• 한국진공학회:학술대회논문집
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• 한국진공학회 2014년도 제46회 동계 정기학술대회 초록집
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• pp.234.2-234.2
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• 2014

Organic light emitting diode (OLED) is considered as the next generation flat panel displays due to its advantages of low power consumption, fast response time, broad viewing angle and flexibility. For the flexible application, it is essential to develop thin film encapsulation (TFE) to protect oxidation of organic materials from oxidative species such as oxygen and water vapor [1]. In many TFE research, the inorganic film by atomic layer deposition (ALD) process demonstrated a good barrier property. However, extremely low throughput of ALD process is considered as a major weakness for industrial application. Recently, there has been developed a high throughput ALD, called 'spatial ALD' [2]. In spatial ALD, the precursors and reactant gases are supplied continuously in same chamber, but they are separated physically using a purge gas streams to prevent mixing of the precursors and reactant gases. In this study, the $Al_2O_3$ thin film was deposited by spatial ALD process. We characterized various process variables in the spatial ALD such as temperature, scanning speed, and chemical compositions. Water vapor transmission rate (WVTR) was determined by calcium resistance test and less than $10-^3g/m^2{\cdot}day$ was achieved. The samples were analyzed by x-ray photoelectron spectroscopy (XPS) and field emission scanning electron microscope (FE-SEM).

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
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• pp.172-172
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• 2012

Non-thermal plasma has attracted medical researchers, since they showed higher apoptosis rate in cancer cells than normal cells. However, it is hard to conclude general cancer cell specific effect because comparison between normal and cancer cell activities after plasma treatment have not been reported yet. This research proposes a comparison of Dielectric Barrier Discharge (DBD) plasma effect on three normal cells lines and three cancer cells lines. We measured cell number, mitochondria activity (MTS assay) and amount of hydrogen peroxide (H2O2) for three days. The results show that the number of cancer cells decreased more than normal cells following of exposure time. On the other hand, mitochondria activities and amounts of H2O2 increased following of exposure time. In addition, we found that DBD plasma exposure on cell suspension in media and media only illustrated no difference in mitochondria activity, H2O2 quantity, and cell number. Thus, we can confirm higher apoptosis rate in cancer cells which is related to the reactive oxygen species (ROS) generated by DBD plasma. The related molecular mechanisms were investigated further.

• Journal of Microbiology and Biotechnology
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• 제25권4호
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• pp.479-491
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• 2015

Lactobacillus species have been shown to enhance intestinal epithelial barrier function, modulate host immune responses, and suppress the growth of pathogenic bacteria, yeasts, molds, and viruses. Thus, lactobacilli have been used as probiotics for treating various diseases, including intestinal disorders, and as biological preservatives in the food and agricultural industries. However, the molecular mechanisms used by lactobacilli to suppress pathogenic bacterial infections have been poorly characterized. We previously isolated Lactobacillus plantarum JSA22 from buckwheat sokseongjang, a traditional Korean fermented soybean food, which possessed high enzymatic, fibrinolytic, and broad-spectrum antimicrobial activity against foodborne pathogens. In this study, we investigated the effects of L. plantarum JSA22 on the growth of S. Typhimurium and S. Typhimurium-induced cytotoxicity by stimulating the host immune response in intestinal epithelial cells. The results showed that coincubation of S. Typhimurium and L. plantarum JSA22 with intestinal epithelial cells suppressed S. Typhimurium infection, S. Typhimurium-induced NF-κB activation, and IL-8 production, and lowered the phosphorylation of both Akt and p38. These data indicated that L. plantarum JSA22 has probiotic properties, and can inhibit S. Typhimurium infection of intestinal epithelial cells. Our findings can be used to develop therapeutic and prophylactic agents against pathogenic bacteria.

• Bulletin of the Korean Chemical Society
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• 제30권12호
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• pp.2973-2978
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• 2009

The decomposition reaction mechanism of $CH_3CF_2O$ radical formed from hydroflurocarbon, $CH_3CHF_2$ (HFC-152a) in the atmosphere has been investigated using ab-initio quantum mechanical methods. The geometries of the reactant, products and transition states involved in the decomposition pathways have been optimized and characterized at DFT-B3LYP and MP2 levels of theories using 6-311++G(d,p) basis set. Calculations have been carried out to observe the effect of basis sets on the optimized geometries of species involved. Single point energy calculations have been performed at QCISD(T) and CCSD(T) level of theories. Out of the two prominent decomposition channels considered viz., C-C bond scission and F-elimination, C-C bond scission is found to be the dominant path involving a barrier height of 12.3 kcal/mol whereas the F-elimination path involves that of a 28.0 kcal/mol. Using transition-state theory, rate constant for the most dominant decomposition pathway viz., C-C bond scission is calculated at 298 K and found to be 1.3 ${\times}$ 10$^4s{-1}$. Transition states are searched on the potential energy surfaces involving both decomposition channels and each of the transition states are characterized. The existence of transition states on the corresponding potential energy surface are ascertained by performing Intrinsic Reaction Coordinate (IRC) calculation.

