• Journal of Trauma and Injury
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• 제25권4호
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• pp.223-229
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• 2012

Purpose: The arterial base deficit and the serum lactate level are widely recognized indicators of injury severity, adequacy of resuscitation and outcome. The purpose of this study is to evaluate the usefulness of the arterial base deficit as an injury-severity indicator in multiple-trauma patients with head injuries. Methods: Data were retrospectively collected from trauma patients over 18 years of age who had been admitted at the emergency center between October 2005 and July 2006. The patients were divided into head-injury and non-head-injury groups. These patients were then sub-divided into minor ($$ISS{\leq_-}15$$)-injury and major ($$ISS{\geq_-}16$$)-injury groups according to their injury severity scores (ISS). We analyzed the differences in the base deficits and the serum lactate levels between the major- and the minor-injury sub-groups in both the head-injury and the non-head-injury groups. Results: In the non-head-injury group, we found statistically significant differences in the arterial base deficit between the major-injury and the minor-injury sub-groups($-6.86{\pm}2.40mmol/L$ vs. $-1.37{\pm}0.73mmol/L$, p=0.010). In the head-injury group, no significant differences were noted between the two sub-groups($-2.50{\pm}1.28mmol/L$ vs. $-1.51{\pm}0.74mmol/L$, p=0.897). Moreover, the differences in arterial base deficit between the major-injury and the minor-injury sub-groups were not significant both for either single-head-trauma or multiple-head-trauma patients (p=0.643 vs. p=0.832). Conclusion: We conclude that neither the arterial base deficit nor the serum lactate level can be used to predict injury severity in multiple-trauma patients with head injuries.

• 한국수자원학회논문집
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• 제46권2호
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• pp.195-204
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• 2013

가뭄은 불가피성과 반복성을 가진 자연 현상이므로 가뭄 발생 전 사전대비계획과 가뭄발생시 가뭄관리체계 구축을 통해 그 피해를 최소화해야 한다. 본 연구에서는 대상지역의 가뭄심도를 평가하여 가뭄상황에 대처하고자 우리나라에 적합한 가뭄 분류기준을 제시하였다. 관측년수 30년 이상의 강우자료를 확보한 61개 지점에 대해 1973년부터 37년 기간의 월강우량 자료를 사용하였고, 현재 국가에서 사용하고 있는 가뭄상황단계를 그대로 적용하여 가뭄 구간을 총 4등급으로 구분하였다. 기존의 주요 가뭄발생현황을 참고하여 우리나라에 맞는 가뭄심도의 분류기준을 가뭄 발생의 누가확률 98~100%는 예외적인 가뭄, 94-98%는 극심 가뭄, 90~94%는 심한 가뭄, 86~90%는 보통 가뭄으로 구분하였다. 각 지점의 가뭄지수(SPI, PDSI)를 내림차순으로 작성하여 가뭄심도 분류기준에 맞는 가뭄지수의 정량적 값을 산정하였다. SPI와 PDSI의 가뭄심도 분류 결과와 실제 가뭄을 비교하기 위해 년 단위 비교와 월 단위 비교를 분석한 결과, 년 단위 비교와 SPI의 월 단위 비교는 각 지역의 가뭄지수 평가가 대부분 일치하게 나타났으나 같은 기간의 PDSI의 월 단위 비교는 일치하지 않는 기간도 나타났다. 이는 이들 지수의 상호보완에 대한 추후 연구의 필요성을 보여주는 것으로 판단되었다.

• 한국ITS학회 논문지
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• 제18권2호
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• pp.12-28
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• 2019

도로기하구조는 교통사고를 발생시키는 다양한 요인 중 하나이지만, 동일한 도로기하구조 조건하에서도 기상상태에 따라 교통사고에 미치는 영향이 다르게 나타난다. 본 연구에서는 2001년부터 2014년까지 14년간 전국 고속도로 사고자료와 기상자료를 매칭하여 교통사고 심각도에 영향을 미치는 변수들을 분석하였다. 도로기하구조와 기상상태의 상호작용이 사고심각도에 미치는 영향뿐만 아니라, 개별사고 심각도 간의 지역별 상관성을 반영하기 위해 위계적 순서형 모형을 사용하였다. 위계적 모형 중에서도 도로기하구조와 기상상태의 상호작용 변수를 포함한 임의절편모형과 기상상태의 지역별 특성을 상위변수로 포함하는 임의계수모형을 모두 활용하였다. 분석결과 톨게이트 및 램프구간, 내리막 경사 3%이상, 콘크리트 방호벽 등이 기상상태에 따라 사고 심각도에 미치는 영향이 달라지는 것을 확인하였다. 또한 도로기하구조와 기상상태의 복합적인 영향은 강우량 또는 강설량에 선형적이지 않을 수 있음을 보여주었다. 끝으로 본 연구의 분석결과를 기반으로 안전개선 대책을 제시하였으며, 이를 토대로 향후 교통사고 심각도 감소가 가능할 것으로 기대된다.

