• Journal of Korean Medicine for Obesity Research
• /
• v.5 no.1
• /
• pp.97-107
• /
• 2005

Objectives The purpose of this study was to investigate correlation between short stature and obese degree. And we also wanted to know the characteristics of patients visited clinic in the name of 'short stature'. Methods Height, body weight, BMI, fat mass, lean body mass, percent body fat were taken intended for 236 patients in the name of short stature. To all the patient questionnaire for growth clinic was drawn up, and ultrasound scan was taken through calcaneous of the right foot. The patients were classified to three groups - short, average, tall group - according to relative position of mid-parental height. It was analysed that the differences between groups in obese degree. Also was investigated correlation between position of short stature and obese degree, and between obese degree and bony maturity. Results & Conclusion 1. The average ages of patients in the name of 'short stature' were $12.69{\pm}3.93$ years old in boys, $10.66{\pm}3.67$ years old in girls. And it seemed to be just before second rapid maturing period. 2. The average BMI were $20.58{\pm}4.07kg/m^2$ in boys, $18.65{\pm}2.85kg/m^2$ in girls, and average percent body fat were $21.99{\pm}7.35%$ in boys, $26.01{\pm}6.35%$ in girls. 3. The numbers of obese children were 34(31.2%) in boys, 19(14.9%) in girls on the basis of BMI. And the numbers were 39(35.8%) in boys, 53(41.7%) in girls on the basis of percent body fat. There was a big difference in case of girls. 4. The numbers of AG(average group) were 48(44.0%) in boys, 60(47.2%) in girls, the numbers of SG(short group) were 35(32.1%) in boys, 31(24.4%) in girls, and numbers of TG(tall group) were 26(23.9%) in boys, 35(27.6%) in girls. 5. There were no significant differences among the groups in BMI, lean body mass, fat mass, percent body fat. Only significant difference in DI(disease index). 6. There were no significant correlation between PH(percent height) and BMI, leanbody mass, fat mass, percent body fat. Only significant correlation in DI(disease index). 7. There were no significant differences between DA(difference between bone age and chronorogical age) and BMI, leanbody mass, percent body fat. Only significant correlation in fat mass.

• Journal of Yeungnam Medical Science
• /
• v.22 no.1
• /
• pp.1-12
• /
• 2005

Normal growth and development is of prime concern during childhood. The treatment of children with growth hormone deficiency has been revolutionized by growth hormone therapy. An improved height outcome with a final height within the target height range has been achieved. However, close follow-up with regular clinical and laboratory monitoring is essential for achieving the desirable height outcome. The theoretical unlimited supply of growth hormone has led to its wide spread use in a variety of disorders other than a growth hormone deficiency. Initially used in children with Turner syndrome, growth hormone is now used to treat chronic renal failure, an idiopathic short stature and intrauterine growth restrictions in addition to a wide array of newly emerging indications. This review summarizes the basics for a proper growth assessment, the differentiation of normal and abnormal growth causes of a short stature, and the indications for growth hormone treatment.

• Journal of the Korea Convergence Society
• /
• v.12 no.10
• /
• pp.89-96
• /
• 2021

This study is aimed to establish the direction of orthodontic treatment by analyzing the differences in the dental arch development due to the cause of short stature. Dental diagnostic tests were conducted on patients who were diagnosed with short stature. Idiopathic short statured children were classified through the paired sampling based on the age and gender of a short statured children with growth hormone shortage. Control groups were classified using same method as above, after selecting candidates with an arch length of less than 3mm and malocclusion. In conclusion, short statured children with growth hormone shortage or idiopathic had the higher rate of crowding and the small value of overbite compared to normal children. Therefore orthodontic treatment for short statured children needs treatment plan included evaluation for Arch length discrepancy to treat a crowding early. This study will provide important data for successful orthodontic treatment according to the characteristics of dental occlusion of short statured children.