• Bulletin of the Korean Chemical Society
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• 제33권6호
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• pp.1934-1938
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• 2012

The reaction mechanism between cyclopropenylidene and formaldehyde has been systematically investigated employing the MP2/6-311+$G^*$ level of theory to better understand the cyclopropenylidene reactivity with carbonyl compound. Geometry optimization, vibrational analysis, and energy property for the involved stationary points on the potential energy surface have been calculated. Energies of all the species are further corrected by the CCSD(T)/6-311+$G^*$ single-point calculations. It was found that one important reaction intermediate (INTa) has been located firstly $via$ a transition state (TSa). After that, the common intermediate (INTb) for the two pathways (1) and (2) has been formed $via$ TSb. At last, two different products possessing three- and four-membered ring characters have been obtained through two possible reaction pathways. In the reaction pathway (1), a three-membered ring alkyne compound has been obtained. As for the reaction pathway (2), it is the formation of the four-membered ring conjugated diene compound. The energy barrier of the ratedetermining step of pathway (1) is lower than that of the pathway (2), and the ultima product of pathway (2) is more stable than that of the pathway (1).

• 한국조경학회지
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• 제23권2호
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• pp.205-212
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• 1995

The effects of noise attenuation among bare land, grassland, dominated broad-leaved (Quercus acutissima Carruth) and dominated coniferous forest (Pignus rigid Mill.) were studied For this study, the field experiment was carried out at playground, orchard grass, and school forest in Yeungnam University, Kyongsan. Sound levels of 500, 630, 800, 1,000, 1,250, 1,600, 2,000, 2,500 and 3,150 Hz, respectively, were projected into the vegetation, and the transmitted levels of sound were recorded at the distances of 1, 5, 10, 20, 30 and 50m, respectively, from the sound source. Both dominated coniferous forest (Pignus riged Mill.) and broad-leaved forest (Quercus acutissima Carruth ) are the more effective than grassland in the rates of attenuation. It is expected that dominated coniferous forest will be the more effective to attenuate sound love교 than dominated broad-leaved forest. In the low frequencies such as 500 and 630 Hz, grassland showed the more effective to attenuate sound levels than forests, while in the high frequency such as 3,150 Hz, the forests are the more effective to attenuate sound levels than grassland The present results suggested that it is the more effective to establish the tree belt for a sound barrier, with dominated coniferous tree species in the upper layer and herbaceous vegetation in the lower layer.

• Journal of Menopausal Medicine
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• 제23권3호
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• pp.139-145
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• 2017

Bacterial vaginosis (BV) and complicated vulvovaginal candidiasis (VVC) are frequently occurring vaginal infections in postmenopausal women, caused by an imbalance in vaginal microflora. Postmenopausal women suffer from decreased ovarian hormones estrogen and progesterone. A normal, healthy vaginal microflora mainly comprises Lactobacillus species (spp.), which act beneficially as a bacterial barrier in the vagina, interfering with uropathogens. During premenopausal period, estrogen promotes vaginal colonization by lactobacilli that metabolizing glycogen and producing lactic acid, and maintains intravaginal health by lowering the intravaginal pH level. A lower vaginal pH inhibits uropathogen growth, preventing vaginal infections. Decreased estrogen secretion in postmenopausal women depletes lactobacilli and increases intravaginal pH, resulting in increased vaginal colonization by harmful microorganisms (e.g., Enterobacter, Escherichia coli, Candida, and Gardnerella). Probiotics positively effects on vaginal microflora composition by promoting the proliferation of beneficial microorganisms, alters the intravaginal microbiota composition, prevents vaginal infections in postmenopausal. Probiotics also reduce the symptoms of vaginal infections (e.g., vaginal discharge, odor, etc.), and are thus helpful for the treatment and prevention of BV and VVC. In this review article, we provide information on the intravaginal mechanism of postmenopausal vaginal infections, and describes the effectiveness of probiotics in the treatment and prevention of BV and VVC.

