• YAKHAK HOEJI
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• v.52 no.2
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• pp.93-100
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• 2008

A liquid chromatographic method with tandom spectrometric detection (LC/MS/MS) for the simultaneous determination of doxifluridine and its active metabolite, 5-fluorouracil (5-FU) was developed over the concentration range of $5{\sim}2000$ ng/ml, respectively. Doxifluridine, 5-FU and internal standard, 5-chlorouracil (5-CU), were extracted from liver and intestine tissue via protein precipitation. Acetonitrile was used as the extraction solvent and the supernatant was evaporated and reconstructed in mobile phase. Optimum chromatographic separation was achieved on a Agilent Zorbax $C_{18}$ ($100\;mm{\times}2.1\;mm$, $3.5\;{\mu}m$) column with mobile phase run in isocratic with methanol : water (20 : 80, v/v). The flow rate was 0.2 ml/min with total cycle time of 5 min. The lower limit of quantification was validated at 5.0 ng/ml of liver and intestine tissue, for both doxifluridine and 5-FU, respectively. The intra-day and inter-day precision and accuracy of quality control (QC) samples were <11% coefficient of variation and <7% relative error from theoretical concentration for both analytes. In addition, the special designed stability study was performed, because the metabolism of doxifluridine occurs spontaneously even in ice bath for monkey liver. The stability of doxifluridine in liver and intestine of monkey and beagle dog was compared. It was found that bioanalytical validation could not be performed for the monkey liver; however, beagle dog's liver has relatively low speed of metabolism compared to monkey liver and instead of monkey liver, beagle dog's liver could be used for the validation. Bioanalytical validation could be performed in monkey intestine. Eventually, this developed method for liver and intestine will be useful in support of the toxicokinetic and pharmacokinetic studies of doxifluridine and 5-FU.

• Journal of Digital Convergence
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• v.14 no.9
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• pp.325-329
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• 2016

Facial authentication has the limelight because it has less resistance and it is hard to falsify among various biometric identification. The algorithm of facial authentication can bring about huge difference in accuracy and speed by the algorithm construction. Along with face-extracted data by tracing and extracting pupil, the thesis studied algorithm which extracts data to improve error rate and to accurately authenticate face. It detects face by cascade, selects as significant area, divides the facial area into 4 equal parts to save the coordinate of object. Also, to detect pupil from the eye, the binarization is conducted and it detects pupil by Hough conversion. The core coordinate of detected pupil is saved and calculated to conduct facial authentication through data matching. The thesis studied optimized facial authentication algorithm which accurately calculates facial data with pupil trace.

• Journal of the Korean Society of Safety
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• v.25 no.6
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• pp.203-209
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• 2010

A compact ANSI/EIA 709.1 protocol analyzer system suited for maintenance of LonWorks network for safety management of underground facilities was developed and tested. The hardware is based on the TMS320LF2406A embedded system, and the software was designed using Visual C++6.0 under Windows XP environment. Connected to the LonWorks network the developed protocol analyzer decodes the raw packets and pass them to the master PC through USB port. Then on the PC the packets are processed and analyzed in various aspects and the key features that are essential to the maintenance of LonWorks network installed at underground facilities are displayed in a user-friendly format. Performance of the developed protocol analyzer was evaluated through a series of experiments, by measuring the speed of packet analysis and the error rate. The protocol analyzer proved to work reliably even under the increased bandwidth. However, more comprehensive tests under various underground environmental conditions are desired.

• Journal of the Korea Society of Computer and Information
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• v.13 no.2
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• pp.79-85
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• 2008

The middleware that provides RFID-based ubiquitous application service should process the data inputted constantly in real time, and acquire and deliver the answers of the questions in the application service. Studies for developing a Data Stream Management System(DSMS) has been performed in order to process a large amount of data stream inputted constantly in this way. Previous algorithms on data stream were mostly focused on reducing the average error between the answers of the successive questions and abandon the data according to the priority of them when a load occurs. This article is composed of presenting the necessity of the studies on the DSMS and speedy data processing, suggesting an algorithm to make Possible the speedy data processing using buffers and prompt questions and answers, and testing the performance of the data processing rate and whether a buffer is generated correspondingly to the algorithm suggested, in either a single or a multiple buffer, through simulations.

