• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10847-10853
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• 2015

Background: Lapatinib, a dual tyrosine kinase inhibitor that interrupts the epidermal growth factor receptor (EGFR) and HER2/neu pathways, has been indicated to have significant efficacy in treating HER2-positive breast cancer. However, acquired drug resistance has become a very serious clinical problem that hampers the use of this agent. In this study, we aimed to screen small molecule drugs that might reverse lapatinib-resistance of breast cancer by exploring differentially expressed genes (DEGs) via a bioinformatics method. Materials and Methods: We downloaded the gene expression profile of BT474-J4 (acquired lapatinib-resistant) and BT474 (lapatinib-sensitive) cell lines from the Gene Expression Omnibus (GEO) database and selected differentially expressed genes (DEGs) using dChip software. Then, gene ontology and pathway enrichment analyses were performed with the DAVID database. Finally, a connectivity map was utilized for predicting potential chemicals that reverse lapatinib-resistance. Results: A total of 1, 657 DEGs were obtained. These DEGs were enriched in 10 pathways, including cell cycling, regulation of actin cytoskeleton and focal adhesion associate examples. In addition, several small molecules were screened as the potential therapeutic agents capable of overcoming lapatinib-resistance. Conclusions: The results of our analysis provided a novel strategy for investigating the mechanism of lapatinib-resistance and identifying potential small molecule drugs for breast cancer treatment.

• 복식문화연구
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• 제8권2호
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• pp.282-292
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• 2000

The purpose of this study is to provide for some basic data useful to the development of the brassieres comfortable and more suitable for obese women. The results of this study can be summarized as follows ; 1. Obese women were categorized using Rohrer index into three groups, and thereupon, their breast forms were analyzed. As a result, it was found that group 1 and 2 had similar small breasts, while group 3 had the largest size of breasts. 2. The forms of obese women's breast split, protrusion and volume, factors related with breast area and drooping, factor affecting the breast protrusion and factor defining the lower form of breast. 3. The actual breast types of obese women could be classified into cone type, protrusion type, drooping type Ⅰ and Ⅱ. The more obese a woman was, her breast tended more to droop.

• Archives of Plastic Surgery
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• 제39권5호
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• pp.489-496
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• 2012

Background In Korean women, many of whom have small to moderate-sized breasts, it is difficult to cover a partial breast defect using oncoplastic volume displacement techniques after removal of an adequate volume of tissue during oncologic surgery. In such cases, oncoplastic volume replacement techniques are more useful. Methods From January 2007 to December 2011, 104 women underwent a total of 107 breast-conserving surgeries with various kinds of oncoplastic volume replacement techniques. We used latissimus dorsi (LD) myocutaneous flap for cases in which the resection mass was greater than 150 g. In case with a resection mass less than 150 g, we used regional flaps such as a lateral thoracodorsal flap, a thoracoepigastric flap, or perforator flaps such as an intercostal artery perforator (ICAP) flap or a thoracodorsal artery perforator (TDAP) flap. Results The mean age was 46.1 years, and the average follow-up interval was 10.3 months. The patients underwent oncoplastic volume replacement techniques with a lateral thoracodorsal flap (n=9), thoracoepigastric flap (n=7), ICAP flap (n=25), TDAP flap (n=12), and LD flap (n=54). There was one case of congestion in an LD flap, and two cases of fat necrosis in an ICAP flap. Most of the patients were satisfied with the cosmetic results. Conclusions Oncoplastic volume replacement techniques can be reliable and useful for the correction of breast deformity after breast-conserving surgery, especially in patients with small to moderate-sized breasts.

