• Proceedings of the KWS Conference
• /
• v.43
• /
• pp.289-291
• /
• 2004

The purpose of this study is to identify the effects of the length of tack weldment on the rotational distortion at the one side SA butt weldment using experiment. The maximum rotational distortion at the end of the SA weldment decrease with an increase in the length of tack weld length, while the maximum rate of the distortion increases. This result indicates that the increase of the length of the tack weldment at the one-side SA butt weldment does not prevent the hot cracks.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1994.04a
• /
• pp.50-62
• /
• 1994

Opium, morphine and rotated natural and synthetic opiates have been used since antiquity, and to the present, for the relief of moderate and severe pain. Morphine and pharmacologically related drugs, however, produced an array of undesired or dangerous side effect that limit their use as analgesics. Prominent among the limiting side effects are constipation, respiratory depression, release of prolactin, and liability for the production of drug dependence. It was our aim to develop, if possible, a drug or class of drugs with analgesic activity similar to that of morphine, but without the serious side effects associated with morphine. Our overall strategy was to take advantage of advancing knowledge concerning multiple types of opioid receptors, to develop ligands selective for the delta type receptors, to determine whether delta receptor agonists offer advantages over mu agonists, then to design compounds with pharmacokinetic properties compatible with practical therapeutic application. All but the last of these objectives have been realized.

• 한국전산유체공학회:학술대회논문집
• /
• 2003.10a
• /
• pp.164-165
• /
• 2003

The problem of a bluff body oscillating in a fluid flow has been receiving a great deal of attention. When a bluff body is placed in a flow, it experiences fluctuating hydraulic forces in both transverse and stream-wise directions. It is caused by the formation of vortices behind the body, which could cause large damages of structures. It is called the flow-induced vibrations. In this article, it is investigated the effects of that side-jets and rear-jet, which is applied to control the vortex shedding. The rear-jet is available to control the flow-induced vibrations according as the body shapes and the velocity of fluid flow in which the galloping phenomena is not appeared.

• Journal of Power System Engineering
• /
• v.17 no.1
• /
• pp.71-76
• /
• 2013

This study is experimentally performed for using the oyster shell as a desiccant in the batch type system. The peltier element(thermoelectric device) is used for absorbing and releasing the adsorption and desorption heat generation. The cooling and heating effects of peltier element exist in this experiment and these effects are generally known phenomena among some references. The increase in electric current induced into peltier element is effectively release the heat generation of adsorption and desorption. Consequently, the non-dimensional adsorption and desorption amount would increase with increase in electric current. However, in the case of adsorption, the increase of induced current into peltier element, the heat of cold side can not release sufficiently. So the heat of hot side of peltier is transferred into the cold side.

• Annals of Clinical Neurophysiology
• /
• v.8 no.1
• /
• pp.48-52
• /
• 2006

Background: Intravenous immunoglobulin (IVIg) has been administered for various immune-mediated neurological diseases such as autoimmune neuropathy, inflammatory myopathies, and other autoimmune neuromuscular disorders. The purpose of this study is to investigate side effects and complications of IVIg therapy in neuromuscular disorders. Methods: We enrolled 29 patients (age 8~63 years) with IVIg therapy for various neurological diseases including Guillain-Barre syndrome, myasthenia gravis, dermatomyositis, polymyositis, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy. IVIg therapy was used at a dose of 0.4 g/kg body weight/day for 5 consecutive days. Results: 10 patients (34%) had adverse events. There are adverse events in 16 courses (11%) among total 145 courses. The majority of patients presented with mild side effects, mostly asymptomatic laboratory changes. Rash or mild headache occurred in 3 patients. One patient showed a serious side effect of deep vein thrombosis. Conclusions: IVIg therapy is safe for a variety of immune-mediated neurological diseases in our study.

• Journal of the Optical Society of Korea
• /
• v.18 no.2
• /
• pp.101-109
• /
• 2014

In this paper, four apodization functions are proposed for silicon-on-insulator (SOI) strip waveguides with sidewall-corrugated gratings. The effects of apodization functions on the full width at half maximum (FWHM), the side-lobe level, and the reflectivity of the reflection spectrum are studied using the coupled-mode theory (CMT) and the transfer-matrix method (TMM). The results show that applying proposed apodization functions creates very good filtering characteristics. Among investigated apodized waveguides, the apodization functions of Polynomial and z-power have the best performance in reducing side-lobes, where the side-lobe oscillations are entirely removed. Four functions are also used for precise adjustment of the bandwidth. Simulation results show that the minimum and maximum values of the FWHM are 0.74 nm and 8.48 nm respectively. In some investigated functions, changing the apodization parameters decreases the reflectivity which is compensated by increasing the grating length.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• v.1 no.1
• /
• pp.89-93
• /
• 1990

60 Attention-deficit hyperactive patients treated with stimulant drugs such as methylphenidate and pemoline were evaluated in regards to the therapeutic benefit and side effects of these drugs. The results were as follows : 1) Of the 60 subjects 34 showed considerable imporvement and only 8 showed little or no improvement. 2) Hyperactivity, inattention and impulsivity were improved markedly by stimulants These behavioral changes were accompanied by improved performance in classroom. 3) School age children tended to show more improvement than preschool children or adolescence. 4) Of the 60 subjects 25 showed no side effect and only 6 showed severe side effects, and common side effects were decreased appetite, insomnia and irritability or nervousness. It is the author's impression that despite of the therapeutic efficacy of these drugs when they were administered on a short-term basis, long-term outcome dose not seem to be altered by the administration of these agents.

