부과학회지
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• 제20권1호통권32호
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• pp.51-65
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• 2007

Objective : The present study was carried out to investigate the preventive effect of Sophorae Flos on streptozotocin - induced Diabetes mellitus. Method : Sophorae Flos was given to rats with oral administration. The experimental animals were divided into 3groups : normal group of rats, control group of Streptozotocin-induced diabetic rats, sample group with Sophorae Flos . The effect of Sophorae Flos on Streptozotocin-induced diabetes was observed by measuring the survival rate of rats, weight of rats, FER, blood glucose, each organ weight of rat, total cholesterol, HDL, GOT, GPT & creatinine. Result : Streptozotocin caused hyperglycemia and hypoinsulinemia by a selectively destroying pancreatic ${\beta}-cell$. Sophorae Flos treatment don't protected them from hyperglycemia and hypoinsulinemia. Organ weight liver, kidney, heart & spleen shows no significant changes. Sophorae Flos significantly don't recoverd the increase of several biochemical parameters such as blood glucose, total cholesterol, HDL, GOT, GPT, antioxidant & creatinine is vice versa. Conclusion : Sophorae Flos extract group did not show significant decrease than Streptozotocin control group.

• 한국식품영양과학회지
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• 제30권6호
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• pp.1278-1282
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• 2001

Astaxanthin을 산란계에 경구 투여하여 얻은 AEY에는 총 2.88 mg%의 carotenoid가 함유되어 있었다. Carotenoid 성분을 HPLC로 분석한 결과, AEY에는 존재하지 않는 $\alpha$- cryptoxanthin, canthaxanthin, cynthiaxanthin, triol 등이 AEY 에서 확인되었다. CEY에서는 존재하지 않기 때문에 이들은 astaxanthin의 대사생성물로 예상할 수 있다 AEY는 LPS로 유발한 mouse의 catabolic response overcome의 효과 시험에서 control구에 비해 유의성 있는 체중 감소 억제 효과를 보였다. 또한 AEY는 LPS 처리에 의한 면역기관에 미치는 영 향에서는 췌장과 간의 체중에 대한 상대적 비율을 증가시켰다. 따라서 AEY 처리가 면역 작용을 하는 세포의 활성에 관여하는 것으로 생각되고 이것은 AEY 처리구에서 관찰되는 $\alpha$-cryptoxanthin, canthaxanthin, cynthiaxanthin, triol 등에 의한 것으로 추측된다.

• Journal of Animal Science and Technology
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• 제45권6호
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• pp.957-966
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• 2003

면역반응중인 육계 병아리의 생산성과 단백질 및 에너지 이용성에 미치는 사료 중 크릴 밀의 영향을 조사하였다. 갓 부화(0 일령) 병아리(Avian)에 기초사료(크릴 밀 0.0%)와 기초 사료중 대두박 대신 0.5 또는 1.0%의 크릴 밀을 각각 대치한 사료(크릴 밀)를 급여하였다. 병아리 2 주령에 2일에 한 번씩 Salmonella typhymurium lipopolisacchaide(LPS)를 복강 내에 주입하여 자극한 면역반응시의 값을 멸균식염수(0.9%)을 주입한 것(대조)과 비교하였다. 대조 병아리에서 크릴 밀 사료는 생산성, 질소밸런스(NB), 뇨산 배설량, 및 ME 이용량에 영향을 미치지 않았다. 그러나, 면역반응은 사료 중 크릴 밀 함량에 관계없이 일당 증체량, 사료 섭취량과 NB를 대조에 비해서 유의하게(p〈0.05) 낮추었고, 뇨산 배설량과 간장 및 비장무게를 유의하게(p〈0.05) 높였다. 크릴 밀 1.0%사료는 사료효율을 유의하게 낮추고, 비장무게, g당 NB 또는 ME 이용량 및 사료 g당 ME값을 유의하게 높였다. 크릴 밀 사료는 면역 자극 후 회복중에는 간장과 비장무게를 감소 시켰다. 본 성적은 크릴 밀 사료가 면역반응중인 육계 병아리에서 단백질 분해는 증가시키나, 에너지 이용량은 높인다는 것을 나타내었다.

