• Journal of Pharmaceutical Investigation
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• 제33권3호
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• pp.163-169
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• 2003

In order to develop a film-forming transdermal drug delivery system, polyurethane (PU) based on poly(ethylene glycol) and poly(tetramethylene oxide) was synthesized and characterized. The synthesized PU was blended with Gantrez ES 225 (GT) to improve the adhesion property of film-forming agent to the skin. When film-forming gel formulation containing 3% ketoprofen (KP) was applied, transparent thin film was obtained within 5 minutes and adhered to the skin for 8 hours. In vitro percutaneous absortion studies were performed to determine the rate of ketoprofen absorption through guinea pig skin. A prominent effect of limonene on the skin permeability of ketoprofen was observed among the various skin permeation enhancers investigated. Considering mechanica properties of film and skin permeability of ketoprofen, 2% of limonene was optimal content in the film forming transdermal formulation.

• 대한물리치료과학회지
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• 제26권2호
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• pp.1-12
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• 2019

Purpose: The purpose of this study is to find out changes in skin temperature, which is one of the regulatory systems of homeostasis, according to the isotonic-isometric exercise type, and changes in skin temperature according to gender and BMI index through isotonic-isometric exercise. Design: Randomized Controlled Trial. Methods: This study was conducted for 28 healthy male and female students from Department of Physical Therapy, G University. Subjects carried out isometric-isotonic exercise using dumbbells of 4kg and 8kg, respectively. And skin temperature was measured by using a computer infrared thermography. Results: The isometric exercise group was significantly difference changes in temperature by measurement time. Conclusion: In order to find out the effect of isometric exercise and isotonic exercise on skin temperature changes of biceps brachii, this study was carried out for 28 healthy male and female adults. The result of this study may helpful as basic data for orthopedic physical therapy.

• Steel and Composite Structures
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• 제14권2호
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• pp.191-204
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• 2013

A hybrid double skin concrete filled (HDSCF) circular steel tube column is proposed in this study. The yield strength of the outer steel tube is larger than 690MPa and the inner tube has less strength. In order to achieve efficiency with the high strength outer tube, a feasibility study on reducing the thickness of the tube below the specified design codes for CFTs was conducted based on an experimental approach. The experiment also took variables such as thickness of the inner tube, hollow ratio, and strength of concrete into consideration to investigate the behavior of the HDSCF column. In order to estimate the applicability of design equations for CFTs to the HDSCF column, test results from CFT and HDSCF columns with design codes were compared. It was found that the axial compressive performance of the proposed HDSCF column is equivalent to that of the conventional CFT member irrespective of design variables. Furthermore, the design equation for a circular CFT given by EC4 is applicable to estimate the ultimate strength of the HDSCF circular steel tube column.

• 한국가구학회지
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• 제21권4호
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• pp.273-283
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• 2010

Structural larger timber have some weak points as like much longer drying time at lower MC(15%), a considerable check developing and the difficulty for the chemicals injection, so it is necessary to develop lighter structural size member for using the new Hanok, heavy timber construction, living necessaries, furniture and industrial goods. The developed skin timber can be a good raw material for those uses. Skin timber is a hollowed timber which be bored out of its considerable cross-sectional area. The intention of this study was the evaluation of compressive capacity of skin timber. Specially, skin timbers which have more than 200mm in sizes were used to analyze the compressive capacity. From the results of this study, the following conclusions have been made: 1. Though considerable inner parts were bored out, both pine skin timber and larch skin timber showed a good compressive capacity to that of non-bored solid timber. 2. According to ASTM, pine skin timber showed various failure types, but Splitting type, Brooming and end rolling type were main failure types for the larch skin timber. 3. Pine skin timber didn't show the significance between cylindrical shape and rectangular shape, but larch skin timber showed the significance between two shapes. Therefore, for the larch skin timber, cylindrical shape and rectangular shape should be used as a column uses and beam uses respectively. 4. Pine skin timber and larch skin timber didn't show the significance on the compressive capacity. There is not much difference of compressive capacity between them, so it can be possible to select on the user convenience.

• 산경연구논집
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• 제10권8호
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• pp.25-32
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• 2019

Purpose - This study aims to explore women's beauty industry market and growth development by identifying the main factors of women's perception of skin health care. Research design, data, and methodology - The survey was conducted on women aged 20 to 60 living in Seoul. For the statistical analysis, frequency analysis, t-test and one-way ANOVA were conducted, and significant differences in p<0.05 were tested through the multiple range test of the Scheffe. The factor analysis was conducted to verify the validity of questions, and the reliability was determined by the coefficient of Cronbach's α. Results - The lower the age, the higher the perception of the skin, and women pay a higher price for skin health as a provisional customer. 'Acne care' was the most common skin condition (32.8%), 'life style' (79.8%) was the most important part of skin care. Final education was the highest level of skin care for women with a professional background (M=3.41) (F=4.028, p<.05). Conclusions - The differences in the recognition of health knowledge by age, marital status, and household monthly income were significant, but there was no difference between jobs and final education. Customers who use less skin care than customers who frequently use the skin care center were more aware of skin health, and women who have a high awareness of skin are more interested in aging and regenerating due to the skin care.

