• 제목/요약/키워드: single period

검색결과 2,551건 처리시간 0.089초

A Single Oral Dose Toxicity Study of Bamboo Leaf Water Extract in Sprague-Dawley Rats

  • Shin, Dong-Ho;Jang, Pan-Gu;Oh, Ki-Seok;Kim, Jae-Ha;Chung, Hee-Jong;Kim, Jong-Choon
    • Biomolecules & Therapeutics
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    • 제11권3호
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    • pp.200-203
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    • 2003
  • The present study was carried out to investigate the potential acute toxicity of bamboo leaf water extract by a single oral dose in Sprague-Dawley rats. Twenty male and female rats aged 5 weeks were randomly assigned to four groups of 5 rats each and were administered singly by gavage at dose levels of 0, 1250, 2500, or 5000 mg/kg body weight. Mortalities, clinical findings, and body weight changes were monitored for the l4-day period following the administration. At the end of 14-day observation period, all animals were sacrificed and complete gross postmortem examinations were performed. Throughout the study period, no treatment-related deaths were observed. There were no adverse effects on clinical signs, body weight, and gross finding at any dose tested. The results showed that the single oral administration of bamboo leaf water extract did not induce any toxic effect at a dose level of below 5000 mg/kg in rats and that the minimal lethal dose were considered to be over 5000 mg/kg body weight for both sexes.

랫드에서 죽여(Balbusae caulis in Taeniam)의 단회경구투여 독성시험 (Single Oral Dose Toxicity Study of Balbusae caulis in Taeniam in Rats)

  • 신동호;신진영;김성호;김재하;정희종;김종춘
    • Toxicological Research
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    • 제20권4호
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    • pp.325-328
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    • 2004
  • The present study was carried out to investigate the potential acute toxicity of Balbusae caulis in taeniam by a single oral dose in Sprague-Dawley rats. Twenty rats of each sex were randomly assigned to four groups of 5 rats each and were administered singly by gavage at dose levels of 0, 1250, 2500, and 5000 mg/kg body weight. Mortalities, clinical findings, and body weight changes were monitored for the 14-day period following administration. At the end of 14-day observation period, all animals were sacrificed and complete gross postmortem examinations were per-formed. Throughout the study period, no treatment-related deaths were observed. There were no adverse effects on clinical signs, body weight, and gross finding at any dose tested. The results showed that the single oral administration of Balbusae caulis in taeniam did not cause any toxic effect at the dose levels of 5000 mg/kg or lower in rats and the minimal lethal dose was considered to be over 5000 mg/kg body weight for both sexes.

Effects of Phase Feeding on Growth Performance, Nutrient Digestibility, Nutrient Excretion and Carcass Characteristics of Finishing Barrow and Gilt

  • Kim, Y.G.;Jin, J.;Kim, J.D.;Shin, I.S.;Han, In K.
    • Asian-Australasian Journal of Animal Sciences
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    • 제13권6호
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    • pp.802-810
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    • 2000
  • A total of 120 finishing crossbred pigs ($Landrace{\times}Large$ $White{\times}Duroc$) with equal numbers of barrows and gilts weighing 58.5 kg body weight were used in a feeding trial, and 6 pigs (three of each sex) were used in a metabolic trial to investigate the effect of phase feeding. Finishing period was divided into two phases and 4 different diets were fed for those periods. Growth performance was not significantly different among treatments within the same sex. This result showed that 16% crude protein for early finishing period and 14% crude protein diet for late finishing period should be optimum. During the early finishing period, only feed intake was significantly different between sexes (p<0.01), but in late finishing period daily weight gain (p<0.001) and feed intake (p<0.01) of barrows were significantly higher than those of gilts. During the early finishing period, digestibilities of dry matter, protein and phosphorus were significantly higher in gilts than in barrows (p<0.05). However, there was no treatment effect within same sex during the early and late finishing period. During early finishing period, excretion of N of pigs fed 16% CP diet in early and 14% CP diet in late-finishing period was less than that of pigs fed 17% CP diet in early and 15% CP diet in late-finishing period (p<0.05), but the difference was not significant. During the late finishing period, N excretion with two phase feeding was reduced by 8.5% compared with single feeding. In gilts, total cost reduction by two phase feeding compared to single feeding was 9.1%, but in barrows it was just 3.19%. Relative margin increased with two phase feeding by 2.5% in gUts and 0.2% in barrows. There was a tendency that backfat thickness at 10th rib of gilts was thinner than that of barrows (p>0.05). Within the same sexes, there was no treatment effect on back fat thickness (p>0.05). Carcass grade was improved by two phase feeding compared to single feeding. Carcass grade of gilts was significantly better than that of barrows (p<0.001). From this results, it is concluded that finishing pigs could be fed two-phase diets to improve profit and reduce pollution.

