• Biomedical Science Letters
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• v.8 no.2
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• pp.83-88
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• 2002

To investigate the skin toxicity of xylene, xylene (25 mg/$\textrm{cm}^2$) has been sequentially applied to the rat skin for four days. On the light microscopic examination, epithelium was left out with infiltration of inflammatory cells in border with dermis, and formation of new epithelial layer was shown under the inflammatory zone. Application of xylene to the rat skin showed the marked rise of cutaneous xanthine oxidase activity whereas, He activities of oxygen free radical scavenging enzymes, superoxide dismutase and glutathione S-transferase, were significantly declined. Furthermore, the content of cutaneous glutathione was more and less decreased in rat skin applied with xylene. In conclusion, these results suggest that a part of oxygen free radical may be responsible for morphological changes in skin by applying xylene to the rat skin.

• Journal of Microbiology and Biotechnology
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• v.30 no.10
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• pp.1567-1573
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• 2020

Ultraviolet (UV) is one of the major factors harmful to skin health. Irradiation with ultraviolet accelerates the decline of skin function, causing the skin to have deep wrinkles, dryness, decreased procollagen production, and degradation of collagen. Novel materials are needed to prevent the aging of the skin by blocking the effects of UV. Safflower seed oil (Charthamus tinctorius L., SSO) contains significantly high levels of unsaturated fatty acids and phytochemicals. SSO has been traditionally used in China, Japan, and Korea to improve skin and hair. Our objective in this study was to determine the effect of SSO and its active compound acacetin on UVB-induced skin photoaging in HaCaT cells and human dermal fibroblasts (HDF). SSO inhibited UVB-induced matrix metalloproteinase-1 (MMP-1) at both protein and mRNA levels in HaCaT cells and HDF. MMP-1 is known to play important roles in collagen degradation and wrinkle formation. Acacetin, a type of flavonoid, is present in SSO. Similar to SSO, acacetin also inhibited UVB-induced MMP-1 protein and mRNA levels in HaCaT cells and HDF. MMP-1 mRNA is primarily regulated by the mitogen-activated kinase (MAPK) signaling pathway. Acacetin regulated the phosphorylation of JNK1/2 and c-jun, but did not inhibit the phosphorylation of ERK1/2, p38 and AKT. Taken together, these results indicate that SSO and its active compound acacetin can prevent UVB-induced MMP-1 expression, which leads to skin photoaging, and may therefore have therapeutic potential as an anti-wrinkle agent to improve skin health.

• Journal of the Korean Society of Fashion and Beauty
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• v.2 no.3 s.3
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• pp.1-10
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• 2004

The purpose of this study is to find out the operant factors, or types of skin care, and, more importantly, to propose the intervention for more effective skin care and marketing strategies in this business. That is the main reason that the study employes Q methodology which measures human subjectivity objectively and scientifically. This study finally revealed three distinctive factors : Type I, The Passive Follower, Type II, The Active Needs, and Type III, The Independent Judgment. The first type includes people who show passive recognition. They want to be put in charge of experts in the skin care center and to buy cosmetics recommended by experts, and are deep interest in the reaction of other people. The second type contains people who desire things actively. To live delightfully and fashionably, they think of the necessity of skin and body care as an important thing, and feel that it is necessary to take care of the skin beauty actively and regularly for the aging resistance. The third type includes people who judge independently. In general, they recognize and desire the necessity of the skin care, but they think of the skin care as a part of the health care more widely rather than a special thing. These three types are not fixed, but continuously changed in the accordance with the condition and interaction with the circumstance, the results will be utilized as basic materials for the skin and health care through the application according to the characteristic of each type they belong.

• Physical Therapy Korea
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• v.3 no.1
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• pp.48-56
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• 1996

The research of cold therapy is preceding rarely nowadays. This study was researched to measure the skin temperature of the right foot malleolus when the leg change the situation precisely speaking it was cold, elevation, cold plus elevation. Twenty young healthy volunteers(M:10, F:10)with no history of cardiopulmonary disease, peripheral artery disease were tested. This study were analyzed by one-way-repeated ANOVA. In the first we examined the within changes of the skin temperature between before and after examination for each modality. The skin temperature at all of modalities had fallen. Therefore we could know the fact that elevation plus cold modality had fallen skin temperature significantly more than elevation or cold. And there were no significant difference between male and female. We conclude that elevation and cold therapy could be better effective on edema, contusion and sprain than cold or elevation therapy independently.

• Journal of Korean Physical Therapy Science
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• v.8 no.1
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• pp.923-934
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• 2001

In order to investigate a pathogenesis of liver damage induced by skin burn, thermal injury was induced by scald burn on entirely dorsal surface in rats (total body surface area 30%) except for inhalated injury. At 5 and 24 h after scald bum, biochemical assay and morphological changes in skin tissue, serum and liver tissue were examined. The effects of bum injury on the levels of glutathione, lipid peroxide and on the activities of oxygen free radical generating and scavenging enzymes have been determined in association with observing of histologic and ultrastructural changes, measuring the protein concentration in plasma, and counting the number of intravascular polymorphonuclear leukocytes. The activity of xanthine oxidase, an enzyme of oxygen free radical generating system. was elevated (p<0.01) in serum, but not in skin and in liver tissue. Futhermore, thermal injury decreased not only the protein concentration in plasma but also the number of leukocytes, that indicates induction of edema formation with protein exudation and inflammation by neutrophil infiltration into the internal organs. These data suggest that acute dermal scald burn injury leads to liver damage, that is related to elevation of xanthine oxidase activity in serum. Xanthine oxidase may be a key role in the pathogenesis of liver damage induced by skin burn.

