• Food Science of Animal Resources
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• v.32 no.3
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• pp.308-315
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• 2012

This study was conducted to examine the effects of egg shell membrane hydrolysates (ESMH) on skin whitening, wound healing, and UV-protection. ESMH was divided into three groups by molecular weight (Fraction I: above 10 kDa of ESMH, Fraction II: 3 kDa-10 kDa of ESMH, Fraction III: below 3 kDa of ESMH). As a result, all of ESMHs showed over 90% of protein contents. The wound healing experiment using HaCaT cells showed that the fraction I was slightly superior to other fractions depending on the concentration though it was not significantly different. In the experiments of inhibition of tyrosinase and L-3,4-dihydroxyphenylalanine (L-DOPA) oxidation to verify the L-DOPA whitening effect, the whole ESMH (before fractioning) showed a similar amount of inhibition effect with arbutin (control). In the inhibition of melanin formation in B16-F1 melanoma cells, the fraction I showed a high inhibitory effect. In the experiment for protecting the skin from ultraviolet rays using HaCaT cells, all the fractions showed a higher rate of cell viability than the control. In conclusion, this study confirmed that the cosmetic effects of ESMHs such as skin whitening, wound healing, and UV-protection, which were divided depending on the molecule weight. We could confirm that the possibility of ESMHs as a material for functional cosmetics.

• Herbal Formula Science
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• v.24 no.4
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• pp.289-300
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• 2016

Objectives : Taglisodog-eum(TSE), a poly herbal formula, has been widely used to improve carbuncles by removing inflammation of the lymphatic channels in Traditional Korean Medicine. We previousely reported the action mechanism of TSE on experimental atopic dermatitis and the establishment of formulation for TSE ointment. In this study, we examined the toxicity test on skin and eye irritation by TSE ointment to prove the safety of Taglisodog-eum ointment in clinical use. Methods : Acute skin toxicity of the TSE ointment was evaluated in Sprague-Dawley(SD) rats. After dermal administration of TSE ointment(2,000mg/kg), body weight, mortality, and clinical signs of the rats were observed for 14days. Primary skin irritation and ocular irritation tests for TSE ointment were performed in male New Zealand White Rabbits. In dermal and ocular irritation test, body weight, mortality, clinical signs, Primary Irritation Index(P.I.I.), and The Index of Acute Ocular Irritaion(I.A.O.I.) of rabbit were observed after applying at abraded skin and eye balls with Taglisodog-eum ointment. Results : In the results of acute skin toxicity, no significant differences were found in body weight, the clinical sign and the mortality between control and TSE ointment treated group. In primary dermal irritation test, body weight, the clinical sign and the mortality were not significantly changed and Primary Irritation Index(P.I.I.) was 0.8, indicating TSE ointment as weak irritant material. In ocular irritation test, The Index of Acute Ocular Irritaion was 0.0, indicating TSE ointment as non-irritating to the eye of the rabbits. To evaluate toxicity of the TSE ointment in animal test, body weight, the clinical signs, the skin and eye irritation check were conducted; TSE ointment was considered to be weak dermal irritant in test animals. The no response of eye irritation test was observed in this experimental condition. Conclusions : According to the above toxicity test, We consider that this results is helpful for saying about the safety of TSE ointment in clinical use.

• Food Science of Animal Resources
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• v.32 no.3
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• pp.316-322
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• 2012

This study was conducted to evaluate the effects of soaking pH and extraction temperature on the physicochemical properties of chicken skin gelatin. In order to extract gelatin from chicken skin, the chicken skin was soaked at various pH ranges (1-13) and was extracted at 75 and $100^{\circ}C$. For the rate of weight increase, the highest value was obtained from two pH ranges (1-2 and 12-13). In addition, the rate of weight increase was affected by soaking time. The alkali treatments had greater crude protein content as well as total extraction yield compared to the acid process (p<0.05), and the increased extraction temperature resulted in a significant (p<0.05) increase of crude protein content and total extraction yield. All treatments showed ${\alpha}1$ and ${\alpha}2$ chains derived from type I collagen on SDS-PAGE. The pH value and color of gelatin gel (6.67%) were affected by soaking pH and extraction temperature. Chicken skin gelatin gel extracted at $75^{\circ}C$ after soaking at a pH of 2 had the highest melting point (p<0.05) and gel strength among all treatments. Although the chicken skin treated with the alkali process had a higher yield, a lower extraction temperature following the acid process would be better for obtaining superior gelatin from chicken skin.

