• Journal of Physiology & Pathology in Korean Medicine
• /
• v.19 no.6
• /
• pp.1585-1593
• /
• 2005

The genetic effects of restraint stress challenge on HPA axis and the therapeutic effect of Boshimgeonbi-tang on the stress were studied with cDNA microarray analyses, RT-PCR on hypothalamus using an immobilization-stress mice as an animal model. Male CD-1 mice were restrained in a tightly fitted and ventilated vinyl holder for 2hrs once a day, and this challenge was repeated for seven· consecutive days. In the change of body weight it showed that the Boshimgeonbi-tang is effected recovery on weight loss caused by the immobilization-stress. Seven days later, total RNA was extracted from the organs of the mouse, body-labeled with $CyDye^{TM}$ fluorescence dyes and then hybridized to CDNA microarray chip. Scanning and analyzing the array slides were carried out using GenePix4000 series scanner and GenePix $Pro^{TM}$ analyzing program, respectively. The expression profiles of 109 genes out of 6000 genes on the chip were significantly modulated in hypothalamus by the immobilization stress. Energy metabolism-, lipid metabolism-, apoptosis-, stress protein, transcriptional factor, and signal transduction-related genes were transcriptionally activated whereas DNA repair-, protein biosysthesis-, and structure integrity-related genes were down-regulated in hypothalamus. The 58 genes were up-regulated by the mRNA expression folds of 1.5 to 7.9. and the 51 genes were down-regulated by 1.5 - 5.5 fold. The 11 genes among them were selected to confirm the expression profiles by RT-PCR. The mRNA expression levels of Tnfrsf1a (apoptosis), Calm2 (cell cycle), Bag3 (apoptosis), Ogg1 (DNA repair), Aatk (apoptosis), Dffa (apoptosis), Fkbp5 (protein folding) were restored to the normal one by the treatment of Boshimgeonbi-tang.

• Journal of Biomedical Engineering Research
• /
• v.23 no.1
• /
• pp.33-38
• /
• 2002

A Ventricular Assist Device(YAD) is used to support the injured natural heart So. when considering a control algorithm for YAD. it is important to reduce a natural heart's load to enhance its recovery condition. To reduce natural heart's load, a counterpulsation algorithm is used commonly. In this study, we developed a counterpulsation control algorithm for moving-actuator type VAD and tested its usefulness using in vitro MOCK circulatory system. To notice a natural heart's Pumping status, electrocardiogram(ECG) signal was used and as a result of test. the counterpulsation effect between YAD and a natural heart was occurred and Automatic Control Mode Transition was occurred properly.

• Journal of the Korean Institute of Telematics and Electronics C
• /
• v.35C no.9
• /
• pp.11-20
• /
• 1998

High-speed complex-number arithmetic units are essential to baseband signal processing of modern digital communication systems such as channel equalization, timing recovery, modulation and demodulation. In this paper, a new complex-number multiplication algorithm is proposed, which is based on redundant binary (RB) arithmetic combined with radix-4 Booth recoding scheme. The proposed algorithm reduces the number of partial product by one-half as compared with the conventional direct method using real-number multipliers and adders. It also leads to a highly parallel architecture and simplified circuit, resulting in high-speed operation and low power dissipation. To demonstrate the proposed algorithm, a prototype complex-number multiplier-accumulator (CMAC) core with 10-bit operands has been designed using 0.8-$\mu\textrm{m}$ N-Well CMOS technology. The designed CMAC core contains about 18,000 transistors on the area of about 1.60 ${\times}$ 1.93 $\textrm{mm}^2$. The functional and speed test results show that it can operate with 120-MHz clock at V$\sub$DD/=3.3-V, and its power consumption is given to about 63-mW.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.15 no.4
• /
• pp.414-420
• /
• 2004

Partial transmit sequence(PTS) scheme has been widely studied to reduce the peak-to-average power ratio(PAPR) of Orthogonal frequency-division multiplexing(OFDM) signal since it is flexible ad any spectral regrowth is not made. A necessity of the PTS scheme is to transmit the side information about the phase rotation factors for correct OFDM symbol recovery. In this paper, a new side information embedded PTS scheme using the reference symbols is proposed fur the PAPR reduction and the BER(bit error rate) performance is analyzed when the erroneous side information is received. In this proposed method, the information about the rotation factors is expressed by the phase of reference symbols. The proposed method maintains the same PAPR reduction performance as the conventional PTS scheme and OFDM symbols are correctly recovered by the side information to meet the required BER level, which is verified via the computer simulation. Also, it is shown that the proposed method can be easily realized and can be used for all kinds of digital modulation formats in the OFDM communication system.

• JSTS:Journal of Semiconductor Technology and Science
• /
• v.15 no.3
• /
• pp.404-416
• /
• 2015

Small-area, low-power coarse and fine frequency detectors (FDs) are proposed for an adaptive bandwidth referenceless CDR with a wide range of input data rate. The coarse FD implemented with two flip-flops eliminates harmonic locking as long as the initial frequency of the CDR is lower than the target frequency. The fine FD samples the incoming input data by using half-rate four phase clocks, while the conventional rotational FD samples the full-rate clock signal by the incoming input data. The fine FD uses only a half number of flip-flops compared to the rotational FD by sharing the sampling and retiming circuitry with PLL. The proposed CDR chip in a 65-nm CMOS process satisfies the jitter tolerance specifications of both USB 3.0 and USB 3.1. The proposed CDR works in the range of input data rate; 2 Gb/s ~ 8 Gb/s at 1.2 V, 4 Gb/s ~ 11 Gb/s at 1.5 V. It consumes 26 mW at 5 Gb/s and 1.2 V, and 41 mW at 10 Gb/s and 1.5 V. The measured phase noise was -97.76 dBc/Hz at the 1 MHz frequency offset from the center frequency of 2.5 GHz. The measured rms jitter was 5.0 ps at 5 Gb/s and 4.5 ps at 10 Gb/s.

