• Journal of the Korean Statistical Society
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• v.26 no.4
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• pp.429-443
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• 1997

We consider the problem of obtaining several types of simultaneous confidence bands for the survival curve under the additive risk model. The derivation uses the weak convergence of normalized cumulative hazard estimator to a mean zero Gaussian process whose distribution can be easily approxomated through simulation. The bands are illustrated by applying them from two well-known clinicla studies. Finally, simulation studies are carried outo to compare the performance of the proposed bands for the survival function under the additive risk model.

• The Korean Journal of Applied Statistics
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• v.22 no.1
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• pp.115-127
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• 2009

The purpose of statistical analyses of array-CGH experiment data is to divide the whole genome into regions of equal copy number, to quantify the copy number in each region and finally to evaluate its significance of being different from two. Several statistical procedures have been proposed which include the circular binary segmentation, and a Gaussian based local regression for detecting break points (GLAD) by estimating a piecewise constant function. We propose in this note a penalized spline regression and its simultaneous confidence band(SCB) approach to evaluate the statistical significance of regions of genetic gain/loss. The region of which the simultaneous confidence band stays above 0 or below 0 can be considered as a region of genetic gain or loss. We compare the performance of the SCB procedure with GLAD and hidden Markov model approaches through a simulation study in which the data were generated from AR(1) and AR(2) models to reflect spatial dependence of the array-CGH data in addition to the independence model. We found that the SCB method is more sensitive in detecting the low level copy number alterations.