• 경영과정보연구
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• 제35권3호
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• pp.1-22
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• 2016

본 연구는 MS-VAR 모형을 이용하여 1971년 1분기부터 2016년 1분기까지 분기별 실질 GDP의 국제적 동조화 및 구조적 변화를 조사하고자 하였다. 본 연구의 주요 결과는 다음과 같다. 첫째, 본 연구에서 실질 GDP에서 모형 또는 개별 시계열에서 발생되는 경기변동현상은 마코프 국면전환 분석으로 파악되었다. 또한 본 연구에서 국가별 실질 GDP를 이용한 MS-VAR 모형의 동조성과 비대칭성을 현저하게 보여 주었다. 둘째, 본 연구에서 부분적으로 차이가 있을지라도 MS-VAR 모형에서 글로벌 오일쇼크위기가 끝나는 1988년 2분기와 글로벌 금융위기가 시작된 2007년 3분기 등에서 경기수축국면(불경기)이 나타나는 구조적 변화가 현저하게 존재하였다. 1988년 2분기 전의 경우 독일과 일본의 상관관계가 가장 높았고 다음으로 미국과 일본, 미국과 독일, 한국과 미국 등의 순으로 높았으며, 이후에는 미국과 독일간의 상관관계가 가장 높았고 미국과 캐나다, 독일과 캐나다, 한국과 일본 등의 순으로 높았다. 셋째, 경기확장과 경기수축국면은 동시적으로 국가간에 대규모로 구조적 변화를 발생시켰다. 1973년과 1974년의 1차의 글로벌 오일쇼크 이후에 동시에 발생한 2차의 전세계 오일쇼크가 대규모의 국제적 실질 GDP의 동조화를 일으킨 주요 원인이었다. 또한 이용되는 G7 국가들이 1997년부터 1999년까지의 아시아의 외환위기 동안에 한국과 관련된 동조화가 미약하게 나타났을지라도 글로벌 금융위기기간인 2007년 말에는 한국과 G7 국가간에 현저한 동조화를 나타내었다. 넷째, 실질 GDP를 이용한 국면전환과 더불어 1973년 이후는 국가별로 발생하는 고유의 충격으로 인해 동시적 상관관계가 높게 나타나는 특징을 보여 주었다. 이러한 결론은 이용가능한 많은 이론적 및 실증적 증거와 일치하였으며, 과거 30년의 거시경제적 변동은 주로 전세계적인 충격에 의해 발생되었다는 것을 확인하였다. 글로벌 경기변동은 대규모의 비대칭적 충격이 일반적 변동으로 인하여 일시적으로 상쇄될 수 있다는 가능성을 배제하지 못할 지라도, 본 연구의 결과는 국가별 고유의 충격으로 인한 주요 국제적 동조화 및 구조적 변화를 보여 주었다.

• 대한소아치과학회지
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• 제25권2호
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• pp.352-367
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• 1998

