• 제목/요약/키워드: sex expression

검색결과 338건 처리시간 0.029초

Estrogen Receptor 1 유전자 내 2개의 단일염기 다형성과 한국인 여성 정신분열병 환자의 연합에 관한 연구 (Association Study between 2 Single Nucleotide Polymorphisms in Estrogen Receptor 1 Gene and Korean Female Schizophrenic Patients)

  • 박진경;이서경;이상민;박준헌;김지영;조아랑
    • 생물정신의학
    • /
    • 제14권4호
    • /
    • pp.241-248
    • /
    • 2007
  • Objectives : Schizophrenia is equally distributed in both sexes. However, later-onset, milder psychopathology, and better outcome are associated with the females. This reason is thought to be partly due to the estrogen system. Recently, it was suggested that estrogen receptor 1(ESR1) gene polymorphisms might affect the expression of ESR1 and were associated with several psychiatric disorders. Thus, we investigated the association between two single nucleotide polymorphisms(SNPs) in the ESR1 gene and Korean schizophrenic patients in this study. Methods : Genotype, allele, and haplotype frequencies of the two SNPs(rs 2234693 and rs 2228480) were analyzed between 218 Korean controls and 158 Korean schizophrenic patients. Also, age of onset and negative symptom scale scores according to genotypes were analyzed in the patients with schizophrenia. Results : There was a significant difference in allele frequencies of rs 2234693 between the schizophrenic patients and the controls(p=0.03). Genotype distributions(p=0.03) and allele frequencies(p=0.01) of rs 2234693 were significantly different between the female schizophrenic patients and the female controls. The frequency of TC-CC genotypes compared with TT genotype in the female schizophrenic patients was significantly higher than that in the female controls(OR=2.36). The mean age of onset in the schizophrenic patients with TC-CC genotypes was significantly lower than that in the patients with TT genotype. The frequency of rs 2234693C- rs 2228480G haplotype in the female schizophrenic patients was relatively higher than that in the female controls. Conclusions : These results of our study support the possibility that the ESR1 gene polymorphisms might be involved in the susceptibility of females to schizophrenia and play a role in sex difference of schizophrenia.

  • PDF

20세기말 현대패션에 나타난 다문화주의(Multiculturalism) 현상에 관한 연구 (A Study on the Multiculturalism Phenomena Expressed in Contemporary Fashion of the End twentieth century)

  • 최혜정;임영자
    • 복식
    • /
    • 제51권2호
    • /
    • pp.149-167
    • /
    • 2001
  • Today, every culture has taken on the compromise form by means of the cultural difference, variety, and pluralism according to the internationalization and the advance so that it has been developed toward the half-blooded and multilayered the aspect. In accordance with this current of the times, this thesis observed the feminism found in the multiculturism of the end of the 20th century, the third world, and technology with the side of the tendency of modern fashion, considered the hybride phenomenon which is pulling down the wall between culture and genre due to the social diversification. and predicted the fashion trend do 21st century serf on it. Multiculturism is the movement that began to arise in the academic world of America and the literary world form the close of 1980's in accepting the variety of culture and regarding the culture with the more balanced and wide view and just as it is, it means the attitude of accepting one or more cultures of variely and the position of taking interest in the culture of minority race not the culture of a governing race. It is the fashion of feminism adapts dualism like unisex, androgynous look, etc of bisexual lendency in the 1980's, it shows new style with crossover of liberal sense because there is not the difference of sex in fashion. The eco-feminism pursues the natural sexuality not being instrumental and dismantling and expressed it in the Gender expression of an integrated human being. The trend of ethnic fashion in the close of 20th century is that the element of hippie is working so strongly. By adding embroidery of Oriental style, accessories of Indian style, feathers, beads, a hempen hood to the ethnic costumes of Asia and Latin, is shows the figure of ethnic hippie. As the cycler fashion is the future clothes through technology of computer, it uses a cool glass material bringing up the image of a spacesuit in order to expresses cyber image through artificial color combination of sheen colors, Though this techno-color fashion has established the fresh stimulation and the innovative aspect with ultramodern materials and image of futurism, it transmits a hope of estranged people and the natural elements. Hybride means a cross and mixture of animal and plant in Korean and is also called fusion. The phenomenon of hybrid predicts to comes the period of a cross and variation because something completely new comes into the world by contamination, mixture and compromise through meeting something different each other and it has on advantage of developing something existing to one more stage. It is prospected that in the society of 21st century, the borderline of traditional gender will be disappeared, variety and individuality will determine the individual behavior, and the masculine value will be substituted by feminine value. In the society giving priority to feminine value, a fashion stuck closely to women is what must reflect lives of woman under the proposition of woman's beauty, being on original function. So, it is considered that a fashion with added convenience and practicality having the function which is easy to put on, comfortable to act, able to express solves so much, and able to show various appearances according to T.P.O will get into the spotlight.