• Journal of Interdisciplinary Genomics
• /
• v.5 no.2
• /
• pp.18-23
• /
• 2023

Conventional evaluation method for identifying the organic cause of short stature has a low detection rate. If an infant who is small for gestational age manifests postnatal growth deterioration, triangular face, relative macrocephaly, and protruding forehead, a genetic testing of IGF2, H19, GRB10, MEST, CDKN1, CUL7, OBSL1, and CCDC9 should be considered to determine the presence of Silver-Russell syndrome and 3-M syndrome. If a short patient with prenatal growth failure also exhibits postnatal growth failure, microcephaly, low IGF-1 levels, sensorineural deafness, or impaired intellectual development, genetic testing of IGF1 and IGFALS should be conducted. Furthermore, genetic testing of GH1, GHRHR, HESX1, SOX3, PROP1, POU1F1, and LHX3 should be considered if patients with isolated growth hormone deficiency have short stature below -3 standard deviation score, barely detectable serum growth hormone concentration, and other deficiencies of anterior pituitary hormone. In short patients with height SDS <-3 and high growth hormone levels, genetic testing should be considered to identify GHR mutations. Lastly, when severe short patients (height z score <-3) exhibit high levels of prolactin and recurrent pulmonary infection, genetic testing should be conducted to identify STAT5B mutations.

• The Journal of Internal Korean Medicine
• /
• v.22 no.4
• /
• pp.513-517
• /
• 2001

Objective : Recently many studies of herbal medication to promote growth have been implemented. The purpose of this study was to identify the feasibility and safety of herbal medication on short stature. Methods : 143 patients(87 males, 56 Females)who visited with short stature at Kangnam CHA Oriental Hospital From February 1999 to January 2000 and were treated during 6 months, were available for this study. We treated with 5 herbal medications.(Soeumin hyangbujapalmultang-gagambang, Soyangin yukmijihwangtang-gagambang, Taeumin chungsimyunjatang-gagambang, Boa-tang, Boikyangwi tang) At the begining of the treatment and after 6 months treatment, We measured height, weight and body mass index(BMI). And we investigated changes of aspartate aminotransferase(AST), alanine aminotransferase(ALT), blood urea nitrogen(BUN), alkaline phosphatase(ALP), creatinine. Results: The distribution of ages was from 5 years old to 17 years old. After herbal treatment, mean height, mean weight, mean BMI and mean percentile grade increased $138.5{\pm}15.6$ to $141.9{\pm}15.1$, from $36.9{\pm}13.2$ to $38.9{\pm}13.2$, from $18.5{\pm}3.29$ to $18.7{\pm}3.21$, from $3.2{\pm}1.2$ to $3.4{\pm}1.2$. The contents of AST, ALT, BUN, ALP and Creatinine were not showed any significant change. Conclusions : In the results We recognized Short stature was showed prominent feasibility and safety of herbal medication. Herbal Medication in patients with short stature will improve height velocity without liver and kidney function disorders.

• Clinical and Experimental Pediatrics
• /
• v.46 no.4
• /
• pp.363-369
• /
• 2003

Purpose : Pharmacologic provocation test of growth hormone(GH) is a non-physiologic method and has several limitations for diagnosing growth hormone(GH) deficiency. Spontaneous GH release studies could be important in understanding the pathophysiology of children with poor growth but normal responses to GH provocation tests. Also, the relationship between nocturnal GH secretions and sleep patterns in short stature children is poorly understood. The aim of this study is to determine whether there are differences in sleep patterns and nocturnal GH secretory profiles between idiopathic short stature children and a normal stature group. Methods : Spontaneous nocturnal GH secretions and sleep patterns were evaluated in 12 prepubertal idiopathic short stature children with normal responses to provocation tests and 9 normal stature controls. Blood samples were taken every 30 minutes from 22:00-06:30 and sleep patterns were analyzed by polysomnography. Results : The mean GH level during sleep was significantly lower in short stature children than in controls. The peak GH level after sleep, coincident with the first slow wave sleep, was lower in the short stature group. The slow wave sleep times of short stature children were decreased compared with those of normal subjects. Conclusion : These results suggest that overnight serial GH sampling is helpful to identify short stature children with subnormal GH secretions, and sleep structure differences may be associated with decreased overnight GH secretions in short stature children.

