• The Korean Journal of Physiology and Pharmacology
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• v.2 no.3
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• pp.323-330
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• 1998

Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines. Many of them, especially with 6,7-disubstitution, demonstrate a relatively high affinity for catecholamines. Present study examines the pharmacological action of limited series of THI, using rats' isolated atria and aorta. In addition, a $[^3H]$ prazosin displacement binding study with THI compounds was performed, using rat brain homogenates to investigate whether these probes have ?${\alpha}$-adrenoceptor affinity. We also compared the vascular relaxation potency of these probes with dobutamine. YS 49, YS 51, higenamine and dobutamine, concentration-dependently, relaxed endothelium-denuded rat thoracic aorta precontracted with phenylephrine (PE, 0.1 ${\mu}M$) in which $pEC_{50}$ were $5.56{\pm}0.32$ and $5.55{\pm}0.21$, $5.99{\pm}1.16$ and $5.57{\pm}0.34$, respectively. These probes except higenamine also relaxed KCl (65.4 mM)-contracted aorta. In isolated rat atria, all THIs and dobutamine increased heart rate and contractile force. In the presence of propranolol, the concentration response curves of YS 49 and YS 51 shifted to the right and resulted in $pA_2$ values of $8.07{\pm}0.84$ and $7.93{\pm}0.11$, respectively. The slope of each compound was not deviated from unity, indicating that these chemicals are highly competitive at the cardiac ?${\beta}-adrenoceptors$. YS 49, YS 51, and higenamine showed ?${\alpha)-adrenoceptor$ affinity in rat brain, in which the dissociation constant $(K_i)$ was 2.75, 2.81, and 1.02 ${\mu}M$, respectively. It is concluded, therefore, that THI alkaloids have weak affinity to ${\alpha)_1-adrenoceptor$ in rat aorta and brain, respectively, while these probes show relatively high affinity for cardiac ${\beta}-adrenoceptors$. Thus, these chemicals may be useful in the treatment of congestive heart failure.

• Journal of Korean Society of Forest Science
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• v.78 no.2
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• pp.228-241
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• 1989

The objectives of this study are to identify flood disasters resulted from heavy rainstorm including earth and stone-debris avalanches and also to develope the scientific data to be needed for establishing the landslide-related disaster prevention countermeasures. For this study, 5 Gun (district) regions including Booyeo, Seochun, Gongju, Boryung, and Chungyang in Chungchongnam-do of the central part of Korea, in which severe landslide damages have been triggered during 3 days from July 21 to July 23, 1987, were investigated. Mostly, landslides having death of human lives triggered from 6 a.m, to 8 a,m. on July 22, and the principal factor was proved to be the continuous heavy rain ; the continuous rainfall of internal region for 3 days measured about 300-673 mm. The structural measures for slope failure prevention countermeasures at the hollow part of upper hillslope should be required. Natural drainage network on slopes should not be disturbed in case of land use alteration, such as a chestnut planting work on hillslopes behind the houses particularly. There are so many problems in recognition of landslide disaster prevention countermeasures including evacuation exercises. More actual education of countermeasures for control of flood and landslide should be put to practice through "civil defense education" and "inhabitants' meeting." In this context, existing Erosion Control Stations of 13 regions established in each Province should not be reduced. The designation criterion and surveying processes of "Landslide Prone Site" published by Forest Administration should also be improved scientifically.

• Journal of the Korean Geotechnical Society
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• v.33 no.5
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• pp.5-13
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• 2017

The sand layer deposited in clay is called a sand seam, which is formed by inflow of sands due to river flooding or slope failure in the middle of sinking and sediment of clay. When the sand seam exists in clay layer, the drainage direction changes from one way to both ways, and the time of consolidation may be reduced. However, it is not clearly proved due to lack of studies of sand seam and currently is not reflected in the design of soft soil improvement. As a fundamental study about sand seam, the oedometer tests and constant rate of strain tests with Rowe cell were conducted on clay specimens with sand seam. For tests, a frozen method was specially designed for making the sand seam. It was concluded that the test results showed the sand seam affects the coefficient of consolidation of clay. If the thickness of sand seam exceeds 0.05 times of specimen height, the sand seam works as drainage layer of pore water horizontally as well as vertically, and consequently the consolidation is accelerated.