• Journal of Communications and Networks
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• v.18 no.3
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• pp.387-396
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• 2016

Multiuser communication has been an important research area of underwater acoustic communications and networking. This paper studies the use of adaptive orthogonal frequency-division multiple access (OFDMA) in a downlink scenario, where a central node sends data to multiple distributed nodes simultaneously. In practical implementations, the instantaneous channel state information (CSI) cannot be perfectly known by the central node in time-varying underwater acoustic (UWA) channels, due to the long propagation delays resulting from the low sound speed. In this paper, we explore the CSI feedback for resource allocation. An adaptive power-bit loading algorithm is presented, which assigns subcarriers to different users and allocates power and bits to each subcarrier, aiming to minimize the bit error rate (BER) under power and throughput constraints. Simulation results show considerable performance gains due to adaptive subcarrier allocation and further improvement through power and bit loading, as compared to the non-adaptive interleave subcarrier allocation scheme. In a lake experiment, channel feedback reduction is implemented through subcarrier clustering and uniform quantization. Although the performance gains are not as large as expected, experiment results confirm that adaptive subcarrier allocation schemes based on delayed channel feedback or long term statistics outperform the interleave subcarrier allocation scheme.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.1
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• pp.187-192
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• 2015

Underwater acoustic communication channels have very complex channel characteristics caused by time-varying sea surface, submarine topography, sound speed, and geometry between transmitter and receiver. Especially, the channel has time-variance and doppler effect due to wind and sea current. We have to recognize the channel state and apply it to communication technique for increasing transmission efficiency in the underwater acoustic channel. In this paper, we present the frame recursive modulation and demodulation method using ambiguity function and autocorrelation function to estimate the doppler frequency. Furthermore, we conducted the simulation and sea experiment to evaluate the performance of the proposed method. When the channel coding technique was not used, the bit error rate performance of the proposed method was improved about 32 % compared with conventional method.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.3A
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• pp.189-197
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• 2011

OFDM systems are much studied for the recent high speed wireless optical communication system. OFDM system has basically high PAPR and ICI easily generated because of non-linearity and RF impairments. In the wireless optical communication system, optical output power driven by current of LED is not linear so that transmission signals are distorted. Therefore, research about reception performance of this nonlinear optical output emitted by non-linear LED transfer function and OFDM signal has been conducted. Nonlinear effect of LED is different from nonlinear effect of OFDM system in the conventional radio communication system, which degrades the BER performance. In this paper, we apply non-linear transfer function of recently studied LED into OFDM system. So, for reducing the PAPR and suppressing the ICI in frequency domain of receiver, we suggest a new PAPR reduction technique to reduce non-linear distortion of LED and an adaptive ICI suppression algorithm so that BER performance may be improved. Also, the proposed method is verified through simulation results.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.15 no.10 s.89
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• pp.1011-1017
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• 2004

Ultra Wideband(UWB) technologies have been developed to exploit a new spectrum resource in substances and to realize ultra-high-speed communication, high precision geolocation, and other applications. The energy of UWB signal is extremely spread from near DC to a few GHz. This means that the interference between conventional narrowband systems and UWB systems is inevitable. However, the interference effects had not previously been studied from UWB wireless systems to conventional mobile wireless systems sharing the frequency bands such as Korean Cellular CDMA and WCDMA. This paper experimentally evaluates the interference from two kinds of UWB sources, namely a direct-sequence spread-spectrum CDMA(DS-CDMA) UWB source and an impulse radio UWB source, to a Cellular CDMA and WCDMA digital transmission system. The average frame error rate degradation of each system are presented. From these experimental results, the interference effects of DS-CDMA UWB source is not severe compared to the Impulse UWB.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.3A
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• pp.188-195
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• 2002

The M-algorithm for decoding convolutional codes can significantly reduce the complexity of the Viterbi algorithm by tracking a fixed number of survivor paths in each level of the decoding trellis. It is an easily-implementable algorithm suited for real-time processing of high-speed data. The algorithm, however, generates a sequence of catastrophic errors when the correct path is not included in the set of survivor paths. In this paper, the performance of the M-algorithm obtained from using various decoding complexity levels, frame lengths, and code constraint lengths is presented. The performance gain is quantified when the algorithm is used in conjunction with codes of increased constraint length. In particular, it is demonstrated the gain from the increased code free distance overcompensates the loss from the correct path being excluded from the survivors, when the frame length is short to moderate. Using 64 survivor paths, the signal-to-noise ratio gain obtained by increasing the constraint length from K=7 to K=9, 11, 15 is respectively 0.6, 0.75, and 08dB, when the frame of length L=100 has the frame error rate of 0.01%.

• Archives of design research
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• v.18 no.3 s.61
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• pp.191-198
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• 2005

Menu is the most common interaction tool to select and execute a specific menu item from multiple menu options. With the very rapid increasing amount of information, various new menu designs have been developed. In this research, the pull-down menu, fisheye menu and grid menu were tested to compare the performance time, error rate, simplicity, usefulness, user friendliness, and overall user preference of each menu type. The grid menu was more efficient in selection speed than the pull-down and fisheye menus when the number of menu-items was 50 and 100. The time needed to choose a menu-item with a grid menu was less affected by the size of menu. The pull-down and the grid menus were considered to be more satisfactory, simple, user friendly, and useful than the fisheye menu. 42.3 percent of subjects indicated that the grid menu was their preferred selection tool among the menus. The grid menu is an efficient and robust alternative menu choice for small and middle size menu list. Further study is required to examine the possibility of grid menu on mobile devices.