  • PDF

Big 5 성격요인에 따른 청소년 성격특성의 발달적 변화 (Developmental Changes of Adolescent's Big Five Personality Factors)

  • 장은지;최은실
    • 한국콘텐츠학회논문지
    • /
    • 제17권10호
    • /
    • pp.307-321
    • /
    • 2017
  • 본 연구는 중 고등학교 학생 2,260명을 대상으로 Big 5 성격요인에 따른 청소년 성격특성에 발달적 변화가 있는지 알아보고자 한다. 성별과 학년에 따라 성격 5요인의 발달적 변화에 차이를 보이는지 확인하였고, 더불어 신경증 하위요인을 추가적으로 분석함으로써 청소년기 문제행동 시기와 특성을 확인 하였다. 분석에는 일원배치변량분석(One-way ANOVA)을 사용하였으며 유의미한 차이가 난 경우 사후검증을 실시하였다. 연구 결과를 요약하면 다음과 같다. 첫째, 청소년의 성격 5요인 특성이 성별에 따라 차이가 있는 것으로 나타났다. 개방성, 성실성, 외향성은 여자가 남자보다 높게 나타났고, 신경증은 남자가 여자보다 높게 나타났다. 둘째, 청소년의 성격 5요인 특성 모두에서 학년에 따라 차이가 있는 것으로 나타났다. 셋째, 청소년기 성격특성에 대한 성별에 따른 학년별 발달적 경향성에서도 성별 간 다른 양상을 보이는 것으로 나타났다. 특히 성별과 학년에 따른 분석에서 남자는 중등 2학년, 여자는 고등 3학년에서 성격특성이 두드러질 것으로 나타났다. 그리고 신경증과 관련된 외현화 행동문제는 중등 1 2학년에서 내현화 행동문제는 고등 3학년에서 주로 발현될 것으로 나타났다. 따라서 본 연구에서는 현재 우리나라 청소년 성격특성의 발달적 변화를 확인할 수 있었으며, 또한 성별과 학년에 따라 상이한 정신건강문제가 발현 될 수 있는 것으로 나타났다.

현실적 맥락을 활용한 수학화 학습이 아동의 수학적 사고에 미치는 효과 -초등학교 5학년 도형 영역을 중심으로- (Effect of Mathematising Learning Using Realistic Context on the Children's Mathematical Thinking)