• Biomedical Science Letters
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• v.7 no.2
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• pp.79-83
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• 2001

To evaluate an effect of toluene application to skin on the enhancement of liver damage in $CCl_4$-pretreated rats, toluene (35 mg/$cm^2$) was sequentially applied for 5 days to the skin of liver damaged rats with $CCl_4$ (6 times every other day: 0.1 ml/100 g body weight-50% $CCl_4$ in olive oil) On the basis of the functional and morphological findings in rat liver, appling toluene to the skin in liver damaged animals led to the more enhanced liver damage. In addition, by applying toluene to skin of liver damaged rats, the hepatic cytochrome P450 content was somewhat more increased, but the hepatic benzylalcohol dehydrogenase activity was significantly decreased (P<0.001), whereas benzaldehyde dehydrogenase activity was not statistically changed. In conclusion, the toluene application to skin in liver-damaged rat led to enhancement of liver injury that may be due to the accumulation of toluene metabolite in liver.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2007.11a
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• pp.140-152
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• 2007

Hyaluronic acid(HA) is a naturally occurring mucopolysaccharide composed of the repeating disaccharide unit of D-glucuronic acid and N-acetyl-D-glucosamine. HA exists as a high molecular weight polymer in the extracellular matrix of many tissues in the body. HA has been widely used not only for osteoarthritis and ophthalmology but also for cosmetics for skin care. Recently HA has drawin much attention for use in health foods. Bioland Corporation started production of HA t1y biotechnological process in 1990 for cosmetical use. At present Bioland produces HA for cosmetic and food use. We have done many researches to evaluate the helpful effect for skin and safety of HA as food. In order to evaluate the effect of HA on the skin after its oral intake, we measured its bioavailability, skin-care effects on anti-wrinkle, moisturization elasticity and desquamation by clinical trial. The results showed that HA is very safe and could bs helpful to improve anti-wrinkling, moisturization, elasticity, and desquamation on the skin.

• Journal of the Korean Society of Clothing and Textiles
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• v.16 no.4 s.44
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• pp.405-416
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• 1992

This study was performed to investigate correlation between total body weight loss and local sweat rate and to find out any possible method that can estimate total body weight loss judging from local sweat rate. Twelve adult females were kept at 44 $\pm1^{\circ}C$, 50 ${\pm}5\%$ R.H. (1) Physiological responses such as total body weight loss, local sweat rate, rectal temperature, skin temperature, blood pressure and pulse, (2) micro climate inside garment and (3) subjective sensation were examined. Two types of garment such as long-sleeves with long pants (Type I) and half·sleeves with short pants (Type II) were used to observe the effect of garment types on sweating response. Both clothing weight was equal (132$\pm$3 g/$m^{2}$). The results were as follows: 1. Regardless of the different types, total body weight loss was more interrelated with the sweat rate on forehead than any other parts of the body. Except the forehead, different parts of body with different types of garment influenced on body weight loss quite differently. 2. Total body weight loss was more interrelated with the weight gain of garment than the local sweat rate. 3. Under the environment of 44$\pm1^{\circ}C,\;50{\pm}5\%$R.H., body weight loss during 1 hour of subject clothed and silted was 275.2 g/hr and weight loss per body surface area was 178.9 g/$m^{2}/hr$ Garment types have no influences on total body weight loss. 4. Local sweat rate (mg/7.07 $cm^{2}/hr$) was 208.0,191.0, 133.0, 115.0,81 0, 75.1 and 66.3 on scruff, breast, forehead, forearm, thigh, upper arm, leg respectively No evidence has been found that garment types influenced on local sweat rate (p<0.1). 5. No interrelationships between rectal temperature and total body weight loss, local skin temperature and total body weight loss, and local skin temperature and local sweat rate were found. From this study, some possible method that we can estimate total body' weight loss judging from weight loss of garment. But considering the fact that clothing design factor, the physical characteristics of fabric and environmental factor such as humidity and wind velocity should be concerned in weight loss of garment, it should be studied further whether the total body weight loss can be estimated properly from the weight loss of garment. This experiment suggest that different parts of body with different types of garment can influence on body weight loss quite differently. Therefore, in order to get more precise results, more studies under the diversity of garment types should be done in the near future.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.22 no.2
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• pp.27-33
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• 2014

There are several methods to improve the flight efficiency of HALE(High Altitude Long Endurance) UAV(Unmaned Aerial Vehicle). Airframe structural point of view, weight reduction of the airframe structure is the most important method to improve the flight efficiency. In order to reduce the weight of airframe structures, new concepts which are different from traditional airframe structure design such as the mylar wing skin should be introduced. The spar is the most important component in a mylar skin wing structure, so the spar weight reduction is the key point for reduction of the wing structural weight. In this study, design trade-off study for the front spar of the HALE UAV wing is conducted in order to reduce the weight. Design and analysis procedure of high aspect ratio wing spar are introduced. Several front spar structures are designed and trade-off study regarding the weight and strength for the each spar are performed. Spar design configurations are verified by the static strength test. Finally, optimal front spar design is decided and applied to the HALE UAV wing design.

