• Biomolecules & Therapeutics
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• 제14권2호
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• pp.83-89
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• 2006

The main aim of this study was to characterize the pharmacological profile of flavonoids utilizing behavioral tests and to investigate how the psychopharmacological activities of wogonin, baicalein and oroxylin A are different. Wogonin, baicalein and oroxylin A were intraperitoneally injected as dosages of 2.5, 5, 10 and 20 mg/kg. In the locomotor activity, Rota-rod test, and elevated plus-maze tests, the behavioral parameters were analyzed by automatic systems. Thiopental induced sleeping time was measured. Water extract of S. baicalensis didn't exhibit sedative effect. Wogonin and bacalein exhibited anxiolytic activity although it was less potent than buspirone. Wogonin and baicalein decreased locomotor activity at a dose of 10 mg/kg. Wogonin also shortened significantly running time on the rota-rod at doses of 5 and 10 mg/kg. Wogonin and baicalein enhanced sleeping at doses of 5 and 10 mg/kg. These results indicate that wogonin produce anxiolysis with sedation and so did bacalein with mild sedation. On the contrary, oroxylin A enhanced running activity on the rotarod and did't depress locomotor activity. Oroxylin A significantly hindered sleeping rather than helped it at doses of 5 and 10 mg/kg. Oroxylin A didn't produce anxiolysis and instead, produce awakening effect. This study demonstrates that wogonin and bacalein exhibited anxiolytic activity with mild sedation, but oroxylin A didn't produce anxiolysis and instead, produce awakening effect. This result indicates that anxiolytic effect without sedation induced by Scutellaria baicalensis is produced by combination of flavonoids.

• Biomolecules & Therapeutics
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• 제25권2호
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• pp.105-111
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• 2017

It has been known that RA, one of major constituents of Perilla frutescens which has been used as a traditional folk remedy for sedation in oriental countries, shows the anxiolytic-like and sedative effects. This study was performed to know whether RA may enhance pentobarbital-induced sleep through ${\gamma}-aminobutyric$ acid $(GABA)_A-ergic$ systems in rodents. RA (0.5, 1.0 and 2.0 mg/kg, p.o.) reduced the locomotor activity in mice. RA decreased sleep latency and increased the total sleep time in pentobarbital (42 mg/kg, i.p.)-induced sleeping mice. RA also increased sleeping time and number of falling sleep mice after treatment with sub-hypnotic pentobarbital (28 mg/kg, i.p.). In electroencephalogram (EEG) recording, RA (2.0 mg/kg) not only decreased the counts of sleep/wake cycles and REM sleep, but also increased the total and NREM sleep in rats. The power density of NREM sleep showed the increase in ${\delta}-waves$ and the decrease in ${\alpha}-waves$. On the other hand, RA (0.1, 1.0 and $10{\mu}g/ml$) increased intracellular $Cl^-$ influx in the primary cultured hypothalamic cells of rats. RA (p.o.) increased the protein expression of glutamic acid decarboxylase ($GAD_{65/67}$) and $GABA_A$ receptors subunits except ${\beta}1$ subunit. In conclusion, RA augmented pentobarbital-induced sleeping behaviors through $GABA_A-ergic$ transmission. Thus, it is suggested that RA may be useful for the treatment of insomnia.

• Animal Bioscience
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• 제36권7호
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• pp.1143-1149
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• 2023

Objective: We investigated the effects of outdoor access for 1 h per day on the animal welfare (AW) of tethered cows, in terms of lying and sleeping postures, and immune function. Methods: A total of five dry cows were tethered all day indoors (tethering) for 30 days and then tethered indoors with 1 h daily outdoor access (ODA-1h) for 30 days. To analyze the effects of ODA-1h, we calculated the total duration and bout frequency per day, and bout duration of lying and sleeping postures during the last five days of each treatment period. We also analyzed the populations of T cells, B cells, and NK cells in peripheral blood mononuclear cells (PBMC) by fluorescence-activated cell sorting and determined the concanavalin A (Con A) -induced proliferation rate of T cells. Results: The mean total time per day of lying during the ODA-1h treatment was significantly shorter than that during the tethering treatment (p<0.001). The Con A-induced proliferation rate of T cells during the ODA-1h treatment was significantly higher than that during the tethering treatment (p = 0.007). The proportion of NK cells in PBMC during the ODA-1h treatment tended to be higher than that during the tethering treatment (p = 0.062). Conclusion: Although ODA-1h may decrease lying time, it increases the available space for tethered cows towards that typically found in grazing and free barn feeding systems. This increased available space promotes the expression of normal behaviors such as walking and social behaviors except lying and may also improve the immune function of tethered dry cows, thereby improving their overall welfare.

• Biomolecules & Therapeutics
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• 제7권3호
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• pp.285-291
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• 1999

DA-7101 is a new combined formulation of cefatrizine:clavulanic acid (2:1) under development as oral abtibiotics. The general pharmacological properties of DA-7101 on central nervous, cardiovascular, gas-trointestinal and other organ systems were studied by oral administration, in vivo and in vitro. DA-7101 had no marked effects all tests studied such as general behavior, hexobarbital-induced sleeping, spontaneous activity, anticonvulsion, body temperature, acetic acid-induced writhing, rotarod performance, heart rate and blood pressure in cats, isolated ileum movement, intestinal transition, gastric juice secretion and urine volume and electrolytes in rats. But exceptionally at the highest dose of 900 mg/kg, DA-7101 increased hexobarbital-induced sleeping time, caused a slight hypotension and decreased the secretion of gastric juice. These results suggest that at the estimated clinical dose DA-7101 would not bring about any serious acute adverse effects clinically.