  • 김유진
    • 한국초등수학교육학회지
    • /
    • 제11권2호
    • /
    • pp.99-115
    • /
    • 2007
  • 본 연구의 목적은 현실적 맥락을 활용한 수학화 학습을 실제 현장에 적용하여 이러한 학습이 아동의 수학적 사고에 어떠한 효과를 나타내는지 알아보는 데에 있다. 이러한 연구 목적을 위해 서울시 D초등학교 5학년 2개 학급을 연구 대상으로 6주간 17차시에 걸쳐 실험이 이루어졌고, 실험 설계는 전후 검사 통제집단 설계를 하였다. 또한 1학기말 수학 학업 성취도 평가 결과를 기준으로 선정된 실험 집단의 상(30%), 하(30%) 집단 학생들을 대상으로 하여 시기별(전기-중기-후기)로 관찰, 질문지, 녹음, 활동지와 형성평가지 분석의 방법을 사용하여 현실적 맥락을 활용한 수학화 학습을 통해 나타난 아동의 수학화 과정이 어떠한지를 각 과정별로 분석하여 살펴보았다. 그 결과 현실적 맥락을 활용한 수학화 학습을 실시한 실험집단의 경우 수학의 방법 및 내용적 측면에서 나타난 수학적 사고에서 평균 점수가 비교 집단보다 향상되었고 통계적으로도 유의미한 차이가 나타났다. 또한 현실적 맥락을 활용한 수학화 학습을 실시한 수학 집단에서 수학화 과정의 4단계인 직관적 탐구, 수평적 수학화, 수직적 수학화, 응용적 수학화 각각의 과정에서 상 하위 집단별 학생들은 수업이 전기-중기-후기로 진행되어 갈수록 각 과정의 수학화가 더욱 활발히 일어났음을 알 수 있었다.

  • PDF

하위문화 맥락에서 본 패션스타일 연구 (Study on the Styles of Subcultural Clothing: from 1930s to 1990s)

  • 양미경
    • 한국의상디자인학회지
    • /
    • 제5권1호
    • /
    • pp.33-45
    • /
    • 2003
  • This is a study that examines the fashion changes in the 20th century in terms of various subcultures in the period. Starting from defining the concept and the developing process of subculture, this study traces the history of subcultural styles from 1930s to 1990s, focusing on the way each generation resisted the main stream through its styles. This study is intended to provide a theoretical frame on the understanding of subcultural styles, with a close examination of its formative and developing process and characteristics. This study understands subcultural style as a way of deviate or resistant expression within a society. It differentiates itself from the main style by deliberately and publicly asserting its own identity, and, as a result, realizes in the form of fashion its repressed subconsciousness, resistance to the alienation from the society, and deviation from the normative ethics and morality of a society. The four types of subcultural styles presented in chapter 4 are based on their form of resistance, and they are classified and analyzed as follows: The first type is revision, which tries to revise and change the given form by adding new elements. There are two kinds of revision, one is dressing up, which dresses for success, and the other is minimal dressing. Hyperbole is the second type, which resists by emphasizing or hyperbolizing the main stream with its erotic, nihilistic, or dynamic forms. Two kinds of hyperbole are examined, one is hyperbole of masculinity, and the other is ostentatious hyperbole. The third type is reversal and rejection, which reverses the forms from the established sign system into its own secret code, or rejects the traditional taboos. This type include no dressing, and the reversal of sex identity. Isolation and redrawal is the fourth type, which tries to distance itself from the ritual code of the day. This type is divided into dressing of the escape from time, and dressing of the escape from space. The first group of this type is characterized by nostalgia or futurism. An emphasis is given on ethnicity, naturalism, or a closed space within a city in dressing of the escape from space. In conclusion, it can be said that subcultural style puts the foremost importance on individual freedom. Since 1990s, the distinction between the subcultural styles and high fashion gets somewhat blurred, while the liberal, sexual, life stylistic tension between the two groups are heightened.

  • PDF

여대생이 지각한 부모의 양육태도 (Woman College Students' Perception of Their Parent's Child-rearing Attitudes)

