• 제목/요약/키워드: site of action

검색결과 429건 처리시간 0.031초

IDENTIFICATION AND CHARACTERIZATION OF PHOSPHOLIPASE $A_2$ IN OAT CELLS

  • Min, Youn-Mi;Choi, Eui-Chang;Chae, Quae
    • Journal of Photoscience
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    • 제2권1호
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    • pp.1-5
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    • 1995
  • The activity of phospholipase A$_2$ (PLA$_2$) was identified and characterized from cytosolic and membrane fractions of oat cells, respectively. PLA$_2$ activity was determined fluorometrically in the presence of serum albumin using phospholipids labeled at sn-2-acyl position with 10-pyrenyldecanoic acid. When the cell-free extracts of oat tissues were fractionated by ultracentrifugation at 100,000 x g and the PLA$_2$ activity was assayed, we found that most of the PLA$_2$ activity was revealed from the cytoplasmic fraction rather than from the membrane fraction. The activity of cytosolic PLA$_2$ was dependent on Ca$^{2+}$ concentration and the optimum concentration of Ca$^{2+}$ was found to be 100 $\mu$M. It was also found that PLA$_2$ could be translocated toward the membrane site from the cytosol upon increasing Ca$^{2+}$ concentration. These results might suggest that an increased [Ca$^{2+}$]$_i$ by phytochrome action could promote the translocation of the cytosolic PLA$_2$ toward the membrane site.

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구조용 강재의 부식피로 강도에 미치는 산성안개 및 염화칼슘의 영향 (Effects of Acid Fog and CaCl2 on the Corrosion Fatigue Strength of Structural Steel)

  • 김민건;김명섭
    • 산업기술연구
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    • 제21권A호
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    • pp.17-26
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    • 2001
  • The fatigue strength of SM55C has significantly decreased by 83% compared with atmosphere where distilled exists due to strong erosive action of acid fog. The reason is inferred in a way that strong acid erosive material such as acid fog act and give rise to multi-site crack on the surface. Several fatigue clacks occurred under the acid fog repeat the process of division and unification on the surface and form a long non-propagating crack throughout the circumference of experimented steel. However, in the depth, many parts do not show much trace of unification, and the depth is not as big as the one of normal crack shape. 10% of $CaCl_2$ causes strong erosive reaction to material. Then eventually make the life of fatigue shooter. On the other hand, 20% of $CaCl_2$ beings about oxidized material organic crack closing due to weak erosive reaction.

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양식어장 생산성 향상을 위한 적정배치방안-부산 기장연안을 중심으로- (Proposed optimal fishing-ground plan to increase productivity in the Ki-jang coastal region of Busan, Korea)

  • 윤한삼;김헌태;류청로;김영표
    • 수산해양교육연구
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    • 제17권3호
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    • pp.361-372
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    • 2005
  • The purpose of this paper was to examine the status of unlawful actions in the fishing grounds located in the Ki-jang coastal region of Busan, Korea, and to develop an optimal fishing-ground plan that will increase the productivity of fisheries resources. We examined the impacts of important factors influencing the basic environment of the fishing grounds at the study site, as including the physical environmental conditions of water temperature and qualies. In addition, we administered a survey that focused on the necessity of enhanced maintenance of the fishing grounds at this site. As a result, we identified some required management action for the fishing grounds and proposed an optimal fishing-ground plan to increase productivity in the Ki-jang coastal region of Busan.

토양에 유출된 유류의 오염도 조사에 관한 사례연구 (Case Study of Oil Spills in Soil; Oil Concentration Distribution in Soil)

  • 박규홍;박준범
    • 상하수도학회지
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    • 제11권2호
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    • pp.31-39
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    • 1997
  • Between 40,000 and 60,000 liters of light oil were spilled when an underground pipe broke at a newly constructed landfill site in coastal area, Korea. Methods were presented to examine the subsurface distribution of the contaminants in hydrocarbon-contaminated soil. As results, large quantities of oil and grease were found to have migrated horizontally at the site. Oil and grease plume at concentrations of 38-88 mg/kg was formed horizontally through silty sand with gravel fill and the vertical movement of the contaminants was thought to be limited to groundwater level between 2 and 4 m corresponding to sea water level. Right after finding the leakage area, the early action of excavation and pumping out the mixture of groundwater and oil was taken and it was proved to be very effective for preventing further contamination. Two months after the leakage, oil and grease in sea water sample near contaminated area was not detectable.