• 대한가정학회지
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• 제41권6호
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• pp.119-129
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• 2003

This study was peformed to establish the standard size system to be required for the production of brassiere. The subject were 155 Korean twenties-aged women and were directly measured anthropometrically. From 27 measurements, 5 factors were extracted through factor analysis. The accumulative contribution ratio is 76.92％. Factor 1 indicates the degree of obesity around the chest, factor 2 is the drooping degree of breast, factor 3 is the contours and prominence, factor 4 is the breast breadth and breadth of bust point, factors 5 is the volume of breast. The subject were classified into 3 cluster as their breast types through cluster analysis. Type 1 is the closest to the ideal breast shape and not too droopy. This group belonged to 75A. Type 2 has small breast and belonged to 70AA group. Type 3 is the obesest and has the biggest and droopy breast. This group belonged to 75B. The distribution of size of brassiere had 3 sections from 70 to 80 showing a rate of 81.94% and the sin of the cup had 4 sections from AAA cup to B cup showing a rate of 89.70％. The production ratio of each brassiere size, it was found that the brassiere size of highest production ratio was 75A(16.39％) in type 1,70AA(16.27%) in type 2, and 75B(13.72％) in type 3. This suggests that it is necessary to adjust for the production rate of brassieres.

• Asian-Australasian Journal of Animal Sciences
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• 제28권12호
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• pp.1760-1766
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• 2015

This study investigated the proximate composition and $\small{L}$-carnitine and betaine content of meats from 5 lines of Korean indigenous chicken (KIC) for developing highly nutritious meat breeds with health benefits from the bioactive compounds such as $\small{L}$-carnitine and betaine in meat. In addition, the relevance of gender (male and female) and meat type (breast and thigh meat) was examined. A total of 595 F1 progeny (black [B], grey-brown [G], red-brown [R], white [W], and yellow-brown [Y]) from 70 full-sib families were used. The moisture, protein, fat, and ash contents of the meats were significantly affected by line, gender, and meat type (p<0.05). The males in line G and females in line B showed the highest protein and the lowest fat content of the meats. $\small{L}$-carnitine and betaine content showed effects of meat type, line, and gender (p<0.05). The highest $\small{L}$-carnitine content was found in breast and thigh meats from line Y in both genders. The breast meat from line G and the thigh meat from line R had the highest betaine content in males. The female breast and thigh meats showed the highest betaine content in line R. These data could be valuable for establishing selection strategies for developing highly nutritious chicken meat breeds in Korea.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.445-453
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• 2016

Epidermal growth factor receptors (EGFRs/HERs) and downstream signaling pathways have been implicated in the pathogenesis of several malignancies including breast cancer and its resistance to treatment with chemotherapeutic drugs. Consequently, several monoclonal antibodies as well as small molecule inhibitors targeting these pathways have emerged as therapeutic tools in the recent past. However, studies have shown that utilizing these molecules in combination with chemotherapy has yielded only limited success. This review describes the current understanding of EGFRs/HERs and associated signaling pathways in relation to development of breast cancer and responses to various cancer treatments in the hope of pointing to improved prevention, diagnosis and treatment. Also, we review the role of breast cancer stem cells (BCSCs) in disease and the potential to target these cells.

• Korean Journal of Radiology
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• 제25권2호
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• pp.134-145
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• 2024

Abnormalities on breast ultrasound (US) images which do not meet the criteria for masses are referred to as nonmass lesions. These features and outcomes have been investigated in several studies conducted by Asian researchers. However, the term "nonmass" is not included in the American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) 5th edition for US. According to the Japan Association of Breast and Thyroid Sonology guidelines, breast lesions are divided into mass and nonmass. US findings of nonmass abnormalities are classified into five subtypes: abnormalities of the ducts, hypoechoic areas in the mammary glands, architectural distortion, multiple small cysts, and echogenic foci without a hypoechoic area. These findings can be benign or malignant; however, focal or segmental distributions and presence of calcifications suggest malignancy. Intraductal, invasive ductal, and lobular carcinomas can present as nonmass abnormalities. For the nonmass concept to be included in the next BI-RADS and be widely accepted in clinical practice, standardized terminologies, an interpretation algorithm, and outcome-based evidence are required for both screening and diagnostic US.