  • 김영희;김신정
    • Child Health Nursing Research
    • /
    • 제9권3호
    • /
    • pp.309-322
    • /
    • 2003
  • Purpose: This study was carried out to show the parental child-rearing attitudes perceived by daughters(woman college students), who were in the process of pursuit of resonable values, ethics and preparing for marriage and settling down, and another purposes were to help them to have positive attitudes toward their child-rearing in the future and set up preliminary parenting education program. Method: The subjects were 120 woman college students who were freshmen to junior in one university in Seoul. Using the self-report questionnaire, data were collected from December in 1999 to March in 2000. The contents which subjects wrote down were categorized by content analysis method. Result: 1) The age range of subjects were 19-25 years old and main rearer was mother(85.84%). 2) The perception of parent's child-rearing by subjects were revealed 555 statements and then tied together 50 themes: 'emphasizing on studying hard'(8.3%), 'doing by oneself'(5.6%), 'sternness'(5.2%), 'respect of personality'(4.5%), 'eagerness'(4.0%), 'humanity education'(4.0%), 'moderating in daily living'(4.0%), 'propriety education'(3.8%), 'sacrificing for children'(3.6%), 'expectation'(3.2%), 'concerning'(3.1%), 'parent-centered'(3.1%), 'giving a free hand'(2.9%), 'sharing with'(2.9%), 'consideration'(2.7%), 'over-protectiveness'(2.3%), 'hostile attitude' (2.2%), 'corporal punishment'(2.2%), 'expression of parental love'(2.0%), 'encouragement'(1.8%), 'family-centered' (1.8%), 'treating fairly'(1.6%), 'offering live experiences'(1.6%), 'exacting obedience'(1.62%), 'exemplary parental role' (1.6%), 'sexual discrimination'(1.6%), 'cooperation'(1.4%), 'giving favors'(1.4%), 'indifference'(1.4%), 'understanding' (1.3%), 'confidence'(1.3%), 'intimacy'(1.3%), 'pursuit of health'(1.3%), 'warm-hearted'(1.1%), 'stinginess'(1.1%),'broad-mindedness'(0.7%), 'granting'(0.7%), 'interfering'(0.7%), 'reproach'(0.7%), 'distinction of sex in household affairs'(0.7%), 'help'(0.5%), 'preparing for the future'(0.5%), 'disregarding'(0.5%), 'making environment'(0.4%), 'bringing up a child personally' (0.4%), 'comparing'(0.4%), 'religious life'(0.4%), 'good deed'(0.4%), invasion of privacy' (0.2%), 'controlling desire'(0.2%). 3) 50 themes were categorized by 18 categories once more: 'control' (13.2%), 'crazy for education'(12.3%), 'endeavoring'(8.6%), 'autonomy'(8.5%), 'home education'(7.7%), 'esteem' (6.67%), 'support'(6.67%), 'pursuit of healthy daily life'(5.6%), 'earnestness'(5.4%), 'disregarding personality'(5.4%), 'emotional bonding'(3.2%), 'imposing a burden'(3.2%). 'inhospitality'(3.1%), 'acceptance'(5%), 'discrimination'(2.3%), 'mature parenthood'(1.8%), 'strengthening family tie'(1.8%), 'psychological intimacy'(1.1%). 4) On the basis of this study, 3/5 of subjects(61.2%) perceived their parents had mature and autonomous child-rearing attitudes, and on the other hand 2/5(39.5%) of them perceived controlling, just forcing to work harder and personally disregarding attitudes. Conclusion: So we need to offer them nursing implementation such as preliminary parenting education program and parenting consulting like to strengthen positive perception and help improving in realistic, developmental child-rearing attitudes.

  • PDF

지역주민과 건강행태와 국민건강증진법에 대한 인식과 태도 (Health Behavior and Attitude of Residents toward the National Health Promotion Law in Kyungsan City)

