• Radiation Oncology Journal
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• v.37 no.2
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• pp.143-148
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• 2019

Although surgery is the mainstay of local treatment for skin cancer, definitive radiation therapy (RT) has been also applied for patients who are unable to tolerate surgery. Definitive RT regimens usually consist of daily treatment for 4-7 weeks. Such protracted daily RT regimens, however, would not be feasible for non-compliant patients or patients who are unable to make multiple daily trips for weeks. Without treatment, however, skin cancers can continuously progress and cause distressing symptoms. A cyclical hypofractionated RT (QUAD Shot: 14 Gy in 4 fractions, twice-daily treatments with 6 hours interval on 2 consecutive days) can be a practical RT regimen for those patients. In this report, we present the successful treatment course of repeated QUAD Shots in a 79-year-old patient with neglected skin cancer that was disfiguring his face yet declined definitive surgery and protracted RT. We also evaluated and compared biologically equivalent doses between QUAD Shots and conventionally fractionated protracted RT regimens.

• The Research Journal of the Costume Culture
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• v.18 no.1
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• pp.150-160
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• 2010

This research was intended to furnish basic data which can be helpful to maintain and improve the skin health and to activate aromatherapy by analyzing the knowledge, attitude and behavior on the aromatherapy skin care of college students. As their grade got higher, students of beauty class showed the level of knowledge on aromatherapy higher than those of non-beauty class, and that of girl students was higher than that of boy students and as the living standard of students got higher, and pocket money of a month of them got more, the level of knowledge on aromatherapy of them was high, and as the interest in appearance and satisfaction on appearance of them got higher, the level of knowledge on aromatherapy of them was high. In common characteristics, as the living standard of them got higher, and pocket money of a month of them got more, the level of attitude on aromatherapy of them was high. As the interest in appearance of them got higher, the level of attitude on aromatherapy on the interest in appearance of them was high. In the characteristics related with the skin, as the skin health condition of students got healthier, the level of attitude on aromatherapy of them was high, and it was high in the students who had much agony on the skin color.

• Journal of The Korean Society of Integrative Medicine
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• v.11 no.1
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• pp.79-86
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• 2023

Purpose : Aging is reflected on the face of women due to the depletion of collagen and hydration in the facial skin overtime. This study investigated the effect of multiple SONO^® ultrasound for a 4-week period on the skin health by measuring the skin elasticity and deeper skin elasticity in the tested women subjects. Methods : Twenty healthy women were recruited for this experiment. All the participants applied multiple ultrasound device (SONO^®) during this experiment. The SONO^® device was set to ANTI-AGING function and five power steps such as 1, 3, 10 and 17 MHz were used during this experiment, and directly contacted with the facial skin. Specifically, the probe was contacted with the entire face except for the nose and eyes for 10 min on each side of the face every day and repeated for 4 weeks. The skin elasticity and the elasticity of deeper skin were measured at three times (0, 2, 4 weeks) using a Ballistometer and dermal torque meter, respectively. The one way repeated ANOVA was used to compare the skin elasticity and the elasticity of deeper skin among three times (0, 2, 4 weeks). Results : The skin elasticity (p<.05) and elasticity of deeper skin (p<.05) were significantly increased at 2 weeks and 4 weeks of intervention compared to that at 0 weeks. For the skin elasticity, there was no significant difference between 2 and 4 weeks of intervention (p>.05). For the elasticity of deeper skin, it increased significantly at 4 weeks compared to 2 weeks of intervention (p<.05). Conclusion : These findings suggest that applying multiple SONO^® ultrasound to the facial skin of healthy women for 4 weeks, can increase the skin elasticity and elasticity of deeper skin by supporting epidermal hydration and dermal collagen production.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.8 no.2
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• pp.289-295
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• 1998

