• Toxicological Research
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• 제30권3호
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• pp.141-148
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• 2014

Endothelium-derived relaxing factors (EDRFs), including nitric oxide (NO), prostacyclin ($PGI_2$), and endothelium-derived hyperpolarizing factor (EDHF), play pivotal roles in regulating vascular tone. Reduced EDRFs cause impaired endothelium-dependent vasorelaxation, or endothelial dysfunction. Impaired endothelium-dependent vasorelaxation in response to acetylcholine (ACh) is consistently observed in conduit vessels in human patients and experimental animal models of hypertension. Because small resistance arteries are known to produce more than one type of EDRF, the mechanism(s) mediating endothelium-dependent vasorelaxation in small resistance arteries may be different from that observed in conduit vessels under hypertensive conditions, where vasorelaxation is mainly dependent on NO. EDHF has been described as one of the principal mediators of endothelium-dependent vasorelaxation in small resistance arteries in normotensive animals. Furthermore, EDHF appears to become the predominant endothelium-dependent vasorelaxation pathway when the endothelial NO synthase (NOS3)/NO pathway is absent, as in NOS3-knockout mice, whereas some studies have shown that the EDHF pathway is dysfunctional in experimental models of hypertension. This article reviews our current knowledge regarding EDRFs in small arteries under normotensive and hypertensive conditions.

• Archives of Pharmacal Research
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• 제6권2호
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• pp.109-114
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• 1983

A mechanism of taurine transfer across the rat small intestine was elucidated by using the in situ recirculation perfusion or loop method. Taurine uptake was saturable, Km= 39.9 mM, and energy dependent, and required sodium. The close structural analogues, aminomethane sulfonic acid, .gamma.-amino-butyric acid, hypotaurine, and .betha.-alanine, reduced significantly taurine uptake when present in 10-fold excess. The .alpha.-amino acid, glycine, did not inhibit uptake. Hence, all of these findings lead to a conclusion that a carrier-mediated transport system for taurine exists in the small intestine.

• Structural Engineering and Mechanics
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• 제70권4호
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• pp.407-420
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• 2019

In the present work, an attempt is made to explore the effects of shear in-plane preload on the wave propagation response of small-scale plates containing nanofibers. The small-scale system is assumed to be embedded in an elastic matrix. The nonlocal elasticity is utilized in order to develop a size-dependent model of plates. The proposed plate model is able to describe both nanofiber effects and the influences of being at small-scales on the wave propagation response. The size-dependent differential equations are derived for motions along all directions. The size-dependent coupled equations are solved analytically to obtain the phase and group velocities of the small-scale plate under a shear in-plane preload. The effects of this shear preload in conjunction with nanofiber and size effects as well as the influences of the elastic matrix on the wave propagation response are analyzed in detail.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2006년도 추계학술대회 논문집
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• pp.7-10
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• 2006

In this study, Curve dependent wheel flange lubricator with spray type is investigated and estimated a point of view reducing wheel flange wear and noise, a small crack in the curve. Advantage of curve dependent wheel flange lubricator spray type is found on the basis of the result of field test in comparison with oil spray type lubricator and wheel without wheel flange lubricator on railroad in korea for noise and wheel abraison. the influence of curve dependent wheel flange lubricator spray type on the small crack of wheel is introduced by research papers

• Journal of the Korean Data and Information Science Society
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• 제24권4호
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• pp.877-883
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• 2013

The quadratic inference functions (QIF) method proposed by Qu et al. (2000) and the generalized method of moments (GMM) for marginal regression analysis of longitudinal data with time-dependent covariates proposed by Lai and Small (2007) both are the methods based on generalized method of moment (GMM) introduced by Hansen (1982) and both use generalized estimating equations (GEE). Lai and Small (2007) divided time-dependent covariates into three types such as: Type I, Type II and Type III. In this paper, we compared these methods in the case of Type II and Type III in which full covariates conditional mean assumption (FCCM) is violated and interested in whether they can improve the results of GEE with independence working correlation. We show that in the marginal regression model with Type II time-dependent covariates, GMM Type II of Lai and Small (2007) provides more ecient result than QIF and for the Type III time-dependent covariates, QIF with independence working correlation and GMM Type III methods provide the same results. Our simulation study showed the same results.