• Journal of Nutrition and Health
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• 제25권6호
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• pp.468-475
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• 1992

본 연구는 식이내 n-6,n-3 지방산과 비타민 A 수준이 흰쥐의 체액면역기능에 미치는 영향을 관찰하기 위해 평균 체중이 $103pm$2.2g인 Sprague-Dawley종 수컷 흰쥐68마리를 6군으로 나누어 6주간 사육하였다. 실험식이는 지방을 식이무게의 10% 수준으로 하여 어유와 옥수수유를 사용하였고 비타민 A 수준은 결핍식이(1240 IU/kg diet), 적정식이(4000 IU/kg diet), 과잉식이(400,000 IU/kg diet)로 하였다. 비장무게는 체중 100g당, 비타민 A 과잉 어유섭취군이 유외하게 낮았으며 plaque-forming cell 반응은 지방종류와 비타민 A수준에 따른 차이가 없었다. 혈청의 혈구응집반응 결과는 어유군이 옥수수군에 비해 항체가가 낮았으며, 비타민 A 수준에 따른 차이는 없었다. IgG 농도는 지방종류에 의한 차이가 있어 어유군이 옥수수군에 비해 높았으며, 비타민 A 과잉 어유군이 다른 식이군에 비해 현저하게 높았다. 비타민 A 과잉 어유군은 비장의 크기가 작고 혈청 IgG 농도가 높게 나타났으므로 비타민 A 과잉시 어유 섭취는 면역기능에 좋은 영향을 주지 못하였다. 광학현미경으로 살펴본 바에 의하면 비장조직은 어유군이 옥수수유군에 비해 발달이 좋았으며 비타민 A 결핍과 과잉시에 발달이 저해되었다. 그러므로 본 연구 결과로 건강한 사람의 경우 면역기능을 온전히 유지하기 위해서는 비타민 A를 적정량 섭취하는 것이 좋으며 비타민 A과잉시에는 어유섭취를 피하는 것이 바람직하다는 것을 알 수 있다.

• Toxicological Research
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• 제11권1호
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• pp.81-89
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• 1995

A teratogenicity study of KTC-1, a new semisynthetic rifamycin antituberculous drug, was conducted in Sprague-Dawley rats. Dosages of KTC-1 0, 7, 21, and 63 mg/kg/day were administered to darns orally gayage from day 7 to day 17 of gestation. Two-third of dams per group were subjected to cesarean section on day 21 of pregnancy for examination of their fetuses, and the remaining one-third of darns per group were allowed to deliver naturally for postnatal examination of their offspring. At 21 mg/kg/day, an increase in the skeletal variations of F1 fetuses and a decrease in the body weight of F1 offspring were seen. At 63 mg/kg/day, a loss in body weight was observed in darns. An increase in fetal death rate, a decrease in litter size and body weight, and an increase in the incidence of visceral malforrnations and skeletal variations were found in F1 fetuses. In particular, lumar rib occurred at an incidence of 31%. In addition, an increase in the dead newborns at birth and neonatal deaths during the lactation period, a loss in body weight, and a decrease in spleen weight were observed in F1 offspring. There were no signs of maternal toxicity or embryotoxicity at 7 mg/kg/day. The results suggest that the no-effect dose level(NOEL)for dams is 21 mg/kg/day, and NOELs for F1 fetuses and offspring are 7 mg/kg/day.

• Environmental Analysis Health and Toxicology
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• 제3권3_4호
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• pp.39-51
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• 1988

Effects of ${\alpha}$-tocopherol and perilla oil on the toxicity of polychlorinated biphenyls (PCB) in male rat were studied. Rats were fed ad libitum for 6 weeks with the animal diet which contains PCB 30 ppm and 100 ppm. Perilla oil (0.5 g/kg body weight) and ${\alpha}$-tocopherol (30 mg/kg body weight) were administered intraperitoneally twice a week for 6 weeks. Rats fed with PCB showed enlargement of liver and spleen, increase in aspartate aminotransferase, alkaline phosphatase, sereum lipid and cytochrome P 450 and decrease in body weight and glutathione. When perilla oil was administered to rats fed with PCB increase in aspartate aminotransferase, alkaline phosphatase, serum lipid and cytochrome P45O and decrease in body weight and glutathione were significantly augmented, compared to rats fed with PCB alone. This means that perilla oil potentiates the toxicity of PCB. On the other hand when ${\alpha}$-tocopherol was administered to rats fed with PCB increase in aspartate aminotransferase, alkaline phosphatase, serum lipid and cytochrome P45O and decrease in body weight and glutathione were signigicantly reduced, compared to rats fed with PCB alone. This means that u-tocopherol reduces the toxicity of PCB. From the above results, it may be concluded that PCB is metabolized by microsomal mixed function oxidase and the metabolite causes the toxicity and microsomal glutathione plays a role of protection on the toxicity of PCB.