• Korean Journal of Acupuncture
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• 제38권2호
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• pp.62-74
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• 2021

Objectives : The aim of this study is to analyze the effect of acupuncture and the details of acupuncture treatment methods on skin wrinkles. Methods : Search was conducted in Pubmed, KISS, and NDSL databases for acupuncture studies on skin wrinkles. The detailed therapeutic techniques of acupuncture used for skin wrinkles and the effect of acupuncture on skin wrinkle improvement were analyzed. Then, the study results using the same indicator were compared through meta-analysis in order to compare the effects of acupuncture with the control group. The quality of randomized controlled trials (RCTs) was assessed using the risk of bias (ROB) assessment tool (Ver. 1.0, Cochrane Collaboration). Results : A total of 10 RCTs and 19 case series were included in this study. The most frequently used therapeutic technique for skin wrinkle improvement was Microneedle therapy system (MTS, n=19), and they were mostly used with aesthetic solutions (13 out of 19 studies). Skin wrinkle related indexes were most commonly used to evaluate skin wrinkle improvement (n=14). Panax Ginseng pharmacopuncture showed the most remarkable effect in improving the range of skin wrinkles and the depth of skin wrinkles. MTS+epidermal growth factor improved the levels of skin hydration, skin elasticity, and variation of skin pigment the most. MTS+Endothelial precursor cell improved the number of skin melanin the most. Three RCTs included in the meta-analysis showed moderate ROB on average. Conclusions : Acupuncture treatment was effective in improving skin wrinkles. However, a precise study design using unified indicators and appropriate controls needs to be performed in further studies in order to establish more convincing evidence of the effectiveness of acupuncture for improving skin wrinkles.

• 대한화장품학회지
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• 제47권2호
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• pp.133-138
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• 2021

본 연구에서는 기능성 미백물질인 나이아신아마이드(NI)의 피부 투과율을 개선시키기 위해 NI를 고형지질 나노입자(solid lipid nanoparticles, SLNs))에 봉입하고 피부 투과율을 평가하였다. NI는 이중 에멀션 가온용융 유화법으로 SLNs 내에 효과적으로 봉입할 수 있었으며, 평균 입자 크기는 263.30 ~ 436.93 nm이었고 제타전위는 -34.77 ~ -57.60 mV인 안정한 입자를 제조하였다. NI의 피부 투과 연구를 위해 인체 표피 조직에서 유래된 피부각질세포로 만든 3차원적 인공피부(SkinEthic^TM RHE)을 사용하였다. NI의 피부 투과 및 침적 실험 결과 모든 SLNs 제형이 NI의 피부 투과 및 침적율을 개선시켰으며, SLNs을 적용하였을 때가 그렇지 않을 때 보다 투과율은 약 5.4 ~ 7.6 배, 침적율은 9.5 ~ 20.8 배 개선되었을을 확인하였다. 따라서, 본 연구에서 제조된 고형지질나노입자는 기능성 미백물질인 나이아신아마이드의 피부 투과율을 개선하기에 충분한 결과를 보여 주었다.

• 기본간호학회지
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• 제1권1호
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• pp.37-49
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• 1994

