• 전자공학회논문지C
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• 제36C권4호
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• pp.31-43
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• 1999

본 논문의 주요 목표는 고성능 SVP(Stack-based Video Processor)를 설계하는 것이다. SVP는 과거에 제안된 스택 머신과 영상 프로세서의 최적의 측면만을 선택함으로써 더 좋은 구조를 갖도록 하는 포괄적인 구조이다. 본 구조는 객체 지향형 프로그램의 소규모의 많은 서브루틴을 가지고 있기 때문에 스택 버퍼를 갖는 준범용 S-RISC(Stack-based Reduced Instruction Set Comuter)를 이용하여 객체 지향형 영상 데이터를 처리한다. 그리고 MPEG-4의 반화소 단위 처리와 고급 모드 움직임 보상, 움직임 예측, SA-DCT(Shape Adaptive-Discrete Cosine Transform)가 가능하며, 절대값기, 반감기를 가지고 있어서 부호화하기로 확장할 수 있도록 하였다. SVP는 0.6㎛ 3-메탈 계층 CMOS 표준 셀 기준을 이용하여 설계되었으며, 110K 로직 게이트와 12Kbit SRAM 내부 버퍼로 이루어지고 50 MHz의 동작 속도를 가진다 . MPEG-4의 VLBL(Very Low Bitrate Video) 최대 전송율인 QCIF 15fps(frame per second)로 영상 재생 알고리즘을 수행한다.

• Genomics & Informatics
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• 제12권4호
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• pp.181-186
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• 2014

Genome-wide association studies have proven the highly polygenic architecture of complex diseases or traits; therefore, single-locus-based methods are usually unable to detect all involved loci, especially when individual loci exert small effects. Moreover, the majority of associated single-nucleotide polymorphisms resides in non-coding regions, making it difficult to understand their phenotypic contribution. In this work, we studied epistatic interactions associated with three common diseases using Korea Association Resource (KARE) data: type 2 diabetes mellitus (DM), hypertension (HT), and coronary artery disease (CAD). We showed that epistatic single-nucleotide polymorphisms (SNPs) were enriched in enhancers, as well as in DNase I footprints (the Encyclopedia of DNA Elements [ENCODE] Project Consortium 2012), which suggested that the disruption of the regulatory regions where transcription factors bind may be involved in the disease mechanism. Accordingly, to identify the genes affected by the SNPs, we employed whole-genome multiple-cell-type enhancer data which discovered using DNase I profiles and Cap Analysis Gene Expression (CAGE). Assigned genes were significantly enriched in known disease associated gene sets, which were explored based on the literature, suggesting that this approach is useful for detecting relevant affected genes. In our knowledge-based epistatic network, the three diseases share many associated genes and are also closely related with each other through many epistatic interactions. These findings elucidate the genetic basis of the close relationship between DM, HT, and CAD.

• 한국컴퓨터그래픽스학회논문지
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• 제28권2호
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• pp.11-19
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• 2022

최근 의료영상의 발전에 따라 의료 영상 생성에 대한 다양한 연구가 제안되고 있는데, 이와 관련하여 생성된 의료 영상의 품질과 다양성을 정확하게 평가하는 것이 중요해지고 있다. 생성된 의료 영상을 평가하는 방법으로는 전문가의 시각적 튜링 테스트(visual turing test), 특징 분포 시각화, IS, FID를 통한 정량적 평가를 통해 평가하고 있으나 의료 영상을 품질(fidelity)과 다양성(diversity) 측면에서 정량적으로 평가 하는 방법은 거의 이루어지고 있지 않다. 본 논문에서는 DCGAN과 PGGAN 생성 모델을 통해 비소세포폐암 환자의 흉부 CT 데이터 셋을 학습하여 영상을 생성하고, 이를 품질(fidelity)과 다양성(diversity) 측면에서 두 생성 모델의 성능을 평가한다. 1차원 점수 기반 평가방법인 IS, FID와 2차원 점수 기반 평가방법인 Precision 및 Recall, 개선된 Precision 및 Recall을 통해 성능을 정량적으로 평가하고, 의료영상에서의 각 평가방법들의 특징과 한계점에 대해서도 분석한다.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2022년도 가을 학술논문 발표대회
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• pp.243-244
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• 2022

In this paper, experiments were conducted on signal amplification of polymer capsules for application to Ground Penetrating Radar so as to enable real-time monitoring of polymer capsules inside concrete using the Morphology Dependent Resonance phenomenon. A TEM CELL and a vector network analyzer were used to analyze the difference in resonance frequency depending on the material of the sphere and the presence or absence of fracture. In order to manufacture a capsule of a size that can be measured using millimeter waves used in GPR, we manufactured a capsule with a 3D printer and analyzed the effects of the presence or absence of coating and the size of the capsule on the resonance frequency. Resonant frequency or signal amplification is more affected by diameter than coating. The capsule showing the highest amplification is the resin-coated 50 mm diameter capsule with a 316-fold increase and the lowest capsule is the uncoated 10 mm diameter capsule with a signal amplification of 11.9 times. These results demonstrate the potential of GPR to measure the position and state of self-healing capsules, which are small-sized polymers, in real time using millimeter waves.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2011년도 추계학술발표대회
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• pp.7-7
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• 2011