  • 이관희;박재용;한창현;윤석옥
    • 보건교육건강증진학회지
    • /
    • 제16권2호
    • /
    • pp.19-40
    • /
    • 1999
  • In order to ascertain the attitudes of residents to their health and the National Health Promotion Law, surveyors interviewed 1,220 subjects, 1% of men and women in Kyungsan city, who were twenty-year-old or more. The major findings are as follows: Men and women were 48.2% and 51.8%, respectively. The recognition rate of enacting and enforcing this law is 59.2% of men and 51.3% of women. With regard to the behavioral attitude to the health in the distinction of sex and age, current smokers are 31.2% of the interviewees, 61.6% of the men and 3.3% of the women. Current drinkers are 35.1%, 59.5% of the men and 12.3% of the women, but on the other hand there is little significance in the distinction of age. The acknowledgement proportion of enacting and enforcing this law is 59.2% of male and 51.3% of female. In terms of the recognition rate of the contents according to the general characteristics of interviewees, it appears that the indication of a warning expression on a packing paper of cigarette case and a liquor bottle is 92.4% and also the designation of a smoking free area in public facilities is 94.8%. Prohibition of cigarette-sale to the teenagers who are under 19, is 96.0%. Considering these facts, the recognition rate is high. On the contrary, 48.8% is accounted for encouraging a medical check-up before marriage which is in a low position. As a result of multiple behavior as a independent educational level, marital significant variables. In case of having undergone a periodic medical examination the recognition rate was high whereas frequent exercise led to the low recognition rate. Concerning the details of the undertaking in accordance with each factor of general characteristics, the greater part of them have been appraised successfully whether it is recognized or not. On the other side, no effect got answered about the result of the undertaking subjects to general and peculiar behavior attitude towards health was in effect or not. A great majority approved of more reinforcement of legal regulation about smoking and drinking regardless of whether they perceived the details of the law of promotion of National Health Promotion Law or not. Additionally there was significant difference in reinforcing legal regulation of smoking and drinking in compliance with the attitude of the substance of this law. With regard to education, public relations and evaluation about national health through public health centers by our government, the younger and the higher in education they are, the more deficient they feel. First of all, those who were aware of the enforcement of this law as well as plenty of scarcity answered that better service of disease prevention had to be expanded than ever. In consideration of the above-stated results, the education to public health and the business of public relations should be reinforced and a practical campaign for health life should also spread out for the purpose of encouraging to practise healthy life-style.

  • PDF

Roles of CYP1A1 and CYP2E1 Gene Polymorphisms in Oral Submucous Fibrosis

  • Yaming, Punyo;Urs, Aadithya Basavaraj;Saxena, Alpana;Zuberi, Mariyam
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제17권7호
    • /
    • pp.3335-3340
    • /
    • 2016
  • Background: Oral submucous fibrosis (OSF) is a precancerous condition with a 4 to13% malignant transformation rate. Related to the habit of areca nut chewing it is mainly prevalent in South-east Asian countries where the habit of betel quid chewing is frequently practised. On chewing, alkaloids and polyphenols are released which undergo nitrosation and give rise to N-nitrosamines which are cytotoxic agents. CYP450 is a microsomal enzyme group which metabolizes various endogenous and exogenous chemicals including those released by areca nut chewing. CYP1A1 plays a central role in metabolic activation of these xenobiotics, whereas CYP2E1 metabolizes nitrosamines and tannins. Polymorphisms in genes that code for these enzymes may alter their expression or function and may therefore affect an individuals susceptibility regarding OSF and oral cancer. The present study was therefore undertaken to investigate the association of polymorphisms in CYP1A1 m2 and CYP2E1 (RsaI/PstI) sites with risk of OSF among areca nut chewers in the Northern India population. A total of 95 histopathologically confirmed cases of OSF with history of areca nut chewing not less than 1 year and 80, age and sex matched controls without any clinical signs and symptoms of OSF with areca nut chewing habit not less than 1 year were enrolled. DNA was extracted from peripheral blood samples and polymorphisms were analyzed by PCR-RFLP method. Gene polymorphism of CYP1A1 at NcoI site was observed to be significantly higher (p = 0.016) in cases of OSF when compared to controls. Association of CYP1A1 gene polymorphism at NcoI site and the risk of OSF (Odd's Ratio = 2.275) was also observed to be significant. However, no such association was observed for the CYP2E1 gene polymorphism (Odd's Ratio = 0.815). Our results suggest that the CYP1A1 gene polymorphism at the NcoI site confers an increased risk for OSF.