• Journal of the Korean GEO-environmental Society
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• v.19 no.12
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• pp.41-46
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• 2018

The wireless sensor network system has the advantage of confirming the behavior of the entire facility by improving the disadvantages of conventional monitoring system. As a result, it is widely proposed as safety diagnosis and measurement of structures, water management systems, and management systems for dam structures. However, there is a lack of research that can evaluate the condition of facilities such as safety at the same time as monitoring. In this study, it is proposed a wireless sensor network system which can evaluate the behavior characteristics of facilities and evaluate the safety status for improving the technical disadvantages on conventional monitoring system. The geotechnical risk factors for the reservoir dam facility were evaluated and the limit values for the risk factors causing the failure of the facility were set. In other words, the system was set up so that the risk factors can be measured and the limit status can be evaluated immediately for each factor. In this study, numerical analysis is carried out for seepage and slope stability analysis using the typical cross section for reservoir dams. The stress-porewater coupling finite difference numerical analysis is performed for establishing the limit displacement for reservoir dam structures. It is developed a system that can estimate the time to reach the critical value by regression analysis using the measured datas.

• Journal of the Korea institute for structural maintenance and inspection
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• v.23 no.5
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• pp.111-117
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• 2019

Shear experiments were carried out to evaluate shear performance of SFRC deep beams with end-anchorage of SD600 high strength headed reinforcing tensile bars. The experimental variables include the end-anchorage methods of tensile bars (headed bar, straight bar), the end-anchorage lengths, and the presence of shear reinforcement. Specimens with a shear span ratio of 1 showed a pattern of the shear compression failure with the slope cracks progressed after the initial bending crack occurred. Specimens with end-anchorage of headed bars (H-specimens) showed a larger shear strengths of 5.6% to 22.4% compared to straight bars (NH-specimens). For H-specimens, bearing stress reached 0.9 to 17.2% of the total stress of tensile bars up to 75% of the maximum load, and reached 22.4% to 46%. This shows that the anchorage strength due to the bearing stress of headed bars has a significant effect on shear strength. The experimental shear strength was 2.68 to 4.65 times the theoretical shear strength by the practical method, and the practical method was evaluated as the safety side.

• Journal of Korea Water Resources Association
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• v.54 no.3
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• pp.181-190
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• 2021

In this study, a large-scale levee breach experiment from lateral overflow was conducted to verify the effect of the new reinforcement method applied to the levee's surface. The new method could prevent levee failure and minimize damage caused by overflow in rivers. The levee was designed at the height of 2.5 m, a length of 12 m, and a slope of 1:2. A new material mixed with biopolymer powder, water, weathered granite, and loess in an appropriate ratio was sprayed on the levee body's surface at a thickness of about 5 cm, and vegetation recruitment was also monitored. At the Andong River Experiment Center, a flow (4 ㎥/s) was introduced from the upstream of the A3 channel to induce the lateral overflow. The change of lateral overflow was measured using an acoustic doppler current profiler in the upstream and downstream. Additionally, cameras and drones were used to analyze the process of the levee breach. Also, a new method using 3D point cloud for calculating the surface loss rate of the levee over time was suggested to evaluate the performance of the levee reinforcement method. It was compared to existing method based on image analysis and the result was reasonable. The proposed 3D point cloud methodology could be a solution for evaluating the performance of levee reinforcement methods.