• Nuclear Engineering and Technology
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• 제56권4호
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• pp.1385-1397
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• 2024

Bentonite is a recommended material for the multiple barriers in the final disposal of low-level radioactive waste (LLW) to prevent groundwater intrusion and nuclear species migration. However, after drying-wetting cycling during the repository construction stage and ion exchange with the concrete barrier in the long-term repository, the bentonite mechanical behaviors, including swelling capacity and hydraulic conductivity, would be further influenced by the groundwater intrusion, resulting in radioactive leakage. To comprehensively examine the factors on the mechanical characteristics of bentonite, this study presented scenarios involving MX-80 and KV-1 bentonites subjected to drying-wetting cycling and accelerated ion migration. The experiments subsequently measured free swelling, swelling pressure, and hydraulic conductivity of bentonites with intrusions of seawater, high pH, and low pH solutions. The results indicated that the solutions caused a reduction in swelling volume and pressure, and an increase in hydraulic conductivity. Specifically, the swelling capability of bentonite with drying-wetting cycling in the seawater decreased significantly by 60%, while hydraulic conductivity increased by more than three times. Therefore, the study suggested minimizing drying-wetting cycling and preventing seawater intrusion, ensuring a long service life of the multiple barriers in the LLW repository.

• 한국해양학회지
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• 제30권5호
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• pp.442-457
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• 1995

한국산 빗살거미불가사리 속의 3종, Ophiura kinbergi, O. sarsi 그리고 O, sarsi vadicola의 서식처를 파악하고, 남황해에 존재하는 생태적 장벽의 실체를 규명하기 위 하여 무기 환경요인을 이용한 서식처 지위에 관한 연구를 수행하였다. 이들의 분포를 지배하는 환경인자의 추출과정에서, 대상이 되어진 7가지 환경요소, 즉 수심, 저층 수 온, 저층 염분도, 밀도, 저층 용존산소량, 퇴적물의 평균 입도, 그리고 분급도 중 저 층 수온, 염분도 그리고 수심등이 서식처의 차이 규명에 유의한 설명력을 갖는 것으로 나타났다. 무기 환경 요소의 공간 위에서 이들 3종은 저층수의 수온와 염분도 그리고 수심 등에 대해 각기 다른 분포 범위의 폭을 나타내었다. O, sarsi vadicola를 중심으 로 한 서식처 지위의 분석에서, 우선 저층수의 염분도와 수온의 공간에서는 그 적정 서식처 범위(약 6~1$0^{\circ}C$, 31~33.5$\textperthousand$)가 황해 저층 냉수괴와 잘 일치하였으며, 수심에 대해서는 천해와 깊은 곳을 제외한 100~200m 범위에서 높은 존재 확률값이 나타났다. 한편, 본 연구에서 채집된 O. kinbergi와 O. sarsi는 O. sarsi vadicola의 적정 서식 처 범위밖에 서식하는 것으로 나타났으며, 황해산 O. sarsi vadicola의 분포 패턴에 관한 자료 분석의 결과로부터 이른바 황해에서의 저서성 무척추동물 분석의 남방 한계 선을 형성하는 생태적 장벽의 실체는 북위 33$^{\circ}$의 황해 남단에서 겨울철(12월)에 발생 하는 황해 난류(약 34$\textperthousand$<,18$^{\circ}C$)인 것으로 밝혀졌다.

• 한국해양생명과학회지
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• 제5권2호
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• pp.81-91
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• 2020

낙동강 하구 울타리섬 주변 갯벌에 서식하는 대형저서동물의 분포현황을 파악하기 위해 2016년과 2017년 5월에 신자도, 진우도, 을숙도에서 현장조사를 수행하였다. 조사 해역에서는 31~39종의 대형저서동물이 출현하였고, 서식밀도는 789~1,644 ind.m^-2의 범위를 보였다. 출현종수는 신자도에서 가장 높았으나, 서식밀도는 신자도에서 가장 낮았고, 진우도에서 높게 나타났다. 본 연구 해역에서 출현한 대형저서동물의 주요 우점종은 갑각류의 Gammaridae unid., 다모류의 Scoletoma heteropoda, Scoloplos armiger, Heteromastus filiformis, Prionospio japonica, 연체동물의 댕가리(Batillaria cumingii), Laternula marilina 등이었다. 세 지역 모두 갯벌의 상부지역에서는 갑각류와 연체동물의 비중이 높았고, 하부로 갈수록 다모류의 비중이 다소 증가하는 경향을 보였다. 전체적으로 육식자의 비중이 높게 나타났으나, 니질 퇴적물의 함량이 높은 지역에서는 퇴적물 안정화에 기여하는 tube-builder가 속한 표층 퇴적물 식자의 비중이 다소 높게 나타났다. 낙동강 하구 모래갯벌의 대형저서생물상은 국내 다른 하구 모래갯벌이나 조간대 모래갯벌의 생물상과 유사한 종조성과 분포양상을 보였다.