• Clinical and Experimental Pediatrics
• /
• v.53 no.5
• /
• pp.661-665
• /
• 2010

Anemia caused by vitamin B12 deficiency resulting from inadequate dietary intake is rare in children in the modern era because of improvements in nutritional status. However, such anemia can be caused by decreased ingestion or impaired absorption and/or utilization of vitamin B12. We report the case of an 18-year-old man with short stature, prepubertal sexual maturation, exertional dyspnea, and severe anemia with a hemoglobin level of 3.3 g/dL. He had a history of small bowel resection from 50 cm below the Treitz ligament to 5 cm above the ileocecal valve necessitated by midgut volvulus in the neonatal period. Laboratory tests showed deficiencies of both vitamin B12 and iron. A bone marrow examination revealed dyserythropoiesis and low levels of hemosiderin particles, and a cytogenetic study disclosed a normal karyotype. After treatment with parenteral vitamin B12 and elemental iron, both anemia and growth showed gradual improvement. This is a rare case that presented with short stature and delayed puberty caused by nutritional deficiency anemia in Korea.

• The Journal of Pediatrics of Korean Medicine
• /
• v.18 no.1
• /
• pp.77-91
• /
• 2004

Objective: The purpose of this study were to examine the growth pattern of weak children by measurement according to the five weak symptoms (respiratory, digestive, psycho-neurological, neuromotor, urogenital symptom). Five weak symptoms are common etiology of short stature in childhood and oriental medicine therapy is used as a treatment in short stature but the effects on height are not conclusive. Methods: This clinical study had been carried out with the 166 case (male 74, female 92) of the children aged 3 to 18 years old who visited in growth clinic of Pediatrics, Dongguk university Bundang Oriental Hospital. They were divided into 3 groups by age (3-10, 11-14, 15-18 years group) Five weak symptoms were studied to determine the association with growth stature among children by comparison with the growth stature of weak children group and normal group Results: The distribution of age showed the highest in 11-14 years(58.4%), followed by I 3-10 years (26.5%), over 15years(15%) in order. In case of male, the distribution of five weak symptoms showed the highest respiratory weak symptom(68.9%), followed by digestive(52.7%), psycho-neurological(43.2%), neuromotor(24.3%), urogenital weak symptom (143.5%) and digestive weak children's Height SDS were lower than normal children in all age groups and respiratory weak children's Height SDS were lower than normal children in age group of 3-10. In case of female, the distribution of five weak symptoms showed the highest digestive weak symptom(59.8%), followed by respiratory(52.5%), psycho-neurological(51.5%), neuromotor (35.9%), urogenital weak symptom (25%) and digestive weak children's Height SDS were lower than normal children in age group of 3-14. Other weak children Height SDS were no significant difference from normal group. Conclusions: From the above result, it was suggested that weak symptoms is cause in short stature. These data indicate that the height was correlated with respiratory, digestive weak symptom and a way to improve the weakness increased significantly height in children growth stature. Growth stature should be investigated as a new field of oriental medical treatment and more controlled, long term studies are required to classify benefits of Oriental medicine therapy in short stature.

• Childhood Kidney Diseases
• /
• v.6 no.2
• /
• pp.259-265
• /
• 2002

Bartter syndrome is a rare disorder characterized by the association of hypokalemic hypochloremic metabolic alkalosis, hyperreninemia, hyperaldosteronemia, short stature and nephrocalcinosis. This disorder presents with hyperplasia of juxtaglomerular apparatus on renal biopsy. We experienced a case of late-onset Bartter syndrome with nephrocalcinosis in a 9-year-old boy, whose chief pictures were muscle weakness, short stature, persistent sterile pyuria and microscopic hematuria. We report this case with a brief review of related literatures.

• The Journal of Internal Korean Medicine
• /
• v.21 no.4
• /
• pp.693-696
• /
• 2000

IShort stature is two standard deviations (SD) below the mean for height (below the third percentile) in a population of children. We treated two cases below the third percentile for height with Boikyangwitang-gamibang(補益養胃湯加味方). During treatment Case I grew 4.2cm and became above the third percentile for height. Case II also grew 5.8cm and became above the third percentile for height. In the results We recognized Short status was showed prominent improvement with Boikyangwitang-gamibang(補益養胃湯加味方).