• Toxicological Research
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• v.30 no.4
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• pp.283-289
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• 2014

Tea flavonoids and polyphenols are well known for their extraordinary antioxidant activity which is considered important for anti-aging processes in animals. This study evaluated the anti-wrinkle effects of three different kinds of tea (Camellia sinensis) water extracts (CSWEs) including green, white, and black teas using a photoaged hairless mouse model. Data showed that the CSWE-treatment greatly improved skin conditions of mice suffering from UVB-induced photoaging, based on the parameters including the skin erythema index, moisture capacity, and transepidermal water loss. In addition, the wrinkle measurement and image analysis of skin replicas indicated that CSWEs remarkably inhibited wrinkle formation. In histological examination, the CSWE-treated mice exhibited diminished epidermal thickness and increased collagen and elastic fiber content, key signatures for skin restoration. Furthermore, the reduced expression of MMP-3, a collagen-degradative enzyme, was observed in the skin of CSWE-treated animals. Interestingly, comparative data between green, white, and black tea indicated that the anti-wrinkle activity of white tea and black tea is equally greater than that of green tea. Taken together, these data clearly demonstrated that CSWEs could be used as an effective anti-wrinkle agent in photoaged animal skin, implying their extended uses in therapeutics.

• Korean Journal of Health Education and Promotion
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• v.18 no.1
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• pp.139-149
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• 2001

With the increasing number of women involved in social activities, beauty industry has flourished. More women than ever before are concerned about make-up, hair care, skin care, and weight control, etc. With the success and commercialization of beauty industry, unconfirmed beauty care services have been introduced in the market. However, the health hazard from diverse beauty care services has not been systematically addressed. This study has the following two purposes: 1) to examine the utilization pattern of diverse beauty care services; and 2) to examine the health hazard from beauty care services. For this study, two major universities located in Seoul area were selected. While 450 female college students were selected from one women's university, the other 450 were from mixed university. Using survey questionnaire, we interviewed with 900 female college students. The results are as follows: As for the beauty care patterns, makeup accounted for 78.6％, Skin care 49.5％, weight/body control 32.0％, hair care 81.5％, and cosmetic operation 14.9％, indicating significant high rates of makeup(x2=9.215, p=0.002) and hair care(x2=4.435, p=0.035) at both mixed and women's universities. The health hazard was measured using four questions. The past studies have not paid special attention to the methodological issue of how to ask health hazard. Depending on how to ask health hazard, the percentage of respondents reporting health problems varied. When the respondents were asked whether or not they had suffered health problems for a short period, over 60％ of respondents reported health problems; when they were asked in other ways-1) whether or not they had suffered health problems for a long period, 2) whether or not they had suffered whole body problems, 3) whether or not they had permanent traces on skin due to beauty care activities-, the percentage of respondents reporting health problems dropped substantially to less than 10％, This finding indicates the importance of ‘words’ used in questions. The relationships between health problems and utilization of beauty care services were examined, using χ2 test or t test. We found that there was a significant relationship between health problem and beauty care.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.17 no.3
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• pp.314-323
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• 2010

Purpose: This study was performed to identify skin hydration status and skin surface pH according to the body parts of the aged with immobilization. Methods: The subjects were 101 aged patients in a hospital and a institution for the elderly in Seoul. Data for skin hydration and skin surface pH were collected using corneo-meter and skin pH-meter. The body parts of measurement were 10 parts; face, forearm, back of the hand, flank, upper abdomen, leg, back of the foot, heel, scapular, and sacrum. The data were analyzed by SPSS/WIN 12.0 program. Results: Skin hydration status were relatively low especially on lower extremity and back of body, and skin surface pH of scapular and sacrum were high. There was significant negative correlation between skin hydration status and skin surface pH on the 6 body parts. Conclusion: Skin hydration status and skin surface pH, especially on scapular, sacrum, and lower extremity need to be considered as important control factors for increasing skin health status of the aged with immobilization.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.7
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• pp.2886-2894
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• 2012

This study is intended to research female university students' concern with beauty care, their skin condition, knowledge and treatment comparing the majors with the non-majors in Seoul. This comparative study between them focused on their educational and behavioral differences in beauty care in the same living space, and the results were as follows: The majors' average point on the concern with skin health care was higher than the non-majors(p<.01). There were more combination skin type in the major group, and more dry skin type in the non-major group. Also, there were meaningful differences among the two groups in frequency of double cleansing after makeup, exfoliating, massaging or applying mask packs, using sunscreen(p<.01, p<.001, p<.01, p<.01). Further, intake rates of instant food and moisture were meaningfully different between them(p<.001, p<.05). In addition, the majors more tended to purchase cosmetics efficiently through lots of channels, and showed more active attitude to buy high-price cosmetics with outstanding properties although they have financial burden(p<.001). It was hoped that the results of this study would be used in skin care industry and education area in the future.

• Journal of Environmental Health Sciences
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• v.30 no.4
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• pp.344-346
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• 2004

During a survey of the helminth parasites of fresh water fishes in Willamette River, metacercariae of Neascus spp. were found on examination of muscle, spinal cord, fin and skin of Chiselmouth, Acrocheilus alutaceus. One hundred percent of 19 Chiselmouth examined were found to be infected with digenetic trematodes. The prevalence of infection was higher in muscle, varying from $95\%\;and\;100\%$. Higher levels were present in muscle, such that the $100\%$ level being found in upper anterior, lower anterior and posterior. Small numbers of metacercariae were found on the fin and skin. The commonest sites of infection were the musculature and spinal cord. Intensities of Neascus spp. metacercariae tended to be and high levels in muscle and spinal cord. Those were low levels occurred in the fin and skin. There was a high degree of Neascus spp. in the occurrence of digenetic trematode from Chiselmouth.