• Korean Journal of Human Ecology
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• v.21 no.2
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• pp.331-347
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• 2012

The purpose of this study was to explore how the Theory of Planned Behavior applies to five appearance management behaviors and the effects of three variables - attitude, subjective norm, and perceived behavior control on appearance management behaviors. The research was conducted by surveying 410 female adult respondents between the ages of 20 to 40 with the goal of predicting the appearance management behavior of women. The data were analyzed using IBM SPSS Statistics 19.0 and Amos 19 in addition to Frequency analysis and path analysis. In the first case, the potential for applying appearance management theory on appearance management behavior of women was observed. The appearance management behavior performed by women was classified into five categories: skin care behavior, makeup management behavior, apparel management behavior, hair care behavior, and weight management behavior. It was determined all five behaviors could be predicted by applying the Theory of Planned Behavior. In the second case, effects of attitude related to subjective norm and perceived behavior control related to skin care behavior was statistically significant. In terms of makeup management behavior, all of the three variables were statistically significant. With regard to apparel management behavior, only subjective norm behavior was statistically significant. Concerning hair care behavior, attitude and perceived behavior control were statistically significant. On weight management behavior only attitude was statistically significant.

• The Korean Journal of Pain
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• v.13 no.1
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• pp.93-96
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• 2000

Background: Psoas compartment block with local anesthetics and corticosteroids is one of the treatments which provides long term analgesia of the lower back and anterior thigh unilaterally, and its technical easiness and safety allows blind application without C-arm guidance in the out-patient clinic. This study aimed to evaluate the mean of the depth from the skin to the psoas compartment, and its correlation to the following attributes: age, weight, height and PI (Ponderal Index). Methods: We investigated 28 patients who underwent psoas compartment block. All blocks were performed using Chayen's method (punctured at the point of 3 cm caudally and 5 cm laterally from the 4th lumbar vertebral spinous process) with a 22 G, 8 cm Tuohy needle under C-arm guidance. We recorded the depth from skin to the psoas compartment, height, weight and PI (weight (kg)/height (cm)$\times100$ (%)). Data were analyzed using the Pearson product-moment correlation coefficients. The correlations between the depth and other attributes identified by p-value of less than 0.05 were considered statistically significant. Results: The mean depths from skin to the psoas compartment were $6.02{\pm}0.28$ cm in men, $5.44{\pm}0.22$ cm in women. There is no significant correlation between the depth and other patient's attributes. Conclusions: The mean depths from skin to the psoas compartment may be one of the guide for psoas compartment block in outpatient clinics without C-arm guidance.

• Journal of the Korean Society of Clothing and Textiles
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• v.9 no.3
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• pp.45-51
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• 1985

The purpose of this study is to research into the thermal condition and the weight of clothes suitable for the officers engagged in light works in an air-conditioned room in summer. The Major findings are as follows: 1. Thermal conditions of the working environment are $24.5^{\circ}C$ (Dry bulb temp.), $68\%$ (Relative humidity) and 2.6m/sec (Air Velocity). 2. Total clothing weights are 416.6 g/$m^2$ (male) and 340.9 g/$m^2$ (female). Underwear weights are 96.8g/$m^2$ (male) and 85.1g/$m^2$ (female). The latter turned out to be statistically significant in Sexual difference. 3. Means of the thermal sensation are 3.0 (comfortable; male) 2.7 ('Slightly cool' -'Comfortable'; female) and the relationship between clothing weights and thermal sensation proves to be significantly correlated in the case of female. 4. $66.7\%$ of the women and $37.1\%$ of the men feel sensation of coldness at the body's specific area and $79.5\%$ of the women and $54.3\%$ of the men reveals air-conditioning disturbance. 5. As the thermal sensation is close to 'cool-cold', sensation of coldness or air conditioning disturbance are showed up more frequently which is reversely related with weight of under-wear. It is also proved that air conditioning disturbances are influenced by sexual difference in addition to sensation of coldness and thermal sensation. 6. According to the result of experiment, we can have the idea that at condition $X_1$, the drop of limbs' skin temp. is remarkable. At condition $X_2$ skin temp. for distal limbs and mean skin temp. are raised and the falling degree is similar. At condition $X_3$, mean skin temp. and distal skin temp. are remarkably raised, and the falling degree decreases and the beats of pulse rate increase and diastoric blood pressure is lowered.