Intracellular pH (pHi) plays an important role in the regulation of cellular processes by influencing the acitivity of various enzymes in cells. Therefore, almost every type of mammalian cell possesses an ability to regulate its pHi. One of the most prominent mechanisms in the regulation of pHi is $Na^+/H^+$ exchanger. This exchanger has been known to be activated when cells are stimulated by the binding of agonist to the muscarinic receptors. Therefore, the aims of this study were to compare the rates of $H^+$ extrusion through $Na^+/H^+$ exchanger before and during muscarinic stimulation and to investigate the possible existence of $HCO_3^-$ transporter which is responsible for the continuous supply of $HCO_3^-$ ion to saliva. Acinar cells were isolated from the rat mandibular salivary glands and loaded with pH-sensitive fluoroprobe, 2', 7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein(BCECF), for 30min at room temperature. Cells were attached onto the coverglass in the perfusion chamber and the changes in pHi were measured on the iverted microscope using spectrofluorometer. 1. By switching the perfusate from $HCO_3^-$-free to $HCO_3^-$-buffered solution, pHi decreased by $0.39{\pm}0.02$ pH units followed by a slow increase at an initial rate of $0.04{\pm}0.007$ pH units/min. The rate of pHi increase was reduced to $0.01{\pm}0.002$ pH units/min by the simultaneous addition of 1 mM amiloride and $100{\mu}M$ DIDS. 2. An addition and removal of $NH_4^+$ caused a decrease in pHi which was followed by an increase in pHi. The increase of pHi was almost completely blocked by 1mM amiloride in $HCO_3^-$-free perfusate which implied that the pHi increase was entired dependent on the activation of $Na^+/H^+$ exchanger in $HCO_3^-$-free condition. 3. An addition of $10{\mu}M$ carbachol increased the initial rate of pHi recovery from $0.16{\pm}0.01$ pH units/min to $0.28{\pm}0.03pH$ units/min. 4. The initial rate of pHi decrease induced by 1mM amiloride was also increased by the exposure of the acinar cells to $10{\mu}M$ carbachol ($0.06{\pm}0.008pH$ unit/min) compared with that obtained before carbachol stimulation ($0.03{\pm}0.004pH$ unit/min). 5. The intracellular buffering capacity ${\beta}1$ was $14.31{\pm}1.82$ at pHi 7.2-7.4 and ${\beta}1$ increased as pHi decreased. 6. The rate of $H^+$ extrusion through $Na^+/H^+$ exchanger was greatly enhanced by the stimulation of the cells with $10{\mu}M$ carbachol and there was an alkaline shift in the activity of the exchanger. 7. An intrusion mechanism of $HCO_3^-$ was identified in rat mandibular salivary acinar cells. Taken all together, I observed 3-fold increase in $Na^+/H^+$ exchanger by the stimulation of the acinar cells with $10{\mu}M$ carbachol at pH 7.25. In addition, I have found an additional mechanism for the regulation of pHi which transported $HCO_3^-$ into the cells.

• 설비공학논문집
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• 제21권12호
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• pp.715-732
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• 2009

This article reviews the papers published in the Korean Journal of Air-Conditioning and Refrigeration Engineering during 2008. It is intended to understand the status of current research in the areas of heating, cooling, ventilation, sanitation, and indoor environments of buildings and plant facilities. Conclusions are as follows. (1) Research trends in thermal and fluid engineering have been surveyed in the categories of general fluid flow, fluid machinery and piping, new and renewable energy, and fire. Well-developed CFD technologies were widely applied in developing facilities and their systems. New research topics include fire, fuel cell, and solar energy. Research was mainly focused on flow distribution and optimization in the fields of fluid machinery and piping. Topics related to the development of fans and compressors had been popular, but were no longer investigated widely. Research papers on micro heat exchangers using nanofluids and micro pumps were also not presented during this period. There were some studies on thermal reliability and performance in the fields of new and renewable energy. Numerical simulations of smoke ventilation and the spread of fire were the main topics in the field of fire. (2) Research works on heat transfer presented in 2008 have been reviewed in the categories of heat transfer characteristics, industrial heat exchangers, and ground heat exchangers. Research on heat transfer characteristics included thermal transport in cryogenic vessels, dish solar collectors, radiative thermal reflectors, variable conductance heat pipes, and flow condensation and evaporation of refrigerants. In the area of industrial heat exchangers, examined are research on micro-channel plate heat exchangers, liquid cooled cold plates, fin-tube heat exchangers, and frost behavior of heat exchanger fins. Measurements on ground thermal conductivity and on the thermal diffusion characteristics of ground heat exchangers were reported. (3) In the field of refrigeration, many studies were presented on simultaneous heating and cooling heat pump systems. Switching between various operation modes and optimizing the refrigerant charge were considered in this research. Studies of heat pump systems using unutilized energy sources such as sewage water and river water were reported. Evaporative cooling was studied both theoretically and experimentally as a potential alternative to the conventional methods. (4) Research papers on building facilities have been reviewed and divided into studies on heat and cold sources, air conditioning and air cleaning, ventilation, automatic control of heat sources with piping systems, and sound reduction in hydraulic turbine dynamo rooms. In particular, considered were efficient and effective uses of energy resulting in reduced environmental pollution and operating costs. (5) In the field of building environments, many studies focused on health and comfort. Ventilation. system performance was considered to be important in improving indoor air conditions. Due to high oil prices, various tests were planned to examine building energy consumption and to cut life cycle costs.