Used gasoline engine oils(UGEO) are carcinogenic in long term studies and capable of increasing the number of carcinogen-DNA adducts in short term studies when dermally applied to mice. The carcinogenic risk of UGEO has been attributed to the concentration of polycyclic aromatic hydrocarbons(PAH) which accumulate in the lubricating system during the combustion of gasoline. When dermally exposed to UGEO, the use of hand cleanser was commonly recommended for removing it. But generally workers who dermally exposed oils, use kerosene as cleaner which make skin trouble. During this study, female mice aged 4-6 weeks were utilized to evaluate the efficiency of kerosene, as solvent-based cleanser, following dermal exposure to UGEO. DNA adduct were detected at skin and lung tissues by using the $^{32}P$-postlabeling method. Washing with cleansers were done at two different interval times following dermal application of UGEO. The total DNA adducts in skin and lung tissues were statistically significantly increased in positive control groups, and of which the total adduct level in skin tissues was statistically significant higher than those in lung tissues(p=0.005). When washing kerosene, the DNA adduct level in skin tissues was statistically significantly decreased(p=0.0001). But DNA adducts in lung tissue was statistically increased(p=0.0039), and that washed at 8hr post exposure was more severly increase(p<0.05). The slope of regression between DNA adducts of lung between skin tissues was 1.0802. In conclusion, skin cleaning with kerosene facilitates passage of carcinogens to the lungs of animals dermally treated with used gasoline engine oils(UGEO).

• Journal of Environmental Health Sciences
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• v.21 no.4
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• pp.75-86
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• 1995

This study was performed to investigate the negative side effects of video display terminal (VDT) work on the human body and to provide data for preventing VDT syndrome. A questionnaire survey was made to 339 VDT workers at 22 offices in Taegu, Kyungpook and Kyungnam areas from July 1 to August 31, 1994, and 280 of them were finally used for statistical analysis. The VDT syndrome in the present study inclhded five factors, namely as eye-related symptom, psychological symptom, general body symptom, musculoskeletal symptom, and skin-related symptom, and the estimates of Crombach coefficients of the five factors were 0.954, 0.952, 0.953, 0.957, and 0.955, respectively, showing very high reliability. In view of socio-economical characteristics, the symptoms of female were higher than those of male in the order of musculoskeletal symptom, eye-related symptom, skin-related symptom and psychological symptom. The age group of 30 years or less was higher than the older groups in the order of musculoskeletal symptom, eye-related symptom, psychological symptom and skinrelated symptom. The group of lower education level showed higher skin-related symptom. The psychological symptom and skin-related symptom increased as the amount of smoking increased. Higher eye-related symptom was observed in the group without glasses. In the job-related variables, the group of working on programming and data input showed higher eye-related symptom and psychological symptom. The group of working on programming and graphic design showed higher musculoskeletal symptom and skin-related symptom. The skin-related symptom increased as the total time of VDT operation per day increased. The group of working 2-4 hours followed by 15 minutes rest was higher in musculoskeletal symptom and psychological symptom. Higher musculoskeletal symptom was observed from the group working on Friday and Sunday. The group of 1 year or less working showed higher in skin-related symptom. In relation with the VDT type, all symptoms except skin-related symptom were higher in the group using monochrome monitor. As showed above, the questionnaire could be a tool for evaluating VDT syndrome and prevention of the syndrome would be possible by a comprehensive consideration of factors including socio-economic characteristics, job-related variables and VDT type.

• Food Science of Animal Resources
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• v.35 no.3
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• pp.413-420
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• 2015

The aim of our study was to evaluate the potential benefits of an oral supplement containing porcine placenta extract (PPE) on skin parameters related to cutaneous physiology and aging. PPEs were administered orally to hairless mice for 12 wk. The effects of oral PPE administration on skin water-holding capacity and Transepidermal Water Loss (TEWL) were similar to those of oral collagen (HYCPU2) administered as a positive control. Magnified photographs and replica images showed a reduction in UVB-induced wrinkle formation after collagen and PPE treatments. PPE treatments ameliorated the thicker skin surface that results from UVB exposure, based on a histological examination of skin tissue. The groups that were orally administered PPE (0.05%, OL; 0.1%, OH group) showed significantly reduced Matrix Metaloproteinase-2 (MMP-2) mRNA expression levels compared with the UVB control (Con), by 33.5% and 35.2%, respectively. The mRNA expression of another collagen-degrading protein, MMP-9, was also significantly lower in the groups that received oral administration of PPE (especially in the OH group) than in the control group. Additionally, oral administration of PPE significantly upregulated tissue inhibitor of metalloproteinase-1 (TIMP-1) and -2 mRNA expression levels compared with expression levels in the control group (p<0.05). This indicates that orally administered PPE activated the expression of Timp-1 and -2, inhibitors of MMP, which is responsible for collagen degradation in skin. Taken together, we propose that long-term oral administration of PPE might have a beneficial effect with respect to skin photo-aging.