• Journal of the Institute of Electronics Engineers of Korea TC
• /
• v.37 no.3
• /
• pp.9-17
• /
• 2000

In this paper we implement computer simulation system of 4FSK signal MODEM using Quadrature detector and analyze overall tranceiver system. We follow the FLEX wireless paging system standards and construct premodulation filter and data frame. We propose an efficient open loop symbol timing recovery algorithm which takes advantage of 128 bit length preamble pattern and also propose a 32 bit UW pattern which Is based on the optimal UW detection method, and excellent aperiodic autocorrelation characteristic. The BER simulation in the fading channel as well as AWGN is performed with BCH coding and Interleaving to the Quadrature detector system and it is shown that a high coding fain occurs in the fading channel rather than AWGN channel.

• Journal of Sensor Science and Technology
• /
• v.14 no.5
• /
• pp.322-330
• /
• 2005

A new type of transducer, piezoelectric floating mass transducer (PFMT) which has advantages of piezoelectric and electromagnetic transducer has been proposed and implemented for the implantable middle ear hearing devices. By the uneven bonding of piezoelectric material to the inner bottom of transducer case, the PFMT can vibrate back-and-forth along the longitudinal axis of the transducer even though the piezoelectric material within the cylindrical case produces only the bilateral expansion and contraction according to the applied electrical signal. To improve efficiency of the PFMT, the multi-layered piezoelectric material has been adapted. The small number of components in the PFMT enables the simple manufacturing and the easy implanting into the middle ear. In order to examine the characteristics of vibration, mechanical modeling and finite element analyses of the proposed transducer have been performed. From the result of theoretical analyses and the measured data from the experiment, it is verified that the implemented PFMT can be used in implantable middle ear hearing devices.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.18 no.8
• /
• pp.1805-1810
• /
• 2014

The phase noise spectrum distribution for remote controller using the BPSK mode and low data rate of 50 kbps was designed and proposed in this paper. In case of applying the BPSK that transmission performance is superior to FSK method, the performance degradations due to phase noise are generated. To minimize the phase noise effect, it is important to dispatch the digital signal in channel environment with required phase noise characteristics. To provide the terminal design technique and the proper channel environment with required phase noise characteristics, the phase noise spectrum distribution was designed for required phase noise characteristics. By analyzing the phase noise effects for damping factor and noise bandwidth of the carrier recovery circuit, the phase noise spectrum design that consider the damping factor and noise bandwidth was performed. Based on the IESS-308 standards, also, the phase noise effects was analyzed. The phase noise spectrum design techniques and phase noise spectrum that is suitable to remote controller were proposed.

• Journal of KIISE:Information Networking
• /
• v.33 no.1
• /
• pp.49-58
• /
• 2006

When the movement of a node breaks the route in ad-hoc network, on-demand routing protocol performs the local route recovery or a new route search for the route maintenance. And when it performs the new route search or the local search, the packet which is transmitted can be delayed. There are ARMP and RPAODV as the methods reducing the delay resulted from the route-breakage. They predict the route-breakage and construct an alterative local route before the occurrence of the route-breakage. When the link state is unstable, the success rate of the alternative local route that can avoid the route-breakage can give a direct effect on the route-breakage and the transmission delay, To estimate the performance of routing protocols avoiding route-breakage, we suggest the numerical formulas of AODV, the representative on-demand routing protocol, and ARMP, RPAODV. To verify the efficiency and accuracy of the proposed numerical formulas, we analysis and compare with the results of the computer simulation and that of the numerical formulas.

• Smart Structures and Systems
• /
• v.15 no.1
• /
• pp.135-150
• /
• 2015

Large concrete structures are prone to cracks and damages over time from human usage, weathers, and other environmental attacks such as flood, earthquakes, and hurricanes. The health of the concrete structures should be monitored regularly to ensure safety. A reliable method of real time communications can facilitate more frequent structural health monitoring (SHM) updates from hard to reach positions, enabling crack detections of embedded concrete structures as they occur to avoid catastrophic failures. By implementing an unconventional mode of communication that utilizes guided stress waves traveling along the concrete structure itself, we may be able to free structural health monitoring from costly (re-)installation of communication wires. In stress-wave communications, piezoelectric transducers can act as actuators and sensors to send and receive modulated signals carrying concrete status information. The new generation of lead zirconate titanate (PZT) based smart aggregates cause multipath propagation in the homogeneous concrete channel, which presents both an opportunity and a challenge for multiple sensors communication. We propose a time reversal based pulse position modulation (TR-PPM) communication for stress wave communication within the concrete structure to combat multipath channel dispersion. Experimental results demonstrate successful transmission and recovery of TR-PPM using stress waves. Compared with PPM, we can achieve higher data rate and longer link distance via TR-PPM. Furthermore, TR-PPM remains effective under low signal-to-noise (SNR) ratio. This work also lays the foundation for implementing multiple-input multiple-output (MIMO) stress wave communication networks in concrete channels.