• Herbal Formula Science
• /
• v.12 no.2
• /
• pp.77-93
• /
• 2004

Depression is a sort of mental disorder which is very common. To treat depression, many drugs such as TCA, MAOI are developed and used. But they have a lot of side effects, so it needs to develop drugs without side effects or with less side effects. Herbal medicines have been used to treat diseases not only physical but also mental and have less side effects. therefore, it has been thoght the need to develop herbal medicine with antidepressant effect. The purpose of this study was to reseach antidepressant effect and influence on monoamines of chunwangboshimdan thought to have antidepressant according to ancient medical book- donguibogam- and recent reports. We used 'forced swimming test(FST)' to know antidepressant effect of chunwangboshimdan and HPLC to check the influence on monoamines and their metabolites(norepinephrine, dopamine, DOPAC, HVA, serotonin, 5-HIAA) of chunwangboshimdan after divided into cerebral cortex, striatum, hypothalamus and hippocampus. The results were obtained as follows: In the study of antidepressant effect by 'forced swimming test(FST)'method, chunwang boshimdan had a significant antidepressant effect. In the study of influence on monoamines by HPLC, chunwangboshimdan mainly increased dopamine among monoamines and their metabolites(norepinephrine, dopamine, DOPAC, HVA, serotonin, 5-HIAA) significantly in 4 parts of rat's brain above-mentioned. Calculated by turnover ratio formulae of monoamine, chunwangboshimdan has more results than Imipramine. These results suggest that chunwangboshimdan has antidepressant effect that is related with the increase of monoamines by suppressing their metabolism as its mechanism.

• Herbal Formula Science
• /
• v.11 no.2
• /
• pp.185-196
• /
• 2003

Depression is very common mental disorder, so many people suffer from it, which makes the treatment of depression important. Many drugs to treat depression were developed and being prescripted. But they have a lot of side effects, so it needs to develop drugs without side effects or with less side effects. Herbal medicines have been used to treat not only physical disorder but also mental disorder and it has been reported that they have less side effects. Therefore, there is the need to discover and use herbal medicine with antidepressant effect. The purpose of this study was to reseach Antidepressant effect of Licium chinense Mill. and its influence on serotonin and its metabolite of depression model rats. We used 'forced swimming test(FST)' to know antidepressant effect of Licium chinense Mill. and HPLC to check the influence on serotonin and its metabolite(5-HIAA) of Licium chinense Mill. after rats' brains were divided into cerebral cortex, striatum, hypothalamus and hippocampus. The results were obtained as follows : In the study of antidepressant effect by 'forced swimming test(FST)' method, Licium chinense Mill. had a significant antidepressant effect. In the study of influence on serotonin and 5-HIAA by HPLC, Licium chinense Mill. mainly increased serotonin and 5-HlAA of cerebral cortex and striatum signigficantly among 4 parts of rat's brain above-mentioned. These results suggest that Licium chinense Mill. has antidepressant effect that may be related with the increase of serotonin and its metabolite as its mechanism, but more precise experiments will be need to prove their relation.

• Journal of Society of Preventive Korean Medicine
• /
• v.17 no.2
• /
• pp.105-127
• /
• 2013

Objectives : We examined the use of the moxibustion through survey on Korean Medicine Doctors (KMDs) on preparation of universal moxa product standard by fully reflecting opinions of practitioners and the industry. Methods : The questionnaire is composed of 25 questions including use of indirect moxa, side effects, complaints and improvements, general characteristics and so on, and were responded by 1,588 KMDs. For statistics, frequency analysis, chi-square analysis, T-test and ANOVA were conducted using SPSS 12.0 for windows, and the significance level was 0.05. Results : In this research, 91% of the responded KMDs was using moxibustion, and the proportion of using mediate moxibustion was shown as 63.2%. They used mediate moxibustion for side effects of direct moxa method such as risk of burn, ease of use, control of stimulation and so on. And it was mostly being conducted to women and 40 ages. Most respondents gave moxibustion treatments for the purpose of thermal stimulation on acupoint to musculoskeletal diseases. Most respondents were treating 1~2 pieces of moxibustion to patients by moxibustion points to those of 1~2 regions every time within 10 minutes. Regarding the frequency of side effects of mediate moxibustion, within 3% of respondents had experienced side effects, and the types were burn, flare and itchiness, odor and smoke. The dissatisfaction of mediate moxibustion products was moderate(2.00 out of 5 point scale), and went up public health doctors, the younger ages and the shorter clinical experience. Complaints on mediate moxibustion products were serious odor, poor attachment, risk of burn etc. Regarding ways to improve mediate moxibustion, the expansion of moxibustion's insurance cost carne out highest, followed by preparation of manual on efficacy, strengthening of training, acquiring evidence on efficacy, diversification of specifications, safety improvement, quality improvement of mediate moxibustion products. Conclusions: Many KMDs use for ease of use and give moxibustion treatments for thermal stimulation but they complain about safety, efficacy and quality of mediate moxibustion. After this it is considered that we have to elevate therapeutic effect through the improvement of mediate moxibustion products.