• 한국의류학회지
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• 제19권6호
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• pp.995-1007
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• 1995

The purpose of this study is to examine on breast shapes of elderly women and provide fundamental data for developing brassiere. Numerous anthropometric measurements and other related data from 398 subjects were analyzed by various statistical methods such as ANOVA, Correlation analysis, Factor analysis and Cluster analysis. 1. Analysis of Breast Measurements The subjects were categorized into three groups(Group I; aged 55 to 64, Group II; aged 65 to 74, Group III; aged more than 75). 1) The results of the comparative analysis of anthropometric data from three groups show that by getting older: - $\circled1$ Breast lengths, widths, heights and bust girths are decreased significantly $\circled2$ Various length measurements related to the drooping degree of breast are increased $\circled3$ Some measurements related to the volume of breast are decreased. 2) The results of the correlation analysis among measurement show that there are no directs linear relationships between under bust girth and bust drooping. Further it turned out that the cup size could be used as a factor explaining the volume of breast due to large subject variation, Thus it is required to have more specific information about the breast volume. 2. Analysis of Breast Shapes 1) From 17 measurements, 5 factor were selected as key factors for the factor analysis of breast analysis of breast shapes. The 5 factors are: $\circled1$ Drooping degree of breast $\circled2$ slope between breast and chest, width of bust point $\circled3$ Contours and prominence of breast at the point of front and side $\circled4$ Breast volume $\circled5$ Breast width. 2) We categorized the breast shapes into three types by Cluster analysis. Type 1 is the most common breast shape in elderly women. $\circled1$ Type L: Not too droopy and large breast $\circled2$ Type 2: A little droopy and small breast $\circled3$ Type 3; Very droopy and wide breast

• 디지털융복합연구
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• 제19권10호
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• pp.491-500
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• 2021

유방암 환자의 제 특성을 파악하여, 유방암 조기 검진의 중요성과 젊은 유방암의 심각성을 알리기 위해 시행하였다. 2010년 5월 1일부터 2020년 4월 30일까지(10년간) 일 유방 클리닉에 내원한 환자 23,200명 중 유방암으로 진단받은 483명의 의무기록을 이용한 후향적 조사연구이다. 유방암으로 진단받은 483명의 나이는 40대(36.0%)가 가장 많았으며, 30대(25.9%)가 다음으로 많았다. 유방암 가족력이 있는 경우가 5.4%, 폐경 상태는 29.2%였으며, 내원 동기로는 종괴가 54.2%로 가장 많았고, 유방 검진 경험은 출산 경험자가 비출산자보다 많았으며, 20-30대에서 유방검사 경험이 가장 적었다. 젊은 여성을 대상으로 유방암 검진의 중요성을 교육할 필요가 있으며, 유방암의 국가암검진 연령에 대한 재검토를 제언한다.

• BMB Reports
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• 제52권2호
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• pp.113-118
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• 2019

The small ubiquitin-related modification molecule (SUMO), one of the post-translational modification molecules, is involved in a variety of cellular functions where it regulates protein activity and stability, transcription, and cell cycling. Modulation of protein SUMOylation or deSUMOylation modification has been associated with regulation of carcinogenesis in breast cancer. In the dynamic processes of SUMOylation and deSUMOylation in a variety of cancers, SUMO proteases (SENPs), reverse SUMOylation by isopeptidase activity and SENPs are mostly elevated, and are related to poor patient prognosis. Although underlying mechanisms have been suggested for how SENPs participate in breast cancer tumorigenesis, such as through regulation of target protein transactivation, cancer cell survival, cell cycle, or other post-translational modification-related machinery recruitment, the effect of SENP isoform-specific inhibitors on the progression of breast cancer have not been well evaluated. This review will introduce the functions of SENP1 and SENP2 and the underlying signaling pathways in breast cancer for use in discovery of new biomarkers for diagnosis or therapeutic targets for treatment.