• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.6
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• pp.1585-1588
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• 2008

The purpose of this study was to investigate the clinical application of oriental medical therapy(OMT) to Speech retardation complained problems of Articulation & Reading fluency. We treated the patient with OMT & others. The recovery of Speech retardation was evaluated by Articulation correction test(ACT) & Reading fluency test(RFT). The applicability of OMT & other therapy has positive effects on the patient with Speech retardation complained problems of Articulation & Reading fluency. The scores of ACT & RFT were increased.

• MALSORI
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• no.60
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• pp.85-96
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• 2006

The aim of the present study was to investigate a simile comprehension of children with and without mental retardation. Thirteen children with mental retardation and ten normal children with matched receptive vocabulary ability participated in the study. They were between five and eight years old in the age of receptive vocabulary. Fourteen picture plates were used and each plate consisted of three pictures. The findings were as fellows. First, children with mental retardation made significantly more errors than normal children in the comprehension of simile. Second, mental retarded children and normal children did not have a significant correlation between receptive vocabulary development and comprehension of simile. Finally, on simile interpretation type, children with mental retardation were likely to think a tenor into a vehicle because they failed to recognize the syntactic structure of simile, 'A is like B'. Thus, It is important to teach mental retarded children the syntactic structures of simile and to provide them with a variety of experience as well as to let them know an exact meaning of words.

• Journal of Oriental Neuropsychiatry
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• v.16 no.2
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• pp.25-34
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• 2005

Background and Objectives There was no clinical data except literary study on mutual correlation with autistic disorder in Western medical diagnosis and five kinds of flaccidity in infants(五軟), five kinds of retardation(五遲) in Oriental medical diagnosis. This study was performed to investigate the correlation of five kinds of flaccidity in infants(五軟), five kinds of retardation(五遲) to the children with autistic disorder and to set the time table for clinical diagnosis of developmental retardation by making a comparative study of normal developmental children so we can treat the children with autistic disorder in good time. Method We made the comparative study of interview sheets recorded by parents of total 163 children who were diagnosed as autistic disorder who visited HaeMa Oriental Medical Clinic with interview sheets recorded by parents of generally accepted normal developmental children(263) and then we took statistics. Results : 1. There was significant correlation with speech and walking among five kinds of flaccidity in infants(五軟), five kinds of retardation(五遲) in autistic disorder statistically and clinically in comparison with normal children. 2. There wasn't significant correlation with growth time of tooth among five kinds of flaccidity in infants(五軟), five kinds of retardation(五遲) on diagnosis of autistic disorder in comparison with normal children. 3. There was significant correlation with retardation of times going to toilet by oneself (it does not consist in five kinds of flaccidity in infants(五軟), five kinds of retardation(五遲).) in both of autistic disorder. Conclusion Autistic disorder was significantly correlated with the faculty of speech(語遲), retardation in walking out(行遲) of five kinds of flaccidity in infants(五軟), five kinds of retardation(五遲). We need to concrete the index of diagnosis, because it is so difficult to measure times and register retardation in tooth eruption(齒遲), retardation in hair-growing(髮遲), debility of neck and nape(頭項軟), flaccidity of extremities(手軟) and flaccidity of muscle(肌肉軟). And we can also use times going to toilet by oneself as one of diagnostic criteria because of its significant correlation. It is required to make early diagnosis of five kinds of flaccidity in infants(五軟), five kinds of retardation(五遲) using these criteria, and to treat them early by oriental medicine.

• Clinical and Experimental Pediatrics
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• v.49 no.10
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• pp.1026-1030
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• 2006

Mental retardation(MR) is one of the most common developmental disabilities, which is characterized by deficits in intellectual and adaptive functions. Most children with MR have cognitive limitation in the mild range. With respect to the etiology, it is believed that genetic and environmental factors are interrelated and show variable pictures. Most children with MR present with speech and language delay during the early years. The diagnosis can be made by clinical features and neuropsychological tests of intelligence and adaptive functioning. The treatment is limited, but many associated problems are amenable to multidisciplinary interventions. The article will review the recent advances in the management of MR and other neurodevelopmental disorders in children.

• Proceedings of the KSPS conference
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• 2007.05a
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• pp.155-157
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• 2007

Objective : There are close relationship between intraoral abnormal structure and speech-functional problem. Patients with cleft palate & ankyloglossia are typical examples. Patients with abnormal structure can be repaired toward normal structure by operation. Ankyloglossia may cause functional limitation - for example, speech disorder - even if adequate surgical treatment were done. And, each individuals have each speech disorders. The objective of this study is to evaluate the speechs of childrens with ankyloglossia, and to determine whether ankyloglossia is associated with articulation problem. We wanted to present criteria for indication of frenectomy. Study design The experimental group is composed of 10 childrens who visited our department of oral and maxillofacial surgery, dental hospital, Chonbuk university, due to ankyloglossia and articulation problem,. The average age is 5 Y 7M, M : F ratio is 4 : 1 at the time of speech test. The VPI consonant discrimination degree, PPVT, PCAT, Nasometer II, Visi-Pitch test result were obtained from each group. Result : There was significant difference for 'language development' through PPVT. Except 3 members of experimental group, all remainder showed retardation for 'language development'. For 'errored consonant rate', data showed more higher scores in alveolar consonant. There 'consonant error' in experimental group, mostly showed 'alveolar consonant', also a major modality of 'consonant error' was mostly distortion. Conclusion : We can judge the severity of ankyloglossia patient by examinig language development degree & speech test of 'alveolar consonant' . And we can make a decision for frenulotomy using these results.