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Subarachnoid Hemorrhage Presenting with Seizure due to Cerebrospinal Fluid Leakage after Spinal Surgery

  • Bozkurt, Gokhan;Yaman, Mesut Emre
    • Journal of Korean Neurosurgical Society
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    • 제59권1호
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    • pp.62-64
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    • 2016
  • Cerebrospinal fluid leakage may commonly occur during spinal surgeries and it may cause dural tears. These tears may result in hemorrhage in the entire compartments of the brain. Most common site of such hemorrhages are the veins in the cerebellar region. We report a case of hemorrhage, mimicking aneurysmal subarachnoid hemorrhage due to a cerebrospinal fluid leakage following lumbar spinal surgery and discuss the possible mechanisms of action.

송과선 호르몬 멜타토닌의 생식 생리학 (Reproductive Physiology of Pineal Hormone Melatonin)

  • 최돈찬
    • 한국동물학회지
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    • 제39권4호
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    • pp.337-351
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    • 1996
  • 멜라토닌은 대뇌와 소뇌 사이에 위치한 송과선에서 분비되는 호르몬으로 빛이 없는 밤에만 분비된다. 멜라토닌은 분자적 수준에서부터 개체의 행동에 이르기 까지 다양한 기능을 보인다. 특히, 생식에 미치는 영향은 광범위하여, 온대지방에 사는 대부분의 동물은 주위 환경에 적응하여 종족을 유지하는 유일한 계절적 번식을 한다. 햄스터의 생식활동은 여름에 왕성하고 겨울에 정지된다.이는 많은 환경요소중 광주기의 효과가 송과선에 의해 제거하면 광주기의 영향은 사라진다. 즉 생식에 미치는 광주기의 효과가 송과선에 의해 중재 됨을 의미한다. 또한 송과선 호르몬인 멜라토닌의 적절한 처리는 생식활동을 억제한다. 따라서 멜라토닌은 생식에 미치는 광주기의 정보를 생식내분비계로 전달하는 신경전달물질로 사료된다. 시상하부의 특정부위를 절제한 후 광주기나 멜라토닌을 처리하여 멜라토닌의 작용부위에 관한 연구가 되었으나 동물마다 차이점을 보인다. 대부부의 동물에서 공통적인 부위는 suprachiasmatic nuclei와 pars tuberalis이다. 멜라토닌이 생식에 미치는 작용기작은 아직 밝혀지지 않았다. 이는 멜라토닌의 지속적 처리가 멜라토닌의 장기적처리는 이들 호르몬의 분비를 저하시키고, 시상하부에서의 gonadotropin-releasing hormone (GnRH)양을 증가시킨다. 이 결과는 멜라토닌의 지속적인 처리가 시상하부로부터의 GnRH 양을 분비를 감소킴으로써 생식활동을 억제하는 것으로 사료된다.그러나, 멜라토닌에서 GnRH 신경까지의 정보전달은 아직 밝혀지지 않았다. Opioid 신경에 대한 광주기와 멜라토닌의 효과가 동일한 점은 opioid신경의 매개체 역할을 제시하고 있다. 최근에 멜라토닌 수용체가 개구리의 피부와 몇몇 동물의 뇌와 시세포에서 크로닝되었다. 이수용체는 G protein과 관련되고 cAMP 생성을 억제한다. 앞으로 이 멜라토닌 수용체의 존재여부와 분자생물학적 연구는 멜라토닌의 작용부위와 표적세포에서의 작용기작을 설명하는 데 크게 기여할 것으로 기대된다.