• Korean Journal of Veterinary Research
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• v.44 no.2
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• pp.225-231
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• 2004

This study was conducted to determine the incidence of microorganisms associated with dressed broiler with intact skin and without skin at different frozen storage periods such as 0, 10, 20, 30 days and to demonstrate the role of packaging and pretreatment chilling on the changes of carcass quality. The values of total viable count (TVC), total coliform count (TCC), total streptococcal count (TStC) and total staphylococcal count (TSC) were determined for meat samples of thigh and breast and swab samples of visceral surfaces of the broilers with intact skin and without skin. It was observed that the values of TVC, TCC, TStC and TSC in both cases of dressed broiler with intact skin and without skin exceeded the International Commission on Microbiological Specification for Foods. However, numbers of microorganisms were considerably decreased during the frozen storage. Packing and prechilled conditions were generally better effective in decrease of the loads of microorganisms than without packing and prechilled conditions, and lower bacterial numbers were also found in dressed broiler with intact skin than that without skin. The highest sensory panel score was obtained at 10 days of frozen storage. These results, thus, indicate that usages of appropriate periods and conditions of frozen storage and packaging systems can minimize the potential health hazards associated with contaminants gaining access to the dressed or processed broilers and improve the quality and shelf life of dressed broilers.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.12
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• pp.5805-5810
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• 2011

This study aims to provide fundamental data to develop anti-aging programs in the aspect of skin care. To attain the goal, manual therapy and low-power laser therapy were conducted separately to 8 women inthe 40's and 50's. They received the facial massage total 8 times twice a week for 4 weeks. According to the result of calculating the average and standard deviation by measuring skin elasticity of the area below their eyes and cheeks and also melanin around eyes and cheeks and conducting comparative analysis, both groups showed significant increase in elasticity and their melanin decreased significantly. The low-power laser therapy showed higher values than the manual therapy both in elasticity increase and melanin reduction; thus, it was analyzed that the low-power laser therapy more highly affects skin elasticity and the amount of melanin in facial skin is greater than that in manual therapy. Therefore, it was analyzed that skin care using low level laser can be significant in anti-aging of facial skin and can be utilized as a program for a new type of skin care.

• The Korea Journal of Herbology
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• v.34 no.2
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• pp.75-82
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• 2019

Objectives : In this study, various biological effects of Curcuma longa L. have been studied, however, beneficial effect of Curcuma longa L. in skin health remain still unclear. In this study, Curcuma longa L. water extract (CLE) was prepared. Inhibitory effect of CLE on melanin accumulation of B16F10 cells and expression levels of skin fibril-related proteins of human skin fibroblasts (HSF) were evaluated. Methods : The cytotoxic effect of CLE in B16F10 cells and HSF were examined by MTT assay. Inhibitory effect of CLE on the ${\alpha}-MSH-$ and IBMX-induced melanin accumulation and tyrosinase activity were evaluated in B16F10 cells. The expression levels of connective tissue growth factor (CCN2), Smad2, procollagen $1{\alpha}2$, collagen $1{\alpha}2$, and fibronectin in CLE-treated HSF were analyzed by western blotting. Results : The CLE treatment (concentrations 10 to $400{\mu}g/ml$) for 72 h did not affect to the B16F10 viability. However, 200 and $400{\mu}g/ml$ of CLE treatment for 24 h showed cytotoxic effect in HSF. Therefore, the concentrations 10, 50, and $100{\mu}g/ml$ of CLE were chosen in this study. The CLE treatment for 72 h dose dependently and significantly suppressed melanin accumulation and tyrosinase activity of B16F10 cells. In addition, the CLE treatment up-regulated expression levels of skin fibril-related proteins such as CCN2, Smad2, procollagen $1{\alpha}2$, collagen $1{\alpha}2$, and fibronectin. Conclusions : In conclusion, these results suggest that the CLE could be used as a natural material for skin health.

• KOREAN ASSOCIATION OF OCCUPATIONAL HEALTH NURSES
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• v.9 no.1 s.30
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• pp.13-20
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• 2002