Association of DNA Base-excision Repair XRCC1, OGG1 and APE1 Gene Polymorphisms with Nasopharyngeal Carcinoma Susceptibility in a Chinese Population

  • Li, Qing;Wang, Jian-Min;Peng, Yu;Zhang, Shi-Heng;Ren, Tao;Luo, Hao;Cheng, Yi;Wang, Dong
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제14권9호
    • /
    • pp.5145-5151
    • /
    • 2013
  • Background: Numerous carcinogens and reactive oxygen species (ROS) may cause DNA damage including oxidative base lesions that lead to risk of nasopharyngeal carcinoma. Genetic susceptibility has been reported to play a key role in the development of this disease. The base excision repair (BER) pathway can effectively remove oxidative lesions, maintaining genomic stability and normal expression, with X-ray repair crosscomplementing1 (XRCC1), 8-oxoguanine glycosylase-1 (OGG1) and apurinic/apyimidinic endonuclease 1 (APE1) playing important roles. Aims: To analyze polymorphisms of DNA BER genes (OOG1, XRCC1 and APE1) and explore their associations, and the combined effects of these variants, with risk of nasopharyngeal carcinoma. Materials and Methods: We detected SNPs of XRCC1 (Arg399Gln), OGG1 (Ser326Cys), APE1 (Asp148Glu and -141T/G) using the polymerase chain reaction (PCR) with peripheral blood samples from 231 patients with NPC and 300 healthy people, furtherly analyzing their relations with the risk of NPC in multivariate logistic regression models. Results: After adjustment for sex and age, individuals with the XRCC1 399Gln/Gln (OR=1.96; 95%CI:1.02-3.78; p=0.04) and Arg/Gln (OR=1.87; 95%CI:1.29-2.71; p=0.001) genotype variants demonstrated a significantly increased risk of nasopharyngeal carcinoma compared with those having the wild-type Arg/Arg genotype. APE1-141G/G was associated with a significantly reduced risk of NPC (OR=0.40;95%CI:0.18-0.89) in the smoking group. The OR calculated for the combination of XRCC1 399Gln and APE1 148Gln, two homozygous variants, was significantly additive for all cases (OR=2.09; 95% CI: 1.27-3.47; p=0.004). Conclusion: This is the first study to focus on the association between DNA base-excision repair genes (XRCC1, OGG1 and APE1) polymorphism and NPC risk. The XRCC1 Arg399Gln variant genotype is associated with an increased risk of NPC. APE1-141G/G may decrease risk of NPC in current smokers. The combined effects of polymorphisms within BER genes of XRCC1 399Gln and APE1 148Gln may contribute to a high risk of nasopharyngeal carcinoma.

구강 편평세포암에서 예후 및 경부임파절 전이와 관련한 증식인자의 발현에 관한 연구 (PROGNOSTIC VALUE OF PROLIFERATION FACTORS IN ORAL SQUAMOUS CELL CARCINOMA)

  • 팽준영;옥용주;윤필영;명훈;황순정;서병무;최진영;이종호;정필훈;김명진
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
    • /
    • 제32권2호
    • /
    • pp.101-106
    • /
    • 2006
  • Purpose: The purpose of this study is to evaluate the value of proliferation factors, Ki67 and PCNA, as prognostic markers predicting the survival and neck metastasis in patients with oral cancer. Methods: 101 patients with HNSCCs, were followed retrospectively for a median period of 60 months(from 16 to 82 months). All tumors were resected surgically and examined by conventional light microscopy, immunohistochemistry. The age, sex, tumor location, clinical stage(size), metastasis, proliferative activity index(assessed by proliferating cell nuclear antigen(PCNA) and Ki67 immunoreactivity) were considered as potential prognostic factors and were correlated with patient survival. Results: Ki67 staining results ranged from 5% to 80% of tumor cell nuclei, with a median of 25%. PCNA staining results ranged from 1% to 90% with a median of 50%. With a cut-off point of 25%, patients with lower Ki67 scores showed survival advantages over those with higher Ki67 scores (p=0.0089). With cut-off point of 50%, patients with lower PCNA scores showed survival advantages over those with higher PCNA scores (p=0.0104). Pathologically neck node positive patients(n=27) showed higher PCNA expression(p=0.02) than pathologically negative neck node patients(n=39). Conclusions: The lower expressions of Ki67 and PCNA were associated with favorable prognosis such as higher survival rate and lower neck node metastasis.