The purpose of this study was to measure the oral temperature, skin temperature, and subjective discomfort according to the application time of ice bag on thigh, head, and abdomen. This study was also intended to suggest nursing principles about ice bag application by exploring the recovery time of skin temperature after the removal of ice bag. The design of this study was $8{\times}3$ factorial design with one sample repeated measure. Here, the application time of ice bag(criteria, 5min, 10min, 20min, 30min, 40min, 50min, 60min) and the application site of ice bag(thigh, head, abdomen) were independent variables. The subjects were 10 university woman students, and data collection was made from July, 1 to August 30, 1992. Rubber ice bag halfly filled with ice was covered with towel and applied on thigh, head and abdomen in other three days. Before applying the ice bag, oral temperature and skin temperature were checked for criteria. After ice bag was applied, skin temperature, oral temperature and VAS score were checked at first 5 minutes elapsed, and every 10 minutes until 60 minutes. After that, ice bag was removed, and oral temperature and skin temperature were also measured every ten minutes until 60 minutes. In this study, skin temperature and core temperature were measured by thermistor probe, and subjective discomfort was measured by 200mm VAS (Visual Analogue Scale). Some of the findings were as follows : 1. There were significant differences in skin temperature among the three application sites of ice bag as time go by. It was most decreased to $15.87^{\circ}C$ in thigh, and $19.47^{\circ}C$ in abdomen at 50 minutes after the application of ice bag, whereas $26.1^{\circ}C$ at 40 minutes in head. Before the application of ice bag, skin temperature showed significant differences in three sites, so that they were compared after the criteria was covariated. In other words, there was significantly more decrease of skin temperature in thigh and abdomen than head, after ice bag was applied for 20 minutes and more. 2. There was no significant difference in core temperature among the three application sites of ice bag during the time of application 3. There was no significant difference in subjective discomfort (VAS) among the three application sites of ice bag. 4. After the removal of ice bag, the recovery of skin temperature was significantly different in three sites during first 30 minutes. In head, skin temperature came up to criteria at 30 minutes after the removal of ice bag, but it was not recovered In thigh and abdomen even 60 minutes elapsed. 5. After the removal of ice bag, there was no significant difference in oral temperature among the three application sites of ice bag. 6. There was significant correlation between the skin temperature and VAS score only in thigh. In conclusion, it is suggested that head in more suitable site for the application of ice bag if it is used for the relief of fever or pain. When we apply ice bag on thigh or abdomen for the relief of pain, careful attention is required.

• 한국지역사회생활과학회지
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• 제28권3호
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• pp.365-375
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• 2017

The purpose of this study was to investigate the maximal elongation rate and area expansion ratio of human skin in various postures. Five males and five females (male: $23{\pm}2yr$ in age, $177.9{\pm}4.8cm$ in height, $76.7{\pm}8.8kg$ in body weight, $24.2{\pm}2.5$ in BMI, $16.2{\pm}3.4%$ in body fat; female: $22{\pm}1yr$, $163.2{\pm}3.6cm$, $51.4{\pm}2.7kg$, $19.3{\pm}1.6$, $27.4{\pm}6.7%BF$) participated in this study. Measurements were conducted using a pen and tape on the elbow, knee, wrist, shoulder, and neck. Subjects held postures so that each joint of the body regions was bent at its maximal level. The results were as follows: 1) The maximal elongation rate of skin showed a significant difference among the regions: $16.6{\pm}3.4%$ for the wrist, $22.4{\pm}5.5%$ for the neck (back), $37.6{\pm}11.3%$ for the shoulder, $42.6{\pm}10.0%$ for the knee, and $43.9{\pm}4.0%$ for the elbow (p<0.05). 2) The maximal expansion rate of the body surface area had the greatest values on the elbow ($93.7{\pm}6.4%$) and knee ($74.8{\pm}10.8%$). 3) No significant difference was found between males and females. In summary, maximal values of skin elongation and expansion rates in vivo were greater than in vitro values known from previous reports. These results can be applied to develop electronic fibers or textiles for wearable tight fit work clothing as well as fitness wear.

• 한국지반공학회논문집
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• 제35권8호
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• pp.17-30
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• 2019

실제 시공된 말뚝들의 재하시험 자료 및 매입 PHC말뚝의 설계 자료로부터 전체지지력에 대한 주면마찰력의 분담율인 SRF를 분석하였다. 현장에서 시험 시공된 말뚝의 SRF는 말뚝의 종류, 상대근입길이, 지반의 종류, 재하시험의 종류에 상관없이 42~99%이었다. 매입 PHC말뚝에 대한 설계 자료에서 구한 SRF는 말뚝의 직경, 상대근입길이에 상관없이 풍화암에 소켓된 경우 20~53%의 범위에 분포하였다. 사용말뚝으로 실제 시공된 매입 PHC말뚝에서 재항타 동재하시험 자료로부터 구한 SRF는 말뚝의 직경, 상대근입길이, 지반의 종류에 상관없이 4~83%의 범위에 분산되어 분포하였다. 사용말뚝에서 SRF가 낮은 수준으로 나타나는 이유는 매입 PHC말뚝의 주면고정액의 충전이 제대로 이루어지지 않은 채 시공된 현황으로 볼 수 있었으며 따라서 주면고정액의 시공관리에서 시급하게 개선해야 할 현황이었다. 풍화암에 소켓된 매입 PHC말뚝의 설계에서 사용하고 있는 극한지지력 산정공식으로 계산한 주면마찰력의 SRF는 실제 현장 시공 말뚝의 SRF보다 평균적으로 2.2배 정도로 낮은 수준으로 평가되었다. 이는 설계에서 사용하고 있는 산정공식에 의한 극한주면마찰력이 매우 낮은 수준으로 계산되기 때문이다. 따라서 SRF를 만족시킬 수 있는 새로운 주면마찰력 산정공식의 제안 필요성이 있는 것으로 판단된다.