Quantum beam technology has been expected to develop breakthroughs for nanotechnology during the third basic plan of science and technology (2006~2010). Recently, Green- or Life Innovations has taken over the national interests in the fourth basic science and technology plan (2011~2015). The NIMS (National Institute for Materials Science) has been conducting the corresponding mid-term research plans, as well as other national projects, such as nano-Green project (Global Research for Environment and Energy based on Nanomaterials science). In this lecture, the research trends in Japan and NIMS are firstly reviewed, and the typical achievements are highlighted over key nanotechnology fields. As one of the key nanotechnologies, the quantum beam research in NIMS focused on synchrotron radiation, neutron beams and ion/atom beams, having complementary attributes. The facilities used are SPring-8, nuclear reactor JRR-3, pulsed neutron source J-PARC and ion-laser-combined beams as well as excited atomic beams. Materials studied are typically fuel cell materials, superconducting/magnetic/multi-ferroic materials, quasicrystals, thermoelectric materials, precipitation-hardened steels, nanoparticle-dispersed materials. Here, we introduce a few topics of neutron scattering and ion beam nanofabrication. For neutron powder diffraction, the NIMS has developed multi-purpose pattern fitting software, post RIETAN2000. An ionic conductor, doped Pr2NiO4, which is a candidate for fuel-cell material, was analyzed by neutron powder diffraction with the software developed. The nuclear-density distribution derived revealed the two-dimensional network of the diffusion paths of oxygen ions at high temperatures. Using the high sensitivity of neutron beams for light elements, hydrogen states in a precipitation-strengthened steel were successfully evaluated. The small-angle neutron scattering (SANS) demonstrated the sensitive detection of hydrogen atoms trapped at the interfaces of nano-sized NbC. This result provides evidence for hydrogen embrittlement due to trapped hydrogen at precipitates. The ion beam technology can give novel functionality on a nano-scale and is targeting applications in plasmonics, ultra-fast optical communications, high-density recording and bio-patterning. The technologies developed are an ion-and-laser combined irradiation method for spatial control of nanoparticles, and a nano-masked ion irradiation method for patterning. Furthermore, we succeeded in implanting a wide-area nanopattern using nano-masks of anodic porous alumina. The patterning of ion implantation will be further applied for controlling protein adhesivity of biopolymers. It has thus been demonstrated that the quantum beam-based nanotechnology will lead the innovations both for nano-characterization and nano-fabrication.

• 한국정보전자통신기술학회논문지
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• 제11권6호
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• pp.638-644
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• 2018

최근 5G에 기술에서는 신호 감쇄와 신호 도달 거리 확장을 위해 사용될 수 있는 릴레이(Relay)를 통한 통신 기술이 주목 받고 있다. 릴레이는 소형 기지국으로 사용이 가능하며, 셀룰러 망으로 지원하기 어려운 환경하에서 통신 기기들이 협력하여 통신하는 자율 네트워크 기법에 사용이 가능하기 때문에, 저전력화와 무선 용량 증대에 활용이 가능할 것으로 기대되고 있다. 한정된 릴레이 자원을 활용하여 최적의 성능을 달성하기 위해서는 효과적인 릴레이 선택 기법이 필요하다. 특히, 두 개의 노드가 릴레이를 통해 메시지를 교환하는 경우, 릴레이 선택 방법에 따라서, 릴레이의 공간적 위치를 활용하여 간섭을 줄이고, 시스템 전송률을 최대화 할 수 있다. 이를 위해서는 릴레이 선택에 따른 평균 데이터 전송률에 대한 분석이 선행되어야 한다. 본 논문은 두 노드가 릴레이를 이용하여 동시 전송을 통해 메시지를 교환할 경우, 평균 데이터 전송률을 분석한다. 이를 위해 Nakagami-m 페이딩 채널 환경하에서 복호 후 전송(Decode and Forward) 방식으로 동작하는 이중홉(dual-hop) 릴레이의 동시 전송으로 인한 간섭을 고려하여 전체 데이터 전송률을 유도한다. 분석식은 m=1인 Rayleigh 페이딩 채널을 포함하여 다양한 Nakagami-m 페이딩 채널에 대한 전체 데이터 전송률을 보여준다. 유도된 분석은 몬테카를로 모의실험을 통해 정확성을 입증하였으며, 요구되는 데이터 전송률이 높을수록, 자원 효율적인 동시 전송 방식이 전체 시스템의 성능을 향상시킬 수 있음을 확인하였다.

• IMMUNE NETWORK
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• 제22권2호
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• pp.16.1-16.20
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• 2022

The gastrointestinal tract is the first organ directly affected by fasting. However, little is known about how fasting influences the intestinal immune system. Intestinal dendritic cells (DCs) capture antigens, migrate to secondary lymphoid organs, and provoke adaptive immune responses. We evaluated the changes of intestinal DCs in mice with short-term fasting and their effects on protective immunity against Listeria monocytogenes (LM). Fasting induced an increased number of CD103⁺CD11b^- DCs in both small intestinal lamina propria (SILP) and mesenteric lymph nodes (mLN). The SILP CD103⁺CD11b^- DCs showed proliferation and migration, coincident with increased levels of GM-CSF and C-C chemokine receptor type 7, respectively. At 24 h post-infection with LM, there was a significant reduction in the bacterial burden in the spleen, liver, and mLN of the short-term-fasted mice compared to those fed ad libitum. Also, short-term-fasted mice showed increased survival after LM infection compared with ad libitum-fed mice. It could be that significantly high TGF-β2 and Aldh1a2 expression in CD103⁺CD11b^- DCs in mice infected with LM might affect to increase of Foxp3⁺ regulatory T cells. Changes of major subset of DCs from CD103⁺ to CD103^- may induce the increase of IFN-γ-producing cells with forming Th1-biased environment. Therefore, the short-term fasting affects protection against LM infection by changing major subset of intestinal DCs from tolerogenic to Th1 immunogenic.