• Molecules and Cells
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• 제40권6호
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• pp.418-425
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• 2017

Interferon-${\gamma}$-inducible protein 10 (IP-10), also known as chemokine C-X-C motif ligand (CXCL) 10, is closely associated with antiviral immunity and the progression of chronic hepatitis B (CHB). However, the value of baseline serological and histological IP-10 expression levels in predicting the efficacy of the antiviral response to nucleoside/nucleotide analogues (NAs) is still unknown. In our research, intrahepatic and peripheral IP-10 expression levels were systemically examined before and after treatment with entecavir (ETV). Baseline serological and histological IP-10 expression levels were significantly increased in patients with CHB, particularly in patients with higher degrees of liver inflammation and liver fibrosis. Moreover, higher baseline intrahepatic IP-10 levels indicated better prognoses in patients with CHB after entecavir therapy. The baseline IP-10 level was also positively associated with several clinical parameters, including baseline levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), hepatitis B virus (HBV) DNA, and hepatitis B surface antigen (HBsAg), and with the decrease in HBsAg levels after treatment. In addition, monocyte-derived IP-10 was expressed at higher levels in patients with CHB than in patients with liver cirrhosis (LC) and healthy controls (HC). According to the results of our in vitro experiments, IP-10 directly promoted hepatocyte apoptosis. Based on these findings, baseline serological and histological IP-10 levels might predict CHB severity and the decrease in HBsAg levels after entecavir therapy.

• 한국군사과학기술학회지
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• 제4권1호
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• pp.234-245
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• 2001

This paper considers the Maximum Pesponse Spectrum for the random vibration, sinusoidal vibration, linear sweep vibration. The random vibration quality levels and the sinusoidal vibration quality level are compared using MRS. And the severity between the vibration test specification and real environments using Maximum Response Spectrum are also compared using it.

• 대한안전경영과학회지
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• 제17권1호
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• pp.169-177
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• 2015

We develop a model to predict typhoons in Korea. We collect data for typhoons and classify those depending on the severity level. Following a Bayesian approach, we develop a model that explains the relationship between different levels of typhoons. Through the analysis of the model, we can predict the rate of typhoons, the probability of approaching Korean peninsular, and the probability of striking Korean peninsular. We show that the uncertainty for the occurrence of various types of typhoons reduces dramatically by adaptively updating model parameters as we acquire data.

• The Plant Pathology Journal
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• 제18권3호
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• pp.147-151
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• 2002

Seven fungicides were compared for the control of downy mildew on midge gourd. All treatments had significantly lower rates of disease progress curves and disease severity levels than that of the control. The highest yields were obtained from crops treated with metalaxyl + mancozeb, fosetyl-Al, and chlorothalonil. These treatments also proved to be the most economical considering the treatment costs.

• 한국안전학회지
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• 제16권1호
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• pp.37-42
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• 2001

The severity of electric shock is entirely dependent on body resistance. When the human body becomes a part of electric circuit, the body resistance is given as a function of shock scenario. Factors which consist of applied voltage, shock duration, body current path and contact area, etc.. The body resistance is defined as the voltage applied to subjects divided by the body current. To secure safety of the subjects, the experiment is conducted on 10 subjects, the body current is limited to 4mA. And only three factors under many shock scenario conditions are used to determine the body resistance. The three factors are the applied voltage, the current pathway and the contact area. The object of this work is to estimate the dynamic resistance of the human body as a function of applied voltage using the body current at low-voltage levels. The data of the body current at low-voltage levels are extrapolated to high-voltage levels using two analytic functions with specified constants calculated by numerical method. Also we can provide permissible body voltage for various copper electrodes on the basis of the data determined with the dynamic resistance and the body current.

• Clinical and Experimental Pediatrics
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• 제56권1호
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• pp.8-12
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• 2013

Asthma is associated with increased levels of eosinophils in tissues, body fluids, and bone marrow. Elevated levels of eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) have been noted in asthma patients. Higher levels of EDN and ECP are also associated with exacerbated asthmatic conditions. Thus, EDN, along with ECP, may aid the diagnosis and monitoring of asthma. Several groups have suggested that EDN is more useful than ECP in evaluating disease severity. This may partially be because of the recoverability of EDN (not sticky, 100% recovery rate), as ECP is a sticky and more highly charged protein. In terms of clinical utility, EDN level is a more accurate biomarker than ECP when analyzing the underlying pathophysiology of asthma. As a monitoring tool, EDN has shown good results in children with asthma as well as other allergic diseases. In children too young to fully participate in lung function tests, EDN levels may be useful as an alter native measurement of eosinophilic inflammation. EDN can also be used in adult patients and in multiple specimen types (e.g., serum, sputum, bronchoalveolar lavage fluid, and nasal lavage fluid). These results are repeatable and reproducible. In conclusion, EDN may be a novel biomarker for the diagnosis, treatment, and monitoring of asthma/allergic disease.

• 음성과학
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• 제8권1호
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• pp.135-142
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• 2001

The present study was performed to investigate adequate levels of utterances which can give essential as well as useful information about the patients' voice, by examining the degrees of correlation between the levels of utterances (vowels, words, and phrase paragraph reading) and the entire utterance including all of the levels. For this purpose, a total of 10 individual utterance samples (5 vowels, 3 words, 1 phrase, 1 paragraph reading) were collected from each of the 30 subjects with voice disorder patients, and four experienced voice therapists evaluated them using GRBAS. The results showed that four therapists highly agreed upon on 'G' parameter. The coefficient of the correlation between each level of utterance and entire utterance tended to be above 0.70. Judgements of the vowel /$\varepsilon$/ as well as /o/ highly correlated with the judgement of the entire utterance. Regardless of severity, the judgement of the entire utterance highly correlated with the judgements of the vowel /u/ and the paragraph reading. These results suggest that experienced voice therapists can precisely evaluate patients' voice quality with only one sustained vowel in the clinic field, as is done with the entire utterance evaluation.