Effects of Phase Feeding on Growth Performance, Nutrient Digestibility and Nutrient Excretion of Growing Barrows and Gilts

  • Kim, Y.G.;Jin, J.;Kim, J.D.;Kim, J.H.;Han, In K.
    • Asian-Australasian Journal of Animal Sciences
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    • 제13권6호
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    • pp.795-801
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    • 2000
  • A total of 120 growing crossbred pigs ($Landrace{\times}Large$ $White{\times}Duroc$) with equal numbers of barrows and gilts were used in the feeding trial in a $2{\times}3$ factorial arrangement (gender by feeding regimens) to investigate the effect of phase feeding on growth performance during the 25 to 58 kg body weight growth stage, and 6 pigs (three of each sex) were used in a metabolic trial. The growing period was divided into two phases and 4 different CP diets were used to make 3 different feeding regimens (GE18-GL18; 18% CP diets for both early and later growing period, GE18-GL16; 18% CP diet for early and 16% CP diet for later growing period, GE19-GL17; 19% CP diet for early and 17% CP diet for later growing period). There were no significant differences in growth performance among treatments during the entire growing period. However, during the later growing period, feed intake of barrows was significantly higher than that of gilts (p<0.05). Average daily gain of barrows was higher than that of gilts (p>0.05). Based on the result, growth performance differences between barrows and gilts appeared to begin after 40 kg of body weight. There was no significant difference in digestibility among treatments or between sexes. During the early growing period the 18% CP diet showed better digestibility than the 19% CP diet. However, during the later growing period, the 18% and 17% CP diets exhibited similar digestibilities, although 16% CP diet showed slightly lower digestibility than 18% and 17% CP diets. During the early growing period, fecal N and P excretion of pigs fed the 19% CP were higher than that of those fed the 18% CP diet. During later growing period, fecal N and P excretion by those receiving the two phase feeding compared to single phase feeding was reduced by 10.2% and 2.0%, respectively. In the gilts, the cost reduction by two phase feeding (GE18-GL16) compared to single feeding was around 3.81%, but that of barrows was only 0.52%. The results suggested that the same nutrient levels could be applied to barrows and gilts during the growing period. Also, this study suggested the optimum protein and lysine level for early and later growing pigs to be 18% CP, 1.0% lysine and 16% CP, 0.8% lysine, respectively. Feeding two diets to growing pigs, i.e., two-phase feeding, would be more appropriate than feeding a single diet on economic and environmental considerations.

mBHT의 랫드를 이용한 단회경구투여 독성시험 (Single-dose oral toxicity study of mBHT in Sprague-Dawley rats)

  • 박영철;박용기
    • 동국한의학연구소논문집
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    • 제11권
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    • pp.66-73
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    • 2008
  • Objectives: The study was designed to evaluate the single dose toxicity of modified Bo-yang-Hwan-o-Tang (mBHT) in Sprague-Dawley (SD) rats. Methods: The mBHT was once administrated orally to both sexes of rats at dose 2,000 mg/kg body weight which are the recommended maximum limit dose for acute toxicity. We recorded clinical signs of toxicity, body weight, gross and histological changes in target organs for all rats. Results: Neither significant changes of body weight not death was observed during the observation period in mBHT-administrated rats. Neither significant toxic signs not histopathological changes were shown during the observation period. There were not observed significant gross abnormality between the control and mBHT-administrated rats. Conclusions: These results indicated that the toxicity of mBHT is greater than 2,000 mg/kg body weight in SD rats.

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축퇴 4 광파 혼합에 의한 광섬유에서의 광영상 직접전송에 관한 연구 (A Study on the One-way Optical Image Transmission Through Optical Fiber by Degenerate Four Wave Mixing)

  • 안병구;이우상;김은수;양인응
    • 대한전자공학회논문지
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    • 제25권4호
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    • pp.460-466
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    • 1988
  • In this paper, the theory and experiments on the one-way optical image transmission through optical fiber by using degenerate four wave mixing in BSO single crystal are demonstrated. From the theoretical analysis, the diffraction efficiency of phase conjugate wave in BSO single crystal is greatly dependent on applied electric field intensity, diffraction grating period formed in the crystal and incident beam ratio, those are also in good agreement with the experimental results. Based on the experimental results, we have arranged the typical degenerate four wave mixing system in the optimal conditions (applied electric field, E. = 5kV/cm` diffraction grating period, 3\ulcorner` beam ratio of backward pump wave versus signal wave, 2.7) and realized one-way optical image transmission system through optical fiber using BSO single crystal.