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패밀리레스토랑의 웹사이트를 활용한 인터넷마케팅 전략에 관한 연구 (A Study on the Internet Market ing Strategy uh ich applies the web site for Family Restaurant)

  • 진양호;전진화
    • 한국조리학회지
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    • 제8권1호
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    • pp.1-21
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    • 2002
  • A study is on the market ing strategy which applied the web site for family restaurant. The internet marketing that the firm uses to attract consumer needs and it can be said to be the strategic effort to cope with dynamic environmental change in the market with strategic flexibility which has competitive advantage and increase its profitablelity. This study establish an internet marketing strategy plan and it presented. First, it constructs a data base using CRM and it manages with to create the benefit model. Second, it constructs the trusted relationship of the customer using Permission marketing. Third, the virus marketing is effect ive to create customers in short duration. Forth, e-mai1 marketing for target customer is also effective Fifth, experienced marketing provides the good experience and an immersion. Sixth, tie-in marketing which co-operate with the other company is magnifies a category of customer therefore this study about internet marketing action will be hopefully continued.

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Java-based LonTaIk/IP Network for Predictive Maintenance (PM)

  • Park, Gi-Heung
    • 한국산업안전학회:학술대회논문집
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    • 한국안전학회 2001년도 공동학술대회
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    • pp.31-35
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    • 2001
  • Recent trends require that access to the device/equipment information be provided from several locations or anywhere in the enterprise. One example is virtual machine/manufacturing system (VMS) where predictive maintenance is performed both on factory floor and in remote site through internet [1]. Internet access is increasingly available and affordable, and along with the "internet" is the backbone of modern enterprise data networks. Typical functions of such a system includes monitoring and control for diagnosis and remedy action in realizing preventive maintenance.(omitted)

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내외과계 환자의 정신과 약물치료에서 약물-약물 상호작용 - 고려대학교 부속병원의 자문조정의 경험을 통하여 - (Drug-drug Interactions between Psychotropic Agents and Other Drugs in Physically Ill Patients - Experience of Consultation-liason in Korea University Hospital -)

  • 이민수;이헌정
    • 생물정신의학
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    • 제6권1호
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    • pp.49-66
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    • 1999
  • Polypharmacotherapy, both psychotropic and nonpsychotropic, is widespread in various situations including psychiatric hospitals and general hospitals. As the clinical practice of using more than one drug at a time increase, the clinician is faced with ever-increasing number of potential drug interactions. Although many interactions have little clinical significances, some may interfere with treatment or even be life-threatening. The objective of this review is evaluation for drug-drug interactions often encountered in psychiatric consultation. Drug interactions can be grouped into two principal subdivisions : pharmacokinetic and pharmacodynamic. These subgroups serve to focus attention on possible sites of interaction as a drug moves from the site of administration and absorption to its site of action. Pharmacokinetic processes are those that include transport to and from the receptor site and consist of absorption, distribution on body tissue, plasma protein binding, metabolism, and excretion. Pharmacodynamic interactions occur at biologically active sites. In psychiatric consultation, these two subdivisions of drug interactions between psychotropic drugs and other drugs are likely to happen. We gathered informations of the drugs used in physically ill patients who are consulted to psychiatric department in Korea University Hospital. And we reviewed the related literatures about the drug-drug interactions between psychotropic drugs and other drugs.

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서중(暑中) 환경에서 현장 콘크리트 시험을 통한 재료 품질관리 방안 (A Study on Concrete Material Quality Management Based on Various Test of Construction Condition under Hot Weather Circumstance)

  • 박신
    • 한국건축시공학회지
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    • 제5권3호
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    • pp.91-99
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    • 2005
  • It is required to study systematical on the concrete quality management to extend structure life because rebuilding effect is reducing under present condition of large sized and high stories structure. Concrete, which shows its intensity by hydrating action and a big change in quality according to hot weather and temperature, produces a lot of qualify problem under hot and cold weather Because of each specification and construction plan which does not have basic standard on site, concrete's quality is irregular and makes some defect. As a result, Daegu is turned out to be the longest area after investigating application period and days focused on 8 cities weather information about relationship between hot weather circumstance and construction environment. Therefore, we first surveyed the concrete material in the region and found out the problem of quality nanagement. Then figure out the way of solution. Moreover, we integrated concrete material quality management, which is applied differently to each site, to have equal quality and to reduce defect from construction site. And then, based on various test of construction condition and analysis of quality management item, we suggest effective concrete quality management to make concrete material construction standard guide and plan under hot weather.