• 약학회지
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• 제33권1호
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• pp.20-29
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• 1989

The humoral immune response of Eicosapentanoic acid(EPA) was investigated in mice. ICR male mice were divided into 8 groups and received intraperitoneal injection of EPA(5 mg, 10 mg, 20 mg/kg) for 4 weeks. Cyclophosphamide(5 mg/kg) was administered i.p. 2 days prior to secondary immunization. Humoral immune response was evaluated by antibody titer, hypersensitivity to SRBC (Arthus), plaque forming cell(PFC) and organ weight. The ontanined results were as followings: The increased rate of body weight, the ratio of liver weight, spleen weight to body weight were decreased by all EPA administration groups as compared to normal group. HA titer, HY titer and Arthus reaction were enhanced according to the increase of EPA doses as compared to normal group. PFC was significantly enhanced by EPA 10 mg administration group. These results suggest that EPA enhances humoral immune response to SRBC in mice, indicating that EPA may block a immunoglobulin synthesis inhibition of arachidonic acid.

• 한국가금학회지
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• 제49권1호
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• pp.9-14
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• 2022

This study was conducted to investigate the effects of dietary inclusion of phytase on the growth performance, organ weight, and tibia ash of broilers. A total of 1008 one-day-old Ross 308 broiler chicks (mixed gender) with body weight 42 ± 0.90 g (mean ± SD) were used in a trial for 32 d. Chicks were assigned to one of the two treatment diets. Each treatment consisted of 28 replicate cages, with 18 birds per cage. The dietary treatments were as follows: CON, basal diet; TRT1, basal diet + phytase 1,500 Fan Terminal Unit (FTU)/kg diet. Dietary inclusion of 1,500 FTU/kg phytase supplementation in broilers showed only slight improvements in daily feed intake (P=0.086) and feed conversion ratio (P=0.065) on day 9 compared with that in the control group. However, organ weights of the breast muscle, liver, spleen, kidney, and bursa of Fabricius were not affected by the dietary treatments. In addition, the dietary inclusion of 1,500 FTU/kg phytase supplementation in the broiler diet had no effect on tibia ash. The addition of 1,500 FTU/kg phytase in the basal diet of broilers did not have any adverse effect on growth performance, organ weight, and tibia ash, suggesting that phytase supplementation in broiler diets will exhibit comparable effects as that of corn-soybean meal-based diet.

• 대한한방내과학회지
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• 제21권3호
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• pp.409-416
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• 2000

Objective : In order to study effects of Chungsanggyuntong-tang on Hyperlipidemia which causes Hypertension, Arteriosclerosis, Cerebral vascular disease and Ischemic heart disease Methods : The changes of serum total lipid, triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol, body weight and organ weight were observed after the liquid extracts of Single-dosage Chungsanggyuntong-tang and Double-dosage Chungsanggyuntong-tang were administered p.o to the Hyperlipidemic rats induced by 1% cholesterol diet for 10, 20 and 30 days. Results : The food consumption and the body weight were significantly decreased in both Chungsanggyuntong-tang group compared with control group, except Double-dosage 30days. The contents of total lipid were significantly decreased in Double-dosage Chungsanggyuntong-tang group for 20, 30 days, but Single-dosage Chungsanggyuntong-tang group did not show any significant change compared with control group. The contents of total cholesterol were decreased in Single-dosage Chungsanggyuntong-tang group and Double-dosage Chungsanggyuntong-tang group, but did not show any significant changes compared with control group. The contents of triglyceride were significantly decreased in Double-dosage Chungsanggyuntong-tang group for 10, 30 days, but Single-dosage Chungsanggyuntong-tang group did not show significant changes compared with control group. The contents of HDL-cholesterol were significantly increased in Single-dosage Chungsanggyuntong-tang group for 10 days compared with control group. The contents of LDL-cholesterol were significantly decreased in both Chungsanggyuntong-tang group for 10 and 30 days compared with control group. The liver and spleen weight were significantly increased in control group compared with normal group. The liver weight was significantly decreased in Single-dosage Chungsanggyuntong-tang group compared with control group. The liver, spleen and kidney weight were significantly decreased in Double-dosage Chungsanggyuntong-tang group compared with control group. Conclusions : It was thought that Single-dosage Chungsanggyuntong-tang and Double-dosage Chungsanggyuntong-tang could be applied effectively to the Hyperlipidemia.