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근휴지기 측정을 위한 새로운 문턱치 결정 알고리즘에 관한 연구 (A Study of new Algorithm for Measuring Myo-silent period)

  • 김덕영
    • 대한전자공학회:학술대회논문집
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    • 대한전자공학회 2008년도 하계종합학술대회
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    • pp.1005-1006
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    • 2008
  • A mechanical or electrical stimulation to the muscle always produces special phenomena, as silent period. Generally, a mechanical stimulation is followed by a single silent period, and an electrical stimulation is followed by multiple silent periods. In this paper, we propose a new algorithm for determining the duration of the silent period.

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Adaptive Reconstruction of Multi-periodic Harmonic Time Series with Only Negative Errors: Simulation Study

  • Lee, Sang-Hoon
    • 대한원격탐사학회지
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    • 제26권6호
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    • pp.721-730
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    • 2010
  • In satellite remote sensing, irregular temporal sampling is a common feature of geophysical and biological process on the earth's surface. Lee (2008) proposed a feed-back system using a harmonic model of single period to adaptively reconstruct observation image series contaminated by noises resulted from mechanical problems or environmental conditions. However, the simple sinusoidal model of single period may not be appropriate for temporal physical processes of land surface. A complex model of multiple periods would be more proper to represent inter-annual and inner-annual variations of surface parameters. This study extended to use a multi-periodic harmonic model, which is expressed as the sum of a series of sine waves, for the adaptive system. For the system assessment, simulation data were generated from a model of negative errors, based on the fact that the observation is mainly suppressed by bad weather. The experimental results of this simulation study show the potentiality of the proposed system for real-time monitoring on the image series observed by imperfect sensing technology from the environment which are frequently influenced by bad weather.

Changes in Maternal Blood Glucose and Plasma Non-Esterified Fatty Acid during Pregnancy and around Parturition in Twin and Single Fetus Bearing Crossbred Goats

  • Khan, J.R.;Ludri, R.S.
    • Asian-Australasian Journal of Animal Sciences
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    • 제15권4호
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    • pp.504-508
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    • 2002
  • The effects of fetal number (single or twin) on blood glucose and plasma NEFA during pregnancy and around parturition were studied on ten Alpine ${\times}$ Beetal crossbred goats in their first to third lactation. The animals were divided in-groups 1(carrying single fetus, n=4) and 2(twin fetus, n=6). The samples were drawn on day1 after estrus and then at 14 days interval (fortnight) for 10 fortnights. Around parturition the samples were taken on days -20, -15, -10, -5, -4, -3, -2, -1 prior to kidding and on day 0 and +1, +2, +3, +4, +5, +10, +15, +20 days post kidding. In twin bearing goats the blood glucose concentration continued to increase from 1st until 4th fortnight and thereafter gradually decline from 5th upto 8th fortnight. In single bearing goats there was increase in levels from 2nd upto 4th fortnight and thereafter it declined from 5th uptill 9th fortnight. The difference in sampling interval was highly significant (p<0.01) in both the groups. However the values were higher in single than in twin bearing goats. The plasma NEFA concentration was low in both the groups' upto 4th fortnight and thereafter it is continuously increased upto 9th fortnight. During prepartum period the blood glucose was higher in single than in twin bearing goats. The values were minimum on the day of kidding in both the groups. During postpartum period the values were significantly (p<0.01) higher in twin than in single fetus bearing goats. The plasma NEFA was significantly (p<0.05) higher in twin than in single fetus bearing goats. The blood glucose and plasma NEFA concentration can be used as index of nutritional status during pregnancy and around parturition in goats.

모자가족의 어머니와 자녀가 지각한 가족기능의 특성 (Some Characteristics of Their Family Functions Perceived by Mothers and Children of Single-Mothers)

  • 권복순
    • 한국사회복지학
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    • 제40권
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    • pp.5-37
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    • 2000
  • The purpose of this study is to find out some characteristics of the family functions of single mothers to provide some useful data for the development of programs which may help single mothers to improve their family functions. The McMaster Family Assessment Device (FAD) which is composed of problem solving function (PS), communication function (CF), role function (RC), emotional reaction function (ER), emotional involvement (EI), behavioral control function (BC), and general function (GC) and McCubbins' FSI were administered to single mothers and their adolescent children and mothers and their adolescent children of ordinary families (control family). The single mothers' perception of their family function was lower than that of control family mothers in an the 7 categories of FAD. The perceptions of the family function of the single mothers' children were lower than those of control family mothers' children. There was on significant difference between the perceptions of single mothers and their children in PS, ER, EI, GC of their family. However, single mothers' perception in RC and BC was lower than that of their children, and the children's perception in CF were lower than that of their mothers. Single mothers who fall on the period of single motherhood was shorter than 7 years perceived their families' function as lower than that of single mothers' who fall on the periods of single motherhood longer than 7 years in all categories. Generally speaking, the single mothers' family functions were lower than that of control family. The different characteristics of each single mother's family functions should be considered in developing programs for single mothers.

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