• 한국멀티미디어학회논문지
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• 제24권3호
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• pp.468-480
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• 2021

Realistic real-time rain streaks rendering has been treated as a very difficult problem because of various natural phenomena. Also, in creating and managing a large number of particles, a large amount of computer resources had to be used. Therefore, in this paper, we propose a more efficient real-time rain streaks rendering algorithm by generating view-dependent rain particles and expressing a large amount of rain even with a small number. By creating a 'rain space' dependent on the field of view of the camera moving in real time, particles are rendered only in that space. Accordingly, even if a small number of particles are rendered, since the rendering is performed in a limited space, an effect of rendering a very large amount of particles can be obtained. This enables very efficient real-time rendering of rain streaks.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2005년도 학술발표회 논문집
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• pp.461-468
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• 2005

In this paper, mixed mode magneto-rheological (MR) damper, which is applicable for vibration control of a small scale multi-story structure, is devised. First, the schematic configurations of the shear, flow, and mixed mode MR dampers are described with design constraints and then the analytical models to predict the field-dependent damping forces are derived for each type. Second, an appropriate size of the mixed mode MR damper is manufactured and its field-dependent damping characteristics are evaluated in time domain. Finally, the performance of the manufactured MR damper which is semi-actively applied to a small scale building excited by earthquake load, is numerically evaluated.

• Journal of Advanced Marine Engineering and Technology
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• 제26권1호
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• pp.76-82
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• 2002

In this study, the rotary bending fatigue test was carried out with low carbon steel(SM25C). The specimens were heat-treated in order to change the grain size, and investigated items are fatigue limit, small crack initiation, fatigue crack propagation behavior and possibility of fatigue life prediction according to the different grain size. The summarized result are as follows ; Fatigue limit of the smooth specimen was dependent upon the grain size. The fatigue crack initiation of the small grain size specimen was delayed more than that of the large grain size specimen. And the small cracks of small grain size specimen were distributed in the narrow region of the main crack circumference contrary to the large grain size specimen. The main crack was grown along the grain boundary having co-alliance with small cracks. The experiment material has quantitatively disclosed the possibility of fatigue life prediction because the fatigue crack propagation behavior is dependent upon the grain size.

• Advances in nano research
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• 제13권3호
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• pp.297-312
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• 2022

Coughing and breath shortness are common symptoms of nano (small) cell lung cancer. Smoking is main factor in causing such cancers. The cancer cells form on the soft tissues of lung. Deformation behavior and wave vibration of lung affected when cancer cells exist. Therefore, in the current work, phase velocity behavior of the small cell lung cancer as a main part of the body via an exact size-dependent theory is presented. Regarding this problem, displacement fields of small cell lung cancer are obtained using first-order shear deformation theory with five parameters. Besides, the size-dependent small cell lung cancer is modeled via nonlocal stress/strain gradient theory (NSGT). An analytical method is applied for solving the governing equations of the small cell lung cancer structure. The novelty of the current study is the consideration of the five-parameter of displacement for curved panel, and porosity as well as NSGT are employed and solved using the analytical method. For more verification, the outcomes of this reports are compared with the predictions of deep neural network (DNN) with adaptive optimization method. A thorough parametric investigation is conducted on the effect of NSGT parameters, porosity and geometry on the phase velocity behavior of the small cell lung cancer structure.

• Advances in materials Research
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• 제7권1호
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• pp.1-16
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• 2018

Thermal bifurcation buckling behavior of fully clamped Euler-Bernoulli nanobeam built of a through thickness functionally graded material is explored for the first time in the present paper. The variation of material properties of the FG nanobeam are graded along the thickness by a power-law form. Temperature dependency of the material constituents is also taken into consideration. Eringen's nonlocal elasticity model is employed to define the small-scale effects and long-range connections between the particles. The stability equations of the thermally induced FG nanobeam are derived via the principal of the minimum total potential energy and solved analytically for clamped boundary conditions, which lead for more accurate results. Moreover, the obtained buckling loads of FG nanobeam are validated with those existing works. Parametric studies are performed to examine the influences of various parameters such as power-law exponent, small scale effects and beam thickness on the critical thermal buckling load of the temperature-dependent FG nanobeams.