• 대한지역사회작업치료학회지
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• 제4권1호
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• pp.11-21
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• 2014

목적 : 20대 및 30대 장애인의 시간사용을 알아보고 많은 시간을 소요하는 활동이 무언인지에 따라 희망이 어떻게 달라지는지를 분석하였다. 연구방법 : 본 연구는 2012년 11월 29일부터 12월 6일까지 부산 및 경남 지역의 재활병원에서 치료를 받고 있는 장애인 52명이 참여하였으며 주말과 평일의 일상생활시간조사를 포함한 설문지로 일대일 면접을 하였다. 결과 : 대상자들은 시간사용에서 주말에는 수면(10시간 47분)과 미디어 사용(3시간 41분), 평일에는 수면(9시간 43분)과 건강관리(5시간 12분)에 많은 시간을 소요하였다. 또한 시간사용과 희망의 관계에서는 가정관리가 주도사고와 양의 상관관계(.688)로 나타났다(p<.05). 그러나 시간사용은 희망에 영향을 미치지 않는 것으로 나타났다. 결론 : 20대 및 30대 장애인의 시간사용과 희망을 확인할 수 있었다. 이는 향후 재활분야의 전문가들에게 20대 및 30대 장애인들이 참여할 수 있는 활동을 다양하게 제시해줄 것을 제안한다.

• 한국전문물리치료학회지
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• 제12권3호
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• pp.84-93
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• 2005

The purpose of this study was to find prevalence and the relevant factors of low back pain among taxi-drivers. Information were obtained by a self-administered questionnaire during september, 2004, from 83 taxi-drivers in Gimhae, Kyung Nam province. The data were analyzed by chi-square test and Multiple Logistic Regression(if this is a proper noun, it needs to be capital, if not it needs lower case) by using SPSS 10.0 program. The result were as follows: 1) The prevalence rate of low back pain during lifetime was 81.9% among 83 taxi-drivers. 2) Statistically significant factors related to low back pain during lifetime were sleeping time(p<.05). 3) Through the multiple logistic regression, significantly relevant factors with low back pain were alcohol drinking (OR=.017, 95% CI=.001~.509), and sleeping time (OR=.111, 95% CI=.020~.636). It is necessary to study on a preventive measure of low back pain and systematic human engineering approach through objective clinical research.

• 기본간호학회지
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• 제14권4호
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• pp.500-506
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• 2007

Purpose: This study was conducted to analyze the health concerns, health behavior, and related factors for elders taking part in activities at senior centers. Method: A total of 811 elders were selected through conveniently sampling. Data were collected from November 21, 2006 to December 20, 2006. Data analysis included frequency, t-test, ANOVA, Duncan test, and Stepwise Multiple Regression using SPSS Win 15.0. Results: For health concerns statistically significant differences were found for gender, age, family, pockety money, sleeping time, regular health check-ups, and exercise. For health behavior statistically significant differences were found for gender, age, family, pocket money, religion, medical insurance, perceived health status, sleeping time, regular health check-ups, chronic illness, regular breakfast, exercise, and drinking. Perceived health status was identified as a variable influencing the health behavior. Conclusion: The results suggest that perceived health status can be considered as factor for significant nursing interventions to help single elders and older elders in senior centers.

• 대한한방내과학회지
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• 제38권2호
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• pp.146-151
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• 2017

The patient was a 69-year-old Korean male with Lewy's body dementia and insomnia. He was treated with acupuncture and a herbal medicine, Ukan-san. To evaluate insomnia, the patient's total sleeping time was recorded. The patient's sleeping time increased after the administration of the Korean medicine treatments. Treatment with Korean medicine may be effective in treating insomnia in cases of Lewy's body dementia.

• 지역사회간호학회지
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• 제19권3호
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• pp.495-505
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• 2008

Purpose: This study was conducted to identify the relation between farmers' syndrome and the quality of life of residents in suburban areas. Methods: A total of 994 subjects were selected through simple random sampling. Data were collected from June 25 to August 31, 2007. Data analysis included frequency, $X^2$-test, Fisher's exact test, t-test, ANOVA, Duncan test, and Pearson's correlation coefficient using SPSS Win 12.0. Results: 1. Analysis of farmers' syndrome showed that there were statistically significant differences according to age, gender, education, living with, family conversation, health security, monthly income, occupation, general health status, systolic blood pressure, and sleeping time. 2. Analysis of the qualify of life showed that there were statistically significant differences according to age, education, religion, family conversation, health security, monthly income, occupation, and sleeping time. 3. Farmers' syndrome was in a significantly negative correlation with quality of life. Conclusions: Considering the results above, we need to develop nursing interventions for decreasing hypertension, high blood sugar, and farmers' syndrome of residents in suburban area.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2009년도 제40회 하계학술대회
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• pp.1925_1926
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• 2009

This paper describes a novel power management circuitry for reducing the sleeping mode power dissipation. Based on the proposed power management circuitry, the sensor module can be activated by RF wake-up signal, perform designated process and deactivate itself. There is absolutely no power dissipation at the sleeping mode which takes almost time of the operation. The temperature sensor module using solar cell as energy source has been fabricated and tested. Experimental results show that the sensor module with 3300 ${\mu}$F for storage capacitor can transmits RF temperature data to a receiver at a distance of 20 m every 15 second in a normal indoor light condition and keep the capacitor voltage over 9 V. And the sensor module can operate 100 times with a single charging, that means it is possible for the sensor module to transmit every 5 minute for 8 hours without light or any other power input during the night time.