• Journal of the Korean Geosynthetics Society
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• v.21 no.4
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• pp.101-109
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• 2022

This study describes the results of model experiment to analyze the effect of backfill material types on the behavior of underground facility. In the model experiment, backfill materials around the existing underground facility were applied with soil (Jumunjin standard sand) and CLSM. The displacement of underground facility was analyzed for each excavation stage considering the separation distance between the excavation surface and the backfill area based on the experimental results. When soil was applied as a backfill material, the soil on the back of the excavation surface collapsed by excavation and formed an angle of repose, and the process of slope stability was repeated at each excavation stage. In addition, the displacement of underground facility began to occur in the excavation stage that the failure line of soil passes the installation location of the underground facility. When CLSM was applied as a backfill material, there was almost no horizontal and vertical displacement of the ground regardless of the separation distance from the excavation surface even when excavation proceeded to the backfill depth. Therefore, this result showed that it can have a resistance effect against the lateral earth pressure generated and the collapse of the original ground by adjacent excavation, if a backfill material with high stiffness such as CLSM is applied.

• Journal of the Korean Society of Marine Environment & Safety
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• v.27 no.7
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• pp.1082-1087
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• 2021

The propeller shaft has different pattern of behaviors at each static, dynamic, and transient condition to a ship shaft system due to the effects of propeller weight and eccentric thrust, which increases the potential risk of bearing failure by causing local load variations. To prevent this, the various research of the shafting system has been conducted with the emphasis on optimizing the relative slope and oil film retention between propeller shaft and stern tube bearing at quasi-static condition, mainly with respect to the Rules for the Classification of Steel Ships. However, to guarantee a stability of the shafting system, it is necessary to consider the dynamic condition including the transient state due to the sudden change in the stern wakefield during rudder turn. In this context, this study cross-validated the ef ect of propeller shaft behavior on the stern tube bearing during port turn operation, which is a typical transient condition, by using the strain gauge method and displacement sensor for 50,000 DWT medium class tanker. And it was confirmed that the propeller eccentric thrust change showing relief the load of the stern tube bearing.

• Journal of the Korean GEO-environmental Society
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• v.24 no.9
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• pp.33-40
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• 2023

The lateral load which is applied to the pile foundation supporting the superstructure during an earthquake is divided into the inertia force of the upper structure and the kinematic force of the ground. The inertia force and the kinematic force could cause failure to the pile foundation through different complex mechanisms. So it is necessary to predict and evaluate interaction of the ground-pile-structure properly for the seismic design of the foundation. The interaction is affected by the lateral behavior of the structure, the length of the pile, the boundary conditions of the head, and the relative density of the ground. Confining pressure and ground stiffness change accordingly when the relative density changes, and it results that the coefficient of subgrade reaction varies depending on each system. Horizontal bearing behavior and capacity of the pile foundation vary depending on lateral load condition and relative density of the sandy soil. Therefore, the 1g shaking table tests were conducted to confirm the effect of the relative density of the dried sandy soil to dynamic behavior of the group pile supporting the superstructure. The result shows that, as the relative density increases, maximum acceleration of the superstructure and the pile cap increases and decreases respectively, and the slope of the p-y curve of the pile decreases.

• Journal of the Korean Geotechnical Society
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• v.26 no.6
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• pp.29-38
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• 2010

Micro-piles have been used to increase the bearing capacity or to restrain settlement of existing shallow foundation. Recently, micro-piles are used to support the shallow foundation, to stabilize the slope and to resist the sliding of retaining wall. Using the micro-piles in geotechnical engineering, some investigators have studied the effective installing method by model test or field test. But most of previous studies are chiefly focused on the micro-piles in sand or clay layer. If a rock layer exists in soil, the installing length of micro-piles may be determined by the depth of rock layer. In this case, the stiffness of pile may be changed by the installing length of pile, and so the installing method has to be altered by the changed stiffness of pile. Model tests have been conducted to study the installation method of micro-pile in soil with rock layer. As a result, when the ratio of length of pile is below 50 ($L/d{\leq}50$), installing of micro-piles in vertical position is effective regardless of the depth of rock layer. If the depth of rock layer is deeper than soil failure zone and the ratio of the length of pile exceeds 50 (L/d>50), installing of the micro-piles in sloped position is effective.