• Archives of Plastic Surgery
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• v.38 no.2
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• pp.203-206
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• 2011

Purpose: Kabuki syndrome is a multiple malformation syndrome that was first reported in Japan. It is characterized by distinctive Kabuki-like facial features, skeletal anomalies, dermatoglyphic abnormalities, short stature, and mental retardation. We report two cases of Kabuki syndrome with the surgical intervention and speech evaluation. Methods: Both patients had velopharyngeal insufficiency and had a superior based pharyngeal flap operation. The preoperative and postoperative speech evaluations were performed by a speech language pathologist. Results: In case 1, hypernasality was reduced in spontaneous speech, and the nasalance scores in syllable repetitions were reduced to be within normal ranges. In case 2, hypernasality in spontaneous speech was reduced from severe level to moderate level and the nasalance scores in syllable repetitions were also reduced to be within normal ranges. Conclusion: The goal of this article is to raise awareness among plastic surgeons who may encounter such patients with unique facial features. This study shows that pharyngeal flap operation can successfully correct the velopharyngeal insufficiency in Kabuki syndrome and post operative speech therapy plays a role in reinforcing surgical result.

• Clinical and Experimental Pediatrics
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• v.49 no.10
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• pp.1019-1025
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• 2006

Motor delay, when present, is usually the first concern brought by the parents of children with developmental delay. Cerebral palsy that is the most common motor delay, is a nonspecific, descriptive term pertaining to disordered motor function that is evident in early infancy and is characterized by changes in muscle tone, muscle weakness, involuntary movements, ataxia, or a combination of these abnormalities. A wide range of causative disorders and risk factors have been identified for cerebral palsy, and broadly classified into 5 groups; perinatal brain injury, brain injury related to prematurity, developmental abnormalities, prenatal risk factors, and postnatal brain injury. Delay in attaining developmental milestones is the most distinctive presenting complaint in children with cerebral palsy. A detailed history and thorough physical and neurologic examinations are crucial in the diagnostic process. The clinician should be cautious about diagnostic pronouncement unless the findings are unequivocal. Several serial examinations and history review are necessary. All children with cerebral palsy should undergo a neuroimaging study, preferably MRI, because an abnormality is documented on head MRI(89%) and CT(77%). The high incidence rates for mental retardation, epilepsy, ophthalmologic defects, speech and language disorders and hearing impairment make it imperative that all children with cerebral palsy be screened for mental retardation, ophthalmologic and hearing impairments, and speech and language disorders; nutrition, growth, and swallowing also should be closely monitored.

• MALSORI
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• no.56
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• pp.15-28
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• 2005

In this study, children with MR were compared with normal children in overall production rate and production types of six semantic categories of negation. For this purpose, 10 children with MR and another 10 language-age matched normal children were selected. The results of this study were as the following: First, the children with MR showed significantly low overall production rate, compared with normal children. Two groups demonstrated signifiant differences in denial, disability, ignorance, prohibition and rejection except nonexistence. Second, in production type, the children with MR tended to use more gestures, and in comparison, normal children used more 'mixed types'.

• Journal of Yeungnam Medical Science
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• v.9 no.2
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• pp.427-435
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• 1992

We have experienced a case of infantile nephrotic syndrome confirmed by renal biopsy in a 13-month-old female patient who showed growth and develop mental retardation and persistent proteinuria. She revealed mild eyelid edema, joint laxity, delayed speech development and adrenal cortical calcification on the radiologic study. Renal biopsy showed microcystic tubular change, micro-glomeruli and marked mesangial proliferation.

• Journal of Genetic Medicine
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• v.19 no.2
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• pp.111-114
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• 2022

Many monogenic neurodevelopmental disorders have been newly identified in recent years owing to the rapid development of genetic sequencing technology. These include variants of the epigenetic machinery - up to 300 known epigenetic factors of which about 50 have been linked to specific clinical phenotypes. Chromodomain, helicase, DNA binding 1 (CHD1) is an ATP-dependent chromatin remodeler, known to be the causative gene of the autosomal dominant neurodevelopmental disorder Pilarowski-Bjornsson syndrome. Patients exhibit various degrees of global developmental delay, autism, speech apraxia, seizures, growth retardation, and craniofacial dysmorphism. We report the first case of Pilarowski-Bjornsson syndrome in Korea, due to a de novo missense variant of the CHD1 gene (c.862A>G, p.Thr288Ala) in a previously undiagnosed 17-year-old male. His infantile onset of severe global developmental delay, intellectual disability, speech apraxia, and failure to thrive are compatible with Pilarowski-Bjornsson syndrome. We also noted some features not previously reported in this syndrome such as skeletal dysplasia and ichthyosis. Further studies are needed to discover the specific phenotypes and